LOCUS       NM_021088               3580 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 2 (ZNF2), transcript variant 1,
            mRNA.
ACCESSION   NM_021088
VERSION     NM_021088.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3580)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3580)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3580)
  AUTHORS   Rivieccio,V., Mannini,R., Concilio,L., D'Auria,S., Pedone,C. and
            Grimaldi,G.
  TITLE     Expression, purification and partial characterization of the
            Kruppel-associated box (KRAB) from the human ZNF2 protein
  JOURNAL   Protein Pept Lett 12 (6), 527-532 (2005)
   PUBMED   16101389
REFERENCE   4  (bases 1 to 3580)
  AUTHORS   Rocchi,M., Gentile,E., Rosati,M. and Grimaldi,G.
  TITLE     The human KRAB/FPB containing zinc finger gene ZNF2 maps to
            chromosome 2q11.2
  JOURNAL   Cytogenet Cell Genet 86 (3-4), 305-306 (1999)
   PUBMED   10575230
REFERENCE   5  (bases 1 to 3580)
  AUTHORS   Witzgall,R., O'Leary,E., Leaf,A., Onaldi,D. and Bonventre,J.V.
  TITLE     The Kruppel-associated box-A (KRAB-A) domain of zinc finger
            proteins mediates transcriptional repression
  JOURNAL   Proc Natl Acad Sci U S A 91 (10), 4514-4518 (1994)
   PUBMED   8183940
REFERENCE   6  (bases 1 to 3580)
  AUTHORS   Rosati,M., Marino,M., Franze,A., Tramontano,A. and Grimaldi,G.
  TITLE     Members of the zinc finger protein gene family sharing a conserved
            N-terminal module
  JOURNAL   Nucleic Acids Res 19 (20), 5661-5667 (1991)
   PUBMED   1945843
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC005068.1, AK295739.1,
            AC092835.4, AV726545.1 and AI631860.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_021088.3.
            
            Summary: The protein encoded by this gene belongs to the C2H2-type
            zinc-finger protein family. The exact function of this gene is not
            known, however, zinc-finger proteins are known to interact with DNA
            and function as transcription regulators. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Apr 2014].
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA312105.1, SRR1803616.846.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000614034.5/ ENSP00000480297.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1195              BC005068.1         365-1559
            1196-1718           AK295739.1         1105-1627
            1719-3031           AC092835.4         100964-102276
            3032-3397           AV726545.1         15-380
            3398-3580           AI631860.1         9-191               c
FEATURES             Location/Qualifiers
     source          1..3580
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.1"
     gene            1..3580
                     /gene="ZNF2"
                     /gene_synonym="A1-5; Zfp661; ZNF661"
                     /note="zinc finger protein 2"
                     /db_xref="GeneID:7549"
                     /db_xref="HGNC:HGNC:12991"
                     /db_xref="MIM:194500"
     exon            1..52
                     /gene="ZNF2"
                     /gene_synonym="A1-5; Zfp661; ZNF661"
                     /inference="alignment:Splign:2.1.0"
     exon            53..124
                     /gene="ZNF2"
                     /gene_synonym="A1-5; Zfp661; ZNF661"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1369
