LOCUS       NM_004220               3311 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 213 (ZNF213), transcript variant
            1, mRNA.
ACCESSION   NM_004220
VERSION     NM_004220.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3311)
  AUTHORS   Liu,Y., Su,P., Zhao,W., Li,X., Yang,X., Fan,J., Yang,H., Yan,C.,
            Mao,L., Ding,Y., Zhu,J., Niu,Z. and Zhuang,T.
  TITLE     ZNF213 negatively controls triple negative breast cancer
            progression via Hippo/YAP signaling
  JOURNAL   Cancer Sci 112 (7), 2714-2727 (2021)
   PUBMED   33939216
  REMARK    GeneRIF: ZNF213 negatively controls triple negative breast cancer
            progression via Hippo/YAP signaling.
REFERENCE   2  (bases 1 to 3311)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3311)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3311)
  AUTHORS   Yu,B., Zheng,Y., Alexander,D., Manolio,T.A., Alonso,A.,
            Nettleton,J.A. and Boerwinkle,E.
  TITLE     Genome-wide association study of a heart failure related
            metabolomic profile among African Americans in the Atherosclerosis
            Risk in Communities (ARIC) study
  JOURNAL   Genet Epidemiol 37 (8), 840-845 (2013)
   PUBMED   23934736
REFERENCE   5  (bases 1 to 3311)
  AUTHORS   Chen,X., Hamon,M., Deng,Z., Centola,M., Sood,R., Taylor,K.,
            Kastner,D.L. and Fischel-Ghodsian,N.
  TITLE     Identification and characterization of a zinc finger gene (ZNF213)
            from 16p13.3
  JOURNAL   Biochim Biophys Acta 1444 (2), 218-230 (1999)
   PUBMED   10023065
REFERENCE   6  (bases 1 to 3311)
  AUTHORS   Bernot,A., Heilig,R., Clepet,C., Smaoui,N., Da Silva,C.,
            Petit,J.L., Devaud,C., Chiannilkulchai,N., Fizames,C., Samson,D.,
            Cruaud,C., Caloustian,C., Gyapay,G., Delpech,M. and Weissenbach,J.
  TITLE     A transcriptional Map of the FMF region
  JOURNAL   Genomics 50 (2), 147-160 (1998)
   PUBMED   9653642
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108134.3, DA811482.1, AK291789.1, BC080572.1 and BM974318.1.
            
            On May 17, 2019 this sequence version replaced NM_004220.2.
            
            Summary: C2H2 zinc finger proteins, such as ZNF213, have bipartite
            structures in which one domain binds DNA or RNA and the other
            modulates target gene expression.[supplied by OMIM, Apr 2004].
            
            Transcript Variant: This variant (1) represents the more
            predominant transcript. Transcript variants 1 and 2 encode the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291789.1, SRR6380201.2465.19
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396878.8/ ENSP00000380087.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC108134.3         146553-146579
            28-226              DA811482.1         1-199
            227-2528            AK291789.1         113-2414
            2529-3310           BC080572.1         197-978
            3311-3311           BM974318.1         18-18               c
FEATURES             Location/Qualifiers
     source          1..3311
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..3311
                     /gene="ZNF213"
                     /gene_synonym="CR53; ZKSCAN21; ZSCAN53"
                     /note="zinc finger protein 213"
                     /db_xref="GeneID:7760"
                     /db_xref="HGNC:HGNC:13005"
                     /db_xref="MIM:608387"
