LOCUS       NM_001301819            4110 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 202 (ZNF202), transcript variant
            4, mRNA.
ACCESSION   NM_001301819
VERSION     NM_001301819.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4110)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4110)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4110)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 4110)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   5  (bases 1 to 4110)
  AUTHORS   Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B.,
            Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N.,
            Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S.,
            Han,J.H., Hashimoto,T., Hide,W., Hofmann,O., Kamburov,A., Kaur,M.,
            Kawaji,H., Kubosaki,A., Lassmann,T., van Nimwegen,E.,
            MacPherson,C.R., Ogawa,C., Radovanovic,A., Schwartz,A.,
            Teasdale,R.D., Tegner,J., Lenhard,B., Teichmann,S.A., Arakawa,T.,
            Ninomiya,N., Murakami,K., Tagami,M., Fukuda,S., Imamura,K., Kai,C.,
            Ishihara,R., Kitazume,Y., Kawai,J., Hume,D.A., Ideker,T. and
            Hayashizaki,Y.
  TITLE     An atlas of combinatorial transcriptional regulation in mouse and
            man
  JOURNAL   Cell 140 (5), 744-752 (2010)
   PUBMED   20211142
  REMARK    Erratum:[Cell. 2010 Apr 16;141(2):369. Kamburov, Atanas [added];
            Kaur, Mandeep [added]; MacPherson, Cameron Ross [added];
            Radovanovic, Aleksandar [added]; Schwartz, Ariel [added]]
REFERENCE   6  (bases 1 to 4110)
  AUTHORS   Porsch-Ozcurumez,M., Langmann,T., Heimerl,S., Borsukova,H.,
            Kaminski,W.E., Drobnik,W., Honer,C., Schumacher,C. and Schmitz,G.
  TITLE     The zinc finger protein 202 (ZNF202) is a transcriptional repressor
            of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene
            expression and a modulator of cellular lipid efflux
  JOURNAL   J Biol Chem 276 (15), 12427-12433 (2001)
   PUBMED   11279031
REFERENCE   7  (bases 1 to 4110)
  AUTHORS   Schumacher,C., Wang,H., Honer,C., Ding,W., Koehn,J., Lawrence,Q.,
            Coulis,C.M., Wang,L.L., Ballinger,D., Bowen,B.R. and Wagner,S.
  TITLE     The SCAN domain mediates selective oligomerization
  JOURNAL   J Biol Chem 275 (22), 17173-17179 (2000)
   PUBMED   10747874
REFERENCE   8  (bases 1 to 4110)
  AUTHORS   Wagner,S., Hess,M.A., Ormonde-Hanson,P., Malandro,J., Hu,H.,
            Chen,M., Kehrer,R., Frodsham,M., Schumacher,C., Beluch,M.,
            Honer,C., Skolnick,M., Ballinger,D. and Bowen,B.R.
  TITLE     A broad role for the zinc finger protein ZNF202 in human lipid
            metabolism
  JOURNAL   J Biol Chem 275 (21), 15685-15690 (2000)
   PUBMED   10748193
REFERENCE   9  (bases 1 to 4110)
  AUTHORS   Scanlan,M.J., Gordan,J.D., Williamson,B., Stockert,E., Bander,N.H.,
            Jongeneel,V., Gure,A.O., Jager,D., Jager,E., Knuth,A., Chen,Y.T.
            and Old,L.J.
  TITLE     Antigens recognized by autologous antibody in patients with
            renal-cell carcinoma
  JOURNAL   Int J Cancer 83 (4), 456-464 (1999)
   PUBMED   10508479
REFERENCE   10 (bases 1 to 4110)
  AUTHORS   Monaco,C., Helmer Citterich,M., Caprini,E., Vorechovsky,I.,
            Russo,G., Croce,C.M., Barbanti-Brodano,G. and Negrini,M.