                     /gene="ZNF2"
                     /gene_synonym="A1-5; Zfp661; ZNF661"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger protein 2.2; zinc finger protein 661"
                     /codon_start=1
                     /product="zinc finger protein 2 isoform a"
                     /protein_id="NP_066574.2"
                     /db_xref="CCDS:CCDS42712.1"
                     /db_xref="GeneID:7549"
                     /db_xref="HGNC:HGNC:12991"
                     /db_xref="MIM:194500"
                     /translation="MAAVSPTTRCQESVTFEDVAVVFTDEEWSRLVPIQRDLYKEVML
                     ENYNSIVSLGLPVPQPDVIFQLKRGDKPWMVDLHGSEEREWPESVSLDWETKPEIHDA
                     SDKKSEGSLRECLGRQSPLCPKFEVHTPNGRMGTEKQSPSGETRKKSLSRDKGLRRRS
                     ALSREILTKERHQECSDCGKTFFDHSSLTRHQRTHTGEKPYDCRECGKAFSHRSSLSR
                     HLMSHTGESPYECSVCSKAFFDRSSLTVHQRIHTGEKPFQCNECGKAFFDRSSLTRHQ
                     RIHTGESPYECHQCGKAFSQKSILTRHQLIHTGRKPYECNECGKAFYGVSSLNRHQKA
                     HAGDPRYQCNECGKAFFDRSSLTQHQKIHTGDKPYECSECGKAFSQRCRLTRHQRVHT
                     GEKPFECTVCGKVFSSKSSVIQHQRRYAKQGID"
     exon            125..251
                     /gene="ZNF2"
                     /gene_synonym="A1-5; Zfp661; ZNF661"
                     /inference="alignment:Splign:2.1.0"
     exon            252..365
                     /gene="ZNF2"
                     /gene_synonym="A1-5; Zfp661; ZNF661"
                     /inference="alignment:Splign:2.1.0"
     exon            366..3580
                     /gene="ZNF2"
                     /gene_synonym="A1-5; Zfp661; ZNF661"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2211..2216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF2"
                     /gene_synonym="A1-5; Zfp661; ZNF661"
                     /note="hexamer: AATAAA"
     polyA_site      2232
                     /gene="ZNF2"
                     /gene_synonym="A1-5; Zfp661; ZNF661"
     regulatory      3559..3564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF2"
                     /gene_synonym="A1-5; Zfp661; ZNF661"
                     /note="hexamer: AATAAA"
     polyA_site      3580
                     /gene="ZNF2"
                     /gene_synonym="A1-5; Zfp661; ZNF661"
                     /note="major polyA site"
ORIGIN      
        1 cccgacctga agaggcgccg tcttcccggg tcccgagcac tctgtgccgg aggactctgc
       61 ccttgtccac aaggagagca cacaggagag aatggctgct gtgtctccga ccaccagatg
      121 ccaggaatca gtgacattcg aagacgttgc cgtggttttc acagatgaag agtggagtcg
      181 tctggtcccc atacagaggg acctctacaa ggaggtgatg ctggagaact ataacagcat
      241 tgtgtcattg ggccttccag ttcctcaacc tgatgtgatt ttccaattga agagagggga
      301 caagccgtgg atggtagatc ttcatgggtc tgaggagaga gaatggccag agagtgtctc
      361 tctagactgg gaaactaagc ctgagattca cgatgcttca gacaaaaaat cagaaggatc
      421 attgagggaa tgccttggaa ggcaaagtcc tctgtgtcct aaatttgaag ttcatacacc
      481 caatggcagg atgggaacag aaaagcaaag cccttcaggg gagactcgta agaaatccct
      541 ctcccgggac aaaggcttgc ggcgacggtc agccctgtcc agggaaattc tcactaaaga
      601 gagacaccag gaatgcagtg actgtgggaa gacctttttt gaccactcat ccctcacccg
      661 ccatcagagg actcacactg gggagaagcc ctacgactgc cgcgagtgtg ggaaagcctt
      721 cagccacagg agcagcctca gcagacatct gatgtcacac actggggaga gcccctacga
      781 gtgcagtgtg tgctcaaaag ccttctttga ccgttcgtcc ctaactgtcc atcagcgaat
      841 tcacactgga gagaaaccct ttcagtgcaa cgagtgtgga aaagcctttt ttgaccgttc
