LOCUS       NM_198088               3008 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens zinc finger protein 200 (ZNF200), transcript variant
            2, mRNA.
ACCESSION   NM_198088
VERSION     NM_198088.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3008)
  AUTHORS   Gupta,S., Verma,M., Kadumuri,R.V., Chutani,N., Khan,M.I.K.,
            Chavali,S. and Dhayalan,A.
  TITLE     The uncharacterized protein ZNF200 interacts with PRMT3 and aids
            its stability and nuclear translocation
  JOURNAL   Biochem J 481 (23), 1723-1740 (2024)
   PUBMED   39513743
REFERENCE   2  (bases 1 to 3008)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3008)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3008)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   5  (bases 1 to 3008)
  AUTHORS   Nishida,M., Kato,M., Kato,Y., Sasai,N., Ueda,J., Tachibana,M.,
            Shinkai,Y. and Yamaguchi,M.
  TITLE     Identification of ZNF200 as a novel binding partner of histone H3
            methyltransferase G9a
  JOURNAL   Genes Cells 12 (7), 877-888 (2007)
   PUBMED   17584299
  REMARK    GeneRIF: ZNF200 is a novel binding partner of G9a.
REFERENCE   6  (bases 1 to 3008)
  AUTHORS   Deng,Z., Centola,M., Chen,X., Sood,R., Vedula,A.,
            Fischel-Ghodsian,N. and Kastner,D.L.
  TITLE     Identification of two Kruppel-related zinc finger genes (ZNF200 and
            ZNF210) from human chromosome 16p13.3
  JOURNAL   Genomics 53 (1), 97-103 (1998)
   PUBMED   9787081
REFERENCE   7  (bases 1 to 3008)
  AUTHORS   Bernot,A., Heilig,R., Clepet,C., Smaoui,N., Da Silva,C.,
            Petit,J.L., Devaud,C., Chiannilkulchai,N., Fizames,C., Samson,D.,
            Cruaud,C., Caloustian,C., Gyapay,G., Delpech,M. and Weissenbach,J.
  TITLE     A transcriptional Map of the FMF region
  JOURNAL   Genomics 50 (2), 147-160 (1998)
   PUBMED   9653642
REFERENCE   8  (bases 1 to 3008)
  CONSRTM   French FMF Consortium
  TITLE     A candidate gene for familial Mediterranean fever
  JOURNAL   Nat Genet 17 (1), 25-31 (1997)
   PUBMED   9288094
REFERENCE   9  (bases 1 to 3008)
  AUTHORS   Adams,M.D., Soares,M.B., Kerlavage,A.R., Fields,C. and Venter,J.C.
  TITLE     Rapid cDNA sequencing (expressed sequence tags) from a
            directionally cloned human infant brain cDNA library
  JOURNAL   Nat Genet 4 (4), 373-380 (1993)
   PUBMED   8401585
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA757518.1, AF060866.1, Y14443.1 and AA338573.1.
