LOCUS       NM_007153               9088 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens zinc finger protein 208 (ZNF208), transcript variant
            1, mRNA.
ACCESSION   NM_007153
VERSION     NM_007153.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9088)
  AUTHORS   Yu,J., Zhou,F., Luo,D., Wang,N., Zhang,C., Jin,T., Liang,X. and
            Yu,D.
  TITLE     ZNF208 polymorphisms associated with ischemic stroke in a southern
            Chinese Han population
  JOURNAL   J Gene Med 19 (1-2) (2017)
   PUBMED   27936511
  REMARK    GeneRIF: three variants were associated with the risk of ischemic
            stroke under allele models (rs2188971, rs2188972, rs8103163 and
            rs7248488). The variant rs2188972 was also associated with the risk
            of ischemic stroke in a recessive model after adjustment for age
            and sex
REFERENCE   2  (bases 1 to 9088)
  AUTHORS   Wang,H., Yu,J., Guo,Y., Zhang,Z., Liu,G., Li,J., Zhang,X., Jin,T.
            and Wang,Z.
  TITLE     Genetic variants in the ZNF208 gene are associated with esophageal
            cancer in a Chinese Han population
  JOURNAL   Oncotarget 7 (52), 86829-86835 (2016)
   PUBMED   27907911
  REMARK    GeneRIF: Data indicate that variants in ZNF208 are contribute to
            the susceptibility to esophageal cancer in a Chinese Han
            population.
REFERENCE   3  (bases 1 to 9088)
  AUTHORS   Oh,H.J., Li,Y. and Lau,Y.F.
  TITLE     Sry associates with the heterochromatin protein 1 complex by
            interacting with a KRAB domain protein
  JOURNAL   Biol Reprod 72 (2), 407-415 (2005)
   PUBMED   15469996
REFERENCE   4  (bases 1 to 9088)
  AUTHORS   Eichler,E.E., Hoffman,S.M., Adamson,A.A., Gordon,L.A., McCready,P.,
            Lamerdin,J.E. and Mohrenweiser,H.W.
  TITLE     Complex beta-satellite repeat structures and the expansion of the
            zinc finger gene cluster in 19p12
  JOURNAL   Genome Res 8 (8), 791-808 (1998)
   PUBMED   9724325
REFERENCE   5  (bases 1 to 9088)
  AUTHORS   Bellefroid,E.J., Marine,J.C., Ried,T., Lecocq,P.J., Riviere,M.,
            Amemiya,C., Poncelet,D.A., Coulie,P.G., de Jong,P., Szpirer,C. et
            al.
  TITLE     Clustered organization of homologous KRAB zinc-finger genes with
            enhanced expression in human T lymphoid cells
  JOURNAL   EMBO J 12 (4), 1363-1374 (1993)
   PUBMED   8467795
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC003973.1.
            
            On Aug 22, 2009 this sequence version replaced NM_007153.2.
            
            Summary: Zinc finger proteins (ZNFs), such as ZNF208, bind DNA and,
            through this binding, regulate gene transcription. Most ZNFs
            contain conserved C2H2 motifs and are classified as Kruppel-type
            zinc fingers. A conserved protein motif, termed the
            Kruppel-associated box (KRAB) domain, mediates protein-protein
            interactions (Eichler et al., 1998 [PubMed 9724325]). See ZNF91
            (MIM 603971) for further information on ZNFs.[supplied by OMIM, Aug
            2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB997649.1, DRR138524.974785.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159764 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397126.9/ ENSP00000380315.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               AC003973.1         42621-42772
