LOCUS       NM_003455               4435 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 202 (ZNF202), transcript variant
            1, mRNA.
ACCESSION   NM_003455
VERSION     NM_003455.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4435)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4435)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4435)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 4435)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   5  (bases 1 to 4435)
  AUTHORS   Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B.,
            Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N.,
            Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S.,
            Han,J.H., Hashimoto,T., Hide,W., Hofmann,O., Kamburov,A., Kaur,M.,
            Kawaji,H., Kubosaki,A., Lassmann,T., van Nimwegen,E.,
            MacPherson,C.R., Ogawa,C., Radovanovic,A., Schwartz,A.,
            Teasdale,R.D., Tegner,J., Lenhard,B., Teichmann,S.A., Arakawa,T.,
            Ninomiya,N., Murakami,K., Tagami,M., Fukuda,S., Imamura,K., Kai,C.,
            Ishihara,R., Kitazume,Y., Kawai,J., Hume,D.A., Ideker,T. and
            Hayashizaki,Y.
  TITLE     An atlas of combinatorial transcriptional regulation in mouse and
            man
  JOURNAL   Cell 140 (5), 744-752 (2010)
   PUBMED   20211142
  REMARK    Erratum:[Cell. 2010 Apr 16;141(2):369. Kamburov, Atanas [added];
            Kaur, Mandeep [added]; MacPherson, Cameron Ross [added];
            Radovanovic, Aleksandar [added]; Schwartz, Ariel [added]]
REFERENCE   6  (bases 1 to 4435)
  AUTHORS   Porsch-Ozcurumez,M., Langmann,T., Heimerl,S., Borsukova,H.,
            Kaminski,W.E., Drobnik,W., Honer,C., Schumacher,C. and Schmitz,G.
  TITLE     The zinc finger protein 202 (ZNF202) is a transcriptional repressor
            of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene
            expression and a modulator of cellular lipid efflux
  JOURNAL   J Biol Chem 276 (15), 12427-12433 (2001)
   PUBMED   11279031
REFERENCE   7  (bases 1 to 4435)
  AUTHORS   Schumacher,C., Wang,H., Honer,C., Ding,W., Koehn,J., Lawrence,Q.,
            Coulis,C.M., Wang,L.L., Ballinger,D., Bowen,B.R. and Wagner,S.
  TITLE     The SCAN domain mediates selective oligomerization
  JOURNAL   J Biol Chem 275 (22), 17173-17179 (2000)
   PUBMED   10747874
REFERENCE   8  (bases 1 to 4435)
  AUTHORS   Wagner,S., Hess,M.A., Ormonde-Hanson,P., Malandro,J., Hu,H.,
            Chen,M., Kehrer,R., Frodsham,M., Schumacher,C., Beluch,M.,
            Honer,C., Skolnick,M., Ballinger,D. and Bowen,B.R.
  TITLE     A broad role for the zinc finger protein ZNF202 in human lipid
            metabolism
  JOURNAL   J Biol Chem 275 (21), 15685-15690 (2000)
   PUBMED   10748193
REFERENCE   9  (bases 1 to 4435)
  AUTHORS   Scanlan,M.J., Gordan,J.D., Williamson,B., Stockert,E., Bander,N.H.,
            Jongeneel,V., Gure,A.O., Jager,D., Jager,E., Knuth,A., Chen,Y.T.
            and Old,L.J.
  TITLE     Antigens recognized by autologous antibody in patients with
            renal-cell carcinoma
  JOURNAL   Int J Cancer 83 (4), 456-464 (1999)
   PUBMED   10508479
REFERENCE   10 (bases 1 to 4435)
  AUTHORS   Monaco,C., Helmer Citterich,M., Caprini,E., Vorechovsky,I.,
            Russo,G., Croce,C.M., Barbanti-Brodano,G. and Negrini,M.
  TITLE     Molecular cloning and characterization of ZNF202: a new gene at
            11q23.3 encoding testis-specific zinc finger proteins
  JOURNAL   Genomics 52 (3), 358-362 (1998)
   PUBMED   9790754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY056142.1, BC013382.2, DA770117.1, AL162031.1, H89560.1, H89561.1
            and AP000868.4.
