LOCUS       NM_001395254            4587 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens zinc finger protein 185 with LIM domain (ZNF185),
            transcript variant 11, mRNA.
ACCESSION   NM_001395254 XM_005274730
VERSION     NM_001395254.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4587)
  AUTHORS   Suzuki,S., Ando,F., Kitagawa,S., Hara,Y., Fujiki,T., Mandai,S.,
            Susa,K., Mori,T., Sohara,E., Rai,T. and Uchida,S.
  TITLE     ZNF185 prevents stress fiber formation through the inhibition of
            RhoA in endothelial cells
  JOURNAL   Commun Biol 6 (1), 29 (2023)
   PUBMED   36631535
  REMARK    GeneRIF: ZNF185 prevents stress fiber formation through the
            inhibition of RhoA in endothelial cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4587)
  AUTHORS   Zheng,Z., Zhang,B., Yu,H., Li,S., Song,N., Jin,X. and Li,J.
  TITLE     UBE3A activates the NOTCH pathway and promotes esophageal cancer
            progression by degradation of ZNF185
  JOURNAL   Int J Biol Sci 17 (12), 3024-3035 (2021)
   PUBMED   34421347
  REMARK    GeneRIF: UBE3A activates the NOTCH pathway and promotes esophageal
            cancer progression by degradation of ZNF185.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4587)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4587)
  AUTHORS   Smirnov,A., Lena,A.M., Cappello,A., Panatta,E., Anemona,L.,
            Bischetti,S., Annicchiarico-Petruzzelli,M., Mauriello,A., Melino,G.
            and Candi,E.
  TITLE     ZNF185 is a p63 target gene critical for epidermal differentiation
            and squamous cell carcinoma development
  JOURNAL   Oncogene 38 (10), 1625-1638 (2019)
   PUBMED   30337687
  REMARK    GeneRIF: Results provide evidence that ZNF185 is a key component of
            the p63-dependent transcriptional program for stratified epithelial
            development and tissue homeostasis. ZNF185 deregulation, beyond
            deregulating cell adhesion in general, is also relevant for
            carcinoma formation of the stratified epithelia suggesting that
            ZNF185 may be a potential biomarker for squamous cell carcinoma
            diagnosis and prognosis.
REFERENCE   5  (bases 1 to 4587)
  AUTHORS   Smirnov,A., Cappello,A., Lena,A.M., Anemona,L., Mauriello,A., Di
            Daniele,N., Annicchiarico-Petruzzelli,M., Melino,G. and Candi,E.
  TITLE     ZNF185 is a p53 target gene following DNA damage
  JOURNAL   Aging (Albany NY) 10 (11), 3308-3326 (2018)
   PUBMED   30446632
  REMARK    GeneRIF: These data highlight the involvement of ZNF185 and
            cytoskeleton changes in p53-mediated cellular response to genotoxic
            stress and indicate ZNF185 as potential biomarker for epithelial
            cancer diagnosis.
REFERENCE   6  (bases 1 to 4587)
  AUTHORS   Zhang,J.S., Gong,A. and Young,C.Y.
  TITLE     ZNF185, an actin-cytoskeleton-associated growth inhibitory LIM
            protein in prostate cancer
  JOURNAL   Oncogene 26 (1), 111-122 (2007)
   PUBMED   16799630
  REMARK    GeneRIF: ZNF185 may function as a tumor-suppressor protein by
            associating with the actin-cytoskeleton
REFERENCE   7  (bases 1 to 4587)
  AUTHORS   Medina,P.P., Carretero,J., Ballestar,E., Angulo,B., Lopez-Rios,F.,
            Esteller,M. and Sanchez-Cespedes,M.
  TITLE     Transcriptional targets of the chromatin-remodelling factor
            SMARCA4/BRG1 in lung cancer cells
  JOURNAL   Hum Mol Genet 14 (7), 973-982 (2005)
   PUBMED   15731117
  REMARK    GeneRIF: transcriptional activation of ZNF185 and CYP3A4 is
            mediated by direct association of BRG1 with their promoters and a
            decreased level of ZNF185 is a common feature of lung tumours
REFERENCE   8  (bases 1 to 4587)
  AUTHORS   Vanaja,D.K., Cheville,J.C., Iturria,S.J. and Young,C.Y.
