LOCUS       NM_001376491            1954 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 165 (ZNF165), transcript variant
            2, mRNA.
ACCESSION   NM_001376491 XM_017011258
VERSION     NM_001376491.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1954)
  AUTHORS   Liu,P., Zhou,Y., Dong,X., Zheng,B., Liang,B., Liang,R., Liu,Z.,
            Li,L. and Gong,P.
  TITLE     ZNF165 Is Involved in the Regulation of Immune Microenvironment and
            Promoting the Proliferation and Migration of Hepatocellular
            Carcinoma by AhR/CYP1A1
  JOURNAL   J Immunol Res 2022, 4446805 (2022)
   PUBMED   35692498
  REMARK    GeneRIF: ZNF165 Is Involved in the Regulation of Immune
            Microenvironment and Promoting the Proliferation and Migration of
            Hepatocellular Carcinoma by AhR/CYP1A1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1954)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1954)
  AUTHORS   Gibbs,Z.A., Reza,L.C., Cheng,C.C., Westcott,J.M., McGlynn,K. and
            Whitehurst,A.W.
  TITLE     The testis protein ZNF165 is a SMAD3 cofactor that coordinates
            oncogenic TGFbeta signaling in triple-negative breast cancer
  JOURNAL   Elife 9, e57679 (2020)
   PUBMED   32515734
  REMARK    GeneRIF: The testis protein ZNF165 is a SMAD3 cofactor that
            coordinates oncogenic TGFbeta signaling in triple-negative breast
            cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1954)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1954)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1954)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   7  (bases 1 to 1954)
  AUTHORS   Paoloni-Giacobino,A., Kern,I., Rumpler,Y., Djlelati,R., Morris,M.A.
            and Dahoun,S.P.
  TITLE     Familial t(6;21)(p21.1;p13) translocation associated with male-only
            sterility
  JOURNAL   Clin Genet 58 (4), 324-328 (2000)
   PUBMED   11076058
REFERENCE   8  (bases 1 to 1954)
  AUTHORS   Lee,P.L., Gelbart,T., West,C., Adams,M., Blackstone,R. and
            Beutler,E.
  TITLE     Three genes encoding zinc finger proteins on human chromosome
            6p21.3: members of a new subclass of the Kruppel gene family
            containing the conserved SCAN box domain
  JOURNAL   Genomics 43 (2), 191-201 (1997)
   PUBMED   9244436
REFERENCE   9  (bases 1 to 1954)
  AUTHORS   Tirosvoutis,K.N., Divane,A., Jones,M. and Affara,N.A.
  TITLE     Characterization of a novel zinc finger gene (ZNF165) mapping to
            6p21 that is expressed specifically in testis
  JOURNAL   Genomics 28 (3), 485-490 (1995)
   PUBMED   7490084
REFERENCE   10 (bases 1 to 1954)
  AUTHORS   Beutler,E., Gelbart,T., West,C., Kuhl,W. and Lee,P.
  TITLE     A strategy for cloning the hereditary hemochromatosis gene
  JOURNAL   Blood Cells Mol Dis 21 (3), 207-216 (1995)
   PUBMED   8673473
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121944.14.
            
            On Nov 15, 2019 this sequence version replaced XM_017011258.1.
            
            Summary: This gene encodes a member of the Kruppel family of zinc
            finger proteins. Members of this DNA-binding protein family act as
            transcriptional regulators. This gene is located within a cluster
            of zinc finger family members. The encoded protein may play a role
            in spermatogenesis. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1-4 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.380755.1,
                                           SRR5189658.221240.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683778.1/ ENSP00000507525.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-403               AL121944.14        99347-99749
            404-814             AL121944.14        104260-104670
            815-953             AL121944.14        104951-105089
            954-1954            AL121944.14        107342-108342
FEATURES             Location/Qualifiers
     source          1..1954
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..1954
                     /gene="ZNF165"
                     /gene_synonym="CT53; LD65; ZSCAN7"
                     /note="zinc finger protein 165"
                     /db_xref="GeneID:7718"
                     /db_xref="HGNC:HGNC:12953"
                     /db_xref="MIM:600834"
     exon            1..403
                     /gene="ZNF165"
                     /gene_synonym="CT53; LD65; ZSCAN7"
                     /inference="alignment:Splign:2.1.0"
     CDS             404..1861
                     /gene="ZNF165"
                     /gene_synonym="CT53; LD65; ZSCAN7"
                     /note="isoform a is encoded by transcript variant 2;
                     cancer/testis antigen 53; zinc finger and SCAN
