LOCUS       NM_001330617            2714 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 17 (ZNF17), transcript variant 1,
            mRNA.
ACCESSION   NM_001330617 XM_017027205
VERSION     NM_001330617.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2714)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2714)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   3  (bases 1 to 2714)
  AUTHORS   Huebner,K., Druck,T., Croce,C.M. and Thiesen,H.J.
  TITLE     Twenty-seven nonoverlapping zinc finger cDNAs from human T cells
            map to nine different chromosomes with apparent clustering
  JOURNAL   Am J Hum Genet 48 (4), 726-740 (1991)
   PUBMED   2014798
REFERENCE   4  (bases 1 to 2714)
  AUTHORS   Kato,N., Shimotohno,K., VanLeeuwen,D. and Cohen,M.
  TITLE     Human proviral mRNAs down regulated in choriocarcinoma encode a
            zinc finger protein related to Kruppel
  JOURNAL   Mol Cell Biol 10 (8), 4401-4405 (1990)
   PUBMED   2115127
REFERENCE   5  (bases 1 to 2714)
  AUTHORS   Thiesen,H.J.
  TITLE     Multiple genes encoding zinc finger domains are expressed in human
            T cells
  JOURNAL   New Biol 2 (4), 363-374 (1990)
   PUBMED   2288909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC003002.1, AK127948.1 and CK906092.1.
            
            On May 20, 2020 this sequence version replaced NM_001330617.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK127948.1, SRR14038196.3486201.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307658.12/ ENSP00000302455.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AC003002.1         60897-61032
            137-931             AK127948.1         135-929
            932-2489            AC003002.1         69888-71445
            2490-2714           CK906092.1         20-244              c
FEATURES             Location/Qualifiers
     source          1..2714
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..2714
                     /gene="ZNF17"
                     /gene_synonym="HPF3; KOX10"
                     /note="zinc finger protein 17"
                     /db_xref="GeneID:7565"
                     /db_xref="HGNC:HGNC:12958"
                     /db_xref="MIM:619254"
     exon            1..246
                     /gene="ZNF17"
                     /gene_synonym="HPF3; KOX10"
                     /inference="alignment:Splign:2.1.0"
     exon            247..287
                     /gene="ZNF17"
                     /gene_synonym="HPF3; KOX10"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..2261
                     /gene="ZNF17"
                     /gene_synonym="HPF3; KOX10"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 17 (HPF3, KOX 10); zinc finger protein
                     HPF3; zinc finger protein KOX10"
                     /codon_start=1
                     /product="zinc finger protein 17 isoform 1"
                     /protein_id="NP_001317546.1"
                     /db_xref="CCDS:CCDS82405.1"
                     /db_xref="GeneID:7565"
                     /db_xref="HGNC:HGNC:12958"
                     /db_xref="MIM:619254"
                     /translation="MLMDAGQDYMVFEDVAIHFSQEEWGILNDVQRHLHSDVMLENFA
                     LLSSVGCWHGAKDEEAPSKQCVSVGVSQVTTLKPALSTQKAQPCETCSSLLKDILHLA
                     EHDGTHPKRTAKLYLHQKEHLREKLTRSDEGRPSFVNDSVHLAKRNLTCMQGGKDFTG
                     DSDLQQQALHSGWKPHRDTHGVEAFQSGQNNYSCTQCGKDFCHQHTLFEHQKIHTEER
                     PYECSECGKLFRYNSDLIKHQRNHTGERPYKCSECGKAFSLKYNVVQHQKIHTGERPY
                     ECSECGKAFLRKSHLLQHQRIHTRPRPYVCSECGKAFLTQAHLVGHQKIHTGERPYGC
                     NECGKYFMYSSALIRHQKVHTGERPFYCCECGKFFMDSCTLIIHQRVHTGEKPYECNE
                     CGKFFRYRSTLIRHQKVHTGEKPYECSECGKFFMDTSTLIIHQRVHTGEKPYECNKCG
                     KFFRYCFTLNRHQRVHSGERPYECSECGKFFVDSCTLKSHQRVHTGERPFECSICGKS
                     FRCRSTLDTHQRIHTGERPYECSECGKFFRHNSNHIRHRRNHFGERSFECTECGRVFS
                     QNSHLIRHQKVHTRERTYKCSKCGKFFMDSSTLISHERVHTGEKPYECSECGKVFRYN
                     SSLIKHRRIHTGERPYQCSECGRVFNQNSHLIQHQKVHTR"
     exon            288..414
                     /gene="ZNF17"
                     /gene_synonym="HPF3; KOX10"
                     /inference="alignment:Splign:2.1.0"
     exon            415..2714
