LOCUS       NP_036388                495 aa            linear   PRI 27-APR-2025
DEFINITION  zinc finger protein 212 [Homo sapiens].
ACCESSION   NP_036388
VERSION     NP_036388.2
DBSOURCE    REFSEQ: accession NM_012256.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 495)
  AUTHORS   Chung,H.J., Lee,J.R., Kim,T.M., Kim,S., Park,K., Kim,M.J., Jung,E.,
            Kim,S., Lee,E.A., Ra,J.S., Hwang,S., Lee,J.Y., Scharer,O.D.,
            Kim,Y., Myung,K. and Kim,H.
  TITLE     ZNF212 promotes genomic integrity through direct interaction with
            TRAIP
  JOURNAL   Nucleic Acids Res 51 (2), 631-649 (2023)
   PUBMED   36594163
  REMARK    GeneRIF: ZNF212 promotes genomic integrity through direct
            interaction with TRAIP.
REFERENCE   2  (residues 1 to 495)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (residues 1 to 495)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 495)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 495)
  AUTHORS   Weimann,M., Grossmann,A., Woodsmith,J., Ozkan,Z., Birth,P.,
            Meierhofer,D., Benlasfer,N., Valovka,T., Timmermann,B.,
            Wanker,E.E., Sauer,S. and Stelzl,U.
  TITLE     A Y2H-seq approach defines the human protein methyltransferase
            interactome
  JOURNAL   Nat Methods 10 (4), 339-342 (2013)
   PUBMED   23455924
REFERENCE   6  (residues 1 to 495)
  AUTHORS   Gao,J., Li,W.X., Feng,S.Q., Yuan,Y.S., Wan,D.F., Han,W. and Yu,Y.
  TITLE     A protein-protein interaction network of transcription factors
            acting during liver cell proliferation
  JOURNAL   Genomics 91 (4), 347-355 (2008)
   PUBMED   18255255
REFERENCE   7  (residues 1 to 495)
  AUTHORS   Becker,K.G., Nagle,J.W., Canning,R.D., Dehejia,A.M.,
            Polymeropoulos,M.H., Gado,A.M., Biddison,W.E. and Drew,P.D.
  TITLE     Molecular cloning and mapping of a novel human KRAB
            domain-containing C2H2-type zinc finger to chromosome 7q36.1
  JOURNAL   Genomics 41 (3), 502-504 (1997)
   PUBMED   9169157
REFERENCE   8  (residues 1 to 495)
  AUTHORS   Becker,K.G., Nagle,J.W., Canning,R.D., Biddison,W.E., Ozato,K. and
            Drew,P.D.
  TITLE     Rapid isolation and characterization of 118 novel C2H2-type zinc
            finger cDNAs expressed in human brain
  JOURNAL   Hum Mol Genet 4 (4), 685-691 (1995)
   PUBMED   7633419
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK074821.1 and BC022785.2.
            
            On Nov 8, 2002 this sequence version replaced NP_036388.1.
            
            Summary: This gene belongs to the C2H2-type zinc finger gene
            family. The zinc finger proteins are involved in gene regulation
            and development, and are quite conserved throughout evolution. Like
            this gene product, a third of the zinc finger proteins containing
            C2H2 fingers also contain the KRAB domain, which has been found to
            be involved in protein-protein interactions. [provided by RefSeq,
            Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022785.2, SRR1660807.111762.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335870.7/ ENSP00000338572.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     Protein         1..495
                     /product="zinc finger protein 212"
                     /note="Zinc finger protein C2H2-150"
                     /calculated_mol_wt=55317
     Region          1..29
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UDV6.3)"
     Region          142..180
                     /region_name="KRAB_A-box"
                     /note="KRAB (Kruppel-associated box) domain -A box;
                     cd07765"
                     /db_xref="CDD:143639"
     Region          264..290
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UDV6.3)"
     Region          316..338
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          318..338
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275370"
     Region          337..361
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UDV6.3)"
     Region          371..391
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(376,378,380,382..383,386..387,390,434,436,440..441,
                     444..445,448,462,464,466,468..469,472..473,476)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          429..449
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          429..449
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          455..477
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          457..477
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          476..495
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UDV6.3)"
     CDS             1..495
                     /gene="ZNF212"
                     /gene_synonym="C2H2-150; ZNF182; ZNFC150"
                     /coded_by="NM_012256.4:129..1616"
                     /db_xref="CCDS:CCDS5896.1"
                     /db_xref="GeneID:7988"
                     /db_xref="HGNC:HGNC:13004"
                     /db_xref="MIM:602386"
ORIGIN      
        1 maesaparhr rkrrstplts stlpsqatek ssyfqtteis lwtvvaaiqa vekkmesqaa
       61 rlqslegrtg taekkladce kmavefgnql egkwavlgtl lqeygllqrr lenvenllrn
      121 rnfwilrlpp gskgeapkvs rslendgvcf teqewenled wqkelyrnvm esnyetlvsl
      181 kvlgqtegea elgtemlgdl eeegpggahp aggvmikqel qytqegpadl pgefsciaee
      241 qaflspeqte lwggqgssvl letgpgdstl eepvgsrvps ssrtvgcpkq kshrqvqldq
      301 ecgqglklkk dtsrpyecse ceitfrykqq lathlrshsg wgsctpeepe eslrprprlk
      361 pqtkkaklhq cdvclrsfsc kvslvthqrc hlqegpsagq hvqerfspns lvalpghipw
      421 rksrsslicg ycgksfshps dlvrhqriht gerpysctec eksfvqkqhl lqhqkihqre
      481 rgglalepgr pngll
//