            
            On Nov 22, 2018 this sequence version replaced NM_003455.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013382.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000530393.6/ ENSP00000432504.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 HY056142.1         25-29
            6-865               BC013382.2         1-860
            866-866             DA770117.1         279-279
            867-3569            BC013382.2         862-3564
            3570-4000           AL162031.1         3125-3555
            4001-4061           H89560.1           226-286
            4062-4422           H89561.1           7-367               c
            4423-4435           AP000868.4         18255-18267         c
FEATURES             Location/Qualifiers
     source          1..4435
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.1"
     gene            1..4435
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /note="zinc finger protein 202"
                     /db_xref="GeneID:7753"
                     /db_xref="HGNC:HGNC:12994"
                     /db_xref="MIM:603430"
     exon            1..112
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /inference="alignment:Splign:2.1.0"
     exon            113..232
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /inference="alignment:Splign:2.1.0"
     exon            233..308
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /inference="alignment:Splign:2.1.0"
     exon            309..807
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /inference="alignment:Splign:2.1.0"
     CDS             406..2352
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein with KRAB and SCAN domains 10"
                     /codon_start=1
                     /product="zinc finger protein 202 isoform 1"
                     /protein_id="NP_003446.2"
                     /db_xref="CCDS:CCDS8443.1"
                     /db_xref="GeneID:7753"
                     /db_xref="HGNC:HGNC:12994"
                     /db_xref="MIM:603430"
                     /translation="MATAVEPEDQDLWEEEGILMVKLEDDFTCRPESVLQRDDPVLET
                     SHQNFRRFRYQEAASPREALIRLRELCHQWLRPERRTKEQILELLVLEQFLTVLPGEL
                     QSWVRGQRPESGEEAVTLVEGLQKQPRRPRRWVTVHVHGQEVLSEETVHLGVEPESPN
                     ELQDPVQSSTPEQSPEETTQSPDLGAPAEQRPHQEEELQTLQESEVPVPEDPDLPAER
                     SSGDSEMVALLTALSQGLVTFKDVAVCFSQDQWSDLDPTQKEFYGEYVLEEDCGIVVS
                     LSFPIPRPDEISQVREEEPWVPDIQEPQETQEPEILSFTYTGDRSKDEEECLEQEDLS
                     LEDIHRPVLGEPEIHQTPDWEIVFEDNPGRLNERRFGTNISQVNSFVNLRETTPVHPL
                     LGRHHDCSVCGKSFTCNSHLVRHLRTHTGEKPYKCMECGKSYTRSSHLARHQKVHKMN
                     APYKYPLNRKNLEETSPVTQAERTPSVEKPYRCDDCGKHFRWTSDLVRHQRTHTGEKP
                     FFCTICGKSFSQKSVLTTHQRIHLGGKPYLCGECGEDFSEHRRYLAHRKTHAAEELYL
                     CSECGRCFTHSAAFAKHLRGHASVRPCRCNECGKSFSRRDHLVRHQRTHTGEKPFTCP
                     TCGKSFSRGYHLIRHQRTHSEKTS"
     exon            808..1018
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1107
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1237
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1357
