LOCUS       NM_021143               3004 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 20 (ZNF20), transcript variant 1,
            mRNA.
ACCESSION   NM_021143 XM_352248
VERSION     NM_021143.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3004)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3004)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3004)
  AUTHORS   Rousseau-Merck,M.F., Koczan,D., Legrand,I., Moller,S., Autran,S.
            and Thiesen,H.J.
  TITLE     The KOX zinc finger genes: genome wide mapping of 368 ZNF PAC
            clones with zinc finger gene clusters predominantly in 23
            chromosomal loci are confirmed by human sequences annotated in
            EnsEMBL
  JOURNAL   Cytogenet Genome Res 98 (2-3), 147-153 (2002)
   PUBMED   12697996
REFERENCE   4  (bases 1 to 3004)
  AUTHORS   Rousseau-Merck,M.F., Hillion,J., Jonveaux,P., Couillin,P.,
            Seite,P., Thiesen,H.J. and Berger,R.
  TITLE     Chromosomal localization of 9 KOX zinc finger genes: physical
            linkages suggest clustering of KOX genes on chromosomes 12, 16, and
            19
  JOURNAL   Hum Genet 92 (6), 583-587 (1993)
   PUBMED   8262519
REFERENCE   5  (bases 1 to 3004)
  AUTHORS   Thiesen,H.J.
  TITLE     Multiple genes encoding zinc finger domains are expressed in human
            T cells
  JOURNAL   New Biol 2 (4), 363-374 (1990)
   PUBMED   2288909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB057678.1, BC036714.2, AC022415.5 and BM142273.1.
            
            On Nov 23, 2018 this sequence version replaced NM_021143.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA875939.1, AK023094.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334213.10/ ENSP00000335437.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                DB057678.1         58-82
            26-2240             BC036714.2         1-2215
            2241-2942           AC022415.5         124259-124960       c
            2943-3004           BM142273.1         270-331
FEATURES             Location/Qualifiers
     source          1..3004
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..3004
                     /gene="ZNF20"
                     /gene_synonym="KOX13"
                     /note="zinc finger protein 20"
                     /db_xref="GeneID:7568"
                     /db_xref="HGNC:HGNC:12992"
                     /db_xref="MIM:194557"
     exon            1..171
                     /gene="ZNF20"
                     /gene_synonym="KOX13"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1767
                     /gene="ZNF20"
                     /gene_synonym="KOX13"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein KOX13"
                     /codon_start=1
                     /product="zinc finger protein 20 isoform 1"
                     /protein_id="NP_066966.2"
                     /db_xref="CCDS:CCDS45986.1"
                     /db_xref="GeneID:7568"
                     /db_xref="HGNC:HGNC:12992"
                     /db_xref="MIM:194557"
                     /translation="MMFQDSVAFEDVAVSFTQEEWALLDPSQKNLYRDVMQETFKNLT
                     SVGKTWKVQNIEDEYKNPRRNLSLMREKLCESKESHHCGESFNQIADDMLNRKTLPGI
                     TPCESSVCGEVGTGHSSLNTHIRADTGHKSSEYQEYGENPYRNKECKKAFSYLDSFQS
                     HDKACTKEKPYDGKECTETFISHSCIQRHRVMHSGDGPYKCKFCGKAFYFLNLCLIHE
                     RIHTGVKPYKCKQCGKAFTRSTTLPVHERTHTGVNADECKECGNAFSFPSEIRRHKRS
                     HTGEKPYECKQCGKVFISFSSIQYHKMTHTGEKPYECKQCGKAFRCGSHLQKHGRTHT
                     GEKPYECRQCGKAFRCTSDLQRHEKTHTEDKPYGCKQCGKGFRCASQLQIHERTHSGE
                     KPHECKECGKVFKYFSSLRIHERTHTGEKPHECKQCGKAFRYFSSLHIHERTHTGDKP
                     YECKVCGKAFTCSSSIRYHERTHTGEKPYECKHCGKAFISNYIRYHERTHTGEKPYQC
                     KQCGKAFIRASSCREHERTHTINR"
     exon            172..307
                     /gene="ZNF20"
                     /gene_synonym="KOX13"
                     /inference="alignment:Splign:2.1.0"
     exon            308..368
                     /gene="ZNF20"
                     /gene_synonym="KOX13"
                     /inference="alignment:Splign:2.1.0"
     exon            369..3004
                     /gene="ZNF20"
                     /gene_synonym="KOX13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2217..2222
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF20"
                     /gene_synonym="KOX13"
                     /note="hexamer: AATAAA"
     polyA_site      2240
                     /gene="ZNF20"
                     /gene_synonym="KOX13"
                     /note="major polyA site"