            153-279             AC003973.1         64655-64781
            280-375             AC003973.1         66253-66348
            376-9088            AC003973.1         78757-87469
FEATURES             Location/Qualifiers
     source          1..9088
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p12"
     gene            1..9088
                     /gene="ZNF208"
                     /gene_synonym="PMIDP; ZNF95"
                     /note="zinc finger protein 208"
                     /db_xref="GeneID:7757"
                     /db_xref="HGNC:HGNC:12999"
                     /db_xref="MIM:603977"
     exon            1..152
                     /gene="ZNF208"
                     /gene_synonym="PMIDP; ZNF95"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..3992
                     /gene="ZNF208"
                     /gene_synonym="PMIDP; ZNF95"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 95"
                     /codon_start=1
                     /product="zinc finger protein 208 isoform 1"
                     /protein_id="NP_009084.2"
                     /db_xref="CCDS:CCDS54240.1"
                     /db_xref="GeneID:7757"
                     /db_xref="HGNC:HGNC:12999"
                     /db_xref="MIM:603977"
                     /translation="MGSLTFRDVAIEFSLEEWQCLDTAQQNLYRNVMLENYRNLVFLG
                     IAAFKPDLIIFLEEGKESWNMKRHEMVEESPVICSHFAQDLWPEQGIEDSFQKVILRR
                     YEKCGHENLHLKIGYTNVDECKVHKEGYNKLNQSLTTTQSKVFQRGKYANVFHKCSNS
                     NRHKIRHTGKKHLQCKEYVRSFCMLSHLSQHKRIYTRENSYKCEEGGKAFNWSSTLTY
                     YKSAHTGEKPYRCKECGKAFSKFSILTKHKVIHTGEKSYKCEECGKAFNQSAILTKHK
                     IIHTGEKPNKCEECGKAFSKVSTLTTHKAIHAGEKPYKCKECGKAFSKVSTLITHKAI
                     HAGEKPYKCKECGKAFSKFSILTKHKVIHTGEKPYKCEECGKAYKWPSTLSYHKKIHT
                     GEKPYKCEECGKGFSMFSILTKHEVIHTGEKPYKCEECGKAFNWSSNLMEHKKIHTGE
                     TPYKCEECGKGFSMFSILTKHKVIHNGEKPYKCEECDKATHAGEKPYKCEECGKAFNW
                     SSNLMEHKRIHTGEKPYKCEECGKSFSTFSILTKHKVIHTGEKPYKCEECGKAYKWSS
                     TLSYHKKIHTVEKPYKCEECGKAFNQSAILIKHKRIHTGEKPYKCEECGKTFSKVSTL
                     TTHKAIHAGEKPYKCKECGKTFIKVSTLTTHKAIHAGEKPYKCKECGKAFSKFSILTK
                     HKVIHTGEKPYKCEECGKAFNWSSNLMEHKRIHTGEKPYKCEECGKSFSTFSVLTKHK
                     VIHTGEKPYKCEECGKAYKWSSTLSYHKKIHTVEKPYKCEECGKAFNRSAILIKHKRI
                     HTDEKPYKCEECGKTFSKVSTLTTHKAIHAGEKPYKCKECGKAFSKFSILTKHKVIHT
                     GEKPYKCEECGKAYKWPSTLSYHKKIHTGEKPYKCEECGKGFSMFSILTKHEVIHTGE
                     KPYKCEECGKAFSWLSVFSKHKKTHAGEKFYKCEACGKAYKSSSTLSYHKKIHTEEKP
                     YKYEECGKGFSTFSILTKHKVIHTGEKPYKCEECGKAFNWSSNLMEHKKIHTGETPYK
                     CEECDKAFSWPSSLTEHKATHAGEKPYKCEECGKAFSWPSRLTEHKATHAGEEPYKCE
                     ECGKAFNWSSNLMEHKRIHTGEKPYKCEECGKSFSTFSILTKHKVIHTGEKPYKCEEC
                     GKAYKWSSTLSYHKKIHTVEKPYKCEECGKGFVMFSILAKHKVIHTGEKLYKCEECGK
                     AYKWPSTLRYHKKIHTGEKPYKCEECGKAFSTFSILTKHKVIHTGEKPYKCEECGKAF
                     SWLSVFSKHKKIHTGEKL"
     exon            153..279
