LOCUS       NM_006961               3206 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 19 (ZNF19), mRNA.
ACCESSION   NM_006961
VERSION     NM_006961.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3206)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3206)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3206)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   4  (bases 1 to 3206)
  AUTHORS   Tommerup,N. and Vissing,H.
  TITLE     Isolation and fine mapping of 16 novel human zinc finger-encoding
            cDNAs identify putative candidate genes for developmental and
            malignant disorders
  JOURNAL   Genomics 27 (2), 259-264 (1995)
   PUBMED   7557990
REFERENCE   5  (bases 1 to 3206)
  AUTHORS   Lichter,P., Bray,P., Ried,T., Dawid,I.B. and Ward,D.C.
  TITLE     Clustering of C2-H2 zinc finger motif sequences within telomeric
            and fragile site regions of human chromosomes
  JOURNAL   Genomics 13 (4), 999-1007 (1992)
   PUBMED   1505991
REFERENCE   6  (bases 1 to 3206)
  AUTHORS   Bray,P., Lichter,P., Thiesen,H.J., Ward,D.C. and Dawid,I.B.
  TITLE     Characterization and mapping of human genes encoding zinc finger
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9563-9567 (1991)
   PUBMED   1946370
REFERENCE   7  (bases 1 to 3206)
  AUTHORS   Thiesen,H.J.
  TITLE     Multiple genes encoding zinc finger domains are expressed in human
            T cells
  JOURNAL   New Biol 2 (4), 363-374 (1990)
   PUBMED   2288909
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC047091.1, AK055567.1,
            AL834237.1, BM981699.1 and AC010547.9.
            
            On May 17, 2019 this sequence version replaced NM_006961.3.
            
            Summary: The protein encoded by this gene contains a zinc finger, a
            nucleic acid-binding domain present in many transcription factors.
            This gene is located in a region next to ZNF23, a gene also
            encoding a zinc finger protein, on chromosome 16. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047091.1, SRR5189667.213629.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000288177.10/ ENSP00000288177.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-342               BC047091.1         15-356
            343-912             AK055567.1         251-820
            913-1006            BC047091.1         927-1020
            1007-2040           AK055567.1         915-1948
            2041-2041           BC047091.1         2055-2055
            2042-2630           AL834237.1         1443-2031
            2631-2716           BM981699.1         508-593             c
            2717-3206           AC010547.9         79510-79999         c
FEATURES             Location/Qualifiers
     source          1..3206
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.2"
     gene            1..3206
                     /gene="ZNF19"
                     /gene_synonym="KOX12"
                     /note="zinc finger protein 19"
                     /db_xref="GeneID:7567"
                     /db_xref="HGNC:HGNC:12981"
                     /db_xref="MIM:194525"
     exon            1..53
                     /gene="ZNF19"
                     /gene_synonym="KOX12"
                     /inference="alignment:Splign:2.1.0"
     exon            54..213
