LOCUS       NM_001029997            5792 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens zinc finger protein 181 (ZNF181), transcript variant
            1, mRNA.
ACCESSION   NM_001029997 XM_290835
VERSION     NM_001029997.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5792)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   2  (bases 1 to 5792)
  AUTHORS   Wang,R., Cukerman,E., Heng,H.H. and Liew,C.C.
  TITLE     Identification of a locus of zinc finger genes in human chromosome
            19q13.1-q13.3 region by fluorescence in situ hybridization
  JOURNAL   Somat Cell Mol Genet 22 (3), 245-248 (1996)
   PUBMED   8914611
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020910.7, DC304794.1, DC299701.1, BC104759.1, AK297316.1 and
            AI800428.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001029997.3.
            
            Summary: Zinc finger proteins have been shown to interact with
            nucleic acids and to have diverse functions. The zinc finger domain
            is a conserved amino acid sequence motif containing 2 specifically
            positioned cysteines and 2 histidines that are involved in
            coordinating zinc. Kruppel-related proteins form 1 family of zinc
            finger proteins. See MIM 604749 for additional information on zinc
            finger proteins.[supplied by OMIM, Jul 2003].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.213776.1,
                                           SRR1660809.238763.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000492450.3/ ENSP00000420727.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-332               AC020910.7         136098-136429
            333-360             DC304794.1         1-28
            361-706             DC299701.1         1-346
            707-2594            BC104759.1         1-1888
            2595-2892           AK297316.1         1095-1392
            2893-3283           AI800428.1         1-391               c
            3284-5792           AC020910.7         144725-147233
FEATURES             Location/Qualifiers
     source          1..5792
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.11"
     gene            1..5792
                     /gene="ZNF181"
                     /gene_synonym="HHZ181"
                     /note="zinc finger protein 181"
                     /db_xref="GeneID:339318"
                     /db_xref="HGNC:HGNC:12971"
                     /db_xref="MIM:606741"
     exon            1..804
                     /gene="ZNF181"
                     /gene_synonym="HHZ181"
                     /inference="alignment:Splign:2.1.0"
     CDS             796..2511
                     /gene="ZNF181"
                     /gene_synonym="HHZ181"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 181 isoform 1"
                     /protein_id="NP_001025168.2"
                     /db_xref="CCDS:CCDS32990.2"
                     /db_xref="GeneID:339318"
                     /db_xref="HGNC:HGNC:12971"
                     /db_xref="MIM:606741"