                     /gene="ZNF208"
                     /gene_synonym="PMIDP; ZNF95"
                     /inference="alignment:Splign:2.1.0"
     exon            280..375
                     /gene="ZNF208"
                     /gene_synonym="PMIDP; ZNF95"
                     /inference="alignment:Splign:2.1.0"
     exon            376..9088
                     /gene="ZNF208"
                     /gene_synonym="PMIDP; ZNF95"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8890..8895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF208"
                     /gene_synonym="PMIDP; ZNF95"
                     /note="hexamer: AATAAA"
     polyA_site      8913
                     /gene="ZNF208"
                     /gene_synonym="PMIDP; ZNF95"
                     /note="major polyA site"
     regulatory      9058..9063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF208"
                     /gene_synonym="PMIDP; ZNF95"
                     /note="hexamer: AATAAA"
     regulatory      9067..9072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF208"
                     /gene_synonym="PMIDP; ZNF95"
                     /note="hexamer: AATAAA"
     polyA_site      9077
                     /gene="ZNF208"
                     /gene_synonym="PMIDP; ZNF95"
     polyA_site      9088
                     /gene="ZNF208"
                     /gene_synonym="PMIDP; ZNF95"
                     /note="major polyA site"
ORIGIN      
        1 cctttgtctc tcgctgcagc cggaggtcaa ggtctcgtcc ttactgctgt gtgtcctctg
       61 ctcctagagt cccagcctct gtggccctat gacctgcagg tattgggaga tccacaacta
      121 agtcgccagg accccctgga agcctagaaa tgggatcatt gacatttagg gatgtggcca
      181 tagaattctc tctggaggag tggcaatgcc tggacactgc acagcagaat ttatatagaa
      241 atgtgatgtt agagaactac agaaacctgg tcttcctggg tattgctgcc tttaagccag
      301 acctgatcat ttttctggag gaaggaaaag agtcctggaa tatgaagaga catgagatgg
      361 tggaagaatc cccagttata tgttctcatt ttgctcaaga tctttggcca gagcagggca
      421 tagaagattc tttccaaaaa gtgatattga gaaggtatga aaaatgtgga catgagaatt
      481 tacacttaaa aattggttat accaatgtgg atgagtgtaa ggtgcacaaa gaaggttata
      541 ataaacttaa ccagagtttg acaactacac agagcaaagt atttcaacgt ggcaaatatg
      601 caaatgtctt tcataaatgt tcaaattcaa acagacataa gataaggcat actggaaaga
      661 aacatttgca atgtaaagaa tacgtcagat cattttgcat gctttcacac ctatctcaac
      721 ataaaagaat ttatactaga gagaattcct acaaatgtga agaaggtggc aaagctttta
      781 actggtcctc aacccttact tattataaga gtgctcatac tggagagaaa ccctacagat
      841 gtaaagaatg tggcaaagcc tttagtaagt tctcaatcct tactaaacat aaggtaattc
      901 atactggaga gaaatcctac aaatgtgaag aatgtggcaa ggcttttaac caatctgcaa
      961 tccttactaa acataagata attcatactg gagagaaacc caacaaatgt gaagaatgtg
     1021 gcaaagcctt tagtaaggtc tcgactctta ctacacataa ggcaattcat gctggagaga
     1081 agccctacaa atgtaaagaa tgtggcaaag ccttcagtaa ggtctcaacc cttattacac
     1141 ataaggcaat tcatgctgga gagaagccct acaaatgtaa agaatgtggc aaagccttta
     1201 gtaagttctc aatccttact aaacataagg taattcatac tggagagaaa ccctacaaat
     1261 gtgaagaatg cggcaaagcc tataagtggc cctcaaccct tagttatcat aagaaaattc
     1321 atactggaga gaaaccctac aaatgtgaag aatgtggcaa aggttttagt atgttctcaa