     exon            1..359
                     /gene="ZNF213"
                     /gene_synonym="CR53; ZKSCAN21; ZSCAN53"
                     /inference="alignment:Splign:2.1.0"
     exon            360..873
                     /gene="ZNF213"
                     /gene_synonym="CR53; ZKSCAN21; ZSCAN53"
                     /inference="alignment:Splign:2.1.0"
     CDS             475..1854
                     /gene="ZNF213"
                     /gene_synonym="CR53; ZKSCAN21; ZSCAN53"
                     /note="putative transcription factor CR53; zinc finger
                     protein with KRAB and SCAN domains 21"
                     /codon_start=1
                     /product="zinc finger protein 213"
                     /protein_id="NP_004211.1"
                     /db_xref="CCDS:CCDS10495.1"
                     /db_xref="GeneID:7760"
                     /db_xref="HGNC:HGNC:13005"
                     /db_xref="MIM:608387"
                     /translation="MAAPLEAQDQAPGEGEGLLIVKVEDSSWEQESAQHEDGRDSEAC
                     RQRFRQFCYGDVHGPHEAFSQLWELCCRWLRPELRTKEQILELLVLEQFLTVLPGEIQ
                     GWVREQHPGSGEEAVALVEDLQKQPVKAWRQDVPSEEAEPEAAGRGSQATGPPPTVGA
                     RRRPSVPQEQHSHSAQPPALLKEGRPGETTDTCFVSGVHGPVALGDIPFYFSREEWGT
                     LDPAQRDLFWDIKRENSRNTTLGFGLKGQSEKSLLQEMVPVVPGQTGSDVTVSWSPEE
                     AEAWESENRPRAALGPVVGARRGRPPTRRRQFRDLAAEKPHSCGQCGKRFRWGSDLAR
                     HQRTHTGEKPHKCPECDKSFRSSSDLVRHQGVHTGEKPFSCSECGKSFSRSAYLADHQ
                     RIHTGEKPFGCSDCGKSFSLRSYLLDHRRVHTGERPFGCGECDKSFKQRAHLIAHQSL
                     HAKMAQPVG"
     exon            874..997
                     /gene="ZNF213"
                     /gene_synonym="CR53; ZKSCAN21; ZSCAN53"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1071
                     /gene="ZNF213"
                     /gene_synonym="CR53; ZKSCAN21; ZSCAN53"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1195
                     /gene="ZNF213"
                     /gene_synonym="CR53; ZKSCAN21; ZSCAN53"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..3311
                     /gene="ZNF213"
                     /gene_synonym="CR53; ZKSCAN21; ZSCAN53"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3294..3299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF213"
                     /gene_synonym="CR53; ZKSCAN21; ZSCAN53"
                     /note="hexamer: AATAAA"
     polyA_site      3311
                     /gene="ZNF213"
                     /gene_synonym="CR53; ZKSCAN21; ZSCAN53"
                     /note="major polyA site"
ORIGIN      
        1 gaggacttcc ggcgccggga gctcgcggcg gaagtgggat ctcctgggcc gtagtgggcg
       61 ttgtgtgttt cgggggcggg ggcgggggcg ggggccgggg cggggacggg gcctctggcc
      121 gcctggctcc aacatcaagc accgggctcc gagtggccgg gatcagcgcc ccgaggcaga
      181 ggccggaggg cgcgcgcact gctaggaagt gctggtcccc cgcgccgctc tgccagcttg
      241 gtcccccggc agacgcccct gtacgatcgc cgctcgcccc gcgggcgagg ctgcggtgga
      301 cagcgcgggg ctccggctgg ctcgccttcc cgcctgccgt gtcctgctga gcgaccctgg
      361 agtacacatc cagatgccag cccagctacc acaggggatc cctctgggag actgaaagta
      421 caggttctgg ggcccaggtt gaagccgacc aaccctgagc ctcaggccag gggaatggca
      481 gcccccttgg aggcccagga ccaggcccct ggggagggag aagggcttct gattgtgaaa
      541 gtggaagatt cctcctggga acaggaatct gcccagcatg aggatggcag ggattccgaa