  TITLE     Molecular cloning and characterization of ZNF202: a new gene at
            11q23.3 encoding testis-specific zinc finger proteins
  JOURNAL   Genomics 52 (3), 358-362 (1998)
   PUBMED   9790754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC013382.2, AF027218.1, DA770117.1, AL162031.1, H89560.1 and
            H89561.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and uses a downstream start codon
            compared to variant 1. It encodes isoform 2 which has a shorter
            N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF027218.1, SRR1803614.178336.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                BC013382.2         304-390
            88-130              AF027218.1         1-43
            131-287             BC013382.2         434-590
            288-553             AF027218.1         201-466
            554-554             DA770117.1         279-279
            555-3257            BC013382.2         862-3564
            3258-3688           AL162031.1         3125-3555
            3689-3749           H89560.1           226-286
            3750-4110           H89561.1           7-367               c
FEATURES             Location/Qualifiers
     source          1..4110
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.1"
     gene            1..4110
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /note="zinc finger protein 202"
                     /db_xref="GeneID:7753"
                     /db_xref="HGNC:HGNC:12994"
                     /db_xref="MIM:603430"
     exon            1..495
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /inference="alignment:Splign:2.1.0"
     exon            496..706
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /inference="alignment:Splign:2.1.0"
     exon            707..795
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /inference="alignment:Splign:2.1.0"
     CDS             766..2040
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /note="isoform 2 is encoded by transcript variant 4; zinc
                     finger protein with KRAB and SCAN domains 10"
                     /codon_start=1
                     /product="zinc finger protein 202 isoform 2"
                     /protein_id="NP_001288748.1"
                     /db_xref="GeneID:7753"
                     /db_xref="HGNC:HGNC:12994"
                     /db_xref="MIM:603430"
                     /translation="MVALLTALSQGLVTFKDVAVCFSQDQWSDLDPTQKEFYGEYVLE
                     EDCGIVVSLSFPIPRPDEISQVREEEPWVPDIQEPQETQEPEILSFTYTGDRSKDEEE
                     CLEQEDLSLEDIHRPVLGEPEIHQTPDWEIVFEDNPGRLNERRFGTNISQVNSFVNLR
                     ETTPVHPLLGRHHDCSVCGKSFTCNSHLVRHLRTHTGEKPYKCMECGKSYTRSSHLAR
                     HQKVHKMNAPYKYPLNRKNLEETSPVTQAERTPSVEKPYRCDDCGKHFRWTSDLVRHQ
                     RTHTGEKPFFCTICGKSFSQKSVLTTHQRIHLGGKPYLCGECGEDFSEHRRYLAHRKT
                     HAAEELYLCSECGRCFTHSAAFAKHLRGHASVRPCRCNECGKSFSRRDHLVRHQRTHT
                     GEKPFTCPTCGKSFSRGYHLIRHQRTHSEKTS"
     exon            796..925
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1045
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..4110
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3239..3244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /note="hexamer: AGTAAA"
     polyA_site      3257
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /note="major polyA site"
     regulatory      3673..3678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /note="hexamer: AATAAA"
     polyA_site      3696
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
ORIGIN      
        1 ggcccttgga agaaaatcct cgctgtgtcc aggctgaggc ggggggctaa tgacagtgtg
       61 agctctagat ggtgtgagac caccccaaag ccaagaaatg gctacagccg tggaaccaga
      121 ggaccaggat ctttgggaag aagagggaat tctgatggtg aaactggaag atgatttcac
      181 ctgtcggcca gagtctgtct tacagaggga tgacccggtg ctggaaacct cccaccagaa
      241 cttccgacgc ttccgctacc aggaggcagc aagccctaga gaagctctca tcagactccg
      301 agaactttgt caccagtggc tgagaccaga gaggcggaca aaggagcaga tcctagagct
      361 gcttgtgctg gaacaatttc ttaccgtcct acctggagaa ctacagagct gggtgcgggg
      421 ccaacggcca gaaagtggcg aggaggcagt gacgctggtg gagggtttgc agaaacaacc
      481 caggagacca aggcggtgac tgtccatgtt cacggccagg aagtcctgtc agaggagacg
      541 gtgcatttag gagtggagcc tgagtcacct aatgagctgc aggatcctgt gcaaagctcg
      601 acccccgagc agtctcctga ggaaaccaca cagagcccag atctgggggc accggcagag
