LOCUS       NM_001042428            1968 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens zinc finger protein 205 (ZNF205), transcript variant
            2, mRNA.
ACCESSION   NM_001042428
VERSION     NM_001042428.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1968)
  AUTHORS   Zhong,N., Wang,C., Weng,G., Ling,T. and Xu,L.
  TITLE     ZNF205 positively regulates RLR antiviral signaling by targeting
            RIG-I
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (10), 1582-1591 (2023)
   PUBMED   37580950
  REMARK    GeneRIF: ZNF205 positively regulates RLR antiviral signaling by
            targeting RIG-I.
REFERENCE   2  (bases 1 to 1968)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1968)
  AUTHORS   Iida,R., Ueki,M. and Yasuda,T.
  TITLE     Identification of Rhit as a novel transcriptional repressor of
            human Mpv17-like protein with a mitigating effect on mitochondrial
            dysfunction, and its transcriptional regulation by FOXD3 and GABP
  JOURNAL   Free Radic Biol Med 52 (8), 1413-1422 (2012)
   PUBMED   22306510
  REMARK    GeneRIF: that knockdown of RhitH or overexpression of M-LPH reduces
            the generation of intracellular H(2)O(2) and loss of mitochondrial
            membrane potential caused by an inhibitor of the respiratory chain,
            antimycin A
REFERENCE   4  (bases 1 to 1968)
  AUTHORS   Iida,R., Ueki,M. and Yasuda,T.
  TITLE     A novel transcriptional repressor, Rhit, is involved in
            heat-inducible and age-dependent expression of Mpv17-like protein,
            a participant in reactive oxygen species metabolism
  JOURNAL   Mol Cell Biol 30 (10), 2306-2315 (2010)
   PUBMED   20231359
REFERENCE   5  (bases 1 to 1968)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (bases 1 to 1968)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   7  (bases 1 to 1968)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   8  (bases 1 to 1968)
  AUTHORS   Deng,Z., Centola,M., Chen,X., Sood,R., Vedula,A.,
            Fischel-Ghodsian,N. and Kastner,D.L.
  TITLE     Identification of two Kruppel-related zinc finger genes (ZNF200 and
            ZNF210) from human chromosome 16p13.3
  JOURNAL   Genomics 53 (1), 97-103 (1998)
   PUBMED   9787081
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB152017.1, AC108134.3 and BM924902.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001042428.1.
            
            Transcript Variant: This variant (2) uses an alternate acceptor
            splice site in the 5' non-coding region and has a shorter 5' UTR
            compared to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.315230.1,
                                           DRR138524.1301561.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000219091.9/ ENSP00000219091.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                CB152017.1         25-63
            40-97               AC108134.3         124149-124206
            98-168              AC108134.3         124941-125011
            169-382             AC108134.3         126879-127092
            383-474             AC108134.3         127353-127444
            475-595             AC108134.3         127951-128071
            596-706             AC108134.3         130429-130539
            707-1934            AC108134.3         130780-132007
            1935-1968           BM924902.1         611-644
FEATURES             Location/Qualifiers
     source          1..1968
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1968
                     /gene="ZNF205"
                     /gene_synonym="RhitH; Zfp13; ZNF210"
                     /note="zinc finger protein 205"
                     /db_xref="GeneID:7755"
                     /db_xref="HGNC:HGNC:12996"
                     /db_xref="MIM:603436"
     exon            1..97
                     /gene="ZNF205"
                     /gene_synonym="RhitH; Zfp13; ZNF210"
                     /inference="alignment:Splign:2.1.0"
     exon            98..168
                     /gene="ZNF205"
                     /gene_synonym="RhitH; Zfp13; ZNF210"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1776
                     /gene="ZNF205"
                     /gene_synonym="RhitH; Zfp13; ZNF210"
                     /note="zinc finger protein 210; repressor of
                     heat-inducible transcription; transcriptional repressor
                     RhitH"
                     /codon_start=1
                     /product="transcriptional repressor RHIT"
                     /protein_id="NP_001035893.1"
                     /db_xref="CCDS:CCDS10494.2"
