LOCUS       NM_001303281            2295 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 18 (ZNF18), transcript variant 2,
            mRNA.
ACCESSION   NM_001303281 XM_005256786
VERSION     NM_001303281.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2295)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2295)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   3  (bases 1 to 2295)
  AUTHORS   Guo,L.L., Ci,H.L., Shan,H.S., Zou,X., Zhai,Y.G. and Li,Y.P.
  TITLE     [Molecular cloning and expression analysis of a novel human gene
            ZNF18]
  JOURNAL   Yi Chuan 27 (4), 523-530 (2005)
   PUBMED   16120570
REFERENCE   4  (bases 1 to 2295)
  AUTHORS   Yoshida,K.
  TITLE     Identification and characterization of human ZNF18 gene in silico
  JOURNAL   Int J Mol Med 15 (3), 545-548 (2005)
   PUBMED   15702252
REFERENCE   5  (bases 1 to 2295)
  AUTHORS   Huebner,K., Druck,T., Croce,C.M. and Thiesen,H.J.
  TITLE     Twenty-seven nonoverlapping zinc finger cDNAs from human T cells
            map to nine different chromosomes with apparent clustering
  JOURNAL   Am J Hum Genet 48 (4), 726-740 (1991)
   PUBMED   2014798
REFERENCE   6  (bases 1 to 2295)
  AUTHORS   Thiesen,H.J.
  TITLE     Multiple genes encoding zinc finger domains are expressed in human
            T cells
  JOURNAL   New Biol 2 (4), 363-374 (1990)
   PUBMED   2288909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB056532.1, AK127908.1, BC036096.2 and AA243557.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001303281.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.284882.1, AK127908.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000580306.7/ ENSP00000463471.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 DB056532.1         36-42
            8-778               AK127908.1         1-771
            779-846             BC036096.2         735-802
            847-1594            AK127908.1         840-1587
            1595-2293           BC036096.2         1551-2249
            2294-2295           AA243557.1         15-16               c
FEATURES             Location/Qualifiers
     source          1..2295
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p12"
     gene            1..2295
                     /gene="ZNF18"
                     /gene_synonym="HDSG1; KOX11; Zfp535; ZKSCAN6; ZNF535;
                     ZSCAN38"
                     /note="zinc finger protein 18"
                     /db_xref="GeneID:7566"
                     /db_xref="HGNC:HGNC:12969"
                     /db_xref="MIM:194524"
     exon            1..45
                     /gene="ZNF18"
                     /gene_synonym="HDSG1; KOX11; Zfp535; ZKSCAN6; ZNF535;
                     ZSCAN38"
                     /inference="alignment:Splign:2.1.0"
     exon            46..514
                     /gene="ZNF18"
                     /gene_synonym="HDSG1; KOX11; Zfp535; ZKSCAN6; ZNF535;
                     ZSCAN38"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1777
                     /gene="ZNF18"
                     /gene_synonym="HDSG1; KOX11; Zfp535; ZKSCAN6; ZNF535;
                     ZSCAN38"
                     /note="isoform 1 is encoded by transcript variant 2; zinc
                     finger protein 18 (KOX 11); heart development-specific
                     gene 1 protein; zinc finger protein with KRAB and SCAN
                     domains 6; zinc finger protein 535"
                     /codon_start=1
                     /product="zinc finger protein 18 isoform 1"
                     /protein_id="NP_001290210.1"
                     /db_xref="CCDS:CCDS32568.1"
                     /db_xref="GeneID:7566"
                     /db_xref="HGNC:HGNC:12969"
                     /db_xref="MIM:194524"
                     /translation="MPVDLGQALGLLPSLAKAEDSQFSESDAALQEELSSPETARQLF
                     RQFRYQVMSGPHETLKQLRKLCFQWLQPEVHTKEQILEILMLEQFLTILPGEIQMWVR
                     KQCPGSGEEAVTLVESLKGDPQRLWQWISIQVLGQDILSEKMESPSCQVGEVEPHLEV
                     VPQELGLENSSSGPGELLSHIVKEESDTEAELALAASQPARLEERLIRDQDLGASLLP
                     AAPQEQWRQLDSTQKEQYWDLMLETYGKMVSGAGISHPKSDLTNSIEFGEELAGIYLH
                     VNEKIPRPTCIGDRQENDKENLNLENHRDQELLHASCQASGEVPSQASLRGFFTEDEP
                     GCFGEGENLPEALQNIQDEGTGEQLSPQERISEKQLGQHLPNPHSGEMSTMWLEEKRE
                     TSQKGQPRAPMAQKLPTCRECGKTFYRNSQLIFHQRTHTGETYFQCTICKKAFLRSSD
                     FVKHQRTHTGEKPCKCDYCGKGFSDFSGLRHHEKIHTGEKPYKCPICEKSFIQRSNFN