     1381 tccttactaa acatgaggtc attcatactg gagagaaacc ctacaaatgt gaagaatgtg
     1441 gcaaagcttt caactggtcc tcaaacctta tggaacataa gaaaattcac actggagaga
     1501 caccctacaa atgtgaagaa tgtggcaaag gctttagtat gttctcaatc cttactaaac
     1561 ataaggtaat tcataatgga gagaaaccct acaaatgtga agaatgtgat aaggcaactc
     1621 atgctggaga gaaaccctac aaatgtgaag aatgtggcaa agctttcaac tggtcctcaa
     1681 accttatgga acataagaga attcatactg gagagaaacc ctacaaatgt gaagaatgtg
     1741 gcaaaagctt cagtacattc tcaatcctta ctaaacataa ggtaattcat actggagaga
     1801 aaccctacaa atgtgaagaa tgtggcaaag cctataagtg gtcctcaacc cttagttatc
     1861 ataagaaaat tcatactgta gagaaaccct acaaatgtga agaatgtggc aaagctttta
     1921 accaatctgc aattcttatt aaacataaga gaattcatac tggtgagaaa ccctacaaat
     1981 gtgaagaatg tggcaaaacc tttagtaagg tctcaaccct tactacacat aaggcaattc
     2041 atgctggaga gaagccctac aaatgtaaag aatgtggcaa aacctttatt aaggtctcaa
     2101 cccttactac acataaggca attcatgctg gagagaagcc ctacaaatgt aaagaatgtg
     2161 gcaaagcctt tagtaagttc tcaatcctta ctaaacataa ggtaattcat actggagaga
     2221 aaccctacaa atgtgaagaa tgtggcaaag ctttcaactg gtcctcaaac cttatggaac
     2281 ataagagaat tcatactgga gagaaaccct acaaatgtga agaatgtggc aaaagcttta
     2341 gtacattctc agtccttact aaacataagg taattcatac tggagagaaa ccctacaaat
     2401 gtgaagaatg tggcaaagcc tataagtggt cctcaaccct tagttatcat aagaaaattc
     2461 atactgtaga gaaaccctac aaatgtgaag aatgtggcaa agcttttaac cgatctgcaa
     2521 tccttattaa acataagaga attcatactg atgagaaacc ctacaaatgt gaagaatgtg
     2581 gcaaaacctt tagtaaggtc tcaaccctta ctacacataa ggcaattcat gctggagaaa
     2641 agccctacaa atgtaaagaa tgtggcaaag cctttagtaa gttctcaatc cttactaaac
     2701 ataaggtaat tcatactgga gagaaaccct acaaatgtga agaatgtggc aaagcctata
     2761 aatggccctc aacccttagt tatcataaga aaattcatac tggagagaaa ccctacaaat
     2821 gtgaagaatg tggcaaaggt tttagtatgt tctccatcct tactaaacat gaggtaattc
     2881 atactggaga gaaaccctac aaatgtgaag aatgtggcaa agccttcagc tggttgtcag
     2941 tctttagtaa acataagaaa actcatgctg gagagaaatt ctacaaatgt gaagcatgtg
     3001 gcaaagccta taagtcatcc tcaaccctta gttatcataa gaaaattcat actgaagaga
     3061 aaccttacaa atatgaagaa tgtggcaaag gctttagtac attctcaatc cttactaaac
     3121 ataaggtaat tcatactgga gagaaaccct acaaatgtga agaatgtggc aaagctttca
     3181 actggtcatc aaaccttatg gaacataaga aaattcacac tggagagaca ccctacaaat
     3241 gtgaagaatg tgacaaagcc ttcagctggc cctcaagcct tactgaacat aaggcaactc
     3301 atgctggaga aaaaccctac aaatgtgaag aatgtggcaa agccttcagc tggccctcaa
     3361 gacttactga acataaggca actcatgctg gagaggaacc ctacaaatgt gaagaatgtg
     3421 gcaaagcttt caactggtcc tcaaacctta tggaacataa gagaattcat actggagaga
     3481 aaccctacaa atgtgaagaa tgtggcaaaa gctttagtac gttctcaatc cttactaaac
     3541 ataaggtaat tcatactgga gagaaaccct acaaatgtga agaatgtggc aaagcctata
     3601 agtggtcctc aacccttagt tatcataaga aaattcatac tgtagagaaa ccctacaaat
     3661 gtgaagaatg tggcaaaggc tttgttatgt tctcaatcct tgcaaaacat aaggtaattc
     3721 atactggaga gaaactctac aaatgtgaag aatgtggcaa agcctataag tggccctcaa
     3781 cccttagata tcacaagaaa attcatactg gagagaaacc ctacaaatgt gaagaatgtg
     3841 gcaaagcctt tagtacgttc tcaatcctca ctaaacataa ggtaattcat actggagaga
     3901 aaccctacaa atgtgaagaa tgtggcaaag ccttcagctg gttatcagtc ttcagtaaac
