LOCUS       NM_001318891            3328 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens zinc finger protein 184 (ZNF184), transcript variant
            1, mRNA.
ACCESSION   NM_001318891 XM_005249379
VERSION     NM_001318891.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3328)
  AUTHORS   Ke,S., Wang,J., Lu,J., Fang,M. and Li,R.
  TITLE     Long intergenic non-protein coding RNA 00858 participates in the
            occurrence and development of esophageal squamous cell carcinoma
            through the activation of the FTO-m6A-MYC axis by recruiting ZNF184
  JOURNAL   Genomics 115 (3), 110593 (2023)
   PUBMED   36868327
  REMARK    GeneRIF: Long intergenic non-protein coding RNA 00858 participates
            in the occurrence and development of esophageal squamous cell
            carcinoma through the activation of the FTO-m6A-MYC axis by
            recruiting ZNF184.
REFERENCE   2  (bases 1 to 3328)
  AUTHORS   Zhang,B., Cui,C., Yu,H. and Li,G.
  TITLE     Association between ZNF184 and symptoms of Parkinson's disease in
            southern Chinese
  JOURNAL   Neurol Sci 41 (8), 2121-2126 (2020)
   PUBMED   32125537
  REMARK    GeneRIF: Association between ZNF184 and symptoms of Parkinson's
            disease in southern Chinese.
REFERENCE   3  (bases 1 to 3328)
  AUTHORS   Zuber,V., Marconett,C.N., Shi,J., Hua,X., Wheeler,W., Yang,C.,
            Song,L., Dale,A.M., Laplana,M., Risch,A., Witoelar,A.,
            Thompson,W.K., Schork,A.J., Bettella,F., Wang,Y., Djurovic,S.,
            Zhou,B., Borok,Z., van der Heijden,H.F., de Graaf,J., Swinkels,D.,
            Aben,K.K., McKay,J., Hung,R.J., Bikeboller,H., Stevens,V.L.,
            Albanes,D., Caporaso,N.E., Han,Y., Wei,Y., Panadero,M.A.,
            Mayordomo,J.I., Christiani,D.C., Kiemeney,L., Andreassen,O.A.,
            Houlston,R., Amos,C.I., Chatterjee,N., Laird-Offringa,I.A.,
            Mills,I.G. and Landi,M.T.
  TITLE     Pleiotropic Analysis of Lung Cancer and Blood Triglycerides
  JOURNAL   J Natl Cancer Inst 108 (12) (2016)
   PUBMED   27565901
  REMARK    GeneRIF: We found that 6p22.1 (rs6904596, ZNF184) was associated
            with both lung cancer and blood triglycerides.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3328)
  AUTHORS   Goldwurm,S., Menzies,M.L., Banyer,J.L., Powell,L.W. and
            Jazwinska,E.C.
  TITLE     Identification of a novel Krueppel-related zinc finger gene
            (ZNF184) mapping to 6p21.3
  JOURNAL   Genomics 40 (3), 486-489 (1997)
   PUBMED   9073517
REFERENCE   5  (bases 1 to 3328)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB090589.1, BX496218.1,
            AK312804.1, AK123011.1, BC022992.1 and BM675205.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_001318891.1.
            
            Summary: The protein encoded by this gene is predicted to be a
            Kruppel C2H2-type zinc-finger protein family member. Sequence
            analysis predicts that the protein contains two Kruppel associated
            box (KRAB) boxes in the N-terminus and highly conserved zinc finger
            motifs at the C-terminus. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Dec 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1, 2, and 3, encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK312804.1, SRR11853560.24388.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683788.1/ ENSP00000508298.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                DB090589.1         14-79
            67-343              BX496218.1         62-338
            344-594             AK312804.1         354-604
            595-595             AK123011.1         890-890
            596-3006            BC022992.1         347-2757
            3007-3328           BM675205.1         23-344              c
FEATURES             Location/Qualifiers
     source          1..3328
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..3328
                     /gene="ZNF184"
