LOCUS       NM_001322131            4431 bp    mRNA    linear   PRI 16-FEB-2024
DEFINITION  Homo sapiens zinc finger protein 160 (ZNF160), transcript variant
            7, mRNA.
ACCESSION   NM_001322131
VERSION     NM_001322131.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4431)
  AUTHORS   Takahashi,K., Sugi,Y., Hosono,A. and Kaminogawa,S.
  TITLE     Epigenetic regulation of TLR4 gene expression in intestinal
            epithelial cells for the maintenance of intestinal homeostasis
  JOURNAL   J Immunol 183 (10), 6522-6529 (2009)
   PUBMED   19846881
  REMARK    GeneRIF: TLR4 gene transcription was repressed by epigenetic
            regulations, which were, at least in part, dependent on ZNF160.
REFERENCE   2  (bases 1 to 4431)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   3  (bases 1 to 4431)
  AUTHORS   Mark,C., Looman,C., Abrink,M. and Hellman,L.
  TITLE     Molecular cloning and preliminary functional analysis of two novel
            human KRAB zinc finger proteins, HKr18 and HKr19
  JOURNAL   DNA Cell Biol 20 (5), 275-286 (2001)
   PUBMED   11410164
REFERENCE   4  (bases 1 to 4431)
  AUTHORS   Hattori,A., Okumura,K., Nagase,T., Kikuno,R., Hirosawa,M. and
            Ohara,O.
  TITLE     Characterization of long cDNA clones from human adult spleen
  JOURNAL   DNA Res 7 (6), 357-366 (2000)
   PUBMED   11214971
REFERENCE   5  (bases 1 to 4431)
  AUTHORS   Abrink,M., Aveskogh,M. and Hellman,L.
  TITLE     Isolation of cDNA clones for 42 different Kruppel-related zinc
            finger proteins expressed in the human monoblast cell line U-937
  JOURNAL   DNA Cell Biol 14 (2), 125-136 (1995)
   PUBMED   7865130
REFERENCE   6  (bases 1 to 4431)
  AUTHORS   Halford,S., Mattei,M.G., Daw,S. and Scambler,P.J.
  TITLE     A novel C2H2 zinc-finger protein gene (ZNF160) maps to human
            chromosome 19q13.3-q13.4
  JOURNAL   Genomics 25 (1), 322-323 (1995)
   PUBMED   7774943
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010328.4.
            
            On Aug 13, 2020 this sequence version replaced NM_001322131.1.
            
            Summary: The protein encoded by this gene is a Kruppel-related zinc
            finger protein which is characterized by the presence of an
            N-terminal repressor domain, the Kruppel-associated box (KRAB). The
            KRAB domain is a potent repressor of transcription; thus this
            protein may function in transcription regulation. Multiple
            transcript variants have been found for this gene. [provided by
            RefSeq, Apr 2016].
            
            Transcript Variant: This variant (7), as well as variants 1-6 and
            8-12, encodes isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.85296.1,
                                           SRR11853560.15217.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144, SAMEA2467148
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683776.1/ ENSP00000507845.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AC010328.4         42779-42936
            159-466             AC010328.4         54481-54788
            467-526             AC010328.4         59880-59939
