LOCUS       NM_003452               3192 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens zinc finger protein 189 (ZNF189), transcript variant
            1, mRNA.
ACCESSION   NM_003452
VERSION     NM_003452.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3192)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
REFERENCE   2  (bases 1 to 3192)
  AUTHORS   Jugessur,A., Shi,M., Gjessing,H.K., Lie,R.T., Wilcox,A.J.,
            Weinberg,C.R., Christensen,K., Boyles,A.L., Daack-Hirsch,S.,
            Nguyen,T.T., Christiansen,L., Lidral,A.C. and Murray,J.C.
  TITLE     Maternal genes and facial clefts in offspring: a comprehensive
            search for genetic associations in two population-based cleft
            studies from Scandinavia
  JOURNAL   PLoS One 5 (7), e11493 (2010)
   PUBMED   20634891
  REMARK    GeneRIF: Maternal genes FLNB, HIC1 and ZNF189 were strongly
            associated with risk of clefting.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3192)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   4  (bases 1 to 3192)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   5  (bases 1 to 3192)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   6  (bases 1 to 3192)
  AUTHORS   Odeberg,J., Ahmadian,A., Williams,C., Uhlen,M., Ponten,F. and
            Lundeberg,J.
  TITLE     Context-dependent Taq-polymerase-mediated nucleotide alterations,
            as revealed by direct sequencing of the ZNF189 gene: implications
            for mutation detection
  JOURNAL   Gene 235 (1-2), 103-109 (1999)
   PUBMED   10415338
REFERENCE   7  (bases 1 to 3192)
  AUTHORS   Odeberg,J., Rosok,O., Gudmundsson,G.H., Ahmadian,A., Roshani,L.,
            Williams,C., Larsson,C., Ponten,F., Uhlen,M., Asheim,H.C. and
            Lundeberg,J.
  TITLE     Cloning and characterization of ZNF189, a novel human Kruppel-like
            zinc finger gene localized to chromosome 9q22-q31
  JOURNAL   Genomics 50 (2), 213-221 (1998)
   PUBMED   9653648
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL353621.19, AK290163.1 and BC092425.1.
            
            On Jun 2, 2019 this sequence version replaced NM_003452.3.
            
            Summary: Kruppel-like zinc finger proteins such as ZNF189 contain a
            conserved stretch of 7 amino acids that connects a variable number
            of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type
            (summarized by Odeberg et al., 1998 [PubMed 9653648]).
            Approximately 30% of human Kruppel-like zinc finger proteins
            contain an N-terminal Kruppel-associated box (KRAB) domain. The
            KRAB domain consists of approximately 75 amino acids that may be
            subdivided into an A box, which is present in every KRAB domain and
            is essential for transcriptional repression, and a B box, which is
            not always present.[supplied by OMIM, May 2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092425.1, U95992.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339664.7/ ENSP00000342019.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL353621.19        22560-22562
            4-21                AK290163.1         1-18