            
            On Jun 2, 2019 this sequence version replaced NM_198088.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to transcript variant 1. Both variants 1 and 2 encode the same
            isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.2939751.1, AF060866.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000414144.7/ ENSP00000405786.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-247               DA757518.1         300-546
            248-2070            AF060866.1         231-2053
            2071-2986           Y14443.1           2145-3060
            2987-3008           AA338573.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..3008
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..3008
                     /gene="ZNF200"
                     /note="zinc finger protein 200"
                     /db_xref="GeneID:7752"
                     /db_xref="HGNC:HGNC:12993"
                     /db_xref="MIM:603231"
     exon            1..172
                     /gene="ZNF200"
                     /inference="alignment:Splign:2.1.0"
     exon            173..503
                     /gene="ZNF200"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..1441
                     /gene="ZNF200"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zinc finger protein 200 isoform 1"
                     /protein_id="NP_932354.1"
                     /db_xref="CCDS:CCDS10497.1"
                     /db_xref="GeneID:7752"
                     /db_xref="HGNC:HGNC:12993"
                     /db_xref="MIM:603231"
                     /translation="MMAAKVVPMPPKPKQSFILRVPPDSKLGQDLLRDATNGPKTIHQ
                     LVLEHFLTFLPKPSLVQPSQKVKETLVIMKDVSSSLQNRVHPRPLVKLLPKGVQKEQE
                     TVSLYLKANPEELVVFEDLNVFHCQEECVSLDPTQQLTSEKEDDSSVGEMMLLAVNGS
                     NPEGEDPEREPVENEDYREKSSDDDEMDSSLVSQQPPDNQEKERLNTSIPQKRKMRNL
                     LVTIENDTPLEELSKYVDISIIALTRNRRTRRWYTCPLCGKQFNESSYLISHQRTHTG
                     EKPYDCNHCGKSFNHKTNLNKHERIHTGEKPYSCSQCGKNFRQNSHRSRHEGIHIREK
                     IFKCPECGKTFPKNEEFVLHLQSHEAERPYGCKKCGRRFGRLSNCTRHEKTHSACKTR
                     KQK"
     exon            504..592
                     /gene="ZNF200"
                     /inference="alignment:Splign:2.1.0"
     exon            593..719
                     /gene="ZNF200"
                     /inference="alignment:Splign:2.1.0"
     exon            720..3008
                     /gene="ZNF200"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2045..2050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF200"
                     /note="hexamer: AATAAT"
     regulatory      2064..2069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF200"
                     /note="hexamer: GATAAA"
     polyA_site      2070
                     /gene="ZNF200"
                     /note="major polyA site"
     polyA_site      2102
                     /gene="ZNF200"
     regulatory      2689..2694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF200"
                     /note="hexamer: AATAAA"
     polyA_site      2710
                     /gene="ZNF200"
     polyA_site      2991
                     /gene="ZNF200"
     polyA_site      3008
                     /gene="ZNF200"
                     /note="major polyA site"
ORIGIN      
        1 gttctcctca actggcggcg gcgcgaacga atagtcgccg gcgacctgtg agggcactcg
       61 gaagggcgag gggagggctc gaccgctcgc gcctagtttt tctatctctc ccggagcctg
      121 agtctctgag ccgtccccag caaacgctca ggggctgcag aggccccgag agcttggctc
