LOCUS       NM_016423               3055 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens zinc finger protein 219 (ZNF219), transcript variant
            1, mRNA.
ACCESSION   NM_016423
VERSION     NM_016423.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3055)
  AUTHORS   Yuan,P., Wang,S., Du,T., Liu,L., Chen,X., Yan,J., Han,S., Peng,B.,
            He,X. and Liu,W.
  TITLE     ZNF219, a novel transcriptional repressor, inhibits transcription
            of the prototype foamy virus by interacting with the viral LTR
            promoter
  JOURNAL   Virus Res 334, 199161 (2023)
   PUBMED   37356580
  REMARK    GeneRIF: ZNF219, a novel transcriptional repressor, inhibits
            transcription of the prototype foamy virus by interacting with the
            viral LTR promoter.
REFERENCE   2  (bases 1 to 3055)
  AUTHORS   Guo,Q., Geletu,Q. and Zhang,Y.
  TITLE     ZNF219 protects human lens epithelial cells against H2O2-induced
            injury via targeting SOX9 through activating AKT/GSK3beta pathway
  JOURNAL   Hum Exp Toxicol 40 (12_suppl), S7-S15 (2021)
   PUBMED   34167360
  REMARK    GeneRIF: ZNF219 protects human lens epithelial cells against
            H2O2-induced injury via targeting SOX9 through activating
            AKT/GSK3beta pathway.
REFERENCE   3  (bases 1 to 3055)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3055)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3055)
  AUTHORS   Takigawa,Y., Hata,K., Muramatsu,S., Amano,K., Ono,K.,
            Wakabayashi,M., Matsuda,A., Takada,K., Nishimura,R. and Yoneda,T.
  TITLE     The transcription factor Znf219 regulates chondrocyte
            differentiation by assembling a transcription factory with Sox9
  JOURNAL   J Cell Sci 123 (Pt 21), 3780-3788 (2010)
   PUBMED   20940257
  REMARK    GeneRIF: regulates chondrocyte differentiation as a transcriptional
            partner of Sox9
REFERENCE   6  (bases 1 to 3055)
  AUTHORS   Clough,R.L., Dermentzaki,G. and Stefanis,L.
  TITLE     Functional dissection of the alpha-synuclein promoter:
            transcriptional regulation by ZSCAN21 and ZNF219
  JOURNAL   J Neurochem 110 (5), 1479-1490 (2009)
   PUBMED   19549071
REFERENCE   7  (bases 1 to 3055)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   8  (bases 1 to 3055)
  AUTHORS   Paces-Fessy,M., Boucher,D., Petit,E., Paute-Briand,S. and
            Blanchet-Tournier,M.F.
  TITLE     The negative regulator of Gli, Suppressor of fused (Sufu),
            interacts with SAP18, Galectin3 and other nuclear proteins
  JOURNAL   Biochem J 378 (Pt 2), 353-362 (2004)
   PUBMED   14611647
REFERENCE   9  (bases 1 to 3055)
  AUTHORS   Sakai,T., Hino,K., Wada,S. and Maeda,H.
  TITLE     Identification of the DNA binding specificity of the human ZNF219
            protein and its function as a transcriptional repressor
  JOURNAL   DNA Res 10 (4), 155-165 (2003)
   PUBMED   14621294
  REMARK    GeneRIF: By using a random oligonucleotide selection assay and the
            electromobility gel shift assay, we have revealed that the ZNF219
            protein recognizes two copies of CCCCCA.
REFERENCE   10 (bases 1 to 3055)
  AUTHORS   Sakai,T., Toyoda,A., Hashimoto,K. and Maeda,H.
  TITLE     Isolation and characterization of a novel zinc finger gene, ZNF219,
            and mapping to the human chromosome 14q11 region
  JOURNAL   DNA Res 7 (2), 137-141 (2000)
   PUBMED   10819330
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL161668.6, CB152705.1,
            AB015427.1 and BC000694.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_016423.2.
