LOCUS       NM_006963               2103 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 22 (ZNF22), mRNA.
ACCESSION   NM_006963
VERSION     NM_006963.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2103)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   2  (bases 1 to 2103)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   3  (bases 1 to 2103)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   4  (bases 1 to 2103)
  AUTHORS   Gao,Y., Kobayashi,H. and Ganss,B.
  TITLE     The human KROX-26/ZNF22 gene is expressed at sites of tooth
            formation and maps to the locus for permanent tooth agenesis
            (He-Zhao deficiency)
  JOURNAL   J Dent Res 82 (12), 1002-1007 (2003)
   PUBMED   14630903
REFERENCE   5  (bases 1 to 2103)
  AUTHORS   Wu,B.Y., Hanley,E.W., Turka,L.A. and Nabel,G.J.
  TITLE     Isolation of a cDNA clone encoding a zinc finger protein highly
            expressed in T-leukemia lines
  JOURNAL   Blood 80 (10), 2571-2576 (1992)
   PUBMED   1421376
REFERENCE   6  (bases 1 to 2103)
  AUTHORS   Lichter,P., Bray,P., Ried,T., Dawid,I.B. and Ward,D.C.
  TITLE     Clustering of C2-H2 zinc finger motif sequences within telomeric
            and fragile site regions of human chromosomes
  JOURNAL   Genomics 13 (4), 999-1007 (1992)
   PUBMED   1505991
REFERENCE   7  (bases 1 to 2103)
  AUTHORS   Rousseau-Merck,M.F., Tunnacliffe,A., Berger,R., Ponder,B.A. and
            Thiesen,H.J.
  TITLE     A cluster of expressed zinc finger protein genes in the
            pericentromeric region of human chromosome 10
  JOURNAL   Genomics 13 (3), 845-848 (1992)
   PUBMED   1639412
REFERENCE   8  (bases 1 to 2103)
  AUTHORS   Bray,P., Lichter,P., Thiesen,H.J., Ward,D.C. and Dawid,I.B.
  TITLE     Characterization and mapping of human genes encoding zinc finger
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9563-9567 (1991)
   PUBMED   1946370
REFERENCE   9  (bases 1 to 2103)
  AUTHORS   Huebner,K., Druck,T., Croce,C.M. and Thiesen,H.J.
  TITLE     Twenty-seven nonoverlapping zinc finger cDNAs from human T cells
            map to nine different chromosomes with apparent clustering
  JOURNAL   Am J Hum Genet 48 (4), 726-740 (1991)
   PUBMED   2014798
REFERENCE   10 (bases 1 to 2103)
  AUTHORS   Thiesen,H.J.
  TITLE     Multiple genes encoding zinc finger domains are expressed in human
            T cells
  JOURNAL   New Biol 2 (4), 363-374 (1990)
   PUBMED   2288909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC041139.1, AL353801.13 and AU310379.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006963.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041139.1, AK291508.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298299.4/ ENSP00000298299.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1127              BC041139.1         450-1576
            1128-1607           AL353801.13        179718-180197
            1608-2103           AU310379.1         6-501               c
FEATURES             Location/Qualifiers
     source          1..2103
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.21"
     gene            1..2103
                     /gene="ZNF22"
                     /gene_synonym="HKR-T1; KOX15; Zfp422; ZNF422"
                     /note="zinc finger protein 22"
                     /db_xref="GeneID:7570"
                     /db_xref="HGNC:HGNC:13012"
                     /db_xref="MIM:194529"
     exon            1..56
                     /gene="ZNF22"
                     /gene_synonym="HKR-T1; KOX15; Zfp422; ZNF422"
                     /inference="alignment:Splign:2.1.0"
     exon            57..2103
                     /gene="ZNF22"
                     /gene_synonym="HKR-T1; KOX15; Zfp422; ZNF422"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..820
                     /gene="ZNF22"
                     /gene_synonym="HKR-T1; KOX15; Zfp422; ZNF422"
                     /note="krox-26 protein; zinc finger protein KOX15; zinc
                     finger protein Krox-26; zinc finger protein 22 (KOX 15)"