            22-22               AL353621.19        22581-22581
            23-102              AK290163.1         20-99
            103-3192            BC092425.1         1-3090
FEATURES             Location/Qualifiers
     source          1..3192
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.1"
     gene            1..3192
                     /gene="ZNF189"
                     /note="zinc finger protein 189"
                     /db_xref="GeneID:7743"
                     /db_xref="HGNC:HGNC:12980"
                     /db_xref="MIM:603132"
     exon            1..339
                     /gene="ZNF189"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..2187
                     /gene="ZNF189"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 189 isoform 1"
                     /protein_id="NP_003443.2"
                     /db_xref="CCDS:CCDS6754.1"
                     /db_xref="GeneID:7743"
                     /db_xref="HGNC:HGNC:12980"
                     /db_xref="MIM:603132"
                     /translation="MASPSPPPESKGLLTFEDVAVFFTQEEWDYLDPAQRSLYKDVMM
                     ENYGNLVSLDVLNRDKDEEPTVKQEIEEIEEEVEPQGVIVTRIKSEIDQDPMGRETFE
                     LVGRLDKQRGIFLWEIPRESLTQEQRMFRENTNIIRKRPNSEEKCHKCEECGKGFVRK
                     AHFIQHQRVHTGEKPFQCNECGKSFSRSSFVIEHQRIHTGERPYECNYCGKTFSVSST
                     LIRHQRIHTGERPYQCNQCKQSFSQRRSLVKHQRIHTGEKPHKCSDCGKAFSWKSHLI
                     EHQRTHTGEKPYHCTKCKKSFSRNSLLVEHQRIHTGERPHKCGECGKAFRLSTYLIQH
                     QKIHTGEKPFLCIECGKSFSRSSFLIEHQRIHTGERPYQCKECGKSFSQLCNLTRHQR
                     IHTGDKPHKCEECGKAFSRSSGLIQHQRIHTREKTYPYNETKESFDPNCSLVIQQEVY
                     PKEKSYKCDECGKTFSVSAHLVQHQRIHTGEKPYLCTVCGKSFSRSSFLIEHQRIHTG
                     ERPYLCRQCGKSFSQLCNLIRHQGVHTGNKPHKCDECGKAFSRNSGLIQHQRIHTGEK
                     PYKCEKCDKSFSQQRSLVNHQKIHAEVKTQETHECDACGEAFNCRISLIQHQKLHTAW
                     MQ"
     exon            340..466
                     /gene="ZNF189"
                     /inference="alignment:Splign:2.1.0"
     exon            467..3192
                     /gene="ZNF189"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3171..3176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF189"
                     /note="hexamer: ATTAAA"
     polyA_site      3192
                     /gene="ZNF189"
                     /note="major polyA site"
ORIGIN      
        1 ggtcatagcg ttacttggct gcaaggagga ggaactggca gcggggagga ggctctagcg
       61 aggcctgaaa ggctgcgtaa ccaggcagga gtaggggttg gggttcgggg ttgggggaca
      121 gccagggatc gcgtctgata tgctgttggg gtcgtgaccg tctgggggcc gaggcaggca
      181 ctggccagac ccagccaggg atcctcgtat tcgtcgagcc taatttccag cagccgggta
      241 ggcctcacca gaggctcctt tccgtgaggc cgcccccaat tcctgcccct attctctgcc
      301 tgggagatgg cttccccgag ccccccgccg gagtcgaagg ggttgctgac atttgaggat
      361 gtggctgtgt tttttaccca ggaggagtgg gattatctgg acccagctca gagaagcctg
      421 tataaagatg tcatgatgga gaattatgga aacctggtct cactggatgt tttgaacaga
      481 gataaggatg aggagccaac tgtaaaacaa gagattgaag aaattgagga agaagtggaa
      541 ccacagggtg taatagttac aagaatcaaa agtgaaattg accaggatcc tatgggtaga
      601 gaaacatttg aacttgttgg taggttagat aaacaaagag ggatcttcct atgggaaata
