LOCUS       NM_001278509            4248 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 180 (ZNF180), transcript variant
            3, mRNA.
ACCESSION   NM_001278509
VERSION     NM_001278509.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4248)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 4248)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4248)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4248)
  AUTHORS   Terracciano,A., Sanna,S., Uda,M., Deiana,B., Usala,G., Busonero,F.,
            Maschio,A., Scally,M., Patriciu,N., Chen,W.M., Distel,M.A.,
            Slagboom,E.P., Boomsma,D.I., Villafuerte,S., Sliwerska,E.,
            Burmeister,M., Amin,N., Janssens,A.C., van Duijn,C.M.,
            Schlessinger,D., Abecasis,G.R. and Costa,P.T. Jr.
  TITLE     Genome-wide association scan for five major dimensions of
            personality
  JOURNAL   Mol Psychiatry 15 (6), 647-656 (2010)
   PUBMED   18957941
REFERENCE   5  (bases 1 to 4248)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (bases 1 to 4248)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   7  (bases 1 to 4248)
  AUTHORS   Shannon,M., Hamilton,A.T., Gordon,L., Branscomb,E. and Stubbs,L.
  TITLE     Differential expansion of zinc-finger transcription factor loci in
            homologous human and mouse gene clusters
  JOURNAL   Genome Res 13 (6A), 1097-1110 (2003)
   PUBMED   12743021
REFERENCE   8  (bases 1 to 4248)
  AUTHORS   Wang,R., Cukerman,E., Heng,H.H. and Liew,C.C.
  TITLE     Identification of a locus of zinc finger genes in human chromosome
            19q13.1-q13.3 region by fluorescence in situ hybridization
  JOURNAL   Somat Cell Mol Genet 22 (3), 245-248 (1996)
   PUBMED   8914611
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA947036.1, AK024047.1, AF192913.1 and AC245748.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001278509.2.
            
            Summary: Zinc finger proteins have been shown to interact with
            nucleic acids and to have diverse functions. The zinc finger domain
            is a conserved amino acid sequence motif containing 2 specifically
            positioned cysteines and 2 histidines that are involved in
            coordinating zinc. Kruppel-related proteins form 1 family of zinc
            finger proteins. See MIM 604749 for additional information on zinc
            finger proteins.[supplied by OMIM, Jul 2002].
            
            Transcript Variant: This variant (3) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon, compared to variant 1. This results in an
            isoform (3) with a shorter N-terminus, compared to isoform 1. Both
            variants 3 and 8 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK024047.1, SRR18074967.3892195.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000592529.6/ ENSP00000468021.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DA947036.1         2-3
            3-331               AK024047.1         1-329
            332-2323            AF192913.1         387-2378
            2324-4248           AC245748.2         144661-146585       c
FEATURES             Location/Qualifiers
     source          1..4248
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..4248
                     /gene="ZNF180"
                     /gene_synonym="HHZ168"
                     /note="zinc finger protein 180"
                     /db_xref="GeneID:7733"
                     /db_xref="HGNC:HGNC:12970"
                     /db_xref="MIM:606740"
     exon            1..248
                     /gene="ZNF180"
                     /gene_synonym="HHZ168"
                     /inference="alignment:Splign:2.1.0"
     exon            249..342
                     /gene="ZNF180"
                     /gene_synonym="HHZ168"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..2289
                     /gene="ZNF180"
                     /gene_synonym="HHZ168"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="zinc finger protein 180 isoform 3"
