LOCUS       NM_013250               3655 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens zinc finger protein 215 (ZNF215), transcript variant
            1, mRNA.
ACCESSION   NM_013250
VERSION     NM_013250.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3655)
  AUTHORS   Liao,W., Du,J., Li,L., Wu,X., Chen,X., Feng,Q., Xu,L., Chen,X.,
            Liao,M., Huang,J., Yuan,K. and Zeng,Y.
  TITLE     CircZNF215 promotes tumor growth and metastasis through
            inactivation of the PTEN/AKT pathway in intrahepatic
            cholangiocarcinoma
  JOURNAL   J Exp Clin Cancer Res 42 (1), 125 (2023)
   PUBMED   37198696
  REMARK    GeneRIF: CircZNF215 promotes tumor growth and metastasis through
            inactivation of the PTEN/AKT pathway in intrahepatic
            cholangiocarcinoma.
            Erratum:[J Exp Clin Cancer Res. 2024 Feb 23;43(1):55. doi:
            10.1186/s13046-024-02977-1.. PMID: 38395941]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3655)
  AUTHORS   Yang,M.Y., Lin,P.M., Yang,C.H., Hu,M.L., Chen,I.Y., Lin,S.F. and
            Hsu,C.M.
  TITLE     Loss of ZNF215 imprinting is associated with poor five-year
            survival in patients with cytogenetically abnormal-acute myeloid
            leukemia
  JOURNAL   Blood Cells Mol Dis 90, 102577 (2021)
   PUBMED   34091126
  REMARK    GeneRIF: Loss of ZNF215 imprinting is associated with poor
            five-year survival in patients with cytogenetically abnormal-acute
            myeloid leukemia.
REFERENCE   3  (bases 1 to 3655)
  AUTHORS   Sofos,E., Pescosolido,M.F., Quintos,J.B., Abuelo,D., Gunn,S.,
            Hovanes,K., Morrow,E.M. and Shur,N.
  TITLE     A novel familial 11p15.4 microduplication associated with
            intellectual disability, dysmorphic features, and obesity with
            involvement of the ZNF214 gene
  JOURNAL   Am J Med Genet A 158A (1), 50-58 (2012)
   PUBMED   22052655
REFERENCE   4  (bases 1 to 3655)
  AUTHORS   Massart,F. and Saggese,G.
  TITLE     Morphogenetic targets and genetics of undescended testis
  JOURNAL   Sex Dev 4 (6), 326-335 (2010)
   PUBMED   20980787
  REMARK    Review article
REFERENCE   5  (bases 1 to 3655)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (bases 1 to 3655)
  AUTHORS   Gianotten,J., van der Veen,F., Alders,M., Leschot,N.J., Tanck,M.W.,
            Land,J.A., Kremer,J.A., Hoefsloot,L.H., Mannens,M.M., Lombardi,M.P.
            and Hoffer,M.J.
  TITLE     Chromosomal region 11p15 is associated with male factor
            subfertility
  JOURNAL   Mol Hum Reprod 9 (10), 587-592 (2003)
   PUBMED   12970396
REFERENCE   7  (bases 1 to 3655)
  AUTHORS   Sander,T.L., Stringer,K.F., Maki,J.L., Szauter,P., Stone,J.R. and
            Collins,T.
  TITLE     The SCAN domain defines a large family of zinc finger transcription
            factors
  JOURNAL   Gene 310, 29-38 (2003)
   PUBMED   12801630
REFERENCE   8  (bases 1 to 3655)
  AUTHORS   Alders,M., Ryan,A., Hodges,M., Bliek,J., Feinberg,A.P.,
            Privitera,O., Westerveld,A., Little,P.F. and Mannens,M.
  TITLE     Disruption of a novel imprinted zinc-finger gene, ZNF215, in
            Beckwith-Wiedemann syndrome
  JOURNAL   Am J Hum Genet 66 (5), 1473-1484 (2000)
   PUBMED   10762538
REFERENCE   9  (bases 1 to 3655)
  AUTHORS   Redeker,E., Hoovers,J.M., Alders,M., van Moorsel,C.J., Ivens,A.C.,
            Gregory,S., Kalikin,L., Bliek,J., de Galan,L., van den Bogaard,R.
            et al.
