LOCUS       NM_012256               2807 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens zinc finger protein 212 (ZNF212), mRNA.
ACCESSION   NM_012256
VERSION     NM_012256.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2807)
  AUTHORS   Chung,H.J., Lee,J.R., Kim,T.M., Kim,S., Park,K., Kim,M.J., Jung,E.,
            Kim,S., Lee,E.A., Ra,J.S., Hwang,S., Lee,J.Y., Scharer,O.D.,
            Kim,Y., Myung,K. and Kim,H.
  TITLE     ZNF212 promotes genomic integrity through direct interaction with
            TRAIP
  JOURNAL   Nucleic Acids Res 51 (2), 631-649 (2023)
   PUBMED   36594163
  REMARK    GeneRIF: ZNF212 promotes genomic integrity through direct
            interaction with TRAIP.
REFERENCE   2  (bases 1 to 2807)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2807)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2807)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2807)
  AUTHORS   Weimann,M., Grossmann,A., Woodsmith,J., Ozkan,Z., Birth,P.,
            Meierhofer,D., Benlasfer,N., Valovka,T., Timmermann,B.,
            Wanker,E.E., Sauer,S. and Stelzl,U.
  TITLE     A Y2H-seq approach defines the human protein methyltransferase
            interactome
  JOURNAL   Nat Methods 10 (4), 339-342 (2013)
   PUBMED   23455924
REFERENCE   6  (bases 1 to 2807)
  AUTHORS   Gao,J., Li,W.X., Feng,S.Q., Yuan,Y.S., Wan,D.F., Han,W. and Yu,Y.
  TITLE     A protein-protein interaction network of transcription factors
            acting during liver cell proliferation
  JOURNAL   Genomics 91 (4), 347-355 (2008)
   PUBMED   18255255
REFERENCE   7  (bases 1 to 2807)
  AUTHORS   Becker,K.G., Nagle,J.W., Canning,R.D., Dehejia,A.M.,
            Polymeropoulos,M.H., Gado,A.M., Biddison,W.E. and Drew,P.D.
  TITLE     Molecular cloning and mapping of a novel human KRAB
            domain-containing C2H2-type zinc finger to chromosome 7q36.1
  JOURNAL   Genomics 41 (3), 502-504 (1997)
   PUBMED   9169157
REFERENCE   8  (bases 1 to 2807)
  AUTHORS   Becker,K.G., Nagle,J.W., Canning,R.D., Biddison,W.E., Ozato,K. and
            Drew,P.D.
  TITLE     Rapid isolation and characterization of 118 novel C2H2-type zinc
            finger cDNAs expressed in human brain
  JOURNAL   Hum Mol Genet 4 (4), 685-691 (1995)
   PUBMED   7633419
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK074821.1 and BC022785.2.
            
            On May 17, 2019 this sequence version replaced NM_012256.3.
