LOCUS       NM_001297588            2382 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens zinc finger protein 221 (ZNF221), transcript variant
            2, mRNA.
ACCESSION   NM_001297588 XM_005259206
VERSION     NM_001297588.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2382)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2382)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   3  (bases 1 to 2382)
  AUTHORS   Shannon,M., Hamilton,A.T., Gordon,L., Branscomb,E. and Stubbs,L.
  TITLE     Differential expansion of zinc-finger transcription factor loci in
            homologous human and mouse gene clusters
  JOURNAL   Genome Res 13 (6A), 1097-1110 (2003)
   PUBMED   12743021
REFERENCE   4  (bases 1 to 2382)
  AUTHORS   Rosati,M., Franze,A., Matarazzo,M.R. and Grimaldi,G.
  TITLE     Coding region intron/exon organization, alternative splicing, and
            X-chromosome inactivation of the KRAB/FPB-domain-containing human
            zinc finger gene ZNF41
  JOURNAL   Cytogenet Cell Genet 85 (3-4), 291-296 (1999)
   PUBMED   10449920
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA493401.1, AF187987.1, AK314207.1, AC006213.1 and KF459580.1.
            
            On Feb 27, 2020 this sequence version replaced NM_001297588.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK314207.1, SRR1803615.160997.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000587682.6/ ENSP00000467367.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                DA493401.1         6-22
            18-44               AF187987.1         1-27
            45-709              AK314207.1         45-709
            710-985             AC006213.1         44343-44618         c
            986-1382            KF459580.1         1-397               c
            1383-2382           AC006213.1         42946-43945         c
FEATURES             Location/Qualifiers
     source          1..2382
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..2382
                     /gene="ZNF221"
                     /note="zinc finger protein 221"
                     /db_xref="GeneID:7638"
                     /db_xref="HGNC:HGNC:13014"
     exon            1..173
                     /gene="ZNF221"
                     /inference="alignment:Splign:2.1.0"
     exon            174..256
                     /gene="ZNF221"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..2029
                     /gene="ZNF221"
                     /codon_start=1
                     /product="zinc finger protein 221"
                     /protein_id="NP_001284517.1"
                     /db_xref="CCDS:CCDS12633.1"
                     /db_xref="GeneID:7638"
                     /db_xref="HGNC:HGNC:13014"
                     /translation="MISPSLELLHSGLCKFPEVEGKMTTFKEAVTFKDVAVVFTEEEL
                     GLLDPAQRKLYRDVMLENFRNLLSVGNQPFHQDTFHFLGKEKFWKMKTTSQREGNSGG
                     KIQIEMETVPEAGPHEEWSCQQIWEQIASDLTRSQNSIRNSSQFFKEGDVPCQIEARL
                     SISHVQQKPYRCNECKQSFSDVSVFDLHQQSHSGEKSHTCGECGKSFCYSPALHIHQR
                     VHMGEKCYKCDVCGKEFNQSSHLQTHQRVHTGEKPFKCGQCGKGFHSRSALNVHCKLH
                     TGEKPYNCEECGKAFIHDSQLQEHQRIHTGEKPFKCDICGKSFRVRSRLNRHSMVHTG
                     EKPFRCDTCGKNFRQRSALNSHSMVHIEEKPYKCEQCGKGFICRRDFCKHQMVHTGEK
                     PYNCKECGKTFRWSSCLLNHQQVHSGQKSFKCEECGKGFYTNSRRSSHQRSHNGEKPY
                     NCEECGKDYKRRLDLEFHQRVHTGERPYNCKECGKSFGWASCLLKHQRLHSGEKPFKC