                     /gene="ZNF19"
                     /gene_synonym="KOX12"
                     /inference="alignment:Splign:2.1.0"
     exon            214..275
                     /gene="ZNF19"
                     /gene_synonym="KOX12"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1619
                     /gene="ZNF19"
                     /gene_synonym="KOX12"
                     /note="zinc finger protein 19 (KOX 12); zinc finger
                     protein KOX12"
                     /codon_start=1
                     /product="zinc finger protein 19"
                     /protein_id="NP_008892.2"
                     /db_xref="CCDS:CCDS10901.1"
                     /db_xref="GeneID:7567"
                     /db_xref="HGNC:HGNC:12981"
                     /db_xref="MIM:194525"
                     /translation="MAAMPLKAQYQEMVTFEDVAVHFTKTEWTGLSPAQRALYRSVML
                     ENFGNLTALGYPVPKPALISLLERGDMAWGLEAQDDPPAERTKNVCKDVETNIDSEST
                     LIQGISEERDGMMSHGQLKSVPQRTDFPETRNVEKHQDIPTVKNIQGKVPRIPCARKP
                     FICEECGKSFSYFSYYARHQRIHTGEKPFECSECGKAFNGNSSLIRHQRIHTGERPYQ
                     CEECGRAFNDNANLIRHQRIHSGDRPYYCTECGNSFTSSSEFVIHQRIHTGEKPYECN
                     ECGKAFVGNSPLLRHQKIHTGEKPYECNECGKSFGRTSHLSQHQRIHTGEKPYSCKVC
                     GQAFNFHTKLTRHQRIHSEEKPFDCVDCGKAFSAQEQLKRHLRIHTQESSYVCDECGK
                     ALTSKRNLHQHQRIHTGEKPYECSKYEKAFGTSSQLGHLEHVYSGEKPVLDICRFGLP
                     EFFTPFYW"
     exon            276..402
                     /gene="ZNF19"
                     /gene_synonym="KOX12"
                     /inference="alignment:Splign:2.1.0"
     exon            403..516
                     /gene="ZNF19"
                     /gene_synonym="KOX12"
                     /inference="alignment:Splign:2.1.0"
     exon            517..3206
                     /gene="ZNF19"
                     /gene_synonym="KOX12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2002..2007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF19"
                     /gene_synonym="KOX12"
                     /note="hexamer: AATAAA"
     polyA_site      2041
                     /gene="ZNF19"
                     /gene_synonym="KOX12"
                     /note="major polyA site"
     regulatory      3188..3193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF19"
                     /gene_synonym="KOX12"
                     /note="hexamer: AATAAA"
     polyA_site      3206
                     /gene="ZNF19"
                     /gene_synonym="KOX12"
ORIGIN      
        1 aaccgttctc gctagcggtg cgcttctggc ctgttttgag tccgcgctca aaggtctctg
       61 aggatccccg ggtggaaact cctcccggga gtaaaaccac acaaccactg agaagaccgc
      121 tccggcatcc tagagagtac gcgtgtgagc ctgggtgcaa ggccaaagta gtgacgcact
      181 tccgttcacg caccgctttc tgtttttcct gagcctttgc ctgctaagag ggagaccagg
      241 tcatggcagc catgcctctg aaagctcaat accaggagat ggtgaccttc gaggatgtgg
      301 ctgtgcactt caccaagaca gaatggactg gcctttctcc tgcccagagg gccctgtaca
      361 gaagtgtgat gttggagaat tttgggaacc tgactgcttt ggggtaccca gttcccaaac
      421 ctgcactgat ctcacttttg gagagagggg acatggcttg gggcctggaa gcacaggatg
      481 atcccccagc agagaggacc aaaaacgtct gtaaagatgt tgagaccaac attgacagtg
      541 agtccacatt aatccaggga atttctgaag aaagagatgg gatgatgtca catggtcagc