            
            Summary: This gene is a member of the Kruppel-like zinc finger gene
            family. The encoded protein functions as a transcriptional
            repressor of the high mobility group nucleosome binding domain 1
            protein, which is associated with transcriptionally active
            chromatin. [provided by RefSeq, Apr 2017].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB015427.1, BC036105.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360947.8/ ENSP00000354206.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AL161668.6         151986-151991       c
            7-30                CB152705.1         5-28
            31-1732             AB015427.1         15-1716
            1733-3055           BC000694.2         1338-2660
FEATURES             Location/Qualifiers
     source          1..3055
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..3055
                     /gene="ZNF219"
                     /gene_synonym="ZFP219"
                     /note="zinc finger protein 219"
                     /db_xref="GeneID:51222"
                     /db_xref="HGNC:HGNC:13011"
                     /db_xref="MIM:605036"
     exon            1..344
                     /gene="ZNF219"
                     /gene_synonym="ZFP219"
                     /inference="alignment:Splign:2.1.0"
     exon            345..433
                     /gene="ZNF219"
                     /gene_synonym="ZFP219"
                     /inference="alignment:Splign:2.1.0"
     CDS             428..2596
                     /gene="ZNF219"
                     /gene_synonym="ZFP219"
                     /codon_start=1
                     /product="zinc finger protein 219"
                     /protein_id="NP_057507.2"
                     /db_xref="CCDS:CCDS9568.1"
                     /db_xref="GeneID:51222"
                     /db_xref="HGNC:HGNC:13011"
                     /db_xref="MIM:605036"
                     /translation="MEGSRPRAPSGHLAPSPPAFDGELDLQRYSNGPAVSAGSLGMGA
                     VSWSESRAGERRFPCPVCGKRFRFNSILALHLRAHPGAQAFQCPHCGHRAAQRALLRS
                     HLRTHQPERPRSPAARLLLELEERALLREARLGRARSSGGMQATPATEGLARPQAPSS
                     SAFRCPYCKGKFRTSAERERHLHILHRPWKCGLCSFGSSQEEELLHHSLTAHGAPERP
                     LAATSAAPPPQPQPQPPPQPEPRSVPQPEPEPEPEREATPTPAPAAPEEPPAPPEFRC
                     QVCGQSFTQSWFLKGHMRKHKASFDHACPVCGRCFKEPWFLKNHMKVHASKLGPLRAP
                     GPASGPARAPQPPDLGLLAYEPLGPALLLAPAPTPAERREPPSLLGYLSLRAGEGRPN
                     GEGAEPGPGRSFGGFRPLSSALPARARRHRAEEPEEEEEVVEAEEETWARGRSLGSLA
                     SLHPRPGEGPGHSASAAGAQARSTATQEENGLLVGGTRPEGGRGATGKDCPFCGKSFR
                     SAHHLKVHLRVHTGERPYKCPHCDYAGTQSGSLKYHLQRHHREQRSGAGPGPPPEPPP
                     PSQRGSAPQSGAKPSPQPATWVEGASSPRPPSSGAGPGSRRKPASPGRTLRNGRGGEA
                     EPLDLSLRAGPGGEAGPGGALHRCLFCPFATGAPELMALHLQVHHSRRARGRRPPQAD
                     ASPPYARVPSGETPPSPSQEGEEGSGLSRPGEAGLGGQER"
     exon            434..1859
                     /gene="ZNF219"
                     /gene_synonym="ZFP219"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1991
                     /gene="ZNF219"
                     /gene_synonym="ZFP219"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..3055
                     /gene="ZNF219"
                     /gene_synonym="ZFP219"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3030..3035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF219"
                     /gene_synonym="ZFP219"
                     /note="hexamer: AATAAA"
     polyA_site      3055
                     /gene="ZNF219"
                     /gene_synonym="ZFP219"
                     /note="major polyA site"
ORIGIN      
        1 gtctccaaac cgcccgcacc ccgcccctgg cggccgcctc tcgcggctcc cggggtcccc