     regulatory      2342..2347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF20"
                     /gene_synonym="KOX13"
                     /note="hexamer: ATTAAA"
     polyA_site      2361
                     /gene="ZNF20"
                     /gene_synonym="KOX13"
     regulatory      2520..2525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF20"
                     /gene_synonym="KOX13"
                     /note="hexamer: ACTAAA"
     polyA_site      2553
                     /gene="ZNF20"
                     /gene_synonym="KOX13"
     regulatory      2969..2974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF20"
                     /gene_synonym="KOX13"
                     /note="hexamer: ATTAAA"
     polyA_site      3004
                     /gene="ZNF20"
                     /gene_synonym="KOX13"
ORIGIN      
        1 agcttctact tttgttgcta tgcaggttgt tgtcgggata ccagatttcc tactccgaga
       61 ggccccgggt ccctctgcca caacttctgt cgctctgccg cctgcaccgt gacccgcact
      121 attcacggga gccctagaga ggacaccggg acacccagaa gccgggaaat gatgtttcag
      181 gattcagtgg cctttgagga tgtggctgtc agcttcaccc aggaggagtg ggctttgctg
      241 gatccttccc agaagaatct ctacagggat gtgatgcagg aaaccttcaa gaacctgacc
      301 tctgtaggaa aaacatggaa agttcagaac attgaagatg agtacaaaaa tcccaggaga
      361 aatctaagtc ttatgagaga gaaactctgt gaaagtaaag aaagtcatca ctgtggagaa
      421 agcttcaacc agattgcaga tgacatgctg aacaggaaaa ctcttcctgg aataacacca
      481 tgtgaaagca gtgtgtgtgg agaagttggc acgggtcatt catctcttaa tacgcatatc
      541 agagctgaca ctggacacaa gtcatctgag tatcaggaat atggagagaa tccatataga
      601 aataaggaat gtaagaaagc cttcagttat cttgactcct ttcaatcaca tgataaagct
      661 tgcactaaag agaaacccta tgatggtaaa gaatgtacag aaaccttcat ttcccattca
      721 tgcattcaaa gacacagggt aatgcacagt ggagatggac cttataaatg taagttttgt
      781 gggaaagcct tctattttct caatttatgt cttatccatg aacgaattca cactggtgtg
      841 aaaccatata agtgtaaaca atgtggtaag gcctttactc gttccactac ccttccagta
      901 catgaaagaa ctcacacagg agtgaatgcc gatgaatgta aagaatgtgg gaatgcattc
      961 agttttccta gtgaaattcg tagacataaa aggtctcaca ctggagaaaa accctatgag
     1021 tgtaagcaat gtgggaaagt cttcatttct ttcagttcca ttcagtatca taagatgact
     1081 cacactggag agaaacccta tgaatgtaag cagtgtggga aagcctttag atgtggctca
     1141 caccttcaaa agcatggaag gactcacact ggagagaaac cctatgaatg taggcaatgt
     1201 ggtaaagcct tcagatgtac ctcggacctt caaaggcatg aaaagacaca cactgaggat
     1261 aaaccctatg gatgtaagca gtgtgggaaa ggctttagat gtgcttcaca acttcaaatt
     1321 catgaaagga cgcacagtgg agagaaaccc catgaatgta aggaatgtgg aaaagtattc
     1381 aagtattttt cttccttgcg tatacatgaa aggacgcaca ctggagagaa gccccatgaa
     1441 tgtaagcaat gtggaaaagc attcaggtat ttctcttcct tgcatataca tgaaaggaca
     1501 cacactggag ataagccata tgagtgtaag gtatgtggca aagccttcac ttgttccagt
     1561 tccattcgat atcatgaaag gactcacact ggagagaaac cctatgaatg taagcactgt
     1621 ggtaaggcct ttatttccaa ttacattcga tatcatgaaa ggactcacac tggagagaaa
     1681 ccctatcaat gcaagcaatg tggcaaagcc tttattcgtg ccagttcatg tcgagaacat
     1741 gaaagaactc ataccattaa tagatgagaa atccttttag tggaagcaac gggagaagct
     1801 ttctgttgtc ccacttcctt tgaaacacaa gaaaagagag tggtgaaaga acctctggat
     1861 aactgctttt tgaattgaga agagagactt gcgataggac aataaaatct agaagaactt
     1921 ggatggtttc gtaatacaat tcacctatag ccaatcttgc atgagatttc aaaggcacag
     1981 aaaaggaagg catcagtcac atattagagg ccccacacag ggagagaggt gtgtggctac
     2041 ccgcttccag cccattttcc tgattctttg gcttgttaat cgagaatatc ccccaaatca
     2101 cttgtctctg ttcctcagag ttgtaggtct ccagatatgt ccccagtgct ccacattaaa
     2161 gatacatgcc cactttgctg tttcttcaga aatgttaaaa tgtttaccag agaactaata
     2221 aatgttgtta tggctggaaa tactcactga tgcccaactc ttctatagat tgagttggtt
     2281 taagaggtct actttgtatt gcaagcattg ttgtttctac ggattagcga gcctgttctt
     2341 gattaaacca actagatggg agcttgttcc tctgctgcat tgtgcagtga ttggtctcac
     2401 caagggcttt tatgtgagaa gagccacctt gctcttatca ggaaatttca agcatttgct
     2461 gttattcaca actgaatgta atgtctcact tcgtttttaa ctttgtatga gtatacctga
     2521 ctaaaaacac taatgcggtt tcttggcaac aaatacttct gttcatgtat tttagaaata
     2581 agcttattaa ctgtttataa caactgcata ctaacaatta ttatttttta atgaagaagc
     2641 tacattacaa cctcccatta acatcatgta ttagatcaag ttgataatgt taccatgtta
     2701 tccggtggtc actgtgagtc agtgttgcca tgtggatgtc aggcatattt ttcctcatgt
     2761 agattttact tttcatgctt atattcttag tttttatctg gatcatgaat tttcatctat
     2821 tctaaatacc aaaggtgatc tcatgttctt atgagtgact tctgaccaaa gaccaccagt
     2881 ggcataagtg tcgtcaaaga gggtgtaata atatactgtg gtaatgaata tgaccaaaag
     2941 ccatagatga ctgtgagatg tgtgagatat taaaagatag tcacatttcg tgagaagaga
     3001 aaaa
//
