LOCUS       NM_001129996            1614 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens zinc finger protein 222 (ZNF222), transcript variant
            1, mRNA.
ACCESSION   NM_001129996
VERSION     NM_001129996.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1614)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   2  (bases 1 to 1614)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   3  (bases 1 to 1614)
  AUTHORS   Shannon,M., Hamilton,A.T., Gordon,L., Branscomb,E. and Stubbs,L.
  TITLE     Differential expansion of zinc-finger transcription factor loci in
            homologous human and mouse gene clusters
  JOURNAL   Genome Res 13 (6A), 1097-1110 (2003)
   PUBMED   12743021
REFERENCE   4  (bases 1 to 1614)
  AUTHORS   Constantinou-Deltas,C.D., Gilbert,J., Bartlett,R.J.,
            Herbstreith,M., Roses,A.D. and Lee,J.E.
  TITLE     The identification and characterization of KRAB-domain-containing
            zinc finger proteins
  JOURNAL   Genomics 12 (3), 581-589 (1992)
   PUBMED   1559709
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB185422.1 and BC030261.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001129996.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and it encodes the longer protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.136505.1,
                                           SRR1803614.114954.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391960.4/ ENSP00000375822.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DB185422.1         38-58
            22-1614             BC030261.1         1-1593
FEATURES             Location/Qualifiers
     source          1..1614
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..1614
                     /gene="ZNF222"
                     /note="zinc finger protein 222"
                     /db_xref="GeneID:7673"
                     /db_xref="HGNC:HGNC:13015"
                     /db_xref="MIM:617357"
     exon            1..100
                     /gene="ZNF222"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1534
                     /gene="ZNF222"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 222 isoform 1"
                     /protein_id="NP_001123468.1"
                     /db_xref="CCDS:CCDS46098.1"
                     /db_xref="GeneID:7673"
                     /db_xref="HGNC:HGNC:13015"
                     /db_xref="MIM:617357"
                     /translation="MIDSGEKKPGRRAEEAVTFKDVAVIFTEEELGLLDPAQRKLYRD
                     VMLENFRNLLSVGHQPFHGDTFHFLREEKFWVMGTTSQREGNLGGKIQTEMETVPEAG
                     THEEFSCKQIWEQIASDLTRSQDTTISNSQLFEQDDNPSQIKARLSTVHTREKPFQGE
                     NCKQFFSDVSFFDLPQQLYSGEKSHTCDECGKSFCYISALHIHQRVHMGVKCYKCDVC
                     GKEFSQSSRLQTHQRVHTGEKPFKCEQCGKGFRCRSALKVHCKLHMREKPYNCEKCGK
                     AFMHNFQLQKHHRIHTGEKPFKCEICGKSFCLRSSLNRHCMVHTAEKLYKSEKYGRGF
                     IDRLDLHKHQMIHMGQKPYNCKECGKSFKWSSYLLVHQRVHTGEKPYKCEECGKGYIS
                     KSGLDFHHRTHTGERSYNCDNCGKSFRHASSILNHKKLHCQRKPLKCEDCGKRLVCRS
                     YCKDQQRDHSGENPSKCEDCGKRYKRRLNLDIILSLFLNDI"
     exon            101..227
                     /gene="ZNF222"
                     /inference="alignment:Splign:2.1.0"
     exon            228..320
                     /gene="ZNF222"
                     /inference="alignment:Splign:2.1.0"
     exon            321..1614
                     /gene="ZNF222"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1588..1593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF222"
                     /note="hexamer: ATTAAA"
     polyA_site      1614
                     /gene="ZNF222"
                     /note="major polyA site"
ORIGIN      
        1 ccacatcttg cgagtccttc cgaacgagtc tcctttcctt ggggctcgca accacccaat
       61 gatcgattca ggagaaaaga agcctgggcg gagagcagag gaggcagtga ccttcaagga
      121 tgtggctgtg atcttcactg aggaggagct ggggctgctg gaccctgccc agaggaagct
      181 gtaccgagat gtgatgcttg agaacttcag gaacctgctc tcagtggggc atcaaccatt
      241 ccatggagat actttccact tcctaaggga agaaaagttt tgggtgatgg ggacaacaag
      301 ccaaagagaa gggaatttgg gaggcaagat ccaaactgag atggagactg ttccagaagc
      361 aggaacacat gaagaatttt cctgcaagca aatttgggaa caaattgcaa gtgacttaac
      421 caggtctcaa gataccacca taagtaactc tcagttattt gaacaagatg acaacccctc
      481 ccagattaaa gcaagactat ctacagttca cacaagagaa aaacctttcc agggtgaaaa
      541 ttgtaaacag ttcttcagtg atgtttcctt ctttgatctt cctcagcagt tatattcagg
      601 agagaagtct catacctgtg atgagtgtgg aaaaagcttc tgttacatct cagcccttca
      661 tattcatcag agggtccaca tgggagtgaa atgctataag tgtgatgtgt gtggtaagga
      721 atttagtcag agctcacgtc tgcaaactca tcaaagagtc cacactggag agaaaccatt
      781 caaatgtgag cagtgtggga aaggcttcag atgtagatca gcacttaaag ttcattgcaa
      841 attacacatg agagagaaac cttataattg tgagaaatgt gggaaggctt tcatgcacaa
      901 tttccagctt cagaaacatc acagaattca tactggggag aagccattca aatgtgaaat
      961 atgtggtaag agcttctgtc ttaggtcaag tcttaatagg cattgcatgg tccacacagc
     1021 agagaaactg tacaaatctg aaaagtatgg aagaggtttc attgataggc tagatttgca
     1081 taagcatcag atgattcata tgggacagaa accatataat tgtaaagaat gtgggaagag
     1141 cttcaaatgg tcctcatatc ttttggtcca tcaacgagtc cacactggag aaaagccata
     1201 caaatgtgag gagtgtggga agggctacat tagtaagtca ggtcttgact tccaccatag
     1261 aacccacacg ggagagagat cttataactg tgataactgc gggaagagct ttagacatgc
     1321 ttctagtatt ttgaatcata agaaactcca ctgccaaaga aagccattga aatgtgaaga
     1381 ctgtggaaag aggcttgtat gccggtcata ctgtaaagac caacaaagag accacagtgg
     1441 agaaaaccca tccaaatgtg aggactgtgg gaagcgctac aagaggcgct tgaatctgga
     1501 tataatttta tcattatttt taaatgacat ataagttata catatttatg gagtgtgaaa
     1561 tttgatacat gtatataatg tgtgctgatt aaatcagttt aatttcacct gaaa
//