  TITLE     An integrated physical map of 210 markers assigned to the short arm
            of human chromosome 11
  JOURNAL   Genomics 21 (3), 538-550 (1994)
   PUBMED   7959730
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090160.6, CN483744.1 and
            AF056618.1.
            
            On Nov 24, 2018 this sequence version replaced NM_013250.3.
            
            Summary: This gene is imprinted in a tissue-specific manner with
            preferential expression in the testis, and encodes a zinc finger
            protein that belongs to a family of zinc finger transcription
            factors. The encoded protein contains an N-terminal SRE-ZBP,
            Ctfin51, AW-1, and Number 18 (SCAN) domain, a kruppel-associated
            box A (KRABA) domain, and four C-terminal zinc finger domains. This
            gene is located within one of three regions on chromosome 11p15
            associated with Beckwith-Wiedemann syndrome, called
            Beckwith-Wiedemann syndrome chromosome region-2 (BWSCR2), and is
            thought to play a role in the etiology of this disease. [provided
            by RefSeq, Aug 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF056618.1, SRR1163658.127946.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000278319.10/ ENSP00000278319.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AC090160.6         13500-13598
            100-413             CN483744.1         63-376
            414-1549            AF056618.1         417-1552
            1550-3655           AC090160.6         43016-45121
FEATURES             Location/Qualifiers
     source          1..3655
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..3655
                     /gene="ZNF215"
                     /gene_synonym="BAZ-2; BAZ2; ZKSCAN11; ZSCAN43"
                     /note="zinc finger protein 215"
                     /db_xref="GeneID:7762"
                     /db_xref="HGNC:HGNC:13007"
                     /db_xref="MIM:605016"
     exon            1..260
                     /gene="ZNF215"
                     /gene_synonym="BAZ-2; BAZ2; ZKSCAN11; ZSCAN43"
                     /inference="alignment:Splign:2.1.0"
     exon            261..406
                     /gene="ZNF215"
                     /gene_synonym="BAZ-2; BAZ2; ZKSCAN11; ZSCAN43"
                     /inference="alignment:Splign:2.1.0"
     exon            407..985
                     /gene="ZNF215"
                     /gene_synonym="BAZ-2; BAZ2; ZKSCAN11; ZSCAN43"
                     /inference="alignment:Splign:2.1.0"
     CDS             586..2139
                     /gene="ZNF215"
                     /gene_synonym="BAZ-2; BAZ2; ZKSCAN11; ZSCAN43"
                     /note="isoform 1 is encoded by transcript variant 1;
                     BWSCR2-associated zinc finger protein 2; zinc finger
                     protein with KRAB and SCAN domains 11"
                     /codon_start=1
                     /product="zinc finger protein 215 isoform 1"
                     /protein_id="NP_037382.2"
                     /db_xref="CCDS:CCDS7775.1"
                     /db_xref="GeneID:7762"
                     /db_xref="HGNC:HGNC:13007"
                     /db_xref="MIM:605016"
                     /translation="MQPLSKLMAISKPRNLSLREQREVLRADMSWQQETNPVVETHDS