                     /protein_id="NP_001265438.2"
                     /db_xref="CCDS:CCDS62707.1"
                     /db_xref="GeneID:7733"
                     /db_xref="HGNC:HGNC:12970"
                     /db_xref="MIM:606740"
                     /translation="MEEQDEKPPEPPKVCAQDSFLPQEIIIKVEGEDTGSLTIPSQEG
                     VNFKIVTVDFTREEQGTCNPAQRTLDRDVILENHRDLVSWDLATAVGKKDSTSKQRIF
                     DEEPANGVKIERFTRDDPWLSSCEEVDDCKDQLEKQQEKQEILLQEVAFTQRKAVIHE
                     RVCKSDETGEKSGLNSSLFSSPVIPIRNHFHKHVSHAKKWHLNAAVNSHQKINENETL
                     YENNECGKPPQSIHLIQFTRTQTKDKSYGFSDRIQSFCHGTPLHIHEKIHGGGKTFDF
                     KECGQVLNPKISHNEQQRIPFEESQYKCSETSHSSSLTQNMRNNSEEKPFECNQCGKS
                     FSWSSHLVAHQRTHTGEKPYECSECGKSFSRSSHLVSHQRTHTGEKPYRCNQCGKSFS
                     QSYVLVVHQRTHTGEKPYECNQCGKSFRQSYKLIAHQRTHTGEKPYECNQCGKSFIQS
                     YKLIAHQRIHTGEKPYECNQCGKSFSQSYKLVAHQRTHTGEKPFECNQCGKSFSWSSQ
                     LVAHQRTHTGEKPYECSECGKSFNRSSHLVMHQRIHTGEKPYECNQCGKSFSQSYVLV
                     VHQRTHTGEKPYECSQCGKSFRQSSCLTQHQRTHTGEKPFECNQCGKTFSLSARLIVH
                     QRTHTGEKPFTCIQCGKAFINSYKLIRHQATHTEEKLYECN"
     exon            343..417
                     /gene="ZNF180"
                     /gene_synonym="HHZ168"
                     /inference="alignment:Splign:2.1.0"
     exon            418..544
                     /gene="ZNF180"
                     /gene_synonym="HHZ168"
                     /inference="alignment:Splign:2.1.0"
     exon            545..4248
                     /gene="ZNF180"
                     /gene_synonym="HHZ168"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2386..2391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF180"
                     /gene_synonym="HHZ168"
                     /note="hexamer: AATATA"
     polyA_site      2401
                     /gene="ZNF180"
                     /gene_synonym="HHZ168"
     regulatory      3028..3033
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF180"
                     /gene_synonym="HHZ168"
                     /note="hexamer: AGTAAA"
     polyA_site      3052
                     /gene="ZNF180"
                     /gene_synonym="HHZ168"
                     /note="major polyA site"
     regulatory      4229..4234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF180"
                     /gene_synonym="HHZ168"
                     /note="hexamer: AATAAA"
     polyA_site      4248
                     /gene="ZNF180"
                     /gene_synonym="HHZ168"
ORIGIN      
        1 acaagagcag ccattgtccc gcgcgcggac gcttgctgtc gccgagcagc tcggcccttc
       61 agacttaacc cccagcggcc ttgcggatgc tgactaggag aggggaccga actagcttaa
      121 cccgagtcgg ccgtgttgca gaatcggggc agggggttgc ctaacccgag ttcgtcctgc
      181 cgcagagccg tgctaggcac tgaggcggtg acaggcccag cctgggctgc gggccagcgg
      241 acgcccagtg cagctcagga cctcagcacc ctgctgtgcc tggaggagag catggaagag
      301 caggatgaga agcccccaga gcccccgaag gtctgtgcac aggattcttt ccttcctcaa
      361 gagattatca tcaaagtcga gggagaagac actgggtctc tgaccatccc atctcaggaa
      421 ggagtgaact tcaaaattgt gactgtggac ttcacacggg aggaacaggg tacttgcaac
      481 cctgctcaga ggaccctgga cagagatgtg atcctggaga accacaggga cctagtctct
      541 tgggacttgg caactgcagt tggaaaaaaa gattcaactt caaagcagag gatttttgat
      601 gaagaaccag ctaatggagt gaagatagaa aggtttacaa gggatgatcc ttggttatct
      661 tcatgtgaag aagtggatga ttgtaaagac cagttggaga agcaacagga aaaacaagag
      721 atacttttgc aggaagtggc attcactcaa aggaaagcag ttattcatga gagagtctgc
      781 aaaagtgatg aaactgggga gaagagtggt ctgaattcca gtctattttc atccccagtt
      841 atacccataa gaaaccattt tcataaacat gtatcacatg ctaaaaaatg gcatcttaat
      901 gctgctgtaa acagtcatca gaagattaat gagaatgaga cactatatga aaataatgaa
      961 tgtggaaaac cccctcagag cattcacctt attcagttta caagaactca aacaaaagat
     1021 aaatcctatg gatttagtga ccgtattcaa tctttttgcc atggtacacc cctacatata