  TITLE     Transcriptional silencing of zinc finger protein 185 identified by
            expression profiling is associated with prostate cancer progression
  JOURNAL   Cancer Res 63 (14), 3877-3882 (2003)
   PUBMED   12873976
  REMARK    GeneRIF: Transcriptional silencing of ZNF185 by methylation in
            prostate tumor tissues implicates the ZNF185 gene in prostate
            tumorigenesis.
REFERENCE   9  (bases 1 to 4587)
  AUTHORS   Mallon,A.M., Platzer,M., Bate,R., Gloeckner,G., Botcherby,M.R.,
            Nordsiek,G., Strivens,M.A., Kioschis,P., Dangel,A., Cunningham,D.,
            Straw,R.N., Weston,P., Gilbert,M., Fernando,S., Goodall,K.,
            Hunter,G., Greystrong,J.S., Clarke,D., Kimberley,C., Goerdes,M.,
            Blechschmidt,K., Rump,A., Hinzmann,B., Mundy,C.R., Miller,W.,
            Poustka,A., Herman,G.E., Rhodes,M., Denny,P., Rosenthal,A. and
            Brown,S.D.
  TITLE     Comparative genome sequence analysis of the Bpa/Str region in mouse
            and Man
  JOURNAL   Genome Res 10 (6), 758-775 (2000)
   PUBMED   10854409
REFERENCE   10 (bases 1 to 4587)
  AUTHORS   Heiss,N.S., Gloeckner,G., Bachner,D., Kioschis,P., Klauck,S.M.,
            Hinzmann,B., Rosenthal,A., Herman,G.E. and Poustka,A.
  TITLE     Genomic structure of a novel LIM domain gene (ZNF185) in Xq28 and
            comparisons with the orthologous murine transcript
  JOURNAL   Genomics 43 (3), 329-338 (1997)
   PUBMED   9268636
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U82671.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 17, 2021 this sequence version replaced XM_005274730.2.
            
            Summary: Zinc-finger proteins bind nucleic acids and play important
            roles in various cellular functions, including cell proliferation,
            differentiation, and apoptosis. This gene encodes a LIM-domain zinc
            finger protein. The LIM domain is composed of two contiguous zinc
            finger domains, separated by a two-amino acid residue hydrophobic
            linker. The LIM domain mediates protein:protein interactions.
            Multiple alternatively spliced transcript variants encoding
            different isoforms have been identified.[provided by RefSeq, May
            2010].
            
            Transcript Variant: This variant (11) represents the longest
            transcript and encodes the longest isoform (10).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.2458680.1,
                                           SRR14038196.2898832.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000695776.1/ ENSP00000512166.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               U82671.5           186826-186997
            173-251             U82671.5           203204-203282
            252-375             U82671.5           203469-203592
            376-441             U82671.5           203897-203962
            442-480             U82671.5           205890-205928
            481-558             U82671.5           206044-206121
            559-648             U82671.5           206824-206913
            649-747             U82671.5           207742-207840
            748-831             U82671.5           209087-209170
            832-873             U82671.5           209466-209507
            874-957             U82671.5           210932-211015
            958-1047            U82671.5           211479-211568
            1048-1134           U82671.5           217334-217420
            1135-1239           U82671.5           220431-220535
