LOCUS       NM_006958               2522 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 16 (ZNF16), transcript variant 1,
            mRNA.
ACCESSION   NM_006958
VERSION     NM_006958.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2522)
  AUTHORS   Zhang,H., Song,Y., Du,Z., Li,X., Zhang,J., Chen,S., Chen,F., Li,T.
            and Zhan,Q.
  TITLE     Exome sequencing identifies new somatic alterations and mutation
            patterns of tongue squamous cell carcinoma in a Chinese population
  JOURNAL   J Pathol 251 (4), 353-364 (2020)
   PUBMED   32432340
  REMARK    GeneRIF: Exome sequencing identifies new somatic alterations and
            mutation patterns of tongue squamous cell carcinoma in a Chinese
            population.
REFERENCE   2  (bases 1 to 2522)
  AUTHORS   Ahn,S.W., Ahn,A.R., Ha,S.H., Hussein,U.K., Do Yang,J., Kim,K.M.,
            Park,H.S., Park,S.H., Yu,H.C. and Jang,K.Y.
  TITLE     Expression of FAM83H and ZNF16 are associated with shorter survival
            of patients with gallbladder carcinoma
  JOURNAL   Diagn Pathol 15 (1), 63 (2020)
   PUBMED   32460791
  REMARK    GeneRIF: Expression of FAM83H and ZNF16 are associated with shorter
            survival of patients with gallbladder carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2522)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2522)
  AUTHORS   Chen,J., Li,X.B., Su,R., Song,L., Wang,F. and Zhang,J.W.
  TITLE     ZNF16 (HZF1) promotes erythropoiesis and megakaryocytopoiesis via
            regulation of the c-KIT gene
  JOURNAL   Biochem J 458 (1), 171-183 (2014)
   PUBMED   24180487
  REMARK    GeneRIF: study demonstrate that ZNF16 plays an important role in
            erythropoiesis and megakaryocytopoiesis via its regulation of the
            c-Kit/c-Raf/MEK/ERK/c-Jun/HEY1/GATA1 cascade
REFERENCE   5  (bases 1 to 2522)
  AUTHORS   Li,X.B., Chen,J., Deng,M.J., Wang,F., Du,Z.W. and Zhang,J.W.
  TITLE     Zinc finger protein HZF1 promotes K562 cell proliferation by
            interacting with and inhibiting INCA1
  JOURNAL   Mol Med Rep 4 (6), 1131-1137 (2011)
   PUBMED   21874239
REFERENCE   6  (bases 1 to 2522)
  AUTHORS   Lorenz,P., Dietmann,S., Wilhelm,T., Koczan,D., Autran,S., Gad,S.,
            Wen,G., Ding,G., Li,Y., Rousseau-Merck,M.F. and Thiesen,H.J.
  TITLE     The ancient mammalian KRAB zinc finger gene cluster on human
            chromosome 8q24.3 illustrates principles of C2H2 zinc finger
            evolution associated with unique expression profiles in human
            tissues
  JOURNAL   BMC Genomics 11, 206 (2010)
   PUBMED   20346131
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2522)
  AUTHORS   Deng,M.J., Li,X.B., Peng,H. and Zhang,J.W.
  TITLE     Identification of the trans-activation domain and the nuclear
            location signals of human zinc finger protein HZF1 (ZNF16)
  JOURNAL   Mol Biotechnol 44 (2), 83-89 (2010)
   PUBMED   19763908
REFERENCE   8  (bases 1 to 2522)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   9  (bases 1 to 2522)
  AUTHORS   Peng,H., Du,Z.W. and Zhang,J.W.
  TITLE     Identification and characterization of a novel zinc finger protein
            (HZF1) gene and its function in erythroid and megakaryocytic
            differentiation of K562 cells
  JOURNAL   Leukemia 20 (6), 1109-1116 (2006)
   PUBMED   16628192
REFERENCE   10 (bases 1 to 2522)
  AUTHORS   Rousseau-Merck,M.F., Duro,D., Berger,R. and Thiesen,H.J.
  TITLE     Chromosomal localization of two KOX zinc finger genes on chromosome
            bands 7q21-q22
  JOURNAL   Ann Genet 38 (2), 81-84 (1995)
   PUBMED   7486829
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK127625.1 and AF244088.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006958.2.
            
            Summary: The protein encoded by this gene contains multiple tandem
            zinc finger motifs. The encoded protein is involved in the
            differentiation of erythroid and megakaryocytic cells. This gene is
            located in a cluster of related genes on chromosome 8 encoding zinc
            finger proteins. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Sep 2012].
