LOCUS       NM_001007088            3499 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens zinc finger protein 182 (ZNF182), transcript variant
            2, mRNA.
ACCESSION   NM_001007088
VERSION     NM_001007088.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3499)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   2  (bases 1 to 3499)
  AUTHORS   Wang,R., Cukerman,E., Heng,H.H. and Liew,C.C.
  TITLE     Localization of a novel zinc finger gene to the human chromosome
            7p11.2-p12 by fluorescence in situ hybridization
  JOURNAL   Somat Cell Mol Genet 22 (3), 237-239 (1996)
   PUBMED   8914609
REFERENCE   3  (bases 1 to 3499)
  AUTHORS   Knight,J.C., Grimaldi,G., Thiesen,H.J., Bech-Hansen,N.T.,
            Fletcher,C.D. and Coleman,M.P.
  TITLE     Clustered organization of Kruppel zinc-finger genes at Xp11.23,
            flanking a translocation breakpoint at OATL1: a physical map with
            locus assignments for ZNF21, ZNF41, ZNF81, and ELK1
  JOURNAL   Genomics 21 (1), 180-187 (1994)
   PUBMED   8088786
REFERENCE   4  (bases 1 to 3499)
  AUTHORS   Huebner,K., Druck,T., Croce,C.M. and Thiesen,H.J.
  TITLE     Twenty-seven nonoverlapping zinc finger cDNAs from human T cells
            map to nine different chromosomes with apparent clustering
  JOURNAL   Am J Hum Genet 48 (4), 726-740 (1991)
   PUBMED   2014798
REFERENCE   5  (bases 1 to 3499)
  AUTHORS   Thiesen,H.J.
  TITLE     Multiple genes encoding zinc finger domains are expressed in human
            T cells
  JOURNAL   New Biol 2 (4), 363-374 (1990)
   PUBMED   2288909
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC244636.2, AK122874.1,
            CN311292.1, BX648401.1 and AW291763.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001007088.1.
            
            Summary: Zinc-finger proteins bind nucleic acids and play important
            roles in various cellular functions, including cell proliferation,
            differentiation, and apoptosis. This gene encodes a zinc finger
            protein, and belongs to the krueppel C2H2-type zinc-finger protein
            family. It may be involved in transcriptional regulation. Multiple
            alternatively spliced transcript variants encoding different
            isoforms have been identified. [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (2) lacks an internal exon in the
            5' region, resulting in an upstream AUG start codon, as compared to
            variant 1. The encoded isoform 2 is shorter and has an alternate
            N-terminus, as compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC114216.1, SRR1660805.231780.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376943.8/ ENSP00000366142.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC244636.2         169563-169573
            12-58               AK122874.1         1-47
            59-683              CN311292.1         1-625
            684-2570            AK122874.1         772-2658
            2571-3033           BX648401.1         1876-2338
            3034-3499           AW291763.1         17-482              c
FEATURES             Location/Qualifiers
     source          1..3499
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.23"
     gene            1..3499
                     /gene="ZNF182"
                     /gene_synonym="HHZ150; KOX14; Zfp182; ZNF21"
                     /note="zinc finger protein 182"
                     /db_xref="GeneID:7569"
                     /db_xref="HGNC:HGNC:13001"
                     /db_xref="MIM:314993"
     exon            1..81
                     /gene="ZNF182"
