LOCUS       NM_194320               2374 bp    mRNA    linear   PRI 07-MAY-2024
DEFINITION  Homo sapiens zinc finger protein 169 (ZNF169), transcript variant
            2, mRNA.
ACCESSION   NM_194320 XM_095971
VERSION     NM_194320.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2374)
  AUTHORS   Zhang,J., Wang,Y., Hou,S., Chi,X., Ding,D., Xue,M., Zhang,M.,
            Wang,J., Shuai,J., Sun,H., Gao,Q. and Kang,C.
  TITLE     Overexpression of ZNF169 promotes the growth and proliferation of
            colorectal cancer cells via the upregulation of ANKZF1
  JOURNAL   Oncol Rep 51 (6) (2024)
   PUBMED   38666541
  REMARK    GeneRIF: Overexpression of ZNF169 promotes the growth and
            proliferation of colorectal cancer cells via the upregulation of
            ANKZF1.
REFERENCE   2  (bases 1 to 2374)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2374)
  AUTHORS   Okada,Y., Kubo,M., Ohmiya,H., Takahashi,A., Kumasaka,N., Hosono,N.,
            Maeda,S., Wen,W., Dorajoo,R., Go,M.J., Zheng,W., Kato,N., Wu,J.Y.,
            Lu,Q., Tsunoda,T., Yamamoto,K., Nakamura,Y., Kamatani,N. and
            Tanaka,T.
  CONSRTM   GIANT consortium
  TITLE     Common variants at CDKAL1 and KLF9 are associated with body mass
            index in east Asian populations
  JOURNAL   Nat Genet 44 (3), 302-306 (2012)
   PUBMED   22344221
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2374)
  AUTHORS   Tsuritani,K., Irie,T., Yamashita,R., Sakakibara,Y., Wakaguri,H.,
            Kanai,A., Mizushima-Sugano,J., Sugano,S., Nakai,K. and Suzuki,Y.
  TITLE     Distinct class of putative 'non-conserved' promoters in humans:
            comparative studies of alternative promoters of human and mouse
            genes
  JOURNAL   Genome Res 17 (7), 1005-1014 (2007)
   PUBMED   17567985
REFERENCE   5  (bases 1 to 2374)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   6  (bases 1 to 2374)
  AUTHORS   Blair,I.P., Hulme,D., Dawkins,J.L. and Nicholson,G.A.
  TITLE     A YAC-based transcript map of human chromosome 9q22.1-q22.3
            encompassing the loci for hereditary sensory neuropathy type I and
            multiple self-healing squamous epithelioma
  JOURNAL   Genomics 51 (2), 277-281 (1998)
   PUBMED   9722951
REFERENCE   7  (bases 1 to 2374)
  AUTHORS   Chidambaram,A., Gailani,M., Gerrard,B., Stewart,C., Goldstein,A.,
            Chumakov,I., Bale,A.E. and Dean,M.
  TITLE     Characterization of a YAC contig containing the NBCCS locus and a
            novel Kruppel-type zinc finger sequence on chromosome segment
            9q22.3
  JOURNAL   Genes Chromosomes Cancer 18 (3), 212-218 (1997)
   PUBMED   9071574
REFERENCE   8  (bases 1 to 2374)
  AUTHORS   Levanat,S., Chidambaram,A., Wicking,C., Bray-Ward,P., Pressman,C.,
            Toftgard,R., Gailani,M.R., Myers,J.C., Wainwright,B., Dean,M. and
            Bale,A.E.
  TITLE     Pulsed-field gel electrophoresis and FISH mapping of chromosome
            9q22: placement of a novel zinc finger gene within the NBCCS and
            ESS1 region
  JOURNAL   Cytogenet Cell Genet 76 (3-4), 208-213 (1997)
   PUBMED   9186526
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY115642.1, BC047702.2 and AL691447.18.
            
            On May 17, 2019 this sequence version replaced NM_194320.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site compared to variant 1. The encoded isoform (2) is
            shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289742.1, SRR1803614.273146.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395395.7/ ENSP00000378792.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                HY115642.1         33-80
            49-1987             BC047702.2         5-1943
            1988-2374           AL691447.18        52239-52625
FEATURES             Location/Qualifiers
     source          1..2374
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.32"
     gene            1..2374
                     /gene="ZNF169"
                     /note="zinc finger protein 169"
                     /db_xref="GeneID:169841"
                     /db_xref="HGNC:HGNC:12957"
                     /db_xref="MIM:603404"
     exon            1..48
                     /gene="ZNF169"
                     /inference="alignment:Splign:2.1.0"
     exon            49..136
                     /gene="ZNF169"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1915
                     /gene="ZNF169"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zinc finger protein 169 isoform 2"
