LOCUS       NM_001130520            3187 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens zinc finger protein 195 (ZNF195), transcript variant
            1, mRNA.
ACCESSION   NM_001130520
VERSION     NM_001130520.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3187)
  AUTHORS   Zhu,M.H., Ji,S.L., Zhang,C.Y., Cui,L., Xiong,L. and Zheng,H.L.
  TITLE     DNA microarray reveals ZNF195 and SBF1 are potential biomarkers for
            gemcitabine sensitivity in head and neck squamous cell carcinoma
            cell lines
  JOURNAL   Int J Clin Exp Pathol 7 (4), 1514-1523 (2014)
   PUBMED   24817947
  REMARK    GeneRIF: ZNF195 and SBF1 are potential biomarkers for gemcitabine
            sensitivity in head and neck squamous cell carcinoma cell lines.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3187)
  AUTHORS   Dao,D., Walsh,C.P., Yuan,L., Gorelov,D., Feng,L., Hensle,T.,
            Nisen,P., Yamashiro,D.J., Bestor,T.H. and Tycko,B.
  TITLE     Multipoint analysis of human chromosome 11p15/mouse distal
            chromosome 7: inclusion of H19/IGF2 in the minimal WT2 region, gene
            specificity of H19 silencing in Wilms' tumorigenesis and
            methylation hyper-dependence of H19 imprinting
  JOURNAL   Hum Mol Genet 8 (7), 1337-1352 (1999)
   PUBMED   10369881
REFERENCE   3  (bases 1 to 3187)
  AUTHORS   Pak,B.J., Park,H., Chang,E.R., Pang,S.C. and Graham,C.H.
  TITLE     Differential display analysis of oxygen-mediated changes in gene
            expression in first trimester human trophoblast cells
  JOURNAL   Placenta 19 (7), 483-488 (1998)
   PUBMED   9778121
REFERENCE   4  (bases 1 to 3187)
  AUTHORS   Hussey,D.J., Parker,N.J., Hussey,N.D., Little,P.F. and Dobrovic,A.
  TITLE     Characterization of a KRAB family zinc finger gene, ZNF195, mapping
            to chromosome band 11p15.5
  JOURNAL   Genomics 45 (2), 451-455 (1997)
   PUBMED   9344677
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC123788.7, AK290099.1 and
            AL833722.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001130520.2.
            
            Summary: This gene encodes a protein belonging to the Krueppel
            C2H2-type zinc-finger protein family. These family members are
            transcription factors that are implicated in a variety of cellular
            processes. This gene is located near the centromeric border of
            chromosome 11p15.5, next to an imprinted domain that is associated
            with maternal-specific loss of heterozygosity in Wilms' tumors.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Feb 2012].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.154126.1, AF003540.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154405 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399602.9/ ENSP00000382511.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC123788.7         64153-64167         c
            16-2218             AK290099.1         1-2203
            2219-3076           AC123788.7         43059-43916         c
            3077-3187           AL833722.1         2901-3011
FEATURES             Location/Qualifiers
     source          1..3187
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..3187
                     /gene="ZNF195"
                     /gene_synonym="HRF1; ZNFP104"
                     /note="zinc finger protein 195"
                     /db_xref="GeneID:7748"
                     /db_xref="HGNC:HGNC:12986"
                     /db_xref="MIM:602187"
     exon            1..109
                     /gene="ZNF195"