      601 gcctgccgcc agcgcttccg gcaattctgc tacggggatg tgcatgggcc tcatgaggcc
      661 ttcagccagc tctgggagct ctgctgccgc tggctgcggc ccgagctgcg taccaaggag
      721 cagatcctgg agctgctggt gctggagcag ttcctgacag tgctgccagg ggagatccag
      781 ggctgggtgc gtgagcagca cccgggaagc ggtgaggagg ctgtcgcctt ggtggaggac
      841 ctacagaagc agccagtgaa agcctggcga caggatgtgc cctcggagga ggcggaaccc
      901 gaggctgcag gccggggatc ccaggccacg gggcctcccc cgacggtggg ggcacggagg
      961 cggccgtctg ttccccagga gcagcacagc catagcgccc agcctcctgc tcttcttaaa
     1021 gagggtcgtc ccggagagac gacggacacc tgctttgtct ctggggtcca tggacctgtg
     1081 gcattgggag acatcccatt ctatttctcc cgggaagaat ggggcaccct ggaccctgct
     1141 cagcgggatc tcttctggga cataaagcgg gagaactccc ggaacaccac cctgggtttt
     1201 gggctcaaag gccaaagtga gaagtccctg ctgcaggaga tggtgccggt ggtgccaggc
     1261 cagacaggca gcgacgtgac tgtgtcctgg agccccgagg aggctgaggc ctgggagagc
     1321 gagaaccggc cgagggcggc cctgggccca gtggtgggcg cgcgacgggg gcggccaccc
     1381 actcgccggc gccagttccg ggacctggca gccgagaagc cgcacagctg cgggcagtgt
     1441 ggaaagcgct tccgctgggg ctcggacctg gcgcggcacc agcgcacgca cacgggcgag
     1501 aagccacaca agtgccctga gtgcgacaag agcttccgca gctcctcgga cctggtgcgc
     1561 caccaaggcg tgcacacggg cgagaagccc ttctcctgtt ccgagtgcgg caagagcttc
     1621 agccgcagcg cctacctggc cgaccaccag cgcatacaca cgggcgagaa gcctttcggc
     1681 tgcagcgact gcggcaagag cttctcgctg cgctcctacc tgctggacca tcggcgtgtg
     1741 cacaccggtg agcggccctt cggctgcgga gagtgcgaca agagcttcaa gcagcgcgcg
     1801 cacctcatcg cgcatcagag cctgcacgcc aagatggccc agcccgtggg gtgagcagct
     1861 ggcttggccg gaaacccggg ggaggcccag ccacggcaca tcctgctttg ttcaccactg
     1921 ggactctcct tccatctgtg gccacctccc gggctgtccg agggacccca gggtacctca
     1981 cactcggagc tcgcctgccc tgcttggctc tgaggacctg cccagcgctc aaagggaacg
     2041 gaagccttcc cctcccgccc ccgatcttgt cctctttccc ccttctgcgc ctagcgttcc
     2101 tcttcccctc tagtttcctg gagccccaac acattcctgg cagggacagc agggtggcaa
     2161 ggactcaggt ctaggtccct tcccagaagc ccccgagcct catttgactg tgtggctctt
     2221 tggcccccac cctgtggggt gggtccatgg gtcaggcctc tgccctacca acctgtgcct
     2281 ttcagtgggc gtggaggact ggccttggcc ccccaggggg ctgctggact ttgggagaga
     2341 cagcccacac ctgtgggacc gcgggtctta gtcacggcgg caggggcttt ctggccccct
     2401 cccactcccg tttccaggcc atgaccactc tgccctgtcc tggccatacg gactcggcct
     2461 gcctttgccc tcggcctact tgccctagca tgaggctctg agagccacct gcccaccaat
     2521 ctggtgagga taatggtggc tccagcgaca ggaggccaac cctggagacc aagaacaggg
     2581 cgcctggctg ccatcttttc ctccagaggt ggggctgcac cagactcagc actagcactc
     2641 catcagcact agcacctcac tccatcagca ctagcacctc actccatcgg ccccggcacc
     2701 ctgctccatc ggcactggcg ccctgctcca tcggcactaa tgctccactc ggcgccccac
     2761 tccatcggcc ccgctccatc ggcactaatg ccccactcgg cgccccactc catcagcact
     2821 aatgctccac tccattggca ctaacgcccc aactccagcg gcactaatga cccgctcctt
     2881 tgacattggt gccccactcc atcagcacta acgccctgct ccatcggcac tggtgtccca
     2941 ctccattgtc actaacgtcc ggctccatcg gcactaccac cccgctccat catcactatg
     3001 tccagctccg tcggcactac caccctgctc catcatcact acgtccagct ccaacggcac
     3061 tggtgcccca ttccatcggc actaacgccc cgctccaccg gcaccagtgc ctcgctccat
     3121 tggcaccaac gcccagctcc accggtactg gctccctgct ccatcggcac taacgccctg
     3181 cttcattggc actttgctgc tgcctcctga gcactgcctt ccatgaacag ggacagacca
     3241 gaggccctgc aaggactccc cctcagacct ccaaagggca acagaagagt attaataaac
     3301 gtgaaaactt a
//
