LOCUS       NP_001007089             620 aa            linear   PRI 28-APR-2025
DEFINITION  zinc finger protein 182 isoform 2 [Homo sapiens].
ACCESSION   NP_001007089
VERSION     NP_001007089.1
DBSOURCE    REFSEQ: accession NM_001007088.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 620)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   2  (residues 1 to 620)
  AUTHORS   Wang,R., Cukerman,E., Heng,H.H. and Liew,C.C.
  TITLE     Localization of a novel zinc finger gene to the human chromosome
            7p11.2-p12 by fluorescence in situ hybridization
  JOURNAL   Somat Cell Mol Genet 22 (3), 237-239 (1996)
   PUBMED   8914609
REFERENCE   3  (residues 1 to 620)
  AUTHORS   Knight,J.C., Grimaldi,G., Thiesen,H.J., Bech-Hansen,N.T.,
            Fletcher,C.D. and Coleman,M.P.
  TITLE     Clustered organization of Kruppel zinc-finger genes at Xp11.23,
            flanking a translocation breakpoint at OATL1: a physical map with
            locus assignments for ZNF21, ZNF41, ZNF81, and ELK1
  JOURNAL   Genomics 21 (1), 180-187 (1994)
   PUBMED   8088786
REFERENCE   4  (residues 1 to 620)
  AUTHORS   Huebner,K., Druck,T., Croce,C.M. and Thiesen,H.J.
  TITLE     Twenty-seven nonoverlapping zinc finger cDNAs from human T cells
            map to nine different chromosomes with apparent clustering
  JOURNAL   Am J Hum Genet 48 (4), 726-740 (1991)
   PUBMED   2014798
REFERENCE   5  (residues 1 to 620)
  AUTHORS   Thiesen,H.J.
  TITLE     Multiple genes encoding zinc finger domains are expressed in human
            T cells
  JOURNAL   New Biol 2 (4), 363-374 (1990)
   PUBMED   2288909
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC244636.2, AK122874.1,
            CN311292.1, BX648401.1 and AW291763.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: Zinc-finger proteins bind nucleic acids and play important
            roles in various cellular functions, including cell proliferation,
            differentiation, and apoptosis. This gene encodes a zinc finger
            protein, and belongs to the krueppel C2H2-type zinc-finger protein
            family. It may be involved in transcriptional regulation. Multiple
            alternatively spliced transcript variants encoding different
            isoforms have been identified. [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (2) lacks an internal exon in the
            5' region, resulting in an upstream AUG start codon, as compared to
            variant 1. The encoded isoform 2 is shorter and has an alternate
            N-terminus, as compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC114216.1, SRR1660805.231780.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376943.8/ ENSP00000366142.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..620
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.23"
     Protein         1..620
                     /product="zinc finger protein 182 isoform 2"
                     /note="zinc finger protein 21 (KOX 14); zinc finger
                     protein KOX14"
                     /calculated_mol_wt=71440
     Region          8..66
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          190..209
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          213..601
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          217..237
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          245..265
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(250,252,254,256..257,260..261,264,278,280,284..285,
                     288..289,292,306,308,310,312..313,316..317,320)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          273..293
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          301..321
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          329..349
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          357..377
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(362,364,366,368..369,372..373,376,390,392,396..397,
                     400..401,404,418,420,422,424..425,428..429,432)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          385..405
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          413..433
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          441..461
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          469..489
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          497..517
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          525..545
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(530,532,534,536..537,540..541,544,558,560,564..565,
                     568..569,572,586,588,590,592..593,596..597,600)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          553..573
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          581..601
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..620
                     /gene="ZNF182"
                     /gene_synonym="HHZ150; KOX14; Zfp182; ZNF21"
                     /coded_by="NM_001007088.2:321..2183"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS35235.1"
                     /db_xref="GeneID:7569"
                     /db_xref="HGNC:HGNC:13001"
                     /db_xref="MIM:314993"
ORIGIN      
        1 makpqglvtf edvavdftqe ewqylnppqr tlyrdvmlet ysnlvfvgqq vtkpnlilkl
       61 eveecpaegk ipfwnfpevc qvdeqierqh qddqdkcllm qvgfsdkkti itksardche
      121 fgnilhlstn lvasiqrpdk hesfgnnmvd nldlfsrssa enkydngcak lffhteyekt
      181 npgmkpygyk ecgkglrrkk glslhqrikn gekpfectac rktfskkshl ivhwrthtge
      241 kpfgctecgk afsqksqlii hlrthtgerp fecpecgkaf rekstviihy rthtgekpye
      301 cnecgkaftq ksnlivhqkt htgektyect kcgesfiqkl dliihhstht gkkphecnec
      361 kktfsdkstl iihqrthtge kphkctecgk sfnekstliv hqrthtgekp yecdvcgktf
      421 tqksnlgvhq rthsgekpfe cnecekafsq ksylmlhqrg htgekpyecn ecekafsqks
      481 yliihqrtht eekpykcnec gkafrekskl iihqrihtge kpyecpvcwk afsqksqlii
      541 hqrthtgekp yactecgkaf rekstftvhq rthtgekpyk ctecgkaftq ksnlivhqrt
      601 hagkkahgrg htrkskfmah
//