       61 agctccctgt ccccggagcc agagcccggc tcccgcgcgg ctcccagccc cgccgcgccg
      121 ccccccgcat gctaatggcc gggccgcctc ccgccgcaca caatgcgggc cagggccggg
      181 ggcgggggac cggggagggg gcgggggccg ggccgggggc gggggggccg gggcccggcg
      241 catctccccc ggccccacgt aacgctgacg cccgcgccgc cggcccgccg cccgccgccg
      301 ccgccgccgc cgccgcccgc tccgccgccg cccgcccggg gctcctccac agcacctgtt
      361 gccttcatta gcagcttttc ctcctcttcc ctgcacttcc cagaaccaaa gaatgtgaag
      421 ggggtccatg gagggctcac gtccccgcgc cccgagcggc cacttagcgc cgtcgccgcc
      481 ggctttcgac ggcgagctgg atctgcagcg atactccaac gggccagccg tgagcgcagg
      541 gtcgctcggg atgggagcgg tgagctggtc tgagagtcgt gcaggcgaac ggcgcttccc
      601 ctgccctgta tgcgggaagc gcttccgctt caactctatc cttgctttgc acctgcgggc
      661 gcacccagga gcccaggcct tccagtgccc tcactgcggc caccgcgcgg cgcagcgggc
      721 tctgctgcgc tcgcacctgc gcacacacca gcccgagcgc ccacgtagtc ctgctgcacg
      781 cctgttgctg gagttggaag agcgcgcgct actacgcgag gcccgactgg ggagagcccg
      841 aagctcaggg ggcatgcagg ccacccctgc cactgagggt ctggcgcggc cccaggctcc
      901 ttcatcgtcc gccttccgtt gcccctactg caaaggcaag tttcgcacct cggcggagcg
      961 cgaacgccac ctgcacatcc tgcataggcc ctggaagtgc ggcctgtgca gtttcggctc
     1021 cagccaggag gaggagctgc tgcaccacag cctgacggcc cacggggctc ccgagcgtcc
     1081 cctggcggcc acctccgctg cgcctccgcc tcagcctcag cctcagcctc caccccagcc
     1141 cgaacccaga tcagtccccc agccggagcc ggagccggag cccgaacgtg aggcaacccc
     1201 gaccccagct cctgccgctc ccgaggagcc cccagcgcct ccggagttcc gctgccaagt
     1261 gtgcggccag agctttacac agtcttggtt tctcaagggc cacatgcgta agcacaaggc
     1321 ctccttcgat catgcgtgtc cggtgtgcgg ccgctgcttc aaggagccct ggttccttaa
     1381 gaaccacatg aaggtgcacg ccagcaagct gggcccactg cgtgccccgg ggcctgcctc
     1441 cgggcctgcc cgcgcccccc agcctcctga cctcggcctg ctggcctatg agccgttggg
     1501 cccagcgctc ctcttggccc cggctcccac cccggccgag cgccgtgagc ccccgagcct
     1561 cttgggctac ctgagcctgc gagctggcga gggccggccc aacggcgagg gtgctgagcc
     1621 cggtcccggc cgcagcttcg gaggcttccg cccgctgtcc tctgctctcc cggcccgggc
     1681 tcgccggcac cgtgcggagg agcctgagga agaagaggag gtggtggagg ccgaggagga
     1741 aacctgggcc cggggcaggt cgctgggctc tctggcttcc ctgcacccgc gcccgggtga
     1801 gggaccgggg cactctgcct ctgctgctgg ggcccaggca agatcgaccg ccacgcagga
     1861 agagaatggg ctgttggttg gagggacccg gcctgaaggg ggccggggcg ccaccggcaa
     1921 ggattgtcct ttctgcggaa aatctttccg ctcagcacat cacctcaaag tgcatctgcg
     1981 agtgcacaca ggcgagcggc cctacaagtg tccgcactgc gactacgcgg gcacccagtc
     2041 cggctcgctc aagtatcacc tacagcgcca ccaccgggag cagaggagcg gggccggccc
     2101 cgggccaccc ccggagccac cgcctccttc ccagcggggt tcggccccgc aatctggagc
     2161 caagccgtct ccgcagcctg cgacctgggt ggagggcgcc tcaagtcccc ggcctccttc
     2221 tagcggtgct gggccggggt cccgtcggaa gcccgccagc cctgggagga ccctgcgcaa
     2281 cgggcgaggc ggtgaggccg aacccctgga cctgtccttg cgggcagggc cgggaggcga
     2341 ggccgggcct gggggtgccc tccaccgctg cctcttctgc ccgttcgcca ctggagcccc
     2401 agagctcatg gccttgcacc ttcaagtgca ccacagccgc cgggctaggg gccgccggcc
     2461 accccaggct gacgcgtccc cgccctatgc ccgagtacca tcaggagaga cccctcccag
     2521 tccttcgcag gaaggggagg agggctccgg gctgtccaga cccggagagg cagggctggg
     2581 ggggcaagaa cggtagtggg ccctcagggg cgattagctt agtgagctta ccccgccgga
     2641 gcgggggagc gctagaggta gttgggtaga gaagccagca gggggcagcg tgggacccat
     2701 atcccagccc caggcggacc agaggtggaa ggcgcggcgg gcgtaggagg gtgggctggc
     2761 ggtacccacc cagcccaagg gagtcacagt gccttagaag tggcagaggt gagggtcaaa
     2821 gaacggggtc cctgggctgg cagagaaggt ttgtgtccct gttgaggagc cactctgcca
     2881 gtctttgctg gtccataggc gtgagagttt atttttgtac aaggggtgag ggtggggggc
     2941 actgtaccct tctagcccca tcaggggccc tgtagacgtc gctatttttg gtacgattcc
     3001 tgtcatccct attgcagagt cgtgtcccca ataaacaggt gtcttgaggc acagg
//