            
            Summary: This gene belongs to the C2H2-type zinc finger gene
            family. The zinc finger proteins are involved in gene regulation
            and development, and are quite conserved throughout evolution. Like
            this gene product, a third of the zinc finger proteins containing
            C2H2 fingers also contain the KRAB domain, which has been found to
            be involved in protein-protein interactions. [provided by RefSeq,
            Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022785.2, SRR1660807.111762.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335870.7/ ENSP00000338572.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AK074821.1         1-33
            34-2807             BC022785.2         1-2774
FEATURES             Location/Qualifiers
     source          1..2807
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..2807
                     /gene="ZNF212"
                     /gene_synonym="C2H2-150; ZNF182; ZNFC150"
                     /note="zinc finger protein 212"
                     /db_xref="GeneID:7988"
                     /db_xref="HGNC:HGNC:13004"
                     /db_xref="MIM:602386"
     exon            1..152
                     /gene="ZNF212"
                     /gene_synonym="C2H2-150; ZNF182; ZNFC150"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1616
                     /gene="ZNF212"
                     /gene_synonym="C2H2-150; ZNF182; ZNFC150"
                     /note="Zinc finger protein C2H2-150"
                     /codon_start=1
                     /product="zinc finger protein 212"
                     /protein_id="NP_036388.2"
                     /db_xref="CCDS:CCDS5896.1"
                     /db_xref="GeneID:7988"
                     /db_xref="HGNC:HGNC:13004"
                     /db_xref="MIM:602386"
                     /translation="MAESAPARHRRKRRSTPLTSSTLPSQATEKSSYFQTTEISLWTV
                     VAAIQAVEKKMESQAARLQSLEGRTGTAEKKLADCEKMAVEFGNQLEGKWAVLGTLLQ
                     EYGLLQRRLENVENLLRNRNFWILRLPPGSKGEAPKVSRSLENDGVCFTEQEWENLED
                     WQKELYRNVMESNYETLVSLKVLGQTEGEAELGTEMLGDLEEEGPGGAHPAGGVMIKQ
                     ELQYTQEGPADLPGEFSCIAEEQAFLSPEQTELWGGQGSSVLLETGPGDSTLEEPVGS
                     RVPSSSRTVGCPKQKSHRQVQLDQECGQGLKLKKDTSRPYECSECEITFRYKQQLATH
                     LRSHSGWGSCTPEEPEESLRPRPRLKPQTKKAKLHQCDVCLRSFSCKVSLVTHQRCHL
                     QEGPSAGQHVQERFSPNSLVALPGHIPWRKSRSSLICGYCGKSFSHPSDLVRHQRIHT
                     GERPYSCTECEKSFVQKQHLLQHQKIHQRERGGLALEPGRPNGLL"
     exon            153..542
                     /gene="ZNF212"
                     /gene_synonym="C2H2-150; ZNF182; ZNFC150"
                     /inference="alignment:Splign:2.1.0"
     exon            543..669
                     /gene="ZNF212"
                     /gene_synonym="C2H2-150; ZNF182; ZNFC150"
                     /inference="alignment:Splign:2.1.0"
     exon            670..759
                     /gene="ZNF212"
                     /gene_synonym="C2H2-150; ZNF182; ZNFC150"
                     /inference="alignment:Splign:2.1.0"
     exon            760..2807
                     /gene="ZNF212"
                     /gene_synonym="C2H2-150; ZNF182; ZNFC150"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2063..2068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF212"
                     /gene_synonym="C2H2-150; ZNF182; ZNFC150"
                     /note="hexamer: AAGAAA"
     polyA_site      2081
                     /gene="ZNF212"
                     /gene_synonym="C2H2-150; ZNF182; ZNFC150"
                     /note="major polyA site"
     polyA_site      2779