            527-653             AC010328.4         71018-71144
            654-782             AC010328.4         71933-72061
            783-4431            AC010328.4         75939-79587
FEATURES             Location/Qualifiers
     source          1..4431
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41-q13.42"
     gene            1..4431
                     /gene="ZNF160"
                     /gene_synonym="F11; HKr18; HZF5; KR18"
                     /note="zinc finger protein 160"
                     /db_xref="GeneID:90338"
                     /db_xref="HGNC:HGNC:12948"
                     /db_xref="MIM:600398"
     exon            1..158
                     /gene="ZNF160"
                     /gene_synonym="F11; HKr18; HZF5; KR18"
                     /inference="alignment:Splign:2.1.0"
     exon            159..466
                     /gene="ZNF160"
                     /gene_synonym="F11; HKr18; HZF5; KR18"
                     /inference="alignment:Splign:2.1.0"
     exon            467..526
                     /gene="ZNF160"
                     /gene_synonym="F11; HKr18; HZF5; KR18"
                     /inference="alignment:Splign:2.1.0"
     CDS             512..2968
                     /gene="ZNF160"
                     /gene_synonym="F11; HKr18; HZF5; KR18"
                     /note="isoform a is encoded by transcript variant 7; KRAB
                     zinc finger protein KR18; zinc finger protein 5; zinc
                     finger protein Kr18; zinc finger protein HZF5"
                     /codon_start=1
                     /product="zinc finger protein 160 isoform a"
                     /protein_id="NP_001309060.1"
                     /db_xref="CCDS:CCDS12859.1"
                     /db_xref="GeneID:90338"
                     /db_xref="HGNC:HGNC:12948"
                     /db_xref="MIM:600398"
                     /translation="MALTQVRLTFRDVAIEFSQEEWKCLDPAQRILYRDVMLENYWNL
                     VSLGLCHFDMNIISMLEEGKEPWTVKSCVKIARKPRTPECVKGVVTDIPPKCTIKDLL
                     PKEKSSTEAVFHTVVLERHESPDIEDFSFKEPQKNVHDFECQWRDDTGNYKGVLMAQK
                     EGKRDQRDRRDIENKLMNNQLGVSFHSHLPELQLFQGEGKMYECNQVEKSTNNGSSVS
                     PLQQIPSSVQTHRSKKYHELNHFSLLTQRRKANSCGKPYKCNECGKAFTQNSNLTSHR
                     RIHSGEKPYKCSECGKTFTVRSNLTIHQVIHTGEKPYKCHECGKVFRHNSYLATHRRI
                     HTGEKPYKCNECGKAFRGHSNLTTHQLIHTGEKPFKCNECGKLFTQNSHLISHWRIHT
                     GEKPYKCNECGKAFSVRSSLAIHQTIHTGEKPYKCNECGKVFRYNSYLGRHRRVHTGE
                     KPYKCNECGKAFSMHSNLATHQVIHTGTKPFKCNECSKVFTQNSQLANHRRIHTGEKP
                     YKCNECGKAFSVRSSLTTHQAIHSGEKPYKCIECGKSFTQKSHLRSHRGIHSGEKPYK
                     CNECGKVFAQTSQLARHWRVHTGEKPYKCNDCGRAFSDRSSLTFHQAIHTGEKPYKCH
                     ECGKVFRHNSYLATHRRIHTGEKPYKCNECGKAFSMHSNLTTHKVIHTGEKPYKCNQC
                     GKVFTQNSHLANHQRTHTGEKPYRCNECGKAFSVRSSLTTHQAIHTGKKPYKCNECGK
                     VFTQNAHLANHRRIHTGEKPYRCTECGKAFRVRSSLTTHMAIHTGEKRYKCNECGKVF
                     RQSSNLASHHRMHTGEKPYK"
     exon            527..653
                     /gene="ZNF160"
                     /gene_synonym="F11; HKr18; HZF5; KR18"