            1240-1338           U82671.5           221632-221730
            1339-1434           U82671.5           225177-225272
            1435-1524           U82671.5           226833-226922
            1525-1722           U82671.5           234026-234223
            1723-1920           U82671.5           248458-248655
            1921-2031           U82671.5           252598-252708
            2032-2112           U82671.5           254206-254286
            2113-2184           U82671.5           255926-255997
            2185-2287           U82671.5           258141-258243
            2288-2386           U82671.5           259202-259300
            2387-4587           U82671.5           260033-262233
FEATURES             Location/Qualifiers
     source          1..4587
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..4587
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /note="zinc finger protein 185 with LIM domain"
                     /db_xref="GeneID:7739"
                     /db_xref="HGNC:HGNC:12976"
                     /db_xref="MIM:300381"
     exon            1..172
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /inference="alignment:Splign:2.1.0"
     exon            173..251
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..2386
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /note="isoform 10 is encoded by transcript variant 11;
                     P1-A; sciellin like; zinc finger protein 185 (LIM domain)"
                     /codon_start=1
                     /product="zinc finger protein 185 isoform 10"
                     /protein_id="NP_001382183.1"
                     /db_xref="CCDS:CCDS94691.1"
                     /db_xref="GeneID:7739"
                     /db_xref="HGNC:HGNC:12976"
                     /db_xref="MIM:300381"
                     /translation="MSISALGGRTKGKPLPPGEEERNNVLKQMKVRTTLKGDKSWITK
                     QDESEGRTIELPSGRSRATSFSSAGEVPKPRPPSTRAPTGYIIRGVFTKPIDSSSQPQ
                     QQFPKANGTPKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTEE
                     EEEEEVVPFSSDEQKRRSEAASGVLRRTAPREHSYVLSAAKKSTGSPTQETQAPFIAK
                     RVEVVEEDGPSEKSQDPPALARSTPGSNSADGGRTKASRAIWIECLPSMPSPAGSQEL
                     SSRGEEIVRLQILTPRAGLRLVAPDVEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRA
                     PNTDAARSSAQLSDGNVGSGATGSRPEGLAAVDIGSERGRLCAAASFASFLEDQDGHS
                     ANSQSCKPRPAAISSSATSVSAVPADRKSNSTAAQEDAKADPKGALADYEGKDVATRV
                     GEAWQERPGAPRGGQGDPAVPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDFE
                     GKDVATKVGEAWQDRPGAPRGGQGDPAVPTQQPADPSTPEQQNSPSGSEQFVRRESCT
                     SRVRSPSSCMVTVTVTATSEQPHIYIPAPASELDSSSTTKGILFVKEYVNASEVSSGK
                     PVSARYSNVSSIEDSFAMEKKPPCGSTPYSERTTGGICTYCNREIRDCPKITLEHLGI
                     CCHEYCFKCGICSKPMGDLLDQIFIHRDTIHCGKCYEKLF"
     exon            252..375
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /inference="alignment:Splign:2.1.0"
     exon            376..441
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /inference="alignment:Splign:2.1.0"
     exon            442..480
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /inference="alignment:Splign:2.1.0"
     exon            481..558
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /inference="alignment:Splign:2.1.0"
     exon            559..648
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /inference="alignment:Splign:2.1.0"
     exon            649..747
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /inference="alignment:Splign:2.1.0"