                     EASRQKFRHFQYLKVSGPHEALSQLWELCLQWLRPEIHTKKQIIELLVLEQFLAILPE
                     EVRTWVNLQHPNNSKDMVTLIEDVIEMLEDEDMPCKDSALQMGSIKEKMKAGSRTGKP
                     QEPVTFKDVVVEFSKEEWGQLDSAVKNLYRNVMLENFRNLNSLRKAHLLSKPFESLKL
                     ESKKKRWIMEKEIPRKTIFDMKSISGEESSHGVIMTRLTESGHPSSDAWKGENWLYRN
                     QKKWDINLPQEAFIPETIYTEEEDFECSENKKSFDINSVSSICAIQVGIPSRKGSPKC
                     DKFKTYFKFNLDSVGKQHSEYEYGNDLSLSTDIRHQKSHTTMNSYECYQCGKAFCRSS
                     SLIRHQIIHTGEKPYKCSECGRFFNRRTNLTKHQKLHAEAKACTSNKCGKAFSKSEDS
                     NNPTLHFGNNFYQCVNCGKSFNRSSSLIRHQMIHTGEKPFKCKECSKAFNRSSNLVKH
                     QKLHTRDKS"
     exon            986..1068
                     /gene="ZNF215"
                     /gene_synonym="BAZ-2; BAZ2; ZKSCAN11; ZSCAN43"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1201
                     /gene="ZNF215"
                     /gene_synonym="BAZ-2; BAZ2; ZKSCAN11; ZSCAN43"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1297
                     /gene="ZNF215"
                     /gene_synonym="BAZ-2; BAZ2; ZKSCAN11; ZSCAN43"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..3655
                     /gene="ZNF215"
                     /gene_synonym="BAZ-2; BAZ2; ZKSCAN11; ZSCAN43"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3426..3431
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF215"
                     /gene_synonym="BAZ-2; BAZ2; ZKSCAN11; ZSCAN43"
                     /note="hexamer: ATTAAA"
     polyA_site      3453
                     /gene="ZNF215"
                     /gene_synonym="BAZ-2; BAZ2; ZKSCAN11; ZSCAN43"
                     /note="major polyA site"
     regulatory      3635..3640
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF215"
                     /gene_synonym="BAZ-2; BAZ2; ZKSCAN11; ZSCAN43"
                     /note="hexamer: ATTAAA"
     polyA_site      3655
                     /gene="ZNF215"
                     /gene_synonym="BAZ-2; BAZ2; ZKSCAN11; ZSCAN43"
ORIGIN      
        1 agaaagggac ggggctggca aaggcctggt ctacctcacc gatccgggtc gcgggggctc
       61 ctagggggtt ccttccacag ctggtgcgcg tgcgcaagag tgcgtcgagg ttgttccgcg
      121 gcaatttatg aaactcggag ccggcagtga gttgagggtt cggcgaggtc agggattcct
      181 agttgcagcg tgattaccaa cgccagctcc cttcactgtc caagacagcg attccgcggc
      241 tcctctgaga actggcgctt tgttcatcat ttgccactta agctacttgc agtcacgtca
      301 caccttggat ctctatcatc aaaactattc cacctcggaa atcttaccta aatgcagcat
      361 gccatcctga acgtctctcc ctgtcctagc tctgtaactg tttacattgc tcaggtacct
      421 gaatattggc tttgtgtcta aagtttctgg aactttcctc cttaccgtga aataacttgg
      481 cttaaatcac actgcatata gtacacaggt gcttagctca agcctgagaa ttactgcaat
      541 ctagtaaggc ggatttgaac tactgtggga gttctattta ggaagatgca gcctctgagc
      601 aagttgatgg ctatctcaaa acctcgaaac ctgtctctac gtgaacaaag agaggttctg
      661 agagcagata tgtcttggca gcaggaaacc aaccccgtcg tggagacaca tgactctgag
      721 gcatctcgtc aaaagttcag acatttccag tatttgaaag tgtctgggcc ccatgaagcc
      781 ctgagccaac tctgggagct ctgtcttcaa tggctgagac cagagattca tacaaagaag
      841 cagattatag aactgttggt gctggaacaa ttcctggcaa tcctgcctga agaagtcagg
      901 acttgggtga atttacaaca tccaaacaac agtaaagata tggtgaccct catagaagat
      961 gtgattgaaa tgcttgaaga tgaagatatg ccctgcaagg actctgccct gcagatgggg