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..4435
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3551..3556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /note="hexamer: AGTAAA"
     polyA_site      3569
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /note="major polyA site"
     regulatory      3985..3990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /note="hexamer: AATAAA"
     polyA_site      4008
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
     regulatory      4402..4407
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /note="hexamer: AATGAA"
     polyA_site      4435
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
ORIGIN      
        1 gtgttccgac ccgctaggcc ccgcgcggct cggatccggc ggcgctgttt cggtcgggag
       61 tgggtgggag agaagccggg gcaggggagg agccgccgga gctgtcggag ccgtgacacc
      121 cagggcagct acactcagaa gccacaagga atgctagtgg agcccctcat ccctcccagc
      181 ttctcttcca agctgccccg tggggcttga tccaggaagc tacttcagaa agtagacaat
      241 cattccaagg gtacaacaag gtttaccaca atgtgaggga ctcagccatt gcaaattgta
      301 cagatgaggg cccttggaag aaaatcctcg ctgtgtccag gctgaggcgg ggggctaatg
      361 acagtgtgag ctctagatgg tgtgagacca ccccaaagcc aagaaatggc tacagccgtg
      421 gaaccagagg accaggatct ttgggaagaa gagggaattc tgatggtgaa actggaagat
      481 gatttcacct gtcggccaga gtctgtctta cagagggatg acccggtgct ggaaacctcc
      541 caccagaact tccgacgctt ccgctaccag gaggcagcaa gccctagaga agctctcatc
      601 agactccgag aactttgtca ccagtggctg agaccagaga ggcggacaaa ggagcagatc
      661 ctagagctgc ttgtgctgga acaatttctt accgtcctac ctggagaact acagagctgg
      721 gtgcggggcc aacggccaga aagtggcgag gaggcagtga cgctggtgga gggtttgcag
      781 aaacaaccca ggagaccaag gcggtgggtg actgtccatg ttcacggcca ggaagtcctg
      841 tcagaggaga cggtgcattt aggagtggag cctgagtcac ctaatgagct gcaggatcct
      901 gtgcaaagct cgacccccga gcagtctcct gaggaaacca cacagagccc agatctgggg
      961 gcaccggcag agcagcgtcc acaccaggaa gaggagctcc agaccctgca ggagagcgag
     1021 gtcccagtgc ccgaggaccc agaccttcct gcagagagga gctctggaga ctcagagatg
     1081 gttgctcttc ttactgctct gtcacaggga ctggtaacgt tcaaggatgt ggccgtatgc
     1141 ttttcccagg accagtggag tgatctggac ccaacacaga aagagttcta tggagaatat
     1201 gtcttggaag aagactgtgg aattgttgtc tctctgtcat ttccaatccc cagacctgat
     1261 gagatctccc aggttagaga ggaagagcct tgggtcccag atatccaaga gcctcaggag
     1321 actcaagagc cagaaatcct gagttttacc tacacaggag ataggagtaa agatgaggaa
     1381 gagtgtctgg agcaggaaga tctgagtttg gaggatatac acaggcctgt tttgggagaa
     1441 ccagaaattc accagactcc agattgggaa atagtctttg aggacaatcc aggtagactt
     1501 aatgaaagaa gatttggtac taatatttct caagtgaata gttttgtgaa ccttcgggaa
     1561 actacacccg tccaccccct gttagggagg catcatgact gttctgtgtg tggaaagagc
     1621 ttcacttgta actcccacct tgttagacac ctgaggactc acacaggaga gaaaccctat
     1681 aaatgtatgg aatgtggaaa aagttacaca cgaagctcac atcttgccag gcaccaaaag
     1741 gttcacaaga tgaacgcgcc ttacaaatat cccctaaacc ggaagaattt ggaagagacc
     1801 tcccctgtga cacaggctga gagaactcca tcagtggaga aaccctatag atgtgatgat
     1861 tgcggaaagc acttccgctg gacttcagac cttgtcagac atcagaggac acatactgga