     1081 catgaaaaaa ttcatggagg aggaaaaacc tttgatttta aagaatgtgg gcaggttttg
     1141 aaccccaaaa tatcccataa tgaacaacag agaattcctt ttgaagagag tcaatataaa
     1201 tgtagtgaaa cctctcatag ttcctccctt actcaaaaca tgagaaataa ttctgaagag
     1261 aaaccttttg aatgtaatca gtgtgggaaa tccttcagct ggagctcgca tcttgttgca
     1321 catcagagaa ctcacacagg ggagaaacct tatgaatgta gtgaatgtgg aaaatccttc
     1381 agccggagct cgcaccttgt ttcccatcag agaactcata ctggagagaa accttacagg
     1441 tgtaatcaat gtgggaaatc ctttagccag agttatgtcc ttgttgtgca tcaaagaact
     1501 catactgggg agaagcctta tgaatgcaat cagtgtggaa agtcattcag gcagagctat
     1561 aaacttattg cacatcaaag aacacatacc ggagagaagc cctatgaatg taatcaatgt
     1621 gggaaatcat ttatccagag ctataaactt attgcacatc aaagaattca tactggggaa
     1681 aaaccctatg aatgcaatca gtgtgggaaa tcctttagtc aaagttataa acttgttgct
     1741 catcagagaa ctcacacagg agaaaaaccc tttgaatgta atcagtgtgg gaaatccttc
     1801 agctggagct ctcagcttgt tgcacatcaa agaactcaca ctggagagaa accgtatgaa
     1861 tgtagtgaat gtggaaaatc ttttaaccgc agttctcacc ttgttatgca tcagagaatt
     1921 cacactgggg aaaaaccgta tgaatgtaat cagtgtggga aatccttcag ccagagttat
     1981 gttcttgttg tacatcagag aactcatact ggagaaaagc cctatgaatg cagtcaatgt
     2041 gggaagtcct tcagacagag ttcatgcctt actcaacatc agagaactca tactggagag
     2101 aaaccatttg aatgtaatca gtgtggaaaa acatttagct tgagtgctcg acttattgtg
     2161 catcaaagaa ctcatactgg agagaaaccc tttacatgta ttcagtgtgg aaaagctttc
     2221 attaatagct ataaacttat taggcatcag gcaactcata ctgaagagaa actctatgaa
     2281 tgtaactagt ttgtaaatca gctgggattt cttccttttt atttcattct tttaaaaaat
     2341 ttattttaag gtagtacatg tagttggaag aactactata aaaacaatat atgtgggaaa
     2401 acttccagcc ctctgttaat tgtgtgtctc aaatttgttc tggaaaagaa agggggaaag
     2461 tctatgaacg acttttcaac ctggcaattc catatacaat gttaaacttg attcttatga
     2521 catattccta tgaaaataat aaatactggc acttttcctt gcagaaagca ctcagacctg
     2581 aatcagagaa aatcatatgc caaagccaac tgccagtgtt agacctcttt ttccataaag
     2641 agtaaatgga atgctaacac tagtgggctt attgagaaaa tttaaaggtt gctgtagtgt
     2701 ttagaactta ggctggaaaa ccatatttta gtgcatcatt ttactacatg atcttccaat
     2761 tagatagctt gtaatctgtt ccttacagca cttgctgttg ttacatgtga agattttata
     2821 aattttagga aagtgtctat gatatatagt gaaaagtgtg ggaaaagaat atagaaataa
     2881 tattcacttc taaaaccatt atgataaaat atttgtgtat ggattagaat agaaagggat
     2941 tatggatgta tctattcaat ttctcagttt atgttgggcc ttcctttttg gaatgtacgc
     3001 tgttatgcta tgataaatga tataatgagt aaaaattatt caaagccaaa aatgaaatac
     3061 aaagatttcc ttctttgact atttaggaaa gactaagcaa ccaaatagca aagatccctc
     3121 aggataatga ggtttatgtt tggaatagca tgagcagatt actacttagg acatagattc
     3181 ctaggaacat tcctcattga aaataaaatg gattcctgga aataggtaac tagaaatttt
     3241 ggccagaaat ggtttcatat gaagaactga gaatgcgtgg gaagtataga gggcaagtgg
     3301 gcttattttc atatatgcaa agcaatatta aggaactcta ttttcatgtt ttagttcttc
     3361 ccctcatgta gcattgtctc tttcctctgg gatatgttcc ctgatgtgag agtcctctga
     3421 atagaagggt gcttccctgg ctcagtgctg accgtctaaa ttatgcttgc aaaaatgctt
     3481 tcatgaggca aagttttagt tactctttga tatttaagat ttgattaaca tgtctttctg
     3541 acctttccct tgaatcatga atttgaatcc tgtggatgac catatattga agcctctgat
     3601 cccagaaagg taataagctg aaagttgaac tgagagacca gataatagag gttaataccc
     3661 ttgggatagg aaagaaaact taaagggtaa ctgatggggt tatccttagc aaaattctat
     3721 ccctatgaga tgaccctaag tggagccatc tctatgagga ttaatccaga gattgttgca
     3781 cacctggcag tgtcaggtct gggaaaacag ttgctgatgt tttcatggag tgtgaaatac
     3841 tgaaagctgc gggcatccct tggggaccac tgacccacac tttgaagaac cctcaatgag
     3901 tctgaaagag gttcagtatc tcttgggaag gatgtgttcc aggctccagg cctagtctta
     3961 catggccagt ggggttgaaa gactgtgccc ctgcaatggt cttttcctaa gacagttgaa
     4021 caaagttcca agtctgtctg tcctatttta accatcttta agaagcacaa aggggatatg
     4081 agaaaaacag atgctgaaat gaaaatttta actgatatct tacttatctc acaagtcgtg
     4141 taaagaaaga aatgatatgg tcgaatatta gattagatgg tttaatgatg ttttgagtgt
     4201 tatatatgag ctatgatgag acctagaaaa taaagtaaaa ataaaaaa
//