      181 tctggcagat ttcctctagt aagaggtggc tctggaggcc ccgcgaaacg agtgtggtgt
      241 gtggttgcaa ggcatgatgg ctgcaaaagt ggttcctatg cccccaaagc caaagcagtc
      301 ctttatactg agagttccgc cagactccaa gctgggccaa gacctacttc gagatgccac
      361 taacgggccc aagaccatcc accagctagt gctggagcac ttcctcacct tcttgcccaa
      421 gccaagcctg gtccagccca gtcagaaagt caaggagacc ttggttatta tgaaagatgt
      481 gagctcaagc cttcagaaca gagtgcatcc tcgtcccttg gtgaagcttc tgcccaaagg
      541 agtccaaaag gaacaagaga cagtgtctct gtatttgaaa gctaaccctg aggagctggt
      601 ggtctttgag gatttgaatg tatttcactg ccaggaagaa tgtgtgagct tggatcctac
      661 tcaacaactc acgtcagaga aggaagatga cagcagtgtc ggggaaatga tgttactggc
      721 agtcaatggc agtaatcctg aaggtgaaga tcctgagagg gaacctgtag aaaatgaaga
      781 ttatagagaa aagtcttcag atgatgatga aatggattct tccttggtct ctcagcagcc
      841 tcccgataac caggaaaagg aacgactaaa tacatccatt ccacaaaaaa ggaaaatgag
      901 aaatctgtta gttaccattg agaatgatac tcctctagag gaactctcaa aatatgtaga
      961 catcagtatt attgccctta ctcgaaatcg gaggacaagg agatggtaca cttgtccact
     1021 gtgtgggaaa cagtttaatg aaagttctta cctcatttcc caccagagga cccacactgg
     1081 agaaaaaccc tatgactgta atcactgtgg gaaaagcttc aatcataaaa caaacctcaa
     1141 taaacatgag cgaattcata caggagagaa accttattcc tgttctcagt gtggaaaaaa
     1201 cttccgtcag aattctcatc ggagtcgtca tgaaggaatc catataaggg agaagatatt
     1261 taagtgtcca gaatgtggga aaaccttccc aaagaatgag gagtttgtgc ttcatctgca
     1321 gagtcatgag gctgagagac catatggttg caaaaaatgt gggagaagat ttggtcggct
     1381 gtcaaactgt acccggcatg agaaaaccca ctcagcctgt aagacccgaa agcagaagta
     1441 atactgggaa ccctttctgg gtctgatggt gctgcctcaa cctgagagct ttcataagta
     1501 gttctgaatt cccaagctgc ctaaaaaggt ataaatgtgt aaaaatctca ttattgccaa
     1561 aattggataa atgcccatct tagctaaaac ctcaaattgc tagaaaattc acagggaaga
     1621 aaacatttca agggctatac ctcagcatct aggctttttg gactaaggag ctttcctttt
     1681 tgaagttata tgataatgta caggtcacag atcccctttc ccaacacttt gaagatgaat
     1741 ctggagtctg cttacttgga aggcaaagag tgacttgtgt ctattgaaag tatatccgtt
     1801 ttccccccac atggggattc atacttgaga aatagtgcaa agatgcttat ctggaactgt
     1861 gttctggtga aagaaccaaa ttactggctt gttagccaac agcttctgat agcaattcat
     1921 ataaccctct aagaatacct gtttaagtct tgagtgttga aaggaattgt ttactttgga
     1981 atataggaaa acagttgaat gtcagactct catttgtatg tgatctaaat ttgcaatcaa
     2041 tttcaataat atttacaatt tgtgataaaa ctgactttta cagattcctt ttcacaacat
     2101 aatttaggtg tctactgttc ttattgtatt ttgttctgct gttgatctct ccagcagccg
     2161 tctcatgctt ctcccttgct aaaagaagtt tggattactc aggcagggcc atccagcccc
     2221 accactagaa aagctcttca gaatcttgtc cctctgttga gcccagatct catgtgctac
     2281 gaaggaaacc ccaagaccca gagaggaagg gtcaacctgg aggcaggaaa aagttggctt
     2341 ggatccatgt ctcatcaata accttaccat atgcttaggt cccctctatg ctgtcatcag
     2401 acctttggca atggggtggt cactacctca caaggcaaag tgttgtatga ttagaaatta
     2461 cgtctccagt ggttagctca cattgcctct caagagacag gtttccaggt gtcttcattg
     2521 tagtgggtat taattgtctt cagcctcttg atatccatac cttcctgtcc tctgcctaga
     2581 agcaaggcca gcggtgcctt tacggactga tcgtgtggtg cgatttaggg attcttcagt
     2641 tttgcttgct ttaggtttcc aaaagttata cattggtgtt ttgattggaa taaagaaatc
     2701 ctataagcta tttgggaaaa attatagtgt atgtttccca tccagaaaca tgcctttcta
     2761 tttattagag tattatattc ctgtgaaaat ttttctaatt ttcttcactt gttttacaca
     2821 attttgttat tgtagttttt tccattatat ttttatagtt gattattgct tttacatggg
     2881 aaagttattt ttaattatat atttgtatag tcatctcact gttgttaatt ttcaatagtt
     2941 tgttggttta gttctgttaa cttttggtaa aatgacacca tctacaaaga atagtttttg
     3001 tttcttgc
//