                     EECGKRFTQSSQLHSHQTCHTGEKLYKCEQCEKGYNSKFNLDMHQRVHGGERPYNCKE
                     CGKSFGWASCLLKHQRLHSGEKPLKSGVWEEIYSEFTASFTSVSLCGRKAI"
     exon            257..383
                     /gene="ZNF221"
                     /inference="alignment:Splign:2.1.0"
     exon            384..476
                     /gene="ZNF221"
                     /inference="alignment:Splign:2.1.0"
     exon            477..2382
                     /gene="ZNF221"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacgctctg tggagtcgcg ggagctacgg ctgcgggagt taccctttat tctgtgatat
       61 tttgagctgt tctgcgtctc gcaggccctt ctgaatttcc tggacctact ctcggaaccc
      121 tcaacgagct agcgatagat ttagaggaaa ggaagcaccg tcggaaagca aaggcatgat
      181 ttcaccttca cttgaactgc ttcattcagg actctgcaaa ttccctgaag tagaaggaaa
      241 aatgaccaca ttcaaagagg cagtgacatt caaggatgtg gctgtggtct tcactgagga
      301 ggagctgggg ctgctggacc ctgcccagag gaagctgtac cgagatgtga tgctagagaa
      361 cttcaggaac ctgctctcag tagggaatca accattccac caagatactt tccacttctt
      421 agggaaggaa aagttttgga agatgaagac aacaagccaa agagaaggga attcaggagg
      481 caagatccaa attgagatgg agactgttcc agaagcagga ccacatgaag agtggtcctg
      541 tcagcaaata tgggaacaaa ttgcaagtga cctaaccagg tctcaaaact ccataaggaa
      601 cagctctcag ttcttcaaag aaggtgatgt cccctgccag attgaggcaa gactatctat
      661 aagtcacgtg caacagaaac cttaccgttg taatgaatgt aaacagtcct tcagtgatgt
      721 ttctgtcttt gatcttcatc aacaatcaca ctcaggagag aaatctcata catgtggtga
      781 gtgtggaaaa agcttctgtt acagcccagc ccttcatatt catcagagag tccatatggg
      841 agaaaaatgc tataagtgtg atgtgtgtgg taaggaattt aatcagagct cacatctgca
      901 aactcatcag agagtccata ctggagagaa accattcaaa tgtgggcaat gtgggaaagg
      961 cttccatagt agatcagcac ttaatgttca ttgcaaattg cacacaggag agaaacctta
     1021 taattgtgag gaatgtggga aagccttcat tcatgattca cagcttcaag aacatcagag
     1081 aatccatact ggggagaagc cattcaaatg tgatatatgt ggtaagagct tccgtgttag
     1141 atcaagactt aataggcatt ccatggttca cacaggagaa aaaccattca gatgtgatac
     1201 atgtggcaag aactttcgtc agagatcagc acttaatagt cattccatgg tccacataga
     1261 agagaagcca tacaaatgtg agcaatgtgg aaaaggcttc atttgtaggc gagatttttg
     1321 taagcatcag atggtccaca caggagagaa accatataat tgtaaagaat gtgggaagac
     1381 cttcagatgg tcctcatgtc ttttgaacca tcagcaagtc cacagtggac aaaaatcctt
     1441 caaatgtgaa gaatgtggga agggatttta tacaaattca cgacgatctt cccatcagag
     1501 atcccacaat ggagaaaagc catataactg tgaggagtgt ggtaaggact ataaaaggag
     1561 gttggatctt gagtttcacc agagggtcca cacgggtgag agaccctata attgtaagga
     1621 atgtggcaag agctttggct gggcctcctg tcttttgaaa catcagagac tccacagtgg
     1681 ggaaaaacct ttcaaatgtg aagagtgtgg aaagagattt actcagagtt cacaacttca
     1741 ttcccatcag acatgccata ctggagaaaa gctatacaaa tgtgagcagt gtgagaaggg
     1801 gtacaacagt aaatttaatc ttgacatgca ccagagggtc cacgggggag agcgacccta
     1861 taattgtaag gaatgtggaa agagctttgg ctgggcttca tgtcttttga aacatcagag
     1921 actccacagt ggagaaaagc cattgaaatc tggagtgtgg gaagagatct actcagaatt
     1981 cacagcttca tttacatcag taagtctatg tgggagaaaa gccatataaa tgtgagaagt
     2041 gtgggaaggg ctttggctgg gcctcaactc atctgaccca tcaattctcc acagcagaga
     2101 aaaaccattc aaatatgaga actgtgggaa gagctttgta catagatcat atcttttttt
     2161 tttttttttg agacagagtc tcactctttc acccaggcct gactgcagtg gcgctatctc
     2221 agctcactgc aagctccgcc tcccaggttc acgccattct cctgcctcag cctcccgagt
     2281 agctgggact acaggtgccc gccaccacac ccagctaatt ttttgtattt ttagtagaga
     2341 cggggtttca ccgtgttagc caggatggtc tcgatctcct ga
//
