LOCUS       NM_001172651            2606 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 177 (ZNF177), transcript variant
            1, mRNA.
ACCESSION   NM_001172651
VERSION     NM_001172651.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2606)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2606)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   3  (bases 1 to 2606)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   4  (bases 1 to 2606)
  AUTHORS   Landry,J.R., Medstrand,P. and Mager,D.L.
  TITLE     Repetitive elements in the 5' untranslated region of a human
            zinc-finger gene modulate transcription and translation efficiency
  JOURNAL   Genomics 76 (1-3), 110-116 (2001)
   PUBMED   11549323
REFERENCE   5  (bases 1 to 2606)
  AUTHORS   Baban,S., Freeman,J.D. and Mager,D.L.
  TITLE     Transcripts from a novel human KRAB zinc finger gene contain
            spliced Alu and endogenous retroviral segments
  JOURNAL   Genomics 33 (3), 463-472 (1996)
   PUBMED   8661005
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011451.6.
            
            On Jun 23, 2020 this sequence version replaced NM_001172651.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.4024795.1,
                                           SRR18074969.3706472.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2146982
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683217.1/ ENSP00000507083.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AC011451.6         106809-106880       c
            73-159              AC011451.6         104945-105031       c
            160-267             AC011451.6         93470-93577         c
            268-353             AC011451.6         91549-91634         c
            354-480             AC011451.6         90805-90931         c
            481-573             AC011451.6         90274-90366         c
            574-656             AC011451.6         89754-89836         c
            657-2606            AC011451.6         87276-89225         c
FEATURES             Location/Qualifiers
     source          1..2606
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..2606
                     /gene="ZNF177"
                     /gene_synonym="PIGX"
                     /note="zinc finger protein 177"
                     /db_xref="GeneID:7730"
                     /db_xref="HGNC:HGNC:12966"
                     /db_xref="MIM:601276"
     exon            1..72
                     /gene="ZNF177"
                     /gene_synonym="PIGX"
                     /inference="alignment:Splign:2.1.0"
     exon            73..159
                     /gene="ZNF177"
                     /gene_synonym="PIGX"
                     /inference="alignment:Splign:2.1.0"
     exon            160..267
                     /gene="ZNF177"
                     /gene_synonym="PIGX"
                     /inference="alignment:Splign:2.1.0"
     exon            268..353
                     /gene="ZNF177"
                     /gene_synonym="PIGX"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..1766
                     /gene="ZNF177"
                     /gene_synonym="PIGX"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 177 isoform a"
                     /protein_id="NP_001166122.1"
                     /db_xref="CCDS:CCDS54214.1"
                     /db_xref="GeneID:7730"
                     /db_xref="HGNC:HGNC:12966"
                     /db_xref="MIM:601276"
                     /translation="MAAGWLTTWSQNSVTFQEVAVDFSQEEWALLDPAQKNLYKDVML
                     ENFRNLASVGYQLCRHSLISKVDQEQLKTDERGILQGDCADWETQLKPKDTIAMQNIP
                     GGKTSNGINTAENQPGEHSLECNHCGKFRKNTRFICTRYCKGEKCYKYIKYSKVFNHP
                     STLRSHVSIHIGEKTLEFTDCRKAFNQESSLRKHLRTPTGQKFQEYEQCDMSFSLHSS
                     CSVREQIPTGEKGDECSDYGKISPLSVHTKTGSVEEGLECNEHEKTFTDPLSLQNCVR
                     THSGEMPYECSDCGKAFIFQSSLKKHMRSHTGEKPYECDHCGKSFSQSSHLNVHKRTH
                     TGEKPYDCKECGKAFTVPSSLQKHVRTHTGEKPYECSDCGKAFIDQSSLKKHTRSHTG
                     EKPYECNQCGKSFSTGSYLIVHKRTHTGEKTYECKECGKAFRNSSCLRVHVRTHTGEK
                     PYKCIQCEKAFSTSTNLIMHKRIHNGQKLHE"
     exon            354..480
                     /gene="ZNF177"
                     /gene_synonym="PIGX"
                     /inference="alignment:Splign:2.1.0"
     exon            481..573