                     /translation="MPQVTFNDVAIDFTHEEWGWLSSAQRDLYKDVMVQNYENLVSVA
                     GLSVTKPYVITLLEDGKEPWMMEKKLSKGMIPDWESRWENKELSTKKDNYDEDSPQTV
                     IIEKVVKQSYEFSNSKKNLEYIEKLEGKHGSQVDHFRPAILTSRESPTADSVYKYNIF
                     RSTFHSKSTLSEPQKISAEGNSHKYDILKKNLPKKSVIKNEKVNGGKKLLNSNKSGAA
                     FSQGKSLTLPQTCNREKIYTCSECGKAFGKQSILNRHWRIHTGEKPYECRECGKTFSH
                     GSSLTRHLISHSGEKPYKCIECGKAFSHVSSLTNHQSTHTGEKPYECMNCGKSFSRVS
                     HLIEHLRIHTQEKLYECRICGKAFIHRSSLIHHQKIHTGEKPYECRECGKAFCCSSHL
                     TRHQRIHTMEKQYECNKCLKVFSSLSFLVQHQSIHTEEKPFECQKCRKSFNQLESLNM
                     HLRNHIRLKPYECSICGKAFSHRSSLLQHHRIHTGEKPYECIKCGKTFSCSSNLTVHQ
                     RIHTGEKPYKCNECGKAFSKGSNLTAHQRVHNGEKPNSVVSVEKPLDYMNHYTCEKSY
                     RRETV"
     exon            805..925
                     /gene="ZNF181"
                     /gene_synonym="HHZ181"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1024
                     /gene="ZNF181"
                     /gene_synonym="HHZ181"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..5792
                     /gene="ZNF181"
                     /gene_synonym="HHZ181"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3261..3266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF181"
                     /gene_synonym="HHZ181"
                     /note="hexamer: AATAAA"
     polyA_site      3286
                     /gene="ZNF181"
                     /gene_synonym="HHZ181"
                     /note="major polyA site"
     regulatory      5773..5778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF181"
                     /gene_synonym="HHZ181"
                     /note="hexamer: AATAAA"
     polyA_site      5792
                     /gene="ZNF181"
                     /gene_synonym="HHZ181"
ORIGIN      
        1 gctgtagcct caggcctgac ggcgactccc aggctccggg acgattctgg gcagtgtcgt
       61 ccccagaggt cggcggccgt tgcccgctca ccagcgacgc ggggcgcctg cggggacggt
      121 gaggccctgc tgaggactcc ggccagtatg agtcccgggg gcggcggcgg ggctcaggcc
      181 ctgggtctgc cccgcggtgt gaccccggcc ggtgccttgg ttttcctggc cttcatgtcc
      241 tcctatgtaa acgcggggtg atgacggcgc cgacctcttg gcgctgttgt gagagtgaag
      301 tgggcgcgtg gttagacgcc agccacagtt gtctttgggt tatgtcgtca tgaagccggc
      361 gctctacagt tgtgtaacct tgaacaaatg ggttcagtat cttggaattt cagttttgtc
      421 atcgtttaaa aaatagatct ggaaaaatgt gaacgcacac cgtgcatagt ggtgaagact
      481 gaacgagctg ataaagtttt taccattgtt ttatgaggat tttatttaca gagtaattga
      541 ttttcctcgc aggtggcacc tggtaaatgg ttagcccttg cggagaaaca ccctgttagt
      601 tcccagggag agattggcgc cctggagagt gattaccagt gtgcctttcc attatggtgt
      661 gtcacaggtg ccgcaagata agcctgattt ttcatgactg ctttttcctg cccttctgtg
      721 ccctcaggac actgcccatc tctaagataa gagcctggaa agaggactct gttggctgtt
      781 ggaaattgca gagtaatgcc tcaggtgaca tttaatgatg tggctataga cttcactcat
      841 gaagagtggg gatggctcag ttctgctcag agggacttat acaaggatgt gatggtccag
      901 aattatgaga acctggtctc tgtagcaggt ctttctgtaa ctaagccata tgtgatcacg