                     RHQRVHTGEKPYKCSHCGKSFSWSSSLDKHQRSHLGKKPFQ"
     exon            515..704
                     /gene="ZNF18"
                     /gene_synonym="HDSG1; KOX11; Zfp535; ZKSCAN6; ZNF535;
                     ZSCAN38"
                     /inference="alignment:Splign:2.1.0"
     exon            705..793
                     /gene="ZNF18"
                     /gene_synonym="HDSG1; KOX11; Zfp535; ZKSCAN6; ZNF535;
                     ZSCAN38"
                     /inference="alignment:Splign:2.1.0"
     exon            794..878
                     /gene="ZNF18"
                     /gene_synonym="HDSG1; KOX11; Zfp535; ZKSCAN6; ZNF535;
                     ZSCAN38"
                     /inference="alignment:Splign:2.1.0"
     exon            879..989
                     /gene="ZNF18"
                     /gene_synonym="HDSG1; KOX11; Zfp535; ZKSCAN6; ZNF535;
                     ZSCAN38"
                     /inference="alignment:Splign:2.1.0"
     exon            990..2295
                     /gene="ZNF18"
                     /gene_synonym="HDSG1; KOX11; Zfp535; ZKSCAN6; ZNF535;
                     ZSCAN38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2265..2270
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF18"
                     /gene_synonym="HDSG1; KOX11; Zfp535; ZKSCAN6; ZNF535;
                     ZSCAN38"
                     /note="hexamer: AATAAA"
     polyA_site      2295
                     /gene="ZNF18"
                     /gene_synonym="HDSG1; KOX11; Zfp535; ZKSCAN6; ZNF535;
                     ZSCAN38"
                     /note="major polyA site"
ORIGIN      
        1 acccagctcc cggaagtgcg cccggagccg gcgccgcggg ccgagtgtcc tggtgaagac
       61 ctagttcttg ccggagacaa ttccactgca gaagcacttt acttaaaagg acttgccagg
      121 ctggacaatg cccgttgact tggggcaggc cctaggcctg ctgccatcgc tggcgaaggc
      181 cgaggactcc cagttctcag aatcagatgc tgcccttcaa gaggaactct ccagccctga
      241 gaccgcacgc cagcttttca ggcagttccg ttaccaggtg atgtctgggc ctcatgagac
      301 cttgaagcaa cttcggaagc tctgtttcca gtggctacag ccagaggttc acaccaaaga
      361 gcagatccta gagatcctca tgttggagca gtttctgacc atcctgcctg gggagatcca
      421 gatgtgggtg cggaaacagt gtccaggaag tggagaagag gcagtgaccc ttgtggaaag
      481 cttgaagggg gacccccaga gactgtggca atggatcagt atccaggttc taggacagga
      541 catcttatca gagaagatgg aatctccaag ctgccaagtg ggggaagtgg agccccatct
      601 tgaagtggtg cctcaggagt tgggacttga gaattcatcc tcagggcctg gggagcttct
      661 gagccacatc gtgaaagagg aatctgacac agaagcagaa ctagccctgg ctgcctccca
      721 gcctgcccga ctggaggaaa ggctgatcag agaccaggac ctcggagcct cactgctccc
      781 agcagcacct caggaacagt ggagacaact ggattccact caaaaggagc aatactggga
      841 tctcatgctg gagacctatg ggaaaatggt ctcaggagca ggcatttccc atcccaaatc
      901 tgacctgact aattcaatag aatttgggga agagctggca ggaatatacc ttcatgtcaa
      961 tgagaagatc ccaagaccca cctgcatagg agatagacaa gagaatgaca aggagaacct
     1021 aaatttggag aatcacaggg accaggagct cctgcatgct tcctgtcaag cttcaggaga
     1081 ggttccttct caggcttcct tgaggggctt cttcactgag gatgagccag gatgctttgg
     1141 agaaggagag aatctccctg aggctctgca aaacattcag gatgagggaa caggggaaca
     1201 gctgtctcct caagaaagga tttctgagaa acaactaggt cagcatttgc ctaatcctca
     1261 ttcaggagaa atgtccacca tgtggcttga ggagaagaga gagacctccc agaaggggca
     1321 gccaagagcc cccatggccc agaagctccc cacctgcagg gagtgtggga agacctttta
     1381 taggaattct cagcttattt ttcaccaaag aactcacacc ggagagacat actttcagtg
     1441 caccatctgc aaaaaagcct ttctgcggag ttcagacttt gtgaagcatc agagaactca
     1501 cacgggagag aagccctgta aatgtgatta ctgtgggaaa ggctttagtg acttctcagg
     1561 attgcgccac cacgagaaaa tccacacagg agagaaaccc tataaatgtc ctatctgtga
     1621 gaaaagtttc attcagagat caaactttaa tagacatcag agggttcaca ctggagagaa
     1681 accttataaa tgttcgcact gtgggaaaag tttcagctgg agctcgagcc ttgacaaaca
     1741 tcaaagatcc cacttaggaa agaagccctt tcaatagcca gtaaccaaac tctctttccc
     1801 catttctatc tcccagccca gtcacaaaaa tactcagctc catcaagagg aattgtgtct
     1861 aagaggatac ccctgttaat ctcctttttt cttggattgg agaggagaga atctggacat
     1921 ggctttggac ttggaggata tcttggattg gattgcacaa tggcttaaat tcttgattct
     1981 gcctcaggag aaagaatagt cttcatgttt ccactcatcc ttcctttgga cccatcgggg
     2041 aaaaagtcta aattggagat ccagttttag aagtgctttc tgggaagcat ttaatgggat
     2101 tagctgtagt cactgcttat gggaagaacc tcagatcagc cccttaaaat gagttctaga
     2161 gcaggtcttc tgttccagaa ggggagaagc atagagggcc tgtgagctca cgtgtgttct
     2221 ttgtcatagg ggtgaaaaac taacttcaag tgtcccttgt ttgaaataaa cttagcagag
     2281 tcactttcta tctta
//