                     /codon_start=1
                     /product="zinc finger protein 22"
                     /protein_id="NP_008894.2"
                     /db_xref="CCDS:CCDS7211.1"
                     /db_xref="GeneID:7570"
                     /db_xref="HGNC:HGNC:13012"
                     /db_xref="MIM:194529"
                     /translation="MRLAKPKAGISRSSSQGKAYENKRKTGRQRQKWGMTIRFDSSFS
                     RLRRSLDDKPYKCTECEKSFSQSSTLFQHQKIHTGKKSHKCADCGKSFFQSSNLIQHR
                     RIHTGEKPYKCDECGESFKQSSNLIQHQRIHTGEKPYQCDECGRCFSQSSHLIQHQRT
                     HTGEKPYQCSECGKCFSQSSHLRQHMKVHKEEKPRKTRGKNIRVKTHLPSWKAGTGRK
                     SVAGLR"
     regulatory      1703..1708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF22"
                     /gene_synonym="HKR-T1; KOX15; Zfp422; ZNF422"
                     /note="hexamer: AACAAA"
     polyA_site      1726
                     /gene="ZNF22"
                     /gene_synonym="HKR-T1; KOX15; Zfp422; ZNF422"
     regulatory      2076..2081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF22"
                     /gene_synonym="HKR-T1; KOX15; Zfp422; ZNF422"
                     /note="hexamer: AATAAA"
     polyA_site      2103
                     /gene="ZNF22"
                     /gene_synonym="HKR-T1; KOX15; Zfp422; ZNF422"
                     /note="major polyA site"
ORIGIN      
        1 acttccggcg gcgcgggagg cgcccagcga gccagagtgg tggctggtcc cgcgcgaaaa
       61 ttctgagctg tacacctcta ggaaatgaaa cactagttca gaagaagcct gtaaactctc
      121 ttacaaatac atttggttat tcaccatgag gttagcaaag cctaaagcgg gtatttctcg
      181 gagctcaagc caaggaaagg cctatgagaa caagcgcaaa acaggccggc agcggcagaa
      241 gtggggcatg actattcgat ttgactcaag cttcagtaga ctcagaagaa gcttggatga
      301 caaaccctat aaatgtactg aatgtgaaaa gagtttcagt cagagttcaa ctctttttca
      361 acaccagaag atccatactg gaaagaaatc ccataaatgt gctgattgtg ggaaaagttt
      421 ctttcagagt tctaatctca ttcagcatcg acggatccat acgggggaaa agccctacaa
      481 atgtgatgag tgtggagaaa gcttcaaaca gagctcaaat ctcattcagc accagagaat
      541 tcatactgga gaaaaaccct atcagtgtga tgagtgtggc cggtgtttca gccagagctc
      601 ccaccttatt caacatcaga gaacccacac tggggagaaa ccctaccagt gcagtgaatg
      661 tggcaaatgt ttcagtcaga gctctcatct gaggcagcac atgaaggtgc ataaagaaga
      721 gaagcctcgt aaaacccggg gcaaaaatat cagggtgaag actcacttac cctcttggaa
      781 agctggtaca ggaaggaagt ctgtggctgg tctccgttaa gtatagggct ttttgacagc
      841 tttttgagac ctcttaagaa aaaataaaaa gtaaaaaatg aaaggaatct tttttagaaa
      901 tagagatgct ttatagtaga tcacttaaat actggatctt ttgctagtgt gaaaacattg
      961 ggaatttaat gacattattg agctgaaaga aattacatga gtccagctac cctcatttct
     1021 tttttatgtg acatggagca caaagaactg aaaatatgtt ttgagggagc atgacatcct
     1081 tgacctcatt tgaaattact tccattttca aaaaccatca tgttttgtag atacattttg
     1141 agaaaaacca tcatgttttg aggatacatt tgtgaaagtg caggcatgcc aatgactact
     1201 cagttttagg actttctgtg gaagaaaaaa gggagaagaa atcaattcca ctacttttga
     1261 agttctgcaa cagatgagat tttgtttgta aagttttgta gtatattaac cattggttta
     1321 tcactctaga ttcaacatat taaaatgtat tcaagctcac agatttttaa tcagtaaggc
     1381 ctatctatat tagttgtctt ttatttcttc tccttgtgga cagttgttaa tgaaaggagt
     1441 aaggatttcc ctttttttgt tttgtttgtt ttgttttttt taaccaaatt cttagagata
     1501 ctatagaatc caaatgagaa ctgaattgga cctcaagtct tctattccta ctaatagagt
     1561 tctttgtgat ggtaactgct gtgtcgtttg ttttccacaa gttgggatgg attcatgtcg
     1621 atacatcccc atgcccttga cctcttctgg cattctcctg tgctctgaca aactgagcca
     1681 gccttttaga tctacatgaa taaacaaact attttaccaa gaaaaatctc agcttgctta
     1741 ctgcttaatt aaaaacctac aatttacaca cctccctgcc ttcaagactg tgagctttgg
     1801 atagccctgc ttaaatgttt gtcaacaaca agagtcgtaa tgtgtcagta cattgtagct
     1861 cctttgaaat ttaactcttt ctgtgttaca tgaattgttt taaggagtcc ggcaaacatg
     1921 tttcttcact tccatgagaa tggtgccaag tgtcagactc taatgagccc tcagctcagg
     1981 ttttaatttc tattgaatgc taacattctt ctgatttttt ggtatctttt ataatcatat
     2041 cggtttctgc tgtattaatg acaattattc atgaaaataa aaaatgaaat attttgtata
     2101 cta
//