      661 cagcgtccac accaggaaga ggagctccag accctgcagg agagcgaggt cccagtgccc
      721 gaggacccag accttcctgc agagaggagc tctggagact cagagatggt tgctcttctt
      781 actgctctgt cacagggact ggtaacgttc aaggatgtgg ccgtatgctt ttcccaggac
      841 cagtggagtg atctggaccc aacacagaaa gagttctatg gagaatatgt cttggaagaa
      901 gactgtggaa ttgttgtctc tctgtcattt ccaatcccca gacctgatga gatctcccag
      961 gttagagagg aagagccttg ggtcccagat atccaagagc ctcaggagac tcaagagcca
     1021 gaaatcctga gttttaccta cacaggagat aggagtaaag atgaggaaga gtgtctggag
     1081 caggaagatc tgagtttgga ggatatacac aggcctgttt tgggagaacc agaaattcac
     1141 cagactccag attgggaaat agtctttgag gacaatccag gtagacttaa tgaaagaaga
     1201 tttggtacta atatttctca agtgaatagt tttgtgaacc ttcgggaaac tacacccgtc
     1261 caccccctgt tagggaggca tcatgactgt tctgtgtgtg gaaagagctt cacttgtaac
     1321 tcccaccttg ttagacacct gaggactcac acaggagaga aaccctataa atgtatggaa
     1381 tgtggaaaaa gttacacacg aagctcacat cttgccaggc accaaaaggt tcacaagatg
     1441 aacgcgcctt acaaatatcc cctaaaccgg aagaatttgg aagagacctc ccctgtgaca
     1501 caggctgaga gaactccatc agtggagaaa ccctatagat gtgatgattg cggaaagcac
     1561 ttccgctgga cttcagacct tgtcagacat cagaggacac atactggaga aaaacccttc
     1621 ttttgtacta tttgtggcaa aagcttcagc cagaaatctg tgttaacaac acaccaaaga
     1681 atccacctgg gaggcaaacc ctacttgtgt ggagagtgtg gtgaggactt cagtgaacac
     1741 aggcggtacc tggcgcaccg gaagacgcac gctgctgagg aactctacct ctgcagcgag
     1801 tgcgggcgct gcttcaccca cagcgcagcg ttcgccaagc acttgagagg acacgcctca
     1861 gtgaggccct gccgatgcaa cgaatgtggg aagagcttca gtcgcaggga ccacctcgtc
     1921 aggcatcaga gaacacacac tggggagaaa ccattcacgt gccctacctg tggaaaaagc
     1981 ttcagcagag gatatcactt aattaggcat cagaggaccc actcagaaaa gacctcctag
     2041 ctaggtcccc atgtgaggag atctgctttc agccctcacc taagggaggt gaggaagagg
     2101 aaaagccctc ttgtcagcct gggaagacct tttcgaggga gtctccctga cctgctcaga
     2161 tctgacatta cctcttcctg caactaaaca cgagcctggg cagaacctct cagccttcct
     2221 ctacgccttg aggggatgtt tcatccaaag tacaacctga attgaggctt ctccttcact
     2281 ggagtgcacc tgcctctacc tcatgggtat aaagtaggag aactaagaga cttaagaggt
     2341 cgtggttcct atatcgtcca aaaaataggc tgttacatat cctaaagact gctcaacagc
     2401 ttcaagttga aagtggccaa ggacagcccc ttaggtttgg gaagggacga gcctgaagga
     2461 ttctgtcttt actggggtca aatcttaaag cacacagctc tggactcaag acaggaggtt
     2521 tgcgtcctga tggctttgcc acacattcac aggataactg catagatccc tcgctgtctg
     2581 attcacttct taccatgcac tttcctttga tgctgaggag aaatggaagt gggcgaaaaa
     2641 tctcaaggct gcttcatgtg gaccttgtca agctgctccc tcccccagcg tcaaattgtt
     2701 atcaggtgcc aaacactgct agaaaggagg gcctagtcag aagcctcttt ccatacgagt
     2761 tttggttttg tttttaatat ttttttctat taaaatactc atgcatttaa ccttcccgtt
     2821 attcaaccag tctcttggtt gcatccctag cacttctact acaagtgaga tggtagtgtt
     2881 tgagtgctta ttgagtaaag cataattcgg tcataatgaa atcgttcaca ttccctcata
     2941 tgcacaagcc caccaacccc ttcacacccc ccttcacagg ggtcgtatga gtaaggggat
     3001 ttggaaactg tcaacttaca aaggcactat aacaattaca gaatcatgat tgccatgggc
     3061 cactttattt acatgaagac aactggagaa cgactaagac caaattatgg aaaataagaa
     3121 aaagctgttg ctggcaagac catcaagact gttctgacac cctgtcccca tcatccctga
     3181 ctgagtactc tgacatcacg gaaagtgttg aacctgggac cctgaggaat tcaccaggag
     3241 taaatggctt tcatgtattt gtgttgtttg ctttttctta cgtgatttta tgttcataga
     3301 gctagaaagt agcatctcat gatggcccaa caatctctgt tgccagttaa aggttccttg
     3361 gagatgaggc tgaataatta tgaacctcac cttctctgat tgtgggagtg gcaagaactg
     3421 gggagacgtc ctccataagt ggagcacagg gtatggggtt aaagcatgac agggagagtc
     3481 ttctgtgcct ggtttcttct cctctatctc ataatgcatt atgggcccga ggaatagggg
     3541 agggttaata agactccaac cctaatggcc caacagggaa attctcattt tggtcgatga
     3601 tattctgatg gactggtttg gtcttaatac cagtcaaccg ttgtccttct ggaaatatac
     3661 atatatgaaa taaataaagg taacacttgc agccaagttc cctggtttct gggacttccc
     3721 atcttaccca ttccttttcc agggcttcag tgtcctgata cttctgaggg tggttcatac
     3781 tcaaatagat ctgggagtac agagtatttt tccttgagga aaggaagggt tgggatgatt
     3841 agcagagtcc ggtgaaacat atgcactctg agataagatc caagcctgga gtttgcagaa
     3901 gatactgtcc taataagcag gcatttctaa accaagtatc taagcctaag cacagcttgt
     3961 cctgggtgaa atgtctgcca caaaagatag tttctcctag ctcagactta accatttata
     4021 aaggttggta aaatactggc agtgacaaca aattgacttt ttaattttct tatttgcatt
     4081 attccaataa atgaaaatct gtcagagttc
//