                     /gene="ZNF177"
                     /gene_synonym="PIGX"
                     /inference="alignment:Splign:2.1.0"
     exon            574..656
                     /gene="ZNF177"
                     /gene_synonym="PIGX"
                     /inference="alignment:Splign:2.1.0"
     exon            657..2606
                     /gene="ZNF177"
                     /gene_synonym="PIGX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2156..2161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF177"
                     /gene_synonym="PIGX"
                     /note="hexamer: AATAAA"
     polyA_site      2179
                     /gene="ZNF177"
                     /gene_synonym="PIGX"
                     /note="major polyA site"
     regulatory      2576..2581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF177"
                     /gene_synonym="PIGX"
                     /note="hexamer: AATAAA"
     polyA_site      2606
                     /gene="ZNF177"
                     /gene_synonym="PIGX"
ORIGIN      
        1 gtcgcctcgc catctcccat agctgtcgcc tgcagctgag aaagggttgc tgtcccagca
       61 ggccaggtcc agggctgggt ataagtaagc aagaagaggg cctgggagaa gagtctgacg
      121 agcaagggga aggtagccaa ggatggagtg aaatacagga gatgcggtct tgctgtgttg
      181 cctaggctgg tctcaaactc ctgctctcaa gtgatcctcc tgcctcagcc tcctgagtac
      241 atttatattt aaagtaatta ttgatggctc tgcctgctta ggactctgcc cagccaggaa
      301 ggaaacctac aggaggaaga atggctgcag ggtggctgac aacctggtca cagaactcag
      361 taaccttcca ggaagtggca gtggactttt cccaggagga gtgggcattg ctggaccctg
      421 ctcaaaaaaa tctatacaaa gatgtgatgc tggagaactt taggaacctg gcctcagtag
      481 ggtatcagct ctgcagacac agtctgatct ccaaggtgga tcaagaacag ctgaagacag
      541 atgaaagagg aattttacaa ggtgactgtg cagactggga aactcaactt aaaccaaaag
      601 atacaattgc tatgcagaac attcctgggg gaaaaacatc caatggcata aacacggcag
      661 aaaatcaacc tggtgagcac tccctggagt gtaaccattg tgggaaattc agaaagaaca
      721 ctcgctttat ttgtacaaga tattgcaagg gagagaaatg ctataaatat ataaagtata
      781 gcaaagtctt caaccatccc tcaactctta ggagtcatgt gagcattcac attggagaga
      841 aaactcttga atttactgat tgtagaaaag ctttcaatca agagtcatcc ctcaggaaac
      901 acttaagaac tcccacagga cagaagtttc aggagtatga gcaatgtgat atgtccttca
      961 gcctacactc ttcctgctca gtacgtgagc aaatacctac tggagagaaa ggtgatgaat
     1021 gcagtgacta tggcaaaata tctcccctta gtgtccacac aaaaactggt agtgtggagg
     1081 agggtttgga atgtaatgaa catgagaaaa ctttcactga ccctttgtcc cttcagaact
     1141 gtgtcagaac tcactctgga gagatgccct atgaatgcag tgactgtggg aaagccttca
     1201 tttttcagtc ttcccttaag aaacacatga gatctcatac tggagagaag ccttatgagt
     1261 gtgatcactg tggaaaatcc tttagccaga gctctcatct gaatgtgcac aaaagaactc
     1321 acactggaga gaaaccctat gactgtaagg aatgtgggaa ggctttcact gttccttcat
     1381 cccttcagaa acatgtgaga acccacactg gagagaaacc ctatgaatgc agtgactgtg
     1441 gaaaagcctt catcgatcag tcatccctta agaaacacac acgctctcac actggagaga
     1501 agccttatga gtgtaaccag tgtggaaagt ccttcagcac aggctcttac cttattgtgc
     1561 acaagagaac tcacactggt gagaaaacct atgagtgtaa agaatgtggg aaggccttta
     1621 ggaattcctc ttgcctgagg gtacacgtga gaactcacac tggagagaag ccttataaat
     1681 gtattcagtg tgaaaaagcc tttagcacaa gcactaacct tataatgcac aagcgaatcc
     1741 acaatggcca gaaactccat gaatgaaatg actcagggaa gtgtttgttg cccctcatgc
     1801 ctcctttctc actttagaac atatattgga gagaagccct gttatggtca cctggaaaca
     1861 gccttctggc ccaactctgg atgcctgtta tactgggaca aaccttataa atgttatagc
     1921 tatgattgtt tttatcagtg agtatttcat tcttatatgt gtcacaactg tagatcctat
     1981 gaatatttta gttatctttt cagtttaatt gcattgtgaa cagaacacat ggtcttcaat
     2041 atgtagattc tgtgtgacat agatttgaac ataattgctg gacactgact gatgtactgt
     2101 ggcagacaga actagttgct gtctcaatat ccattcctcc cttctttctt aaagtaataa
     2161 aatttaccat ttagttcaag ctggcaatgt ggacagtttt cacccagctt cccttacagc
     2221 tgtgagcggc caaatatgtt cacatcccta gcccatgcaa agtaggcaga agtcactgga
     2281 tacagctgct aaggaagctc atggaaatgg gaatatctca tctggtgttt ttttcttaac
     2341 tatttgccct ttgtcttgtc ccttatttcc tagaaaatat atacaccaag aggaggacag
     2401 agaaaggata ctaaatgaaa caacagggga gatacaatat tatctggttg cactaatcct
     2461 gtgctgctta tctctggatt tcatgttaca tgagaaaaat taactgccat gtggtttaaa
     2521 ccactcttgt gggaagttcc tctttcagct gatttcagtc ccaactgtta catctaataa
     2581 atggtcaagt tttaggaatc gttcaa
//