                     domain-containing protein 7"
                     /codon_start=1
                     /product="zinc finger protein 165 isoform a"
                     /protein_id="NP_001363420.1"
                     /db_xref="CCDS:CCDS4643.1"
                     /db_xref="GeneID:7718"
                     /db_xref="HGNC:HGNC:12953"
                     /db_xref="MIM:600834"
                     /translation="MATEPKKAAAQNSPEDEGLLIVKIEEEEFIHGQDTCLQRSELLK
                     QELCRQLFRQFCYQDSPGPREALSRLRELCCQWLKPEIHTKEQILELLVLEQFLTILP
                     GDLQAWVHEHYPESGEEAVTILEDLERGTDEAVLQVQAHEHGQEIFQKKVSPPGPALN
                     VKLQPVETKAHFDSSEPQLLWDCDNESENSRSMPKLEIFEKIESQRIISGRISGYISE
                     ASGESQDICKSAGRVKRQWEKESGESQRLSSAQDEGFGKILTHKNTVRGEIISHDGCE
                     RRLNLNSNEFTHQKSCKHGTCDQSFKWNSDFINHQIIYAGEKNHQYGKSFKSPKLAKH
                     AAVFSGDKTHQCNECGKAFRHSSKLARHQRIHTGERCYECNECGKSFAESSDLTRHRR
                     IHTGERPFGCKECGRAFNLNSHLIRHQRIHTREKPYECSECGKTFRVSSHLIRHFRIH
                     TGEKPYECSECGRAFSQSSNLSQHQRIHMRENLLM"
     exon            404..814
                     /gene="ZNF165"
                     /gene_synonym="CT53; LD65; ZSCAN7"
                     /inference="alignment:Splign:2.1.0"
     exon            815..953
                     /gene="ZNF165"
                     /gene_synonym="CT53; LD65; ZSCAN7"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1954
                     /gene="ZNF165"
                     /gene_synonym="CT53; LD65; ZSCAN7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1917..1922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF165"
                     /gene_synonym="CT53; LD65; ZSCAN7"
                     /note="hexamer: AATAAA"
     regulatory      1924..1929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF165"
                     /gene_synonym="CT53; LD65; ZSCAN7"
                     /note="hexamer: AATAAA"
     polyA_site      1941
                     /gene="ZNF165"
                     /gene_synonym="CT53; LD65; ZSCAN7"
                     /note="major polyA site"
     polyA_site      1954
                     /gene="ZNF165"
                     /gene_synonym="CT53; LD65; ZSCAN7"
                     /note="major polyA site"
ORIGIN      
        1 tatttttagt agacacaggg tgtcaccgcg taaaccagga tagtctcgat ctcctgacct
       61 cgtgatccgc ccgtctcggc ctcccaaagt gctgggactg caggcgtgag ccaccgcgcc
      121 cggccaacgt cattttcttt tcaggagtcc cttctgttat ttagcaagac acactactac
      181 aatggagaaa aaagatgccc cctccttcaa gccctgagat cttcaggact ttggcgaaaa
      241 gtctgcgccc gaagagaccc aggaaggatt cttggaattg tagtccaaag gcatcccgcc
      301 ttctgcgcag actcacaagt ccctgtggac ggaattcttg aagtgtagcg ccgctcagtc
      361 cttccaccgg aagtgtccga tcggaatcag ccctgtccga gagatggcta cagaaccaaa
      421 gaaagctgca gcccagaact ctccagagga tgaaggactt ctgatagtga agatagaaga
      481 ggaagaattt atccatgggc aggacacttg cttacagaga agtgaactcc ttaagcagga
      541 gctctgcagg cagcttttta ggcagttctg ctaccaggat tctcctggac ctcgcgaggc
      601 actgagccgc ctccgggagc tctgctgtca gtggctgaag ccagagatcc ataccaagga
      661 acagattctg gaactgctgg tgctagagca gttcctgacc atcctgccag gagatttgca
      721 ggcctgggta catgaacatt acccagagag tggagaggag gcagtgacca tactagaaga
      781 tttggagaga ggcactgatg aagcagtact ccaggttcaa gcccatgaac atggacaaga
      841 aatattccag aaaaaagtgt cacctcctgg accagcactt aatgtcaagt tacagccagt
      901 ggagaccaag gcccattttg attcatcaga accccagctc ctatgggact gtgataatga
      961 gagtgaaaac agtagatcca tgccaaagct ggaaattttt gaaaaaattg aatcacagag
     1021 aattatatct ggaagaatct caggatacat atcagaagca tctggtgagt ctcaagacat
     1081 ctgtaagtct gcaggcaggg taaagagaca atgggaaaaa gaatcagggg agtctcagag
     1141 actctcgtct gcccaggatg aaggttttgg taaaatcctc acccacaaaa atacagtcag
     1201 aggtgaaata ataagccacg atggatgtga gaggagatta aatctgaact caaatgaatt
     1261 cacacaccag aaatcttgta aacatggtac ctgtgaccag agcttcaaat ggaactcaga
     1321 ttttattaac catcaaataa tttatgctgg agaaaaaaat caccaatatg gaaaatcttt
     1381 caagagccca aaacttgcta aacatgcagc agttttcagt ggagataaaa ctcatcagtg
     1441 taatgaatgt gggaaagctt tcaggcacag ctcaaaactt gctaggcatc agagaatcca
     1501 cactggagag agatgctatg aatgtaatga atgtgggaaa agctttgcag agagctcaga
     1561 tcttactaga catcggcgaa ttcacactgg ggaaagaccc tttggttgca aagaatgtgg
     1621 gagagcattc aacctgaact cacatcttat caggcatcag agaattcaca ccagagagaa
     1681 accctacgag tgtagtgaat gtgggaaaac cttccgagtg agctcacatc ttattcgaca
     1741 ctttagaatt cacactggag aaaaacccta tgaatgcagt gagtgtggaa gagccttcag
     1801 tcagagctca aaccttagtc aacaccagag aattcacatg agggaaaacc tattaatgta
     1861 aggaacttaa atttgtaagt aaatgctgag gaaatggcac aatatgaaaa atattaaata
     1921 aaaaataaat attgggcaag atggaagact gaaa
//