      961 ttattggagg atggaaaaga gccctggatg atggagaaaa aactgtcaaa aggtatgatt
     1021 ccagattggg aatcaagatg ggaaaacaag gaattatcaa caaagaagga taattatgat
     1081 gaagattcac cccaaacagt aataatagaa aaagttgtaa aacaaagtta tgaattttca
     1141 aattctaaga agaatttgga atatatagag aagttggaag ggaagcatgg aagtcaggta
     1201 gaccatttca gaccagcaat tctcacctct agagaaagcc ccactgcaga cagtgtttac
     1261 aaatacaata tatttagaag cacctttcat tcaaagtcta ctctttctga accacaaaaa
     1321 atttctgctg aagggaattc acacaaatat gatatattaa agaagaactt accaaaaaag
     1381 tcagttataa aaaatgagaa agtcaatggt ggaaagaaac ttttgaattc taataaaagt
     1441 ggggcagcct tcagccaggg caaatctctt acccttcccc agacttgtaa tagagagaaa
     1501 atctatacat gcagtgaatg tgggaaagcc tttggcaaac agtcaatcct caatcgccac
     1561 tggagaattc atacaggaga gaagccctat gaatgtcgtg aatgtgggaa gacttttagc
     1621 catggctcat cccttacacg acatctgata agccatagtg gagagaaacc ttacaaatgt
     1681 attgaatgtg ggaaggcctt tagccatgtc tcatcactta ctaaccatca gagcactcac
     1741 actggagaga aaccatatga atgtatgaac tgtggaaagt cttttagtcg tgtgtcccat
     1801 cttattgaac atctaagaat tcatactcaa gaaaaactct atgagtgtcg tatatgtgga
     1861 aaggccttca ttcataggtc atctctcatt caccatcaga aaatccatac tggagagaag
     1921 ccttatgaat gtagagaatg tgggaaagct ttctgctgta gctcacacct tactcgacat
     1981 caaagaattc acactatgga gaaacaatat gaatgcaaca aatgtctgaa agtctttagt
     2041 agcctctcat ttcttgttca gcatcagagt attcatactg aagaaaaacc ctttgaatgt
     2101 cagaaatgca ggaaatcctt caaccagctt gaatcactga atatgcattt gagaaatcac
     2161 attagattga aaccctacga atgcagtata tgtgggaaag cctttagtca taggtcatcc
     2221 ctgcttcaac atcacagaat tcatactgga gagaaacctt atgaatgtat taaatgtggg
     2281 aagaccttca gctgtagttc aaaccttacc gtacatcaga gaattcacac tggagaaaag
     2341 ccatataaat gtaatgagtg tgggaaagct tttagcaaag gctcaaatct tactgcccat
     2401 caaagagtac ataatggaga gaaacccaat agtgtggtaa gtgtggaaaa gcctttagac
     2461 tatatgaatc actatacatg tgagaaatct tacagaagag aaactgtatg aagcagtggt
     2521 tatcatggta aatttcctag attctccctt atttaacatt agaaaaattt atactgggga
     2581 aagtcttatg aatgtggtga atataggaag accttttagc aaagatgcag gccagtttgt
     2641 ttattagact ttatactgta gagaaatcat atgaagacca taaatgtggg aaagcctttg
     2701 tcagtattaa tcccttaatt gacataagta tactcacact aggataaaac cctgtacatg
     2761 tagcaaatgt gggaaagact acagacaata ggaatctttt acaaactcct acaggagaga
     2821 agctgtatga atgtagaaaa tttagaaatt gagggaagtc ttcagttcca agtatatccc
     2881 ttattctaca gcagagaact caaaatggag agaaatctca tttaagagat gtagcaaagt
     2941 gttcactaag agtgtttatc ttggtacaca tcagaagatt aatggtagaa caacctgaag
     3001 gatttaggag ttatgtgtaa atctttgcag tcatgctatt tgtaaactgg attctacagg
     3061 agagcaaata aacattataa taaaatatgc atttcttaga gcagtagctt gcagtttcag
     3121 ttgagttcta cttagaaatt ctttttagct agtgggcatg tgaagatatt tagtcaccca
     3181 gaggagccag taagtgttat aatattgaaa attaaagctg caaaagaaat aaagtgatgt
     3241 taataaaagt tttggcatct aataaaatca ttttgtatat cacaaactct ttcactgtga
     3301 ctatttcctg taaaaaaaat ttcactaaga ttagccttag cgtagccttt agtgggagac