                     /gene_synonym="HRF1; ZNFP104"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1996
                     /gene="ZNF195"
                     /gene_synonym="HRF1; ZNFP104"
                     /note="isoform 1 is encoded by transcript variant 1;
                     krueppel family zinc finger protein (znfp104);
                     hypoxia-regulated factor-1"
                     /codon_start=1
                     /product="zinc finger protein 195 isoform 1"
                     /protein_id="NP_001123992.1"
                     /db_xref="CCDS:CCDS44522.1"
                     /db_xref="GeneID:7748"
                     /db_xref="HGNC:HGNC:12986"
                     /db_xref="MIM:602187"
                     /translation="MTLLTFRDVAIEFSLEEWKCLDLAQQNLYRDVMLENYRNLFSVG
                     LTVCKPGLITCLEQRKEPWNVKRQEAADGHPEMGFHHATQACLELLGSSDLPASASQS
                     AGITGVNHRAQPGLNVSVDKFTALCSPGVLQTVKWFLEFRCIFSLAMSSHFTQDLLPE
                     QGIQDAFPKRILRGYGNCGLDNLYLRKDWESLDECKLQKDYNGLNQCSSTTHSKIFQY
                     NKYVKIFDNFSNLHRRNISNTGEKPFKCQECGKSFQMLSFLTEHQKIHTGKKFQKCGE
                     CGKTFIQCSHFTEPENIDTGEKPYKCQECNNVIKTCSVLTKNRIYAGGEHYRCEEFGK
                     VFNQCSHLTEHEHGTEEKPCKYEECSSVFISCSSLSNQQMILAGEKLSKCETWYKGFN
                     HSPNPSKHQRNEIGGKPFKCEECDSIFKWFSDLTKHKRIHTGEKPYKCDECGKAYTQS
                     SHLSEHRRIHTGEKPYQCEECGKVFRTCSSLSNHKRTHSEEKPYTCEECGNIFKQLSD
                     LTKHKKTHTGEKPYKCDECGKNFTQSSNLIVHKRIHTGEKPYKCEECGRVFMWFSDIT
                     KHKKTHTGEKPYKCDECGKNFTQSSNLIVHKRIHTGEKPYKCEKCGKAFTQFSHLTVH
                     ESIHT"
     exon            110..236
                     /gene="ZNF195"
                     /gene_synonym="HRF1; ZNFP104"
                     /inference="alignment:Splign:2.1.0"
     exon            237..332
                     /gene="ZNF195"
                     /gene_synonym="HRF1; ZNFP104"
                     /inference="alignment:Splign:2.1.0"
     exon            333..479
                     /gene="ZNF195"
                     /gene_synonym="HRF1; ZNFP104"
                     /inference="alignment:Splign:2.1.0"
     exon            480..548
                     /gene="ZNF195"
                     /gene_synonym="HRF1; ZNFP104"
                     /inference="alignment:Splign:2.1.0"
     exon            549..3187
                     /gene="ZNF195"
                     /gene_synonym="HRF1; ZNFP104"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2551
                     /gene="ZNF195"
                     /gene_synonym="HRF1; ZNFP104"
     regulatory      2707..2712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF195"
                     /gene_synonym="HRF1; ZNFP104"
                     /note="hexamer: AGTAAA"
     polyA_site      2728
                     /gene="ZNF195"
                     /gene_synonym="HRF1; ZNFP104"
                     /note="major polyA site"
     regulatory      3168..3173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF195"
                     /gene_synonym="HRF1; ZNFP104"
                     /note="hexamer: AATAAA"
     polyA_site      3187
                     /gene="ZNF195"
                     /gene_synonym="HRF1; ZNFP104"
ORIGIN      
        1 acttcctgtc cccgcggctc tgtgtcccct gctagccgta ggtcgtgtga cccgcaggca
       61 ccgggagatc cagaagtgaa acgccaggct ctctggaggc caggagatga ctctgttgac
      121 gttcagggat gtggccatag aattctccct ggaggagtgg aaatgcctgg acctcgctca
      181 gcagaatttg tacagggatg tgatgttgga gaactacaga aacttgttct ccgttggtct
      241 cactgtctgt aagccaggcc tgatcacctg cctggagcaa cgaaaagagc cctggaatgt
      301 gaagagacag gaggcagcag acggacatcc agagatggga tttcaccatg ctactcaggc