     exon            748..831
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /inference="alignment:Splign:2.1.0"
     exon            832..873
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /inference="alignment:Splign:2.1.0"
     exon            874..957
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1047
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1134
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1239
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1338
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1434
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1524
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1722
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1920
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2031
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2112
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2184
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2287
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2386
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..4587
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4567..4572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /note="hexamer: AATAAA"
     polyA_site      4587
                     /gene="ZNF185"
                     /gene_synonym="SCELL"
                     /note="major polyA site"
ORIGIN      
        1 agtccgcgcc tcctcgcctc cctgcgcgct ccccgctgtg caccgcgccc cgcgccccgc
       61 gcctgcctcc ccggcccggc ccggcccggc cgggcgccgt ccacccgagg gagcccgcgc
      121 cctgcgactg cccgaccctc cacccgcccc acgagccggg caccggtgcc agaagccctg
      181 ctgaatcaag tgagaggaga gctgcggagc aatcaccatg agtatctcag ctcttggagg
      241 ccgcaccaaa gggaagcctc tgccaccagg cgaggaggag cgcaataacg ttctcaagca
      301 gatgaaagtg cgaaccacgc tgaaggggga caagagctgg attaccaagc aggatgaatc
      361 ggagggtcgc accatagagc tgccctcagg ccggagtcgc gccacatcct tttcatcagc
      421 tggggaggtt ccgaagccta ggcctccgag cacaagggct cccactggct acatcatccg
      481 gggagtgttc accaagccca tagacagctc ttcccagccc cagcagcagt tccccaaggc
      541 caacgggact ccaaaaagtg ctgccagtct ggtgagaaca gctaacgctg gtcctccccg
      601 cccctcctcc tctggctaca agatgaccac tgaggattac aagaagctgg caccctacaa
      661 tatcaggcgc agctctacat caggggacac cgaggaggag gaggaggagg aggtggtgcc
      721 attctcctca gatgaacaga aacggaggtc agaggctgca agcggtgttc tgaggaggac
      781 agctccccgg gagcactcct acgtcctgtc agcggccaag aagagcactg gcagtcctac
      841 ccaggagaca caggcaccgt ttatcgcgaa gagggtggag gtggtggaag aggacgggcc
      901 ttctgagaag agccaggacc cacctgctct ggcaagatcc actcctggct caaacagtgc
      961 ggatggaggc aggaccaaag cgtctcgggc aatttggatc gagtgcctgc caagtatgcc
     1021 tagccccgct gggagccagg agctcagctc aagaggtgag gaaattgtcc gcctgcagat
     1081 cctgacaccc agggcaggac tccgcctggt ggccccagac gtggaaggca tgaggtcttc
     1141 cccaggcaac aaagacaagg aggccccctg ctccagagag ctccagaggg acttggctgg
     1201 tgaggaggct ttcagggccc ccaacacaga tgctgcaagg tcaagtgcac agttgagtga
     1261 tggcaatgtg ggatccggag ccacgggctc ccggcctgaa ggcttggctg cagtagacat
     1321 cggctccgag agaggaaggc tgtgtgcagc tgctagcttt gcctctttcc tggaagacca
     1381 ggatgggcac agtgccaact ctcagtcctg caagcctaga ccagcagcca tcagctccag
     1441 tgccacttca gtctctgctg tccctgctga taggaagagc aacagcacag cagcccagga
     1501 ggatgcaaag gcagacccaa agggggcctt ggctgattat gaggggaagg atgtggccac
     1561 cagggtcgga gaggcctggc aggagaggcc tggagctcca agaggtggcc aaggagaccc
     1621 agctgtaccc gctcagcaac ctgcagatcc cagcacccca gagcggcaga gcagccccag
     1681 cggatctgag caacttgtca gacgagagag ttgtggcagc agcgtgttga ctgattttga
