LOCUS       NM_013361               2399 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens zinc finger protein 223 (ZNF223), mRNA.
ACCESSION   NM_013361
VERSION     NM_013361.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2399)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   2  (bases 1 to 2399)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2399)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2399)
  AUTHORS   Shannon,M., Hamilton,A.T., Gordon,L., Branscomb,E. and Stubbs,L.
  TITLE     Differential expansion of zinc-finger transcription factor loci in
            homologous human and mouse gene clusters
  JOURNAL   Genome Res 13 (6A), 1097-1110 (2003)
   PUBMED   12743021
REFERENCE   5  (bases 1 to 2399)
  AUTHORS   Rosati,M., Franze,A., Matarazzo,M.R. and Grimaldi,G.
  TITLE     Coding region intron/exon organization, alternative splicing, and
            X-chromosome inactivation of the KRAB/FPB-domain-containing human
            zinc finger gene ZNF41
  JOURNAL   Cytogenet Cell Genet 85 (3-4), 291-296 (1999)
   PUBMED   10449920
REFERENCE   6  (bases 1 to 2399)
  AUTHORS   Shannon,M., Ashworth,L.K., Mucenski,M.L., Lamerdin,J.E.,
            Branscomb,E. and Stubbs,L.
  TITLE     Comparative analysis of a conserved zinc finger gene cluster on
            human chromosome 19q and mouse chromosome 7
  JOURNAL   Genomics 33 (1), 112-120 (1996)
   PUBMED   8617494
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC022466.1, DR761157.1, AF187989.1, AC092072.2 and HY311227.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_013361.5.
            
            Summary: This gene encodes a protein containing a
            Kruppel-associated box domain and multiple zinc finger domains. The
            function of this protein has yet to be determined. [provided by
            RefSeq, Mar 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA626060.1, SRR1803612.91965.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000434772.8/ ENSP00000401947.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-449               BC022466.1         26-474
            450-1002            DR761157.1         302-854
            1003-1400           BC022466.1         1028-1425
            1401-1967           AF187989.1         1411-1977
            1968-2294           BC022466.1         1993-2319
            2295-2295           AC092072.2         27434-27434
            2296-2394           HY311227.1         1-99                c
            2395-2399           AC092072.2         27534-27538
FEATURES             Location/Qualifiers
     source          1..2399
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..2399
                     /gene="ZNF223"
                     /note="zinc finger protein 223"
                     /db_xref="GeneID:7766"
                     /db_xref="HGNC:HGNC:13016"
     exon            1..160
                     /gene="ZNF223"
                     /inference="alignment:Splign:2.1.0"
     exon            161..243
                     /gene="ZNF223"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..1677
                     /gene="ZNF223"
                     /note="Homo sapiens zinc finger protein 223; KRAB A
                     domain"
                     /codon_start=1
                     /product="zinc finger protein 223"
                     /protein_id="NP_037493.3"
                     /db_xref="CCDS:CCDS12635.1"
                     /db_xref="GeneID:7766"
                     /db_xref="HGNC:HGNC:13016"
                     /translation="MTMSKEAVTFKDVAVVFTEEELGLLDLAQRKLYRDVMLENFRNL
                     LSVGHQPFHRDTFHFLREEKFWMMDIATQREGNSGGKIQPEMKTFPEAGPHEGWSCQQ
                     IWEEIASDLTRPQDSTIKSSQFFEQGDAHSQVEEGLSIMHTGQKPSNCGKCKQSFSDM
                     SIFDLPQQIRSAEKSHSCDECGKSFCYISALHIHQRVHLGEKLFKCDVCGKEFSQSLH
                     LQTHQRVHTGEKPFKCEQCGRGFRCRSALTVHCKLHMGEKHYNCEACGRAFIHDFQLQ
                     KHQRIHTGEKPFKCEICSVSFRLRSSLNRHCVVHTGKKPNSTGEYGKGFIRRLDLCKH
                     QTIHTGEKPYNCKECGKSFRRSSYLLIHQRVHTGEKPYKCDKCGKSYITKSGLDLHHR
                     AHTGERPYNCDDCGKSFRQASSILNHKRLHCRKKPFKCEDCGKKLVYRSYRKDQQKNH