      601 tgaagagtgt ccctcagaga actgacttcc cagaaacacg taatgtggaa aagcaccagg
      661 acatccccac agtgaaaaat atccaaggaa aggttccaag aatcccctgt gcaaggaaac
      721 ctttcatatg tgaggagtgt gggaaatcct tcagctactt ttcttactat gctagacacc
      781 agagaatcca cactggggag aaaccttttg agtgtagtga gtgtggaaaa gcctttaatg
      841 gtaattcttc gttaattcgg caccagagga ttcacactgg agagagaccc tatcagtgtg
      901 aggagtgtgg gcgagccttt aatgataatg caaatctgat caggcatcag agaatccaca
      961 gtggggacag accctattac tgtacagagt gtgggaatag tttcacgagt agttccgagt
     1021 ttgttataca tcagagaatc cacactgggg agaaacccta tgagtgtaat gagtgtggca
     1081 aagcttttgt tggtaattca cccctacttc ggcatcagaa aatccacact ggagagaaac
     1141 cctatgagtg taatgagtgt ggcaaaagct ttggaaggac ttcccatcta agccaacatc
     1201 agcgtattca cacaggggaa aagccttatt cttgtaaagt atgtggacaa gccttcaatt
     1261 ttcatacaaa actaactcgg caccagagaa ttcacagtga ggagaaaccc tttgactgtg
     1321 tagattgtgg aaaagccttc agtgctcagg aacaattaaa aaggcatctg agaattcata
     1381 ctcaggagtc ttcctatgta tgtgatgagt gtggaaaagc cttgactagc aaaagaaatc
     1441 ttcatcagca tcaaagaatc catactggag agaaacccta tgagtgtagc aagtatgaga
     1501 aggcctttgg gacttcttcc cagctaggtc accttgagca tgtctactct ggagagaagc
     1561 ctgtgctgga catttgtcgt tttggcctcc cagaattttt tacccccttt tactggtaat
     1621 agtacactcc agtgaaatgt actgagtgga ttccgtcttc tactcaggaa tggaatgtgt
     1681 gacacaggcc tgactcagcc tctgatccat ccctcaagcc acagttaatg attcagatgt
     1741 cagtagatga ccaaagatgg ttcaattaga gtcccaggat tgcaagagct aataggaaca
     1801 aatactctcc ccccgcccac ccccattggt tttaatgctg agaagaagaa ctagactctt
     1861 acagaggtga gaatgaagtc cacacagcaa aaatgcatct gagaattgga gagcagtaaa
     1921 agactgaaga taatgtttga acagccacat acaccatgcc tgaagctaaa aatatatacg
     1981 ggtttttgaa ttgcagcagc caataaattc catttttgtt tggttggttt tggctttggc
     2041 acacctgagt taggttttct tgccttggaa cagaattttg acttaaacag tgttgtcatt
     2101 gtagcagttg tttgaagttt tcagggataa catacctgat ggagaaatgt tttgtgtgta
     2161 tgatatatgg gaaagtcttt agttatagtc atggcagctc ctcaacccca tgattgtgat
     2221 gagattggga agcccactgt aacactggag agcccaggtt atatcagaca ccactagtag
     2281 atagaagttc taacaacttg agctctgtaa caaaaatctc attgtactac aaaattatgt
     2341 ctgcaccagt gaatccattc tcaagaaaag tcttaactag gaaactaaaa gctttcactc
     2401 ttaaagcttt cattttctgt ttattcagtt ttttatttgg aatggatgct actctaggcc
     2461 ttaaactgag aaatgccagg ctattgtagc tattatatct tggtatttgc cattttaatt
     2521 cctaggacag cacgcccgct ttgcccttga cctggctagg gagccaagga aatgccatgg
     2581 ttcttggtca taagacacac tgcagagatc tctcagtagg aaaacagggc tggccctttt
     2641 ctttggtgat gaacacaaac tgcacccttt ttttctccca cgtgtccttc cgctgccagc
     2701 cagtgttgga atctccctac ccaattccag acttaattgc ttactgcgtc tagcacctgg
     2761 gtggcttcac cacctcttcc ttacttgtca gcagatgaat gagcagttgt atcatgtgct
     2821 tgggttgacc aatgaatgat agacttgggg aattgagtaa acacctttta attgaagtat
     2881 aacacaaaca taaaaatgca tgagtcagcc aggcgcggtg gctcacactt gtaatcccag
     2941 tactttggga ggccgaggtg ggcgattcat caggtcaaga gatcgagacc atcctggcca
     3001 acatggtgaa accccgtctc tactaaaaat acaagaatta gctgggcgtg gtggtgcatg
     3061 cctgtagtcc cagctgctca ggaagctggg gcaggcgaat tgcttgaacc cgggaggcgg
     3121 aggttgtagt gagccgagat tacaccactg cactccagcc tggtgacaga gtgagattcc
     3181 tcaataaaat aaaataaaac catgaa
//