                     /gene="ZNF212"
                     /gene_synonym="C2H2-150; ZNF182; ZNFC150"
                     /note="major polyA site"
ORIGIN      
        1 agaatgcacc tggcatcaac acggcggcgg cggcggcggc ttccaacagg ctctggggcg
       61 ccgagcggac aggaacgcag cacgggggct ccgaggcggg gtctgggtgt tgaggggcga
      121 ctggagccat ggcggagtcg gcgcctgctc ggcacaggag aaaacgacgc tccacacctt
      181 taacttcttc cacacttcct tcacaagcaa cagagaaaag ctcctatttt cagaccaccg
      241 agatttcact ctggacggtg gtggccgcta ttcaggctgt ggagaagaag atggagtccc
      301 aggctgcccg gctacagagc ctggaggggc gcacggggac agccgagaag aagctggctg
      361 actgcgagaa gatggccgtg gagttcggga accagctgga gggcaagtgg gccgtgctgg
      421 ggaccctgct gcaggagtat gggctactgc agaggcggct ggagaacgtg gagaacctgc
      481 tgcgcaacag gaacttctgg atcctgcggc tgcccccggg cagcaagggg gaggccccca
      541 aggtgtccag gtcactggag aatgatggcg tctgtttcac cgagcaggaa tgggagaatc
      601 tggaggattg gcagaaggag ctctacagaa acgtgatgga gagtaactat gagacactgg
      661 tctctctgaa ggtccttggc cagacagagg gagaagcgga gttgggtaca gagatgctgg
      721 gtgacttgga agaggaaggt cctggtggtg cccacccagc aggtggggtc atgatcaaac
      781 aggagctaca gtatacacag gaaggccctg cggatcttcc tggagagttc tcatgcattg
      841 ctgaagagca ggctttcctg agcccagagc agaccgaact ctggggtggt cagggcagtt
      901 ctgtcctctt ggaaacaggt cctggggact ctactctaga ggagcctgtt ggtagtagag
      961 ttcctagcag cagcagaact gtgggctgcc cgaagcagaa atctcatagg caggtacagc
     1021 tggaccagga atgtgggcag ggcctgaagc tgaaaaagga cacttcccgc ccctacgaat
     1081 gttctgagtg tgagatcacc ttccgctata agcagcagct ggccacacat ctgcgcagcc
     1141 actctgggtg ggggtcttgt acacctgagg agccagagga gagccttagg cccaggccac
     1201 ggctgaaacc acagaccaaa aaggccaagc tgcatcagtg tgatgtgtgc ctgaggagct
     1261 tcagctgcaa ggtgagcctg gtgacccatc agcgttgcca cctgcaggag gggcccagtg
     1321 ccggccagca tgtccaagag aggttctcac ccaacagcct ggttgccctg cctggccaca
     1381 tcccttggag gaaaagccgg agttccctca tctgtggtta ctgtggcaag agcttcagtc
     1441 acccatctga cttggtgcgg caccagcgca tccacacggg tgagcggccc tacagctgca
     1501 ctgagtgtga gaagagcttt gtccagaagc agcacctcct gcagcaccag aagatccacc
     1561 agcgggagcg gggtgggctg gccctggagc ccggaaggcc caatggcctg ctttaagggt
     1621 gcagcccctc gcccgtctgg gggatggagg ggggtggcat tggttccccc gaagagacac
     1681 tgcagtcagg gactgagttc ttcctgaggg cagttgtttg tgattgcctt cccttgtccc
     1741 agtaccaagc caagcccaaa ggctgtcctg aaaaccctgt ggaagaagag tccaggccag
     1801 gtcttcatcc tgctgccaag tttgctgttt cttggcacct tcaggtctct ggttttctca
     1861 ttcatgccaa tgcttgtggg ctggggttgg cgttctgacc ccacagggac tggtggctgg
     1921 ttccagggct cgtcccggca tttcatgtct tcccacgggg ttgagtcggg ccataggggt
     1981 gagcagctgc ctggaagagt tctgggaagt ataaccctcc attttttctt gttttataat
     2041 ctctttgttt aataataagt agaagaaata atttaaatga actgcttagc cctgctctga
     2101 agaacctttt ttggaattag attttagttg attttttaaa gaatacagcc caacacttgt
     2161 tttttacatt ttaagagttg tagaagttgt tcctaacttg gggactggac ctaccctcta
     2221 ggagggagtt gttaatgggg ctcttttagc ccactgatgc ttacttaggc cggagagcag
     2281 gggacacggt gctaggttcc ctcgtgcagt gcctggtgct ctcaaattgt ctcaaaagga
     2341 ccaagaggaa aagagtcgga ggggtagacc ctgcagccct gttgagaaga aagattccag
     2401 tgaagttgct gatggtatgg ctgtggtctg ggacttgcgg tgtctcggca tacccctctc
     2461 ctcttcccac ctcctcctgg ctatgttctg cagcctccca gagtagaaaa ctactttgtt
     2521 acttaaggtt gttcaccttg taccagtggt tatttgagtt tgttcctatt acaccaatcc
     2581 ttacttgagg tggttcggat tacagtttcc aaatgcattc tgggattgcc tattccagag
     2641 agggtacaga aaaagcacac agatggcttg tctcaggagt gttgaatgtg tgccccgctg
     2701 ctgtctgggg ggatgggagt gggctctggg gtcatatgtg aacatcccct tggatgattt
     2761 gcggttgctt agaataaaac ttgctactag caaaagaaaa aaaaaaa
//