                     SGENPSKCEDCGKRYKRRLNLDIILSLFLNDT"
     exon            244..370
                     /gene="ZNF223"
                     /inference="alignment:Splign:2.1.0"
     exon            371..463
                     /gene="ZNF223"
                     /inference="alignment:Splign:2.1.0"
     exon            464..2399
                     /gene="ZNF223"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1799..1804
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF223"
                     /note="hexamer: ATTAAA"
     polyA_site      1821
                     /gene="ZNF223"
                     /note="major polyA site"
     regulatory      1829..1834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF223"
                     /note="hexamer: AATAAA"
     polyA_site      1849
                     /gene="ZNF223"
     regulatory      2368..2373
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF223"
                     /note="hexamer: AATAAA"
     polyA_site      2399
                     /gene="ZNF223"
ORIGIN      
        1 agtctgaggt tcctgcttta atgaccgggg tagtttgagc catttctgcg tcttgcagga
       61 cattttgaac gaaccccctt tgcttgaggc tcgcaaccac ccgatgatcg atgatcgtct
      121 caggggaaaa gaagccttgg cgaagagcag aggtttagag gcacaattct gctttccctg
      181 gaactgtgtc attcaggact ctgcaaattc cctaaagtag gaggaaaaat gaccatgtcc
      241 aaggaggcag tgaccttcaa ggatgtggca gtggtcttca ctgaggagga gctggggctg
      301 ctggaccttg cccagaggaa gctgtatcga gatgtgatgc tggagaactt caggaacctg
      361 ctgtcagtgg ggcatcaacc attccaccga gatactttcc actttctaag ggaggaaaag
      421 ttttggatga tggatatagc aacccaaagg gaagggaatt caggaggcaa gatccaacct
      481 gagatgaaga cttttccaga agcaggacca catgaagggt ggtcctgcca gcagatctgg
      541 gaagaaattg caagtgattt aaccaggcct caagactcta ccataaagag ctctcagttc
      601 tttgaacagg gtgatgccca ctcccaggtt gaggaaggac tatctataat gcacacagga
      661 cagaaacctt ccaattgtgg gaagtgtaaa caatccttca gtgatatgtc catctttgat
      721 cttcctcagc aaatacgctc agcagagaag tctcattcct gtgatgagtg tggaaaaagc
      781 ttctgttaca tctcagcgct tcatattcat cagagagtcc acctgggaga gaaactcttt
      841 aagtgtgacg tgtgtggtaa ggaattcagt cagagtttac atctgcaaac tcatcagaga
      901 gtccatactg gagagaaacc tttcaaatgt gaacaatgtg ggagaggctt cagatgtaga
      961 tcagcactta cagttcattg caaattacac atgggagaga aacattataa ttgtgaggca
     1021 tgtgggaggg ccttcattca tgatttccag cttcagaaac atcagagaat tcacacaggg
     1081 gagaagccat tcaaatgtga gatatgtagt gtgagcttcc gtcttaggtc aagtcttaat
     1141 aggcattgtg tggtccacac aggaaagaaa ccaaacagca ctggggaata tggaaaaggc
     1201 ttcattcgta ggctggattt gtgtaagcat cagacgatcc acacaggaga gaaaccatat
     1261 aattgtaaag aatgtgggaa gagcttcaga cggtcctcct atcttttgat ccatcagcga
     1321 gtccacactg gagaaaagcc atacaaatgt gacaagtgtg ggaagagcta cattactaag
     1381 tcaggtcttg acttgcacca tagagcccac acaggagaga gaccttataa ctgtgatgac
     1441 tgtgggaaga gctttagaca ggcctcaagt attttgaatc ataagagact ccattgccga
     1501 aaaaaaccat tcaaatgtga ggattgtgga aagaagcttg tataccggtc ataccgtaaa
     1561 gaccaacaaa aaaaccacag tggagaaaat ccatccaaat gtgaagactg tgggaagcgc
     1621 tacaagaggc gcttgaatct tgatataatt ttatcattat ttttaaatga cacgtaagtg
     1681 ttgtacatat ttatggggta cagtgtgata tttaaatata tgtatatgat gtataatgat
     1741 caaatcagtg taattagcac atttatcacc tcaattatct cttttttgtg ttgagaaaat
     1801 taaaaattca ttgttccagc agtttgaaaa taaattgttg tcgatgatag tcacctttag
     1861 tgctgcagaa cagcagaact tcttcctctt atctacctgt acttttgcat ccattagcca
     1921 acctttggcc atcccaccta tcccttaccc ttccctgcct ctagagccac tgttctcact
     1981 acttctaaga aatcagcttt ttaagcttcc ccatgtgatt gaggacagtt tgaagttagt
     2041 gtttcagcca tagctcagca taccccagtg gtcgtgggac tgtcagagca gagaatgctg
     2101 cagggtttct aacagaagtt tgacaattag ttattattca ggagacaggt cttagtataa
     2161 gagtttgttc acacactttc aaaacactaa tgatgaacat gtcaaaattg atgaccacta
     2221 gaatgtcagc cacatgtgtc tttgtatttt tgctgcatcc ttacattgct tgagtctgga
     2281 agattgaggc tgcactgacc tatggtagtg ctactgcact ccagccaggg caacagagtg
     2341 agaccctgtc tccaaaaaaa aaaattaaat aaataccttt ctttgtttct agacaagca
//