                     /gene_synonym="kr-ZNF3"
                     /note="zinc finger protein 184"
                     /db_xref="GeneID:7738"
                     /db_xref="HGNC:HGNC:12975"
                     /db_xref="MIM:602277"
     exon            1..377
                     /gene="ZNF184"
                     /gene_synonym="kr-ZNF3"
                     /inference="alignment:Splign:2.1.0"
     exon            378..523
                     /gene="ZNF184"
                     /gene_synonym="kr-ZNF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             517..2772
                     /gene="ZNF184"
                     /gene_synonym="kr-ZNF3"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 184 (Kruppel-like)"
                     /codon_start=1
                     /product="zinc finger protein 184 isoform 1"
                     /protein_id="NP_001305820.1"
                     /db_xref="CCDS:CCDS4624.1"
                     /db_xref="GeneID:7738"
                     /db_xref="HGNC:HGNC:12975"
                     /db_xref="MIM:602277"
                     /translation="MEDLSSPDSTLLQGGHNLLSSASFQEAVTFKDVIVDFTQEEWKQ
                     LDPGQRDLFRDVTLENYTHLVSIGLQVSKPDVISQLEQGTEPWIMEPSIPVGTCADWE
                     TRLENSVSAPEPDISEEELSPEVIVEKHKRDDSWSSNLLESWEYEGSLERQQANQQTL
                     PKEIKVTEKTIPSWEKGPVNNEFGKSVNVSSNLVTQEPSPEETSTKRSIKQNSNPVKK
                     EKSCKCNECGKAFSYCSALIRHQRTHTGEKPYKCNECEKAFSRSENLINHQRIHTGDK
                     PYKCDQCGKGFIEGPSLTQHQRIHTGEKPYKCDECGKAFSQRTHLVQHQRIHTGEKPY
                     TCNECGKAFSQRGHFMEHQKIHTGEKPFKCDECDKTFTRSTHLTQHQKIHTGEKTYKC
                     NECGKAFNGPSTFIRHHMIHTGEKPYECNECGKAFSQHSNLTQHQKTHTGEKPYDCAE
                     CGKSFSYWSSLAQHLKIHTGEKPYKCNECGKAFSYCSSLTQHRRIHTREKPFECSECG
                     KAFSYLSNLNQHQKTHTQEKAYECKECGKAFIRSSSLAKHERIHTGEKPYQCHECGKT
                     FSYGSSLIQHRKIHTGERPYKCNECGRAFNQNIHLTQHKRIHTGAKPYECAECGKAFR
                     HCSSLAQHQKTHTEEKPYQCNKCEKTFSQSSHLTQHQRIHTGEKPYKCNECDKAFSRS
                     THLTEHQNTHTGEKPYNCNECRKTFSQSTYLIQHQRIHSGEKPFGCNDCGKSFRYRSA
                     LNKHQRLHPGI"
     exon            524..591
                     /gene="ZNF184"
                     /gene_synonym="kr-ZNF3"
                     /inference="alignment:Splign:2.1.0"
     exon            592..718
                     /gene="ZNF184"
                     /gene_synonym="kr-ZNF3"
                     /inference="alignment:Splign:2.1.0"
     exon            719..814
                     /gene="ZNF184"
                     /gene_synonym="kr-ZNF3"
                     /inference="alignment:Splign:2.1.0"
     exon            815..3328
                     /gene="ZNF184"
                     /gene_synonym="kr-ZNF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3235..3240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF184"
                     /gene_synonym="kr-ZNF3"
                     /note="hexamer: AATAAA"
     regulatory      3247..3252
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF184"
                     /gene_synonym="kr-ZNF3"
                     /note="hexamer: TATAAA"
     polyA_site      3255
                     /gene="ZNF184"
                     /gene_synonym="kr-ZNF3"
                     /note="major polyA site"
     polyA_site      3263
                     /gene="ZNF184"
                     /gene_synonym="kr-ZNF3"
     regulatory      3306..3311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF184"
                     /gene_synonym="kr-ZNF3"
                     /note="hexamer: ATTAAA"
     polyA_site      3328
                     /gene="ZNF184"
                     /gene_synonym="kr-ZNF3"
                     /note="major polyA site"
ORIGIN      
        1 gtaggcgtgg aaagaggttg gcgcgctgga agtccagttg cttcggctcc ctgcgttagg
       61 tctggtggcg gtcaatgcgc ttccggaccc gggatcagag tgtgtggatc gctatagggg
      121 gaggggagct caggtatcac catggcaaca gccagccctc cggactcgtg acgtcaccct