     1741 ggggaaggat gtggccacca aggtcggaga ggcctggcag gacaggcctg gagccccaag
     1801 aggtggccaa ggagacccag ctgtacccac tcagcaacct gcagatccca gtaccccaga
     1861 acagcagaac agccccagcg gatctgagca attcgtcaga cgagagagct gcaccagcag
     1921 ggtgaggagc ccctcgagct gcatggtcac tgttactgtc actgccacat ctgagcagcc
     1981 tcacatttat attccagccc ccgcaagtga attggactcc agctctacca ccaaagggat
     2041 tctcttcgtg aaggagtacg tgaatgctag tgaagtgtct tctgggaagc cagtatctgc
     2101 acgctatagc aacgtcagca gcattgagga ctcattcgcc atggagaaga agcctccatg
     2161 tggcagcact ccatactctg agaggacaac tggagggatc tgtacttact gcaaccgtga
     2221 gatccgagac tgtccaaaga ttaccctaga acatcttggt atctgctgcc atgaatattg
     2281 ctttaagtgt gggatttgca gtaaaccgat gggcgatctc ctggatcaga tcttcattca
     2341 ccgtgacacc attcactgtg ggaaatgcta tgagaagctc ttctagcgac cccccaccgc
     2401 caggctgatc agaagctgat gactcgtgga caaatttggc tgtccccagt tttgccccaa
     2461 gttgctgtct ccccttccct cacctcctcc ctccctgttt gatttcttca tgcttttgcc
     2521 cttctcaagt tgaagttgca tacatccaat atcgtatctt aatgatgcta tgataattgc
     2581 ttgtgtgtgt agcttcttgt agcttagaaa gcgctttatg cccatgatgt catttcaggc
     2641 tcaaccaaag aggatcaaac aggaattcca tcttggcttc cctaagacag attggctttc
     2701 taatgagttt aagtgggcag aagtgtaggg ttcagtgtgt cctgactccc ttgaggctta
     2761 taatgggcca agttgaagac tgttgatgat ccctggtggg taaattgcag acatcaaatg
     2821 ctagggattg gcataggcta gtgtttagct tgtctatttg ccatatctat tttttttaaa
     2881 tttccataca cttgtaaaag tagttagttg cttttgattg agttatatag cagtttttca
     2941 tttggtcttc cactcacctt tcactatatt tgagtgttcc cttacaggta tgttggcatg
     3001 tgttggaaaa tttacacaat taggtttaaa ttcagtagga tgtgatttta ggatgctact
     3061 gatcaaagtg atatctgtgt ctgttggaat cttgatagct gattaatttg ccctcaattc
     3121 tgctccctga acttcacaca taaatcttcc caagtgggtt ttagggtgta tagatcccag
     3181 caggattaag gaggtggaaa agcagctaac atttcttgag gctctaccac atagcaggca
     3241 ctgtcacaga gtaatggcat taatccccat aataatcctg tgaaggtgat attctcatcc
     3301 catcttagac atgaggatat tggaactcag agaggtggct attgcattgc gcagaacgct
     3361 acagagccca tgctcttccc agagcagcac ccacaaaagc aagcattgat tttgtgctca
     3421 gtgtgtgcca agcactgtgc agagggtaca cagttcctgc caggttaaca ccctcccttc
     3481 aggcctccca aaggcatagg cttgcaaaga gcagaaggtg tgaaatcaca ctcttcctct
     3541 gggcatcctg gatccctgaa ttatcccccc ccccatgaag tacttcaagg gccaagctgc
     3601 ccctttccct cctctccgcc catgaaaatg cctccaaact gagatgcttt cagctgagaa
     3661 cagatttgac tcacagacat taccaaagag gagcttgtga atccaggaaa agctccaggg
     3721 ggctagctga tctgagcaga gagctttcag tgacccattt tcctgtctag actctgcctt
     3781 aagctagtgg caactgctgg ggccccaggt acttgggaca tggaaactcg ttggatggct
     3841 gggcagatgt aagcctgtcc atgcagtcag ccgatcctct gctcaggttc agctggactc
     3901 tgccatctgt gggcccagca tcactctgta agttccttga aaggaagaac aaccttagag
     3961 tatttctgat acaaaatgag ggcctctgct cttgatttaa ttataaaatg tctacgtctt
     4021 tctccagttt ctgagcccta tgcacattgg cttgtgggct tgttcttcct gccaaatgat
     4081 cagagaggaa cattccattt atttgtagtg gatttcctct ggagggcatg tacccacact
     4141 aaataccaac tgctcttcct cagctgtagt ccccaacatc agacttggca cgtggtggac
     4201 actaacacac aggcactcaa tgaatgagtg aaggaaataa aagtcacccc gttggtgaga
     4261 ggtgctatcc ctgagtctca gtgcaggacc agtggatgaa aggcaaggta aagaggccca
     4321 agataggctg gcttcccccg ttcaaggtat agtctgcctt taagggagtt ttagaaccaa
     4381 catgcaagac attgaaagaa atcttgcaag agccattatt gacttagatc caaaacagcc
     4441 tctctcatgt ctaaaaaggc acagaatttt gcagatctga ggaagaggga tgcattacct
     4501 ttttgcttct tttcaattgc ttagtgtttc taatcatact taatccacac taatgtgcgc
     4561 aattataata aatggtaaga tatcaca
//