     3961 ataagaaaat tcatactgga gagaaactct agaaatgtga agaatgtggc aaagcctata
     4021 agtggccctc aacccttagt tatcataaga aaattcatac tggagagaaa ccctacaaat
     4081 gtgaagaatg tggtgaggct ttcaactggt cctcaaacct tatggaacat aagagaattc
     4141 atactggaga gacaccctac aaatgtgaag aatgtggtaa aggctttagt atgttctcaa
     4201 tccttactaa acataaggta attcatactg gagagaaacc atacaaatgc aaagaatgtg
     4261 gcaaagccta taagtggtcc tcaaccctca gttatcatag aaaattcata ctggagagaa
     4321 accctacaaa tgtgaagaaa gtggcaaagc cttcagctgg ttctcagtct ttagtaaaca
     4381 taagaaaatt catgctggag agaaattcta aaaatgtgaa gaatttggca aagcttttaa
     4441 acagttccca accctcctac acataagaaa attcatgctg gagagaaact ctacaaatga
     4501 gaagaatgtg gcaaaggctt caaccagtcc tcaaacctta tggaacataa gagaattcat
     4561 actggtgaga agccctacaa atgtgaagaa tgtgataaag acttcaactg gtcctcacac
     4621 cttactactc ataaaagaat tcatactgga ggaaaaaccc tacaaatatg aaaaatgtgg
     4681 caaaactatt aattaattct caacgcttac tgaacataag ggaatttgta caggagggaa
     4741 accctacaaa tctgaagaat gtggcaagcc ttttagctat tcctcaatcc ttactaaaca
     4801 ttcatgtaat tcatactgga gggaattcct acaattgtgt ggaatgttgc aatgccctta
     4861 accagtcctt aaggcttact acatataaga caactcatac tggagagaaa ccatgcatgt
     4921 gtgaagaatg tgggaaagcc tctaatagat cctcaattct taagagacat aagctaattc
     4981 atacacaaga gagactctac aaacctgaaa gatgtgacaa tgcttttggc aacacctcag
     5041 acttttctga atataaaaga aatcgtacag atgagaaatc ctagaaaagt gaagaatatg
     5101 acaaagcctt taagtggctg tcacacttga ttgtaggtaa gataactcat actggagaaa
     5161 actactgtaa taaacaatgt gacaaacatt taaccagtgc tcatgcctta ttgcaaagga
     5221 aagcatttac actagcctgg gcaacagaga gagactgtct ggaaaaaaaa atttttgtta
     5281 atgccagtaa tatcttctca cagcttatta aacatcagag agttcatact aaataaaagt
     5341 attaaaagtg caatcactgt cactagatct ttcagaaaat aaaagctgtt aaagtacaga
     5401 agaatattta ttttgaggaa acacattata aatattaaga gggttgtagt acatgtactt
     5461 gtatcacaga ttttattgta cacattttgt actacaggaa aacctgaggt agttgttcca
     5521 actttgctca acatcaggga atttatattg aagaataacc ctgcaaattt aataaatttg
     5581 gaaaaacatt ttttcaaaaa ctacagatta taaaacacaa atgcgtttat actaaaatat
     5641 gtttttgcag atacagtaaa tataaaaaat atttaatcca aaattaagtt tatgtaaata
     5701 tcagctaatt cacagtagaa atacctgtca ctcaaacttc agatattaca ctaaatcaga
     5761 ctgctgagta taggaaaaaa tccaaaacta aagttggcaa aaagaagaat tatttgtata
     5821 taactttaaa agaagtagat ctttgaagag ttataattaa atttaaagta tacttttttc
     5881 ttcaaaacac agattttttt tttttccaga cacattggct tactgtggcc aatactttgt
     5941 gatgccaagg tgggcagatc acctgaggtc aggagttcaa gaccagcctt gccaacatag
     6001 tggaactaaa aagaaatgtt tactaaacat gtttactaaa aagaaataaa gaaattagcc
     6061 aaggtctagc ttccaggttc atgccattct cccacctcag cctcccaatt agctgggact
     6121 acaggcgccc gccgccactc ccagctaatt ttttgtattt ttagtacaga tggggtttca
     6181 ccatattagc caggacggtc tctatctcct gacctcatga tatgcccacc ttggccaccc
     6241 aaagtcctgg gattgcaggc atgagccaca gtgcctggcc taataacaga agtctttagc
     6301 agagcaaaaa tgtataaaat gtataatgac attgtataag taataataaa cctactaacc
     6361 ataaaaagcc ctggatcata tgaaatcaca gcgaagtttt accacattgc aaagagtttt
     6421 acctaagcct actgaatgca ttcgaaaaaa tcaaggtggg atttcaccct aacttgttat
     6481 attaaatcag tgaaatatat gaaactaaaa tctagtgaag gcaccacaaa aaaaggaaag