                     /gene="ZNF17"
                     /gene_synonym="HPF3; KOX10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2567..2572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF17"
                     /gene_synonym="HPF3; KOX10"
                     /note="hexamer: AAGAAA"
     polyA_site      2589
                     /gene="ZNF17"
                     /gene_synonym="HPF3; KOX10"
                     /note="major polyA site"
     regulatory      2684..2689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF17"
                     /gene_synonym="HPF3; KOX10"
                     /note="hexamer: AATAAA"
     polyA_site      2714
                     /gene="ZNF17"
                     /gene_synonym="HPF3; KOX10"
                     /note="major polyA site"
ORIGIN      
        1 gcaacgcctc ctggggttgt caatatggct gcgttgggat ctgttcacct tcaggctgag
       61 tcgagactga ggtgaaaaag cggaaaaacg cgagaaaagg tttccccgtt gtacagaggc
      121 tagagtgagg ctcggttgaa tcggttgcag gcgttggtgc ctctgtcagc gtccaggtca
      181 ctgccgctcc cgccccgctc ttccctggct gtgctggcgg aggctgcgcc gatgaacctg
      241 actgagggtt catagcagtg gcagcaatgc ttatggatgc tggacaggat tatatggttt
      301 ttgaggacgt ggccatacat ttctcccagg aggagtgggg aattcttaat gacgttcaga
      361 gacacctgca cagcgatgtg atgctggaga actttgcact tttgtcctca gtaggttgtt
      421 ggcatggagc caaggatgag gaggcacctt ccaagcaatg tgtttctgta ggagtgtcac
      481 aggtcacaac tttaaagcca gctttgtcca cccagaaggc ccagccctgt gagacatgta
      541 gctcacttct gaaggacatt ctacacctgg ctgagcatga cggaacacac cccaagcgta
      601 cagccaagct ttacctgcac caaaaggagc atcttagaga gaagctcacc agaagtgatg
      661 aagggaggcc ttcgtttgtg aatgacagtg ttcacctggc aaagaggaac ctcacatgca
      721 tgcagggtgg caaggatttt actggtgatt cagatcttca acaacaggct cttcacagtg
      781 ggtggaagcc acacagggac actcatggtg tggaggcctt tcaaagtgga cagaataatt
      841 acagctgcac ccaatgtggg aaagactttt gccaccaaca tacactgttt gagcaccaga
      901 aaatccacac agaggaaagg ccttatgagt gcagtgaatg tggcaaattg tttaggtaca
      961 actccgacct tattaaacat cagcgaaatc atactggaga aaggccttat aagtgtagtg
     1021 aatgtggaaa agccttcagc ctcaaataca atgttgttca acaccagaaa attcacactg
     1081 gagaaaggcc ttatgagtgc agtgaatgtg ggaaagcttt tcttagaaag tctcacctac
     1141 ttcagcacca gaggattcac accaggccaa ggccttatgt gtgtagtgaa tgtgggaagg
     1201 ccttccttac acaggctcac cttgttggtc accagaaaat tcatactgga gaacggcctt
     1261 atggatgcaa tgaatgtggg aaatacttta tgtacagttc agcactcatt agacatcaga
     1321 aagttcacac tggagaaagg cctttttatt gctgtgaatg tgggaaattc tttatggaca
     1381 gctgcacact cattattcac cagagagttc atactggaga aaaaccttat gaatgcaacg
     1441 aatgtgggaa attctttaga taccgttcca cactcattag acatcagaaa gttcacactg
     1501 gagaaaagcc ttatgagtgt agtgaatgtg ggaagttctt tatggacact tccacactca
     1561 ttattcatca gagagttcat actggagaaa agccttatga atgcaacaaa tgtgggaaat
     1621 tctttaggta ttgcttcaca ctgaatagac atcagagagt tcactctgga gagaggcctt
     1681 atgaatgcag tgaatgtggc aaattctttg tggacagctg tacactgaag agtcatcaga
     1741 gagttcacac tggagaaaga ccttttgaat gcagcatttg tgggaaatcc tttagatgtc
     1801 gctccacact tgatacacat cagagaattc acactggtga aaggccttat gagtgtagtg
     1861 aatgtgggaa attctttagg cacaactcaa atcatattag acatcggaga aatcactttg
     1921 gagaaaggtc ttttgagtgc actgagtgtg ggagagtttt tagccaaaat tcccacctca
     1981 ttcggcacca aaaagttcac actagggaaa gaacttacaa atgcagcaaa tgtgggaaat
     2041 tttttatgga cagctccaca ctcattagtc atgagagagt tcatactgga gaaaagcctt
     2101 atgagtgcag tgaatgtggg aaagtcttta gatacaactc cagcctcatt aaacatcgga
     2161 gaattcacac tggagagaga ccttatcagt gcagtgaatg tggaagagtc tttaaccaaa
     2221 attctcatct cattcagcac cagaaagttc acaccagata aagaatgtat atataaagca
     2281 gatggggaaa gacttcacac agaaatctac tctgatttag cactgggacc tacgttttaa
     2341 aaaaagtatt cttgtagaat acagataaca taaaatctaa catcttaacc atgttaaagt
     2401 gtatagttca gtactgttaa gtcattcaca ttgtgcaatg aatatctaga agtcttttca
     2461 acttatgaaa ctaagtctat accttttaaa accttattcc tcactccatc cagcctcttg
     2521 acaagcaccg ctctgtatga attttactag tccgggtacc tcatataaga aaacttaagt
     2581 tttggtcttc ttgtggttta ttttgtggct tattttgctt aacgttatat ttttaaggtt
     2641 tcatgttcta atccattaga atttccatcc tttttaaagg ctgaataaaa ttctgttagt
     2701 catgtgttgc ttaa
//