                     /gene_synonym="HHZ150; KOX14; Zfp182; ZNF21"
                     /inference="alignment:Splign:2.1.0"
     exon            82..276
                     /gene="ZNF182"
                     /gene_synonym="HHZ150; KOX14; Zfp182; ZNF21"
                     /inference="alignment:Splign:2.1.0"
     exon            277..335
                     /gene="ZNF182"
                     /gene_synonym="HHZ150; KOX14; Zfp182; ZNF21"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..2183
                     /gene="ZNF182"
                     /gene_synonym="HHZ150; KOX14; Zfp182; ZNF21"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger protein 21 (KOX 14); zinc finger protein KOX14"
                     /codon_start=1
                     /product="zinc finger protein 182 isoform 2"
                     /protein_id="NP_001007089.1"
                     /db_xref="CCDS:CCDS35235.1"
                     /db_xref="GeneID:7569"
                     /db_xref="HGNC:HGNC:13001"
                     /db_xref="MIM:314993"
                     /translation="MAKPQGLVTFEDVAVDFTQEEWQYLNPPQRTLYRDVMLETYSNL
                     VFVGQQVTKPNLILKLEVEECPAEGKIPFWNFPEVCQVDEQIERQHQDDQDKCLLMQV
                     GFSDKKTIITKSARDCHEFGNILHLSTNLVASIQRPDKHESFGNNMVDNLDLFSRSSA
                     ENKYDNGCAKLFFHTEYEKTNPGMKPYGYKECGKGLRRKKGLSLHQRIKNGEKPFECT
                     ACRKTFSKKSHLIVHWRTHTGEKPFGCTECGKAFSQKSQLIIHLRTHTGERPFECPEC
                     GKAFREKSTVIIHYRTHTGEKPYECNECGKAFTQKSNLIVHQKTHTGEKTYECTKCGE
                     SFIQKLDLIIHHSTHTGKKPHECNECKKTFSDKSTLIIHQRTHTGEKPHKCTECGKSF
                     NEKSTLIVHQRTHTGEKPYECDVCGKTFTQKSNLGVHQRTHSGEKPFECNECEKAFSQ
                     KSYLMLHQRGHTGEKPYECNECEKAFSQKSYLIIHQRTHTEEKPYKCNECGKAFREKS
                     KLIIHQRIHTGEKPYECPVCWKAFSQKSQLIIHQRTHTGEKPYACTECGKAFREKSTF
                     TVHQRTHTGEKPYKCTECGKAFTQKSNLIVHQRTHAGKKAHGRGHTRKSKFMAH"
     exon            336..462
                     /gene="ZNF182"
                     /gene_synonym="HHZ150; KOX14; Zfp182; ZNF21"
                     /inference="alignment:Splign:2.1.0"
     exon            463..552
                     /gene="ZNF182"
                     /gene_synonym="HHZ150; KOX14; Zfp182; ZNF21"
                     /inference="alignment:Splign:2.1.0"
     exon            553..3499
                     /gene="ZNF182"
                     /gene_synonym="HHZ150; KOX14; Zfp182; ZNF21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3479..3484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF182"
                     /gene_synonym="HHZ150; KOX14; Zfp182; ZNF21"
                     /note="hexamer: AATAAA"
     polyA_site      3499
                     /gene="ZNF182"
                     /gene_synonym="HHZ150; KOX14; Zfp182; ZNF21"
                     /note="major polyA site"
ORIGIN      
        1 cccgaagcgg aagtgcttgt tggggccagg ctttgtaacg gtctcctgag cagcgagcag
       61 aaaatctgtt atcgagagag acacagtgac ctgcccctaa aggttcatgc gcatccctca
      121 gacccctctt tagacgcgcc ccgcttctcc ctctgccctc tccccttgcc caagccccga
      181 ggtgggggcc tggtgtgaat gctccggccg aagtgaacct gcacccccgc acccgaaggc
      241 ctctttccgg cttctgggca aggcggcccc ggtgagctcg gccgtcacac atctctgctt
      301 tttcccaaga agagcaggaa atggccaaac cccaggggct agtgacattt gaagatgtag
      361 ctgtggattt cacccaggag gagtggcagt acctgaaccc accacagagg accctgtaca
      421 gagacgtgat gctggagacc tacagcaact tggtctttgt ggggcagcag gttaccaaac
      481 caaacctcat cctcaagttg gaggtagaag aatgcccggc agaaggaaaa atcccatttt
      541 ggaactttcc agaagtctgt caagttgatg aacagattga gaggcaacat caggatgacc