                     /db_xref="GeneID:7755"
                     /db_xref="HGNC:HGNC:12996"
                     /db_xref="MIM:603436"
                     /translation="MSADGGGIQDTQDKETPPEVPDRGHPHQEMPSKLGEAVPSGDTQ
                     ESLHIKMEPEEPHSEGASQEDGAQGAWGWAPLSHGSKEKALFLPGGALPSPRIPVLSR
                     EGRTRDRQMAAALLTAWSQMPVTFEDVALYLSREEWGRLDHTQQNFYRDVLQKKNGLS
                     LGFPFSRPFWAPQAHGKGEASGSSRQAGDEKEWRGACTGAVEVGQRVQTSSVAALGNV
                     KPFRTRAGRVQWGVPQCAQEAACGRSSGPAKDSGQPAEPDRTPDAAPPDPSPTEPQEY
                     RVPEKPNEEEKGAPESGEEGLAPDSEVGRKSYRCEQCGKGFSWHSHLVTHRRTHTGEK
                     PYACTDCGKRFGRSSHLIQHQIIHTGEKPYTCPACRKSFSHHSTLIQHQRIHTGEKPY
                     VCDRCAKRFTRRSDLVTHQGTHTGAKPHKCPICAKCFTQSSALVTHQRTHTGVKPYPC
                     PECGKCFSQRSNLIAHNRTHTGEKPYHCLDCGKSFSHSSHLTAHQRTHRGVRPYACPL
                     CGKSFSRRSNLHRHEKIHTTGPKALAMLMLGAAAAGALATPPPAPT"
     exon            169..382
                     /gene="ZNF205"
                     /gene_synonym="RhitH; Zfp13; ZNF210"
                     /inference="alignment:Splign:2.1.0"
     exon            383..474
                     /gene="ZNF205"
                     /gene_synonym="RhitH; Zfp13; ZNF210"
                     /inference="alignment:Splign:2.1.0"
     exon            475..595
                     /gene="ZNF205"
                     /gene_synonym="RhitH; Zfp13; ZNF210"
                     /inference="alignment:Splign:2.1.0"
     exon            596..706
                     /gene="ZNF205"
                     /gene_synonym="RhitH; Zfp13; ZNF210"
                     /inference="alignment:Splign:2.1.0"
     exon            707..1968
                     /gene="ZNF205"
                     /gene_synonym="RhitH; Zfp13; ZNF210"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1948..1953
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF205"
                     /gene_synonym="RhitH; Zfp13; ZNF210"
                     /note="hexamer: ATTAAA"
     polyA_site      1968
                     /gene="ZNF205"
                     /gene_synonym="RhitH; Zfp13; ZNF210"
                     /note="major polyA site"
ORIGIN      
        1 acccaactcc cccgcccgcc ccgtgcaggc tgtggagact cccttcccgg gggagggggc
       61 ccccactgcc gcaggtgccc cctctgcctc caccccgctc tgaaatagaa aatgtctgca
      121 gacggcggag gcatccagga cacccaggac aaggagacac ccccggaggt tccagatcgt
      181 ggacatcctc atcaggaaat gccttctaag ctgggggagg cggtaccttc aggggacact
      241 caggagtcac tgcacattaa gatggagccc gaagagccac actccgaggg ggcatcgcag
      301 gaggatgggg ctcaaggtgc ctggggctgg gcacccctaa gtcacggctc taaggagaaa
      361 gctctcttcc tgcctggcgg agccctcccc tccccccgga tccccgtgct ttcccgagag
      421 gggaggacca gagaccggca gatggctgca gcgctcctca ctgcctggtc ccagatgcca
      481 gtgactttcg aggatgtggc cttgtacctc tcccgggagg agtggggacg gctggaccac
      541 acgcagcaga acttctacag ggatgtcctg cagaagaaaa atgggctgtc actgggcttt
      601 cccttcagca ggcctttctg ggcccctcaa gcgcacggca agggtgaggc ctcgggctcc
      661 agccggcagg caggagatga gaaggagtgg agaggcgcgt gcacaggagc cgtcgaggtg
      721 gggcagaggg tgcagacctc atccgtggca gcccttggga atgtgaagcc cttcagaacc
      781 agggcaggga gagtccagtg gggcgtcccg cagtgcgcgc aggaagcagc ctgcggccgg
      841 agctcagggc cggccaaaga ctccgggcag ccggctgagc cagatcgcac cccggatgca
      901 gctccgccag accccagtcc cacggagccc caggagtacc gcgtcccgga gaagcccaac
      961 gaggaggaga agggcgcccc ggagagtggc gaggagggcc tggcccctga cagtgaggtg
     1021 ggcaggaaga gctaccggtg cgagcagtgc ggcaagggct tcagctggca ctcgcacctg
     1081 gtgacgcacc ggcgcacgca cacgggcgag aagccctacg cctgcactga ctgcgggaag
     1141 cgcttcggcc gcagctcgca cctcatccag caccagatca tccacacggg cgagaagccc
     1201 tacacctgcc ccgcctgccg gaagagcttc agccaccact ccacgctgat tcagcaccag
     1261 cgcatccaca ccggagagaa gccctacgtg tgcgaccgct gcgccaagcg cttcacccgc
     1321 cgctcggact tggtcaccca ccagggcacc cacacgggcg ccaagccgca caagtgcccc
     1381 atctgcgcca agtgcttcac gcagagctcg gcgctagtca cccaccagcg cacccacact
     1441 ggggtcaagc cctatccgtg ccccgagtgc ggcaagtgct tcagccagcg ttccaacctc
     1501 atcgcgcaca accgcacaca cacaggcgag aagccctacc actgcctcga ctgcggcaag
     1561 agcttcagcc acagctcgca cctcaccgcg caccagcgca cccaccgtgg cgtgcggccc
     1621 tacgcctgcc cgttgtgcgg caagagcttc agccggcgct ccaacctgca ccggcacgag
     1681 aagatccaca ccaccgggcc caaggccctg gccatgctga tgctgggggc ggcggcggcg
     1741 ggggctctgg ccacaccccc acccgctccc acctaggagg ccaggaaagg gggagcgggg
     1801 cgcccagggc cactggaaca gccccactgg agtcaaggct ccgagggagg agagaggggc
     1861 tcgggaaggg agctggggcg gtgagggcat ggggtgaggc atggcgatgg gggagggcga
     1921 gggcgagaaa gggcaggcac tctgcgaatt aaaggccttg gacttgaa
//