      661 ccaagggaat ctttgaccca ggaacagaga atgttcagag aaaacactaa cattatccgt
      721 aaaagaccaa actcagaaga gaaatgccat aaatgtgaag aatgtggaaa gggttttgtc
      781 cgcaaggccc atttcattca acatcaaagg gtccatactg gtgagaaacc ttttcagtgc
      841 aatgaatgtg ggaaaagttt tagtcgcagt tcatttgtta ttgaacatca gagaattcac
      901 actggggaaa ggccctatga gtgtaattac tgtggaaaaa cctttagtgt gagctcaacc
      961 cttattagac atcagagaat ccacactgga gaaagaccct atcagtgtaa tcagtgtaaa
     1021 cagagcttca gccagagaag gagccttgtt aaacatcaaa ggattcatac aggtgagaaa
     1081 ccccataaat gtagtgactg tgggaaagcc ttcagttgga aatcacacct tattgagcat
     1141 caaagaactc acactggtga gaaaccttat cactgtacca aatgtaagaa gagctttagt
     1201 cgaaattcat tgcttgttga gcatcaaaga attcacactg gggaaagacc ccataaatgt
     1261 ggtgaatgtg ggaaagcctt tcgattaagc acatacctta tacaacacca aaaaattcac
     1321 actggcgaga agccttttct ttgtattgag tgtggaaaaa gtttcagtcg gagctcattc
     1381 cttattgaac atcagaggat ccatactggt gaaagacctt atcagtgcaa agagtgtggg
     1441 aaaagtttca gtcagctttg caaccttact cgtcatcaga gaattcacac aggagacaag
     1501 ccccataaat gtgaggaatg tggaaaagcc tttagtagaa gctcaggtct tattcagcat
     1561 cagagaattc acaccaggga gaagacttat ccatacaatg aaactaagga aagttttgat
     1621 ccaaattgca gtcttgttat acagcaggaa gtctacccta aggagaaatc ttataaatgt
     1681 gatgaatgtg ggaaaacttt tagtgttagt gctcatcttg tacaacatca aagaatccac
     1741 actggtgaaa agccctatct atgtactgtc tgtgggaaaa gcttcagccg gagctcattt
     1801 cttattgaac atcagagaat ccacactggt gagagaccct atctgtgcag acagtgtgga
     1861 aaaagcttta gtcagctttg taatcttatt cgacatcagg gtgttcacac aggtaataaa
     1921 ccccataaat gtgatgaatg tggaaaggcc tttagccgga actcgggtct tattcagcat
     1981 cagagaatac acacaggaga gaaaccttat aagtgtgaga agtgcgacaa aagtttcagt
     2041 caacagcgca gtcttgtcaa ccatcagaag atccatgcag aggtgaaaac ccaagaaacc
     2101 catgaatgtg acgcttgtgg tgaagccttt aattgccgta tttctcttat tcagcatcag
     2161 aaattgcaca cagcatggat gcaataaatg tagagcaata cataagctca atttgatttg
     2221 agactagtac ccaagtgcag ttttagtatg gctcaacatg ggtcagattt agtgataaag
     2281 caaattctcc ttggcctcag gcaaatagtt tctaaagatt ctgtgaatag tggacaactg
     2341 cccatgagca tttgacttcc cttactcttt gatgatcgta gagaaagact tggtaattta
     2401 tctaagtatc tttaataaat ctttcagcag agagattaaa cctaggttca gagcatgggt
     2461 gctctgaggg acaaagttgg attagtataa gggagctgga gcagctgata gtggaaaaca
     2521 gaataatgat tcaaagagtc ttctgtcacc atgtcatatt gtggttcttt cagttccatg
     2581 atatgtttgg ctctgcatgc caaagtccag tgattaagca tatataagtt gtcaaggaaa
     2641 caaagcccaa atgtttttaa aacaagtata cagtttttgt cattgtttaa gaaagccagt
     2701 tgtttggcat gtgagttaaa ggcagttcca atgcctgatg gttcccagat ctatgaaatg
     2761 agtggaccat taaccttaca tgtaaagatt atgttagtaa ttaagaaacc taacaaaggt
     2821 gttaccaagg aacctttggg agtgcctttt ttgtttttca agatggaccc aaaaaagtgg
     2881 aggaagatat tgttcttttg tgccctccta cctgtgagag atatttgtag tcctatgtga
     2941 atgagcttat ccctccacaa ccaggtgcat atgaaagtgt acatattatg actgccaagt
     3001 attggaaatg aaaagacctg gagtctatgc taggaagctg agatattttg gtattgcatt
     3061 ggtttttatg gtaactaggt tttgcatgca attaaaaatc cttatttctt gttctagggc
     3121 ttcccttagt taatggttat tataaaccta ttaattcatc tgttttaacc attaaaacct
     3181 gttttgtttt ta
//