      361 ttgtcttgaa ctcctgggct caagcgatct gcctgcctca gcctcccaaa gtgctgggat
      421 tacaggtgtg aaccaccgtg cccagccagg cctcaatgtt tctgtggaca aattcactgc
      481 actgtgctca cctggggtgc tgcaaactgt gaaatggttt ttagagttca gatgcatctt
      541 ctcactagct atgtcttctc attttaccca agaccttctg ccagagcagg gcatacaaga
      601 tgcattccca aaaagaatac tgagaggata tggaaattgt ggccttgata atttatattt
      661 aaggaaagac tgggaaagtt tagatgagtg taagttgcaa aaagattata atggacttaa
      721 ccaatgttca tcaactaccc atagcaaaat ctttcaatat aataaatatg ttaaaatctt
      781 tgataacttt tcaaatttac atagacgtaa tataagtaat actggagaga aacctttcaa
      841 atgtcaagaa tgtggcaaat cctttcaaat gctctcattc ctaactgaac atcagaaaat
      901 tcacactgga aaaaaattcc aaaaatgtgg agaatgtggc aaaaccttta tccagtgctc
      961 acactttact gaacctgaga acattgacac tggagagaaa ccttacaagt gtcaagaatg
     1021 taacaacgtc attaaaactt gctcagtcct tactaaaaat agaatttatg ccggagggga
     1081 acattacaga tgtgaagaat ttggcaaagt atttaaccag tgctcccacc ttactgaaca
     1141 tgagcatggt actgaggaaa aaccctgcaa atatgaagag tgcagcagtg tctttatctc
     1201 ttgctcaagc ctttctaatc aacagatgat tcttgctgga gagaagctct ccaaatgtga
     1261 aacatggtac aaaggtttta accacagccc aaatccttcc aaacaccaga gaaatgagat
     1321 tggagggaaa cctttcaaat gtgaggaatg tgacagcatc ttcaagtggt tctcagacct
     1381 tactaaacat aagagaattc acactggtga gaaaccatac aaatgtgacg aatgtgggaa
     1441 agcctataca cagtcctcac acctcagtga acacaggagg attcacaccg gagagaaacc
     1501 ctaccaatgt gaagaatgtg ggaaggtctt cagaacttgc tcaagccttt ctaaccataa
     1561 gagaactcat tctgaagaaa aaccctacac gtgtgaagaa tgtggcaaca tctttaagca
     1621 gttatcagac ctcactaagc ataagaaaac ccatactgga gagaagccct acaaatgtga
     1681 cgaatgtgga aaaaacttta cccagtcctc caaccttatt gtacataaga gaattcatac
     1741 tggagagaaa ccctacaagt gtgaagaatg tggcagagtc ttcatgtggt tctcagacat
     1801 taccaaacat aagaaaaccc atactggaga gaaaccctac aaatgtgacg aatgtggaaa
     1861 aaactttacc cagtcctcaa accttattgt acataagaga attcatactg gagagaaacc
     1921 ctacaagtgt gaaaagtgtg gcaaagcctt cacccagttc tcacacctga ctgtacatga
     1981 aagcattcat acttgagaaa aaaataaaca aatataaaaa taggcaaagc cgttagtatc
     2041 tgctcgcatc ccactttaca tcagagttca gacttaataa agttatcata aatgtaatta
     2101 ctattgaaag acctttcatg aaatataagt ctccagagca cacaagagta tttcttctga
     2161 aaaaaatgtt acaattatac tagatggaag acttgcatca gttgcttaaa ctttcagaaa
     2221 atttgtagag aaacccaaca aatctcataa atgtggaata acatttgttc aaaaatgata
     2281 gcttagaaaa cactagagtt catactaaaa gatattttgc aaatacacta aatgggaaaa
     2341 ataagcaagg acacgttcag aaatgacact gaatccctgt gttgagtcta cagagacatc
     2401 tagacttaaa atagatcatt tatatttaag tttaaaagga ggatgagact gagtttttgt
     2461 agagttataa ttacattcaa aatatacttt tttgcattga aaaaatgtta aatttttgaa
     2521 aagcgaatat tgatgtcatt ctattctcaa atcagtagat gctgtgtctt catttctagt
     2581 gctgatgtga aaacacatgg tcagttgttg ctgcgtcaga gatatgagaa attcttttct
     2641 cttaggtgtg catcactgat atacttgtcc gtgaaaggtg aaagacactg aaatgtaaga
     2701 tgcgtgagta aaatcttggt agagaggctc tttgtggttg ttttatatac ttgtaagtga
     2761 tttatgagat aggtgtttag aataatactc ttctgttagg gtcaccctga tcagaccgtt
     2821 cccttcccct cccacaggac ttacaatacg gtcccttgtg ctctctgcac agctacccca
     2881 gggcaaaaaa caaacccccc ttcactgatc cctccagtaa ctgtgcagac agttacagga
     2941 tgcggttaac atgtctgttc acctcgcata acaaagctgg caaaaaacat ctccaggatg
     3001 cagacaagac acctgcaccc tcgactaagc tcccccaccc caacccagtt ctcctgcacc
     3061 cccaactcag ctcccgcacc ccgacctagt tctggcccta taaaaacctg ctatagtctg
     3121 taagcagggc tgcctcctct aactgtggtg gagcagccaa gcagctcaat aaagcttgct
     3181 tgcctga
//