      901 atcccttact cgacaccaga gaattcacac tggagaaagt ccttatgaat gtcatcagtg
      961 tgggaaagcc tttagccaga aaagtattct tactcgccat cagctaatcc acactggcag
     1021 gaagccttat gagtgtaacg agtgcgggaa agctttctat ggtgtctcgt ctctgaatag
     1081 acatcagaaa gctcatgctg gggaccctcg ctatcagtgt aacgagtgtg gcaaagcttt
     1141 ctttgaccgc tcatccctta cacagcatca gaagatccac actggagaca agccatatga
     1201 atgcagcgaa tgcgggaaag cctttagcca gcggtgccgg ctcacgcggc atcagcgtgt
     1261 ccacacggga gagaagccct ttgaatgcac tgtgtgtggg aaagttttca gttcaaaatc
     1321 ttctgttatt caacatcaac ggcgttacgc caaacaggga atagactgag ttgggcaaaa
     1381 gcttgggtag gacaagaact tccatacaaa tttgagatag atctcgcctg tcttaaagct
     1441 gccatttgct cattctaccc actctggctg ccgttgtcct gtcctgcttc tgcgccagag
     1501 tgtttaataa gcactccctt cctgctgtgt tatagaactg taggggaggc catggaaatg
     1561 actctaaaga tacaaaattt tgaagaggtt tgtcagacaa taggatagat gttaggagga
     1621 gacacacctc ttgtctgaga acctaggccc caggtatcac tgcactttaa gaaactggag
     1681 gctgcaacag gagggaaagg cagaatgata tcacagcagt actatttttt tttttcagaa
     1741 catttgtttt gatggctgtt agtccccctc tcttggagca ttttggggca ctaatcttgt
     1801 tctcttgtgt cccagctttt agacctctta cttccactgc tagtagctag cacttactga
     1861 gcacctgcga tgaggtaaag actcagctaa gggttttaca ggaagtagat taattgatcc
     1921 tgtcaccaac catatgaagt aggcactgtt accatctgca tctccagatg agcaccctga
     1981 ggtttagaga gattaaatca cttgcccaag gtgaaccagc tggtaaaagg tgatgccagg
     2041 tcttgaagac aggtccacct tcaaaatcta ttctctttac cattatgctc gatggtttgt
     2101 ttgttttata atttatgtat atgtattatc ctctcaacta gattgtaagc acttggaggt
     2161 gtgacttaca ggtctttgta tctcacacag tgccttgcta ataggtgctc aataaatatt
     2221 tatatgagtg aatgactttt ctacttacca aattctctcc attcagaaca cctcttggat
     2281 ttgcatactt tctctgaatt cacagcccag cctatacttt tatcatcccc agctcccact
     2341 cctggcagca gtagctttct aattccagtt cttcctgctt tattgaagag ggatgtgcta
     2401 agctgtggta cagtaacaag cccgcagaga gctatgtctc ccttaaaacc tgacgggaac
     2461 cattctgtct tattctatcc tcattatttg gaacatctgg cttccaaagt caccacaagg
     2521 gcggaagaga aagctagagg aatttgtagg atattttctt agacccaggc ttacatcact
     2581 tctgtccaca tctaataagc cagaacccag cacctagaag ctaggaaagt aaacaagcac
     2641 ctcgaaagtt ggttaatacc aagaacctct ctcacagtta tattttgcat actactgtta
     2701 agccagtctt tgcaaatgac cccttcctgc ccatcactgc cttcctcaag acctaaaata
     2761 gctccctatt tagtgaaaaa ttatctgaat atttaaggtc tgccttaacg tgatccccat
     2821 tgctgaattt tacctcctga ctccaaaaac tcttctcttc cctgggccca gtcctatttt
     2881 tttttttttt tttttttttg tgagacagag tctcactctg tcacccaggt tggaatgcaa
     2941 tggcacaatc tccgctcact gcaagctccg cctcccgggt tcacgccatt ctcctgcctc
     3001 agcctcccga atagctggga ctacaggtgc ccgccaacac gcccggctaa ttttttgtat
     3061 ttttagtaga gacggggttt caccgtgtta gccaggatgg tctcaatctc ctgacctcgt
     3121 gatccgcccg cctcggcctc ccaaagtgct gggattacag acgtaagtca ccgtgcccgg
     3181 cctatatttt tattttatta aaggttaggc actagatgac cttgactcta ggcatctgca
     3241 ttctcttgat ctttgcttag ggtgaagctc agaaaaggac ttggttctga aaggctgtct
     3301 ggaattagat tgtcctacgt gattcccagt gaattgagat gaatttcctc tggaagttca
     3361 agtcggattc gagaagctga attaccaaac agaccctccc caacctacta acgaccctat
     3421 tactctgttc accctagagc agacgaacgg cagggaagac ttgatctgtg gacttttgaa
     3481 agcaacttga ggaaaaacac ataacagaat ctataggtgt ggacaatatg tgatattgct
     3541 aaataatgtc aagtaggaaa taaaagagac tattgacaaa
//