     3361 tagcaaacct agagaaaaat gacctgctct ttatactaag aatagcagta ttttgatgag
     3421 gattattcag agtcaatttc cagtaggctt aatcaaatac atttcaaaaa aatttactga
     3481 gcatcactcg tgtattatta cacagcgatg ggatatagga atccagtagt tctgagcttt
     3541 agtggtgtgt caaagtcagt aggagggctt gttaaagcac agattgctaa gtctgaatct
     3601 tagggtttct gtatgagttg atttgaattt gcatttttca tgcgttctta ggcgacacac
     3661 tgtccagaaa gcacattttg ataaccattg taataatgaa caaaacaaat ctgatctttt
     3721 tctcgcaggg atgttatctg acaagaaaga tggatagcaa ataaatttga aataatggtt
     3781 tacaagtgct atgaggacat aaccaagaaa caacatacta caagagatca gagcaggctt
     3841 agcgagatgt gatttttgaa atgaatccta aatgatgaac actaattatg taatgagtac
     3901 tactcatgta gccatgtgca tccctgcatg tgcctgtgcg tgtgtgtatg cggtgtgctg
     3961 ggtgttaatc taggtaaagc agacagtcga gttctgtcat acttgctgca gctggattcc
     4021 acgttcccat gtctagtttc agattctgtg gctttgaggt agtgctgctg gcagcatcat
     4081 tgcagcaacc gtcatttctc tatccctgag tcatagttac gggagtttac cttgaaatca
     4141 ctagcccaga agtgttctca ttacttttac agcccaccta ccaattttga aagcactaat
     4201 ttgcagcaat atatgtcttg aaatagttaa gagagatttt gttctctgca ctgaaccttg
     4261 acagataatt atgttttgta aggaggcagg atggcttcaa atattctaag ttctagataa
     4321 gaaatggaac agtctcactg gccctgtgat tagaatccta tcttgtgatt agaaaggtaa
     4381 tgcagatcaa tttgatttgg agtgtatgga cactgatgca agtgaagggg tgtgatatgg
     4441 attatgcttc agattttgtt ctttatctca ggtgagagta gtaagatatg ttattttaaa
     4501 aaggaacatt atgttatagt tatgataatt ctggtgtgga atgagtgata aggtttctga
     4561 ctttcaacaa aatgtatctc ctctgatata tgtgctacct taacagaaag ccaaagcaca
     4621 gaggcatatt ccaatagcaa tttgcaagag acagtaggtt tggaatgggg tggtaaactt
     4681 ttactatttt gcagggattt tatctttcat ttgatttatt tttaatcatg aaatttatat
     4741 tgaaattctg tgaaacattg aaggatcttt ggaagattta taattaggga agggccagat
     4801 gtagtggcta atgtctgtac tcccagcact ttgggagacc gaggcaggag gattgcttga
     4861 ggccaggagt ttgagaccag cctgggcaat atagcaaaac tcattagtct gttaaaaaaa
     4921 aaaattaccc aggtgtaggc acacatctgc agtcctagct attcaggagg ctgagtgggg
     4981 agggattgct tgagtacagg agttttaagg tcacagtgag ctatcatcac accactgctt
     5041 tccagcctgg acagcagaac accaccctgt ctccaaagta aataaataca attaaggaag
     5101 catgatgtgg tatcagacag ttgcaagtat ggatagactg gctaccacat atatacttat
     5161 gggataatga gagtagcttt cttttctctc attctgtgtc ctttctctgc tctcccaagc
     5221 aactggtacc acagagatga agtagtccta taatgcccag attttgtttc cactacacat
     5281 agtttaatgc taccatgtca ctttgttatg agaggattca tcgaaatacc tgtgctttgt
     5341 catttaaaaa gcatgggcat acacatgata atgctttacg tttctggatt taaagtgcct
     5401 tcacaataca gaactaggaa aaagaaggcc atctttttaa atgaagatag ttttaagaga
     5461 gcaataagag actattactt tgttatgata gaaggttggg ctgatgtcat aatgatgtta
     5521 tgatgtcact gacatcatat tatttcctca gtcataccta ttaaccattt cttgagcatc
     5581 cactatgggc ttaatagata agaaacactc catacccttt aagagccctg aggtgtgtgt
     5641 gtgtgaacag cattaaactt tggagtcatg ttacctgggt ttaaatccaa gttgcatgaa
     5701 tactggcttt gtgtgacctt ggacaaacta tttcactgtg tcttgcctca gtttctccat
     5761 ctgtaaaatg ataataaagc tatctcacag ca
//