     1921 gaaaaaccct tcttttgtac tatttgtggc aaaagcttca gccagaaatc tgtgttaaca
     1981 acacaccaaa gaatccacct gggaggcaaa ccctacttgt gtggagagtg tggtgaggac
     2041 ttcagtgaac acaggcggta cctggcgcac cggaagacgc acgctgctga ggaactctac
     2101 ctctgcagcg agtgcgggcg ctgcttcacc cacagcgcag cgttcgccaa gcacttgaga
     2161 ggacacgcct cagtgaggcc ctgccgatgc aacgaatgtg ggaagagctt cagtcgcagg
     2221 gaccacctcg tcaggcatca gagaacacac actggggaga aaccattcac gtgccctacc
     2281 tgtggaaaaa gcttcagcag aggatatcac ttaattaggc atcagaggac ccactcagaa
     2341 aagacctcct agctaggtcc ccatgtgagg agatctgctt tcagccctca cctaagggag
     2401 gtgaggaaga ggaaaagccc tcttgtcagc ctgggaagac cttttcgagg gagtctccct
     2461 gacctgctca gatctgacat tacctcttcc tgcaactaaa cacgagcctg ggcagaacct
     2521 ctcagccttc ctctacgcct tgaggggatg tttcatccaa agtacaacct gaattgaggc
     2581 ttctccttca ctggagtgca cctgcctcta cctcatgggt ataaagtagg agaactaaga
     2641 gacttaagag gtcgtggttc ctatatcgtc caaaaaatag gctgttacat atcctaaaga
     2701 ctgctcaaca gcttcaagtt gaaagtggcc aaggacagcc ccttaggttt gggaagggac
     2761 gagcctgaag gattctgtct ttactggggt caaatcttaa agcacacagc tctggactca
     2821 agacaggagg tttgcgtcct gatggctttg ccacacattc acaggataac tgcatagatc
     2881 cctcgctgtc tgattcactt cttaccatgc actttccttt gatgctgagg agaaatggaa
     2941 gtgggcgaaa aatctcaagg ctgcttcatg tggaccttgt caagctgctc cctcccccag
     3001 cgtcaaattg ttatcaggtg ccaaacactg ctagaaagga gggcctagtc agaagcctct
     3061 ttccatacga gttttggttt tgtttttaat atttttttct attaaaatac tcatgcattt
     3121 aaccttcccg ttattcaacc agtctcttgg ttgcatccct agcacttcta ctacaagtga
     3181 gatggtagtg tttgagtgct tattgagtaa agcataattc ggtcataatg aaatcgttca
     3241 cattccctca tatgcacaag cccaccaacc ccttcacacc ccccttcaca ggggtcgtat
     3301 gagtaagggg atttggaaac tgtcaactta caaaggcact ataacaatta cagaatcatg
     3361 attgccatgg gccactttat ttacatgaag acaactggag aacgactaag accaaattat
     3421 ggaaaataag aaaaagctgt tgctggcaag accatcaaga ctgttctgac accctgtccc
     3481 catcatccct gactgagtac tctgacatca cggaaagtgt tgaacctggg accctgagga
     3541 attcaccagg agtaaatggc tttcatgtat ttgtgttgtt tgctttttct tacgtgattt
     3601 tatgttcata gagctagaaa gtagcatctc atgatggccc aacaatctct gttgccagtt
     3661 aaaggttcct tggagatgag gctgaataat tatgaacctc accttctctg attgtgggag
     3721 tggcaagaac tggggagacg tcctccataa gtggagcaca gggtatgggg ttaaagcatg
     3781 acagggagag tcttctgtgc ctggtttctt ctcctctatc tcataatgca ttatgggccc
     3841 gaggaatagg ggagggttaa taagactcca accctaatgg cccaacaggg aaattctcat
     3901 tttggtcgat gatattctga tggactggtt tggtcttaat accagtcaac cgttgtcctt
     3961 ctggaaatat acatatatga aataaataaa ggtaacactt gcagccaagt tccctggttt
     4021 ctgggacttc ccatcttacc cattcctttt ccagggcttc agtgtcctga tacttctgag
     4081 ggtggttcat actcaaatag atctgggagt acagagtatt tttccttgag gaaaggaagg
     4141 gttgggatga ttagcagagt ccggtgaaac atatgcactc tgagataaga tccaagcctg
     4201 gagtttgcag aagatactgt cctaataagc aggcatttct aaaccaagta tctaagccta
     4261 agcacagctt gtcctgggtg aaatgtctgc cacaaaagat agtttctcct agctcagact
     4321 taaccattta taaaggttgg taaaatactg gcagtgacaa caaattgact ttttaatttt
     4381 cttatttgca ttattccaat aaatgaaaat ctgtcagagt tctacatgag ggaaa
//