                     /inference="alignment:Splign:2.1.0"
     exon            654..782
                     /gene="ZNF160"
                     /gene_synonym="F11; HKr18; HZF5; KR18"
                     /inference="alignment:Splign:2.1.0"
     exon            783..4431
                     /gene="ZNF160"
                     /gene_synonym="F11; HKr18; HZF5; KR18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4407..4412
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF160"
                     /gene_synonym="F11; HKr18; HZF5; KR18"
                     /note="hexamer: AATAAA"
     polyA_site      4431
                     /gene="ZNF160"
                     /gene_synonym="F11; HKr18; HZF5; KR18"
                     /note="major polyA site"
ORIGIN      
        1 agacccggaa gtggatcgtg cggagcaagc atcacaccat ggcgtatgag tgttcctctg
       61 tgtagactca acctgcgcct cgccgtcccc cattcgcaca cccgatgccc gggggtcgct
      121 acggacttaa aatctccgca ccgcaccctc cacctcagaa acgttcctgg atccgaacac
      181 tgccccctga cgacctagag agatcccggc tcccagccca ctgagtggct tcagcctcgc
      241 tggtaggtct ctcctccaaa gctctggaaa cagactcctg ggagtgagag ggaggggagc
      301 gcaggcaccg ccccctttcc ccaagtcccc cgcccacttc atccctcagg cacctcccaa
      361 ctcctggcct ctctgcacga ggcgcctgcc ccgggccccg cctacagggg acccagctct
      421 tcttgcagcc actggaagct gatcacctgg agtgaagacc tcacacgaag aagtctggaa
      481 gaagaggaag aggaaagaaa aggagtcagg gatggccctt actcaggtac ggttgacatt
      541 tagggatgtg gccatagaat tctctcagga ggagtggaaa tgcctggacc ctgctcagag
      601 gatcttatac agggacgtga tgttggagaa ctactggaac cttgtttctc tgggactgtg
      661 tcattttgat atgaatatta tctccatgtt ggaggaaggg aaagagccct ggactgtgaa
      721 gagctgtgtg aaaatagcaa gaaaaccaag aacgccggaa tgtgtcaaag gcgtggtcac
      781 agatatccct cctaaatgta caatcaagga tttgctacca aaagagaaga gcagtacaga
      841 agcagtattc cacacagtgg tgttggaaag acacgaaagc cctgacattg aagacttttc
      901 cttcaaggaa ccccagaaaa atgtgcatga ttttgagtgt caatggagag atgacacagg
      961 aaattacaag ggagtgctta tggcccagaa agaaggtaaa agagatcaac gcgacagaag
     1021 agacatagaa aacaagctta tgaacaatca gcttggagta agctttcatt ctcatctgcc
     1081 tgaactgcag ctatttcaag gtgaggggaa aatgtatgaa tgtaatcaag ttgagaagtc
     1141 taccaacaat ggttcctcag tgtcaccact tcaacaaatt ccttctagtg tccaaaccca
     1201 caggtctaaa aaatatcatg aacttaacca tttttcatta ctcacacaaa gacgaaaagc
     1261 aaacagttgt ggaaaacctt ataaatgtaa tgaatgtggc aaggcgttca ctcagaattc
     1321 gaaccttaca agtcatagga gaattcatag tggagagaag ccttacaaat gcagtgagtg
     1381 cggcaaaacc tttactgttc gttcaaatct aactattcat caggtcatcc atactggaga
     1441 aaaaccttac aaatgtcatg agtgtggcaa ggtcttcagg cacaattcat accttgcaac
     1501 tcatcggcga attcatactg gagagaaacc ttacaagtgt aatgagtgtg gaaaagcctt
     1561 tagaggacat tcaaacctaa ctacccatca gttaattcat actggagaaa aaccgttcaa
     1621 atgtaatgaa tgtggcaagc tcttcactca aaattcacac cttataagtc attggagaat
     1681 tcacactgga gagaaacctt acaagtgcaa tgagtgcggc aaagccttta gtgttcgttc
     1741 aagcctagca atccatcaga caatccacac tggagaaaaa ccttacaaat gtaatgaatg
     1801 tggcaaagtc tttaggtaca attcatacct cggaaggcat cggagagttc atactggtga
     1861 gaaaccttac aagtgtaatg aatgtggcaa agccttcagt atgcattcaa acctagctac