      601 aagataaatg tctgctgatg caagttggat tttctgacaa gaaaacaatt atcaccaaga
      661 gtgctcgtga ctgtcatgag tttggaaaca tacttcatct gagtacaaac cttgttgctt
      721 caatacaaag acccgataaa cacgaatcat ttggaaataa tatggtagat aatttagact
      781 tatttagtag aagttctgca gaaaataaat atgataatgg atgtgcaaaa ttgttcttcc
      841 atactgagta tgagaaaaca aatcctggaa tgaagcccta tggctataaa gagtgtggga
      901 aaggtcttag gcgaaagaaa ggccttagtc tacatcagag aattaaaaat ggagagaaac
      961 cctttgaatg tactgcatgt aggaaaacct tcagcaagaa gtcacacctc attgtacatt
     1021 ggagaactca tacgggagag aaaccttttg gatgtaccga atgtggaaaa gcttttagcc
     1081 aaaaatctca gctcattata cacttgcgaa ctcatacagg agagagaccc tttgagtgtc
     1141 ctgaatgtgg aaaagccttc agagaaaagt caactgtcat catacattac aggactcaca
     1201 caggagaaaa accttatgaa tgtaatgaat gtggaaaagc cttcactcag aagtccaacc
     1261 tcattgtcca tcagaaaacc cacactggag agaaaaccta tgaatgcact aaatgtggag
     1321 aatctttcat acagaagctt gatctaatta tacatcatag tacccataca ggaaagaaac
     1381 cccatgaatg taatgagtgt aagaaaactt tcagtgataa gtcaactctc attatacacc
     1441 agagaactca tacgggagag aaacctcata aatgtactga atgtgggaag tctttcaatg
     1501 agaagtcaac cctcattgtg catcaaagaa ctcatacagg agagaaaccc tatgaatgtg
     1561 atgtgtgtgg aaaaaccttc acgcaaaagt caaaccttgg tgtacatcag agaactcatt
     1621 caggagagaa accctttgaa tgtaatgaat gtgagaaagc cttctctcag aagtcctacc
     1681 tcatgctgca tcagagaggt catacaggag agaaacctta cgagtgcaat gaatgtgaaa
     1741 aagcattttc acagaaatca tatctcatta tacatcaaag aactcataca gaagaaaaac
     1801 cctataaatg taatgaatgt ggcaaagcct tcagagaaaa gtcaaagctc attatacatc
     1861 agagaattca tacaggagag aaaccttatg aatgtcctgt gtgttggaaa gcttttagcc
     1921 agaagtcaca gctcataata catcagagaa cgcacacggg agagaaaccc tatgcatgca
     1981 ctgagtgtgg caaagccttc cgagaaaagt caacattcac tgtacatcaa agaactcata
     2041 ctggagagaa accctataaa tgtacagaat gtgggaaagc ctttacccaa aaatcaaacc
     2101 ttattgtaca tcagcgaacc catgcaggaa agaaagccca tggaagaggc cacactcgga
     2161 agtcaaagtt catggcacat tagagagcta atcagcagta tctattatgg acactgaaag
     2221 aaagttgtgt caattttact cacattttaa aagtatattt tgacttgtgg tttaaatatg
     2281 ggagtaaatt cagcctttct tcttttcatc tcagtcataa cccaaaagct acgggagaaa
     2341 aagcagaagt gtaatctctg tatctgacaa aattaggaga cagctgcaac cctaatgaga
     2401 gggctgccac aggcagagga aatgaagcac tggtgcagga gatttcagag tgagagtgct
     2461 caaggctgca ggtgcaagac agcactggta aggactctta gctgaggttc gggatatacc
     2521 ccgaggcgcg gaaccataga tataacagtg gtaacagtgc gtgggcaggt aggaggtagg
     2581 atgtttccta gaccatttgg ggtctgagga gaaacaggct ggggcctcga gaaggagtca
     2641 ctcagacaag ccatattttt agaaagtagt ctactgatgg gagcaacagt tatggcatgc
     2701 tgggggaaga gaagggactt ttccttgtga agagccctac agctgcccct atttactgac
     2761 ttgggagaag taaagtcaga aagaacgaac agctgtgggg ggaaaaaatt ctcagttgtc
     2821 aaaaaaaaaa aaaactgatc tgcttagaat gtggccctgg tttcttttcc cacatgaacc
     2881 tccagcaaat agcaagtcca ggaaaaactc ttctcattca aagaggaatt attcaaaagt
     2941 aatcaaaacc acaaatgcat ttggtttttg ggccagcaat tccacttcta ggaatgtaca
     3001 tactcacaca tgtacaaaat gatgaacata cagtattcat taatgcagcg tttgtgaaaa
     3061 caaaagattg gaagctgttt aaatgacacc atatcagggt tctggttccc taaattgtgg
     3121 tatattcata cagcctactc ctgggtagac aacaatgaat aaataaggag aacttggaaa
     3181 ccatttatgt agtgatgtgg gataaccttc agtttatgtt attaggtagg aaaaataagg
     3241 ttgaggacag tgactgccat ttgtatataa aaaggagaaa aatggtaagt acataattgt
     3301 gaattcataa gttatctctg gaaagagaca tgagaacctg gtaaccctga ttaccttggg
     3361 aggggaaggg gcagtggtgg ctggggggat ggaattgaga gggagacaac tgtatccttt
     3421 catagctttt gaaaatgtgg gtgtactatg tactatgtgg atgtactacc ttttcaaaaa
     3481 taaaacattt aaaaagcta
//