     1021 agcatcaagg agaaaatgaa agctggctca cgaacaggca aaccacagga accagtgaca
     1081 ttcaaagatg tggttgtgga attcagcaag gaagagtggg ggcaactgga ctctgctgta
     1141 aagaacctgt acaggaatgt gatgctggaa aactttagga acctgaattc attgcgtaaa
     1201 gcacatctac tttccaaacc atttgagagc cttaagttgg agagtaagaa aaaaagatgg
     1261 ataatggaga aagaaatacc aaggaagact atttttgaca tgaagagtat ttctggagaa
     1321 gaatcatccc atggagtgat tatgacaagg cttaccgaaa gtggacaccc ttcttcagat
     1381 gcctggaaag gtgagaattg gttatatagg aaccagaaaa aatgggacat aaatttgcca
     1441 caagaggctt tcattcctga gacaatttac actgaggagg aagattttga atgtagtgaa
     1501 aataagaaaa gctttgatat taattcagtt agctcaattt gtgctataca agtgggaatt
     1561 ccttcaagaa aggggtctcc aaaatgtgat aagtttaaaa cttacttcaa atttaattta
     1621 gactcagtag gtaagcaaca ttcagaatat gaatatggga atgacttgag tttgagtaca
     1681 gatattcgac accaaaaaag tcatactaca atgaattcct atgaatgtta tcaatgtggg
     1741 aaagccttct gccgaagttc atcccttatt cgacatcaga tcattcacac aggagagaaa
     1801 ccctataaat gcagtgaatg tgggagattc ttcaaccgac gtacaaacct tactaagcat
     1861 caaaaacttc atgctgaagc aaaggcctgc acaagcaata aatgtggaaa ggccttcagt
     1921 aaaagtgaag acagtaataa tccaacactc cattttggaa acaatttcta tcaatgtgtt
     1981 aactgtggaa aatccttcaa ccggagctcc tctcttattc gacaccaaat gattcacacg
     2041 ggagagaaac cattcaaatg taaggaatgt agtaaagcct tcaacaggag ttcaaacctt
     2101 gttaaacatc aaaaactgca tactcgagat aagtcctgaa aaaagaaaaa atgaaagatt
     2161 accttcagtc agaatgcaga actcatttaa catcatgaat ttatgctgga taaaatctca
     2221 tgaatataat gtaagaaaac atttgtcaga tttttcttta aatgatatca cagaattaat
     2281 gttggataga aatatcattg gatagaaatc tgtttgaagg aattttcctg gttttcagat
     2341 gaagccataa ggctttggag ttaaaccaca gtatcaccat acaagtattt gtttatcatt
     2401 attttgatat ccattaccct cacctctccc tagttcataa ataggtctat agcatactaa
     2461 tatccacctg atttattgac gaagtagaca ttaggcaaag ccaaacaata ctcttggagt
     2521 tgatatttaa taaaactcag cccttttaag aaggtcacaa gaaatcatta gctcatgcga
     2581 atataagaga atacttctaa ggacagaaat ctctgaatca atggctaaga caacagtaac
     2641 agccatttac tccactcctg acaataccct ttgttgtctt gctgttgaat ggagactaga
     2701 gttgggaaag ggttatcaac tgcaatggga gaagtatgta ttgctgttaa tctatatgta
     2761 ttcttaaaat ctgcatttgt ttatagcagg tccttgaaaa atgtttttgt tttgttataa
     2821 tgttataatt gttatgatgt tgatgagaaa aatatcgatt cccagccagg gacactgtgt
     2881 ggagttcgca cactctccct atgtctccgg gtgctccagt ttcaaacccc aaagatgtat
     2941 acattaggtt aattgacata tctaaattat ctcagtctga gtttgtgagg aagtgtgccc
     3001 tgcagtggaa tggctcctaa tcagggtttg ttcccaccat tgccctgagc tgctaggatg
     3061 cgctctgtcc acccatggcc ctgtactgga ataacagggt aaataattat cttatctgtt
     3121 tttattaatc cgtcttaaat gtgtatatag ctcagattta ttttaatgtc tgatattgga
     3181 agcgtttggg gtctttagaa gtttgatgat gttgtgacca gacatttgcc ttaggaactt
     3241 aactcttgtt tgtatccatt agtctatggt aaaattggtt ttgttataca tcatttcact
     3301 taaagttgca gttcctaaga acctattgat gatgttcagt gcagacttac tgtacctttg
     3361 ggaatttagg ctggagagac gtccatagcc ttaggtatat catttatacc agacattatg
     3421 aagttattaa agtctcctat actctgtaca ccagaactgt gtcttctgta aactacctca
     3481 ggatcccatc tggttcttga gccaagaagt atgacttaat ctgccccaaa aaattcacac
     3541 tggagacatt cccaattaat gatgatggta gctttttgtg aaggttcata ccttattcaa
     3601 aggcagaaaa ggtatactgg agtgaactcc tatgattaaa taatgtcaaa atcta
//