      181 tctgatttcg cgcttagagg cctctgcagg agaaagctgg ggagtcctcg aagggggcgc
      241 acctcgcctc cttctgtgcg gggcggtccc gccctgatcc cttggagggc tttgttcttt
      301 tgttctggcc taaggggaag tcgggtgccg ggccccgccc tgtttgtcca ccttccagct
      361 ttaacgctct gcaacagggt agacaacctc agcgtgttgc agattccctg caaggggagt
      421 tagacatctg agtcctagac cgagatacca gctgaaggaa cgctgcctgg cgaaccctgg
      481 tgttcaagtt ccagaggaac gggatgagct cctgagatgg aagatctgtc ctctccagac
      541 tccacccttc tccaaggggg acataatcta ctctcatcag ccagttttca ggaagcggtg
      601 actttcaagg atgtgatagt ggactttacc caggaagaat ggaaacagct ggaccctggc
      661 cagagagatt tgttcaggga tgtgacattg gaaaattata cacacctggt ctctatagga
      721 ctccaagttt ctaaacctga tgtgatttcc cagttagagc aagggacaga gccatggatc
      781 atggagccaa gcattccagt aggtacctgt gcagactggg agacaagact tgaaaatagt
      841 gtgtcagccc cagagcctga catttctgaa gaagagctat ctccagaggt aatagtggaa
      901 aaacacaaaa gagatgattc ttggagttcc aacttgctag aaagttggga atatgaaggc
      961 agtttagaga gacagcaggc aaaccaacag acactgccaa aggaaataaa ggtaaccgaa
     1021 aagacaatac ccagttggga aaaaggccct gtaaataatg aatttgggaa aagtgtcaat
     1081 gtgagttcaa accttgtaac acaagaacca tctccagaag agacctctac taaaagaagc
     1141 atcaaacaga attcaaaccc agttaaaaaa gagaaatctt gtaagtgcaa tgaatgtggg
     1201 aaagccttta gttattgttc agctcttatt cgccatcaga gaacacatac tggagaaaaa
     1261 ccctacaaat gtaatgaatg tgaaaaagcc ttcagccgga gtgaaaacct tataaaccat
     1321 caaagaattc atactggaga taaaccatat aaatgtgatc agtgtggaaa aggcttcatt
     1381 gagggtccat ctcttactca acatcaaaga attcatactg gagaaaaacc atataaatgt
     1441 gatgaatgtg ggaaagcctt tagtcagagg acccatcttg ttcagcatca gagaattcat
     1501 actggcgaga agccatacac ttgtaatgag tgtggaaaag cctttagcca gagaggccac
     1561 tttatggaac atcagaaaat tcatacggga gaaaaacctt ttaaatgtga tgaatgtgat
     1621 aaaaccttca ccaggagcac acaccttact caacatcaaa aaattcatac tggagaaaaa
     1681 acctataaat gtaatgaatg tggaaaggcc ttcaacgggc cctcaacttt tatccgtcat
     1741 catatgattc atactggtga aaaaccgtac gaatgcaatg aatgtgggaa agccttcagc
     1801 cagcactcaa acctcactca gcatcaaaaa actcatactg gggagaaacc ctatgattgt
     1861 gcagaatgtg gaaaatcttt tagttactgg tcatcccttg ctcaacacct gaaaattcat
     1921 actggagaaa aaccttacaa atgcaatgaa tgtggaaagg ccttcagtta ctgctcatcc
     1981 cttactcaac atcggagaat tcacacgaga gaaaagccct ttgaatgcag tgaatgtgga
     2041 aaggctttca gttatctctc aaaccttaat cagcatcaga aaactcatac tcaagagaaa
     2101 gcttatgaat gtaaagaatg tgggaaagct tttattcgga gttcatctct tgctaagcat
     2161 gaaagaattc atactggaga gaaaccctat cagtgtcatg aatgtgggaa aaccttcagt
     2221 tatggttcat cccttattca gcataggaag atccatactg gagaacgacc ttacaagtgt
     2281 aatgagtgtg ggagagcatt caaccagaac atacacctta cacagcataa gagaattcat
     2341 acaggagcca agccttatga gtgtgctgag tgtggtaaag cctttcgaca ttgttcatct
     2401 cttgctcaac atcaaaaaac tcacacagaa gaaaaaccct accagtgtaa taaatgtgaa
     2461 aagaccttta gccagagctc ccatctaact cagcatcaac gaattcacac tggggagaag
     2521 ccctataagt gcaatgaatg tgacaaagcc tttagccgga gcactcatct gactgaacat
     2581 cagaatactc atactggaga gaaaccttat aactgtaatg aatgcagaaa gacttttagc
     2641 cagagcacat atctcattca gcaccagaga attcattcag gagagaagcc ttttggatgt
     2701 aatgattgtg gaaaatcctt cagatatcgc tctgctctca acaaacatca gagactgcat
     2761 cctggcatat gacaattcta ggaacatcat aaatttaggg gagatattta ctttagtttg
     2821 tccttttgtt aagtactgaa gaatcagagt ggatttagaa actgccttga aatcttttaa
     2881 attttcacta tcatgttatg gaatggaaag tacattgggc tgaactaatc caattgttat
     2941 taagccactc tgtgacatta gaaaactcta ctgttttaag ctttagtttc ctttatggaa
     3001 tgaaggattt ggagtagatt atttcaaagg tagtttggag ttttataatc agttttgtat
     3061 atttacaata ttttcttgaa tgggtttact atacatcagc attttgctgt gttgcatcta
     3121 gaatgtgtat gtttatgcat gttttgccaa tagaatttgt gcttcagtaa ctagatcggg
     3181 gatctagtat gctcctggtc taatgcattt acattgttta ggtaactggt tcctaataaa
     3241 aagaattata aaataccctc aaattaacaa ttcaattgca tataatagcc taactcagta
     3301 agaatattaa aacttactat tattcttc
//