     1921 ccatcaggtc atccatactg gaacaaaacc tttcaaatgc aatgaatgca gcaaggtttt
     1981 cactcaaaat tcacaacttg caaatcatcg aagaattcat actggagaga aaccttacaa
     2041 gtgtaatgag tgtgggaaag ccttcagtgt tcgttcaagt ctgactaccc atcaggcaat
     2101 ccattctgga gagaaacctt acaaatgtat tgaatgtggc aagagcttca ctcaaaaatc
     2161 acaccttaga agtcatcggg gaattcattc tggagagaaa ccttacaagt gtaatgaatg
     2221 tggtaaagtc ttcgctcaaa catcacaact tgcaaggcat tggagagttc atactggaga
     2281 aaaaccttac aagtgtaatg actgtggcag agcctttagt gatcgttcaa gcctaacttt
     2341 tcatcaggca atacatactg gagagaaacc ttacaaatgt catgaatgcg gcaaggtttt
     2401 taggcacaat tcataccttg caactcatcg gcgaattcat actggagaga aaccttacaa
     2461 gtgtaatgag tgtgggaaag cctttagtat gcattcaaac ctaactaccc ataaggtcat
     2521 ccatactgga gagaagcctt acaaatgtaa tcaatgtggc aaggtcttca ctcagaactc
     2581 acaccttgca aatcatcaaa ggactcacac cggagagaaa ccttaccgat gcaatgagtg
     2641 tgggaaagcc ttcagtgttc gttcaagcct aaccacccat caggcaatcc atactgggaa
     2701 aaaaccttac aaatgtaatg aatgtggcaa ggtctttact caaaatgctc acctggcaaa
     2761 tcaccgaaga attcatactg gggagaaacc ttacaggtgt acagagtgtg ggaaagcctt
     2821 tagggtaaga tcaagtctaa ctacccatat ggcaatccac actggagaaa agcgttacaa
     2881 atgtaatgag tgtggcaagg tcttcaggca gagttcaaat cttgcaagtc atcacagaat
     2941 gcataccgga gagaaacctt acaaatgagt gtggtgaggt cattaggtac aattcactcc
     3001 tttcacatca gttaatttca ttcttgacag aatccttaca aatgtagtga cagtggccaa
     3061 tccctcatga gttgaagcat taatagatat gagaggccat aagcaagaga catcatgtaa
     3121 acatatgtgg cagagggtct atccaggcct cgcaggttac taggcatcaa gatttatatc
     3181 tttgatgaaa cgaaacaaat gtaatatgca tcctgaggcc attacccagt gaccgatggt
     3241 aagtgaggat tcctaggagg aataacagtc tctggtttcc ctgtttgcct ttgatattat
     3301 acactgtaga atactcacaa gtccaaatat gctaaaaatt atatattttt aactcacata
     3361 cgaaaaggtt gcaggatatt tgtaggcagt cagttacctt caccttatga aatgtttcac
     3421 tgagttattt gaggtttttt ggaaagccta ctattgcgtt tcaatgtgaa ctttgaaatc
     3481 ttattgtgca tccttacaca ccttccatgg tgctttcttg gaaagatcat tgggatggaa
     3541 ggatcattga ttgggtgaag atcattgatt aggtgaagga ttatttctat ccaatttgtg
     3601 aagaaggagg actttgcttt taaaattaag tatcatctga attagcattt gggagtggcg
     3661 aaaaacaatg taaaactatg atgtcactca ccattctgat aatgttcagg gtgcctttct
     3721 cctaccagga gagtactgtg gcttagagga aagaaatggt ctatcaactg aacatgaaat
     3781 ggagcaggcc aagaccttag gacattggga tttttgtggg aggagagtaa taggtaatta
     3841 gacactgatt gtgtggtaga aatactgcag gggaaaaggt cgccctctta tgcatcaaag
     3901 agcaatacct gttgtttagc aaagagtgat gaaaaattga tcttgttttg aaattgaaga
     3961 gagaggccag gcgcggtggc tcacacctgt aatcccagca ctttgggagg ctgaggcagg
     4021 tggatcacct gaggtcggga gttcgagacc agcctgacca acatggagaa accccaattg
     4081 tactaaaaat acaaaattag ccgggcgtgg tggcaggtgc ctgtaatccc agctacttgg
     4141 gaggctgagg caggagagtg cttgaaccca ggaggcggag gttgtggtga gccaagatca
     4201 tgccactgca ctccagcctg ggcaacaaga acaaaactcc atctaaagaa gaaaaagaaa
     4261 aactgaagag agagtagttg tcagagtgaa gagtttaatc aacagaagta gagtaacata
     4321 ttctttagta gaactcacat tatctgcttg aagcacattt tgctaatgtt ttattcagaa
     4381 tgtatcatag atataatgtt ttaactaata aaatagaatg gtttttctct a
//