                     /protein_id="NP_919301.2"
                     /db_xref="CCDS:CCDS6709.2"
                     /db_xref="GeneID:169841"
                     /db_xref="HGNC:HGNC:12957"
                     /db_xref="MIM:603404"
                     /translation="MSPGLLTTRKEALMAFRDVAVAFTQKEWKLLSSAQRTLYREVML
                     ENYSHLVSLGIAFSKPKLIEQLEQGDEPWREENEHLLDLCPEPRTEFQPSFPHLVAFS
                     SSQLLRQYALSGHPTQIFPSSSAGGDFQLEAPRCSSEKGESGETEGPDSSLRKRPSRI
                     SRTFFSPHQGDPVEWVEGNREGGTDLRLAQRMSLGGSDTMLKGADTSESGAVIRGNYR
                     LGLSKKSSLFSHQKHHVCPECGRGFCQRSDLIKHQRTHTGEKPYLCPECGRRFSQKAS
                     LSIHQRKHSGEKPYVCRECGRHFRYTSSLTNHKRIHSGERPFVCQECGRGFRQKIALL
                     LHQRTHLEEKPFVCPECGRGFCQKASLLQHQSSHTGERPFLCLECGRSFRQQSLLLSH
                     QVTHSGEKPYVCAECGHSFRQKVTLIRHQRTHTGEKPYLCPQCGRGFSQKVTLIGHQR
                     THTGEKPYLCPDCGRGFGQKVTLIRHQRTHTGEKPYLCPKCGRAFGFKSLLTRHQRTH
                     SEEELYVDRVCGQGLGQKSHLISDQRTHSGEKPCICDECGRGFGFKSALIRHQRTHSG
                     EKPYVCRECGRGFSQKSHLHRHRRTKSGHQLLPQEVF"
     exon            137..263
                     /gene="ZNF169"
                     /inference="alignment:Splign:2.1.0"
     exon            264..359
                     /gene="ZNF169"
                     /inference="alignment:Splign:2.1.0"
     exon            360..2374
                     /gene="ZNF169"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccggctc gcgtacttcc gcgttccggc atcgtcgcct ggtgcgtgat ttgcctctgc
       61 aacttgactc tcctctagga agagtactcc agagagcagg gatatgtcac caggactcct
      121 gacaaccagg aaggaggcat tgatggcctt ccgggatgtg gctgtggcct tcacccagaa
      181 ggagtggaag ctattgagtt ctgctcagag gaccctgtac agggaggtga tgctggagaa
      241 ctacagccat ctggtctccc tgggaattgc attttccaaa ccaaaactca tcgaacagct
      301 ggagcaaggc gacgaacctt ggagagagga gaacgaacat cttctggacc tttgtccaga
      361 gcctagaaca gaattccagc caagttttcc ccacctggtg gccttttcta gctcgcagct
      421 cctcagacaa tatgcgctaa gtggccatcc cacacagatc ttcccaagct catctgcagg
      481 aggtgacttc caactagaag ctccaagatg ctctagtgaa aaaggagaaa gtggagagac
      541 agaaggcccc gacagctcat taagaaagag gccaagcaga atttctagga cattcttcag
      601 cccacatcaa ggtgacccag tagaatgggt agaagggaac agagaaggag gaacagacct
      661 tcgcctggcc caaaggatga gtcttggggg gtcagacaca atgttgaagg gagcagacac
      721 ttcagaatct ggagcagtca tacgtggaaa ctatagactg ggacttagca aaaagtcaag
      781 cctgttcagc caccagaagc atcatgtgtg ccctgaatgc gggagaggct tttgccagag
      841 atcagacctt atcaagcacc agaggacaca caccggggag aagccatacc tgtgtcctga
      901 gtgtgggcgt cggtttagcc agaaggcctc cctctccata caccagagga agcactcggg
      961 ggagaagccg tatgtgtgca gggaatgtgg gcgacacttc aggtatacat cctctctcac
     1021 taatcacaag aggattcact ccggggagag gccctttgta tgtcaggagt gtgggcgagg
     1081 ctttcgccag aagatagccc tccttctaca ccagaggacg cacttggagg agaagccctt
     1141 cgtgtgtcct gagtgtggga gaggcttttg ccagaaggca tcactcctcc agcaccagag
     1201 ctcacacaca ggggagaggc ccttcctgtg ccttgagtgt gggcgtagct tcaggcagca
     1261 gtcactcctc cttagtcacc aggtcacaca ctcaggagag aagccttatg tctgtgctga
     1321 gtgtgggcac agctttcgcc aaaaggtcac tctcatcagg caccagagga cacacacagg
     1381 ggagaagcct tacctgtgcc cccagtgtgg gcggggtttt agccagaagg tcaccctcat
     1441 tggacaccag aggacacaca caggggagaa gccctacctg tgccctgatt gtgggcgtgg
     1501 ctttggtcag aaggtcaccc tcatcagaca ccagaggaca cacacagggg agaagcctta
     1561 tctgtgcccc aagtgtgggc gtgcatttgg ctttaagtcg ctcctcaccc gacaccagag
     1621 gacacactca gaggaggagc tttacgtaga cagggtgtgt ggacaaggac ttggccagaa
     1681 gtcacacctt atctctgacc aaaggacaca ctcaggagag aagccctgca tttgcgatga
     1741 atgtgggcgc ggctttggct ttaagtctgc cctcatccga catcagcgga cccattctgg
     1801 ggagaagccg tatgtctgca gggagtgtgg gcgtggcttt agccagaagt ctcacttgca
     1861 tagacacagg aggaccaagt ctggtcatca gctcctaccc caagaggtct tctgaccttt
     1921 cctttccccg tgagtgtgaa gctggcagaa atcactagta aatgcttcag tttcctgaaa
     1981 tggaatggaa aaaaaaaaat gttgctttct ttcatcgatc atgagatagt tgatttttgg
     2041 tttactttct atattcacaa tttgtcttgg cttgctaggg gttccataac aaagtacccc
     2101 aggctgggtg attttgacaa cggaaatata ttttcatatt tatggaggct ggaagtccca
     2161 gatgaacgta ttggtaggtt tggctgctgc ttaagcctct ctgtttggct tgcggatggc
     2221 tgctttctgg ccacgtcctc acgtgggctt ttttctgtgt gtatgctttc ctggtgtggc
     2281 ttcctcctct tctagggaca ccagtcattt tggatagagc cacagccaca tggcctcgtt
     2341 taaccttaat aaccttccta aaggccttat ctct
//