     6541 tacaggtcaa tattctgggt gaatattgga ataataatcc tccatgaaat actagcaaac
     6601 tgaattcaaa agcaaatcag aaagttattt tgctacatta atgtgagctt ttccatatat
     6661 atgaaggtgt ttcatgatat ggaagtcaat aagtgtgatt caccatgtaa agataattaa
     6721 aagaaaaaaa aataacagta ggggcagaaa aagcattcaa gaaaacccaa tattaactca
     6781 aaaatgttgt caacacactg gacattgatg aaaatatctt aataagagtc atctatgaca
     6841 aatccttagc caacatcata ctaaaagagc aaaaactgga agcattctcc atgagaataa
     6901 aaataagaat atccattcta aacagtccta ttgaagttat gaaatcctag ccagagaata
     6961 aaaggaatcc aaacagaaaa caaagaaagt caaattatct ttactgatga aagaattgtc
     7021 cacctagaat actttaaagg tttcaccaaa agagttctaa gcctggaaaa agacttcaaa
     7081 aaaaatctta gaatacaaaa tcagcacaaa tgcatagcat ttctgtacac caataatatt
     7141 caaactgaga acaaaataaa aaacacagct ctatttacaa tagcaacaaa cacacaaaaa
     7201 aatacctaga aatacattaa atcaaggggg taaaatatct ctacaaagaa caacaaaaca
     7261 ttgctgaaag aaacgagaga caatgcaaat aaatggaaaa atattgctca tggattcaaa
     7321 taatataatt aaaatggtca ttctgcctaa agcaacctac agattaagtg ctatttttat
     7381 cagactatcc atgacgattt ttattgaatt agaaaaagaa aactattcta aaatacattc
     7441 aaaagaatta aagagctcaa atagccaaga aaacttcaga ctaaaagaat aaatctgggc
     7501 caagcatggt ggctcatgcc tgtcatctca gccctttggg aggctgagat ggatggatca
     7561 cctgaggtca gaagtttgag accagcctgg ccaacatggt gaaacctgca tctctactaa
     7621 atgtaaaaaa ttagccaggt gtggtggtgc atgcctgtaa tcccagctac ttgggaggct
     7681 gaggaaagag aaccatttga gcctgggagg tggaggttgc agtgagccaa gattgcatca
     7741 gaataaccag tataacatgg ttctggtaca aaaataaaca tctagaccaa tgaaatggaa
     7801 gagagagtac tgaattaagc tatactttgc aatcaggtta tttttacaaa gccaacagaa
     7861 ataaacaaaa ggggaattaa ctccctattt agtaagtaat actgggaaaa ctggttagtc
     7921 atatgtggaa gaaaactgta ctaccttttt ctataaaaaa aaaacaactc aatatagatt
     7981 aaagacttga tctgtgagtc tccaagctac aaaaatctta gaataacact tagataatac
     8041 tggcctctgt aaagaattta tgactaacat ctaacatgag tgcaacaaaa ataaaaataa
     8101 aaaatggcat ctaagccaaa gagcttctgc acagtaaaag aaactatcag caaagtaaac
     8161 agatgaccta cagtatgaaa taaaatattt gcaaactgca gacaatgaag gattaatgta
     8221 cagaatctat aatacattta ataaaaaagc aaacatgata tgaatagcca gcttcttctc
     8281 aaaggaagac ataagagctg ccaataaaca tgtaaaaatt gctcaacgtt cctaattatc
     8341 agaaagatgt aaatcaaagt gacagtgtga tactatttca taccagtaag aatgacttat
     8401 taaaagtaag ataaataaga tgttgaagtt gtagagataa ggaaatcttt ctacactgtt
     8461 ggtgggaatg caaattaatt cagaacctgt gcaaagcagt ttggggactt ctcaaagaac
     8521 tagaaataga attgccattt gaccaatcaa gccgattact ggatatctgc ccccaaaaag
     8581 aataaataat tttgccaaag agacaccagc actcacatgt tcattgcagc actattcaca
     8641 atagcaaaaa cagaatttaa ccagttaccc atgaatcttt tattggataa gaaaaatgat
     8701 gtacttatac aacctccaat actatgcagc aacagaagag aatgaagtaa cgtcttttgc
     8761 agcaacatga atgcagctct gcttcaggcc attctaagca aattattgca tcagaaaaac
     8821 aaatgccaca tgttctcact catacatgga tgctaaaaat tgggcgcaca tggaaacaaa
     8881 gatgaaaaca ataaacactg agaattctaa aaagaaggag gaaggatggg agacaagcat
     8941 agaaaatctg cttaggtatg atgtacacta cttgggcaat ggaattatta agtatccaaa
     9001 cctcaacatc atgtagtcta cctgttttac aaatctgcac atgtacctta aatataaaat
     9061 aaaaataata aaatgttttt tggtataa
//