            
            Transcript Variant: This variant (1) lacks an alternate exon in the
            5' UTR and encodes the same protein, as compared to transcript
            variant 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.463278.1, AK127625.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146, SAMEA2467148
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394909.7/ ENSP00000378369.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2495              AK127625.1         9-2503
            2496-2522           AF244088.1         2415-2441
FEATURES             Location/Qualifiers
     source          1..2522
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..2522
                     /gene="ZNF16"
                     /gene_synonym="HZF1; KOX9"
                     /note="zinc finger protein 16"
                     /db_xref="GeneID:7564"
                     /db_xref="HGNC:HGNC:12947"
                     /db_xref="MIM:601262"
     exon            1..84
                     /gene="ZNF16"
                     /gene_synonym="HZF1; KOX9"
                     /inference="alignment:Splign:2.1.0"
     exon            85..289
                     /gene="ZNF16"
                     /gene_synonym="HZF1; KOX9"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..2142
                     /gene="ZNF16"
                     /gene_synonym="HZF1; KOX9"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein KOX9; zinc finger protein Kruppel type 9"
                     /codon_start=1
                     /product="zinc finger protein 16 isoform 1"
                     /protein_id="NP_008889.2"
                     /db_xref="CCDS:CCDS6437.1"
                     /db_xref="GeneID:7564"
                     /db_xref="HGNC:HGNC:12947"
                     /db_xref="MIM:601262"
                     /translation="MPSLRTRREEAEMELSVPGPSPWTPAAQARVRDAPAVTHPGSAA
                     CGTPCCSDTELEAICPHYQQPDCDTRTEDKEFLHKEDIHEDLESQAEISENYAGDVSQ
                     VPELGDLCDDVSERDWGVPEGRRLPQSLSQEGDFTPAAMGLLRGPLGEKDLDCNGFDS
                     RFSLSPNLMACQEIPTEERPHPYDMGGQSFQHSVDLTGHEGVPTAESPLICNECGKTF
                     QGNPDLIQRQIVHTGEASFMCDDCGKTFSQNSVLKNRHRSHMSEKAYQCSECGKAFRG
                     HSDFSRHQSHHSSERPYMCNECGKAFSQNSSLKKHQKSHMSEKPYECNECGKAFRRSS
                     NLIQHQRIHSGEKPYVCSECGKAFRRSSNLIKHHRTHTGEKPFECGECGKAFSQSAHL
                     RKHQRVHTGEKPYECNDCGKPFSRVSNLIKHHRVHTGEKPYKCSDCGKAFSQSSSLIQ
                     HRRIHTGEKPHVCNVCGKAFSYSSVLRKHQIIHTGEKPYRCSVCGKAFSHSSALIQHQ
                     GVHTGDKPYACHECGKTFGRSSNLILHQRVHTGEKPYECTECGKTFSQSSTLIQHQRI
                     HNGLKPHECNQCGKAFNRSSNLIHHQKVHTGEKPYTCVECGKGFSQSSHLIQHQIIHT
                     GERPYKCSECGKAFSQRSVLIQHQRIHTGVKPYDCAACGKAFSQRSKLIKHQLIHTRE
                     "
     exon            290..2522
                     /gene="ZNF16"
                     /gene_synonym="HZF1; KOX9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2452..2457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF16"
                     /gene_synonym="HZF1; KOX9"
                     /note="hexamer: AATGAA"
     regulatory      2471..2476
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF16"
                     /gene_synonym="HZF1; KOX9"
                     /note="hexamer: AGTAAA"
     polyA_site      2471
                     /gene="ZNF16"
                     /gene_synonym="HZF1; KOX9"
                     /note="major polyA site"
     polyA_site      2497
                     /gene="ZNF16"
                     /gene_synonym="HZF1; KOX9"
                     /note="major polyA site"
     polyA_site      2522
                     /gene="ZNF16"
                     /gene_synonym="HZF1; KOX9"
ORIGIN      
        1 gcgggacttc cgggggtcag ccggcgttgg ctgagacgtc ttcgtgccac ggtgctgcct
       61 cctttccaag cgcgacccgt tgaggtcctt gtcatgccca gcctcagaac tcgccgtgag
      121 gaggcagaga tggagctctc agttccagga ccatccccct ggacccctgc agcccaggcc
      181 cgtgtgagag atgctcctgc tgtgacccac cctggatctg cagcctgtgg taccccctgc
      241 tgtagtgata ctgagctgga agccatctgc cctcactatc agcagccaga ttgtgacacc
      301 aggactgaag acaaggagtt tcttcacaag gaagacattc atgaagattt ggaatcacag
      361 gcagaaatat cagaaaacta tgctggtgat gtttcccagg tacccgagct tggagatctg
      421 tgtgatgatg tatcagaaag agactgggga gtccccgaag gcaggaggct gccacagtcc
      481 ctctcccagg agggggactt cacaccagct gccatggggc tccttagggg ccccttaggg
      541 gagaaagatc tggactgtaa tggttttgac agtcgcttca gtctgagccc aaacctgatg
      601 gcatgtcagg aaatccctac agaagagagg ccacatccat atgacatggg tggccagagt
      661 ttccagcaca gtgtggacct aactggtcat gagggggttc ccacagctga aagtccactc
      721 atatgtaatg agtgtgggaa aaccttccaa ggaaatcctg accttattca gcgtcaaata
      781 gtccacactg gggaggcttc ctttatgtgt gatgattgtg ggaaaacctt cagccagaac
      841 tcagttctta aaaaccgtca tcgatctcat atgagtgaga aagcttacca gtgcagcgaa
      901 tgtgggaaag ccttccgagg gcactcagac ttttctaggc atcagagtca ccacagcagt
      961 gagaggcctt atatgtgtaa tgaatgtgga aaagccttca gccagaactc gagccttaaa
     1021 aagcaccaaa agtctcacat gagtgagaag ccctatgaat gcaatgaatg tgggaaggct
     1081 tttaggcgga gctcaaacct catccaacat caaagaatcc attctgggga gaaaccgtat
     1141 gtgtgcagtg agtgtgggaa ggccttcagg cgaagctcaa acctcatcaa acaccacagg
     1201 actcacacag gagagaagcc ttttgagtgt ggcgagtgtg ggaaagcctt cagccagagt
     1261 gcacacctga ggaagcacca gagggtccac actggagaga agccttatga gtgtaatgat
     1321 tgtggcaagc ccttcagtcg ggtctccaac ctcattaagc accacagggt tcacactgga
     1381 gagaagccct ataagtgcag tgactgtggg aaagcattta gtcagagctc cagccttatt
     1441 cagcatcgga gaattcacac tggagaaaag cctcacgtgt gtaatgtatg tggaaaagcc
     1501 tttagttata gctcagtgct ccgaaagcac cagatcatcc acacgggaga gaagccgtac
     1561 agatgcagtg tctgtgggaa ggccttcagc cacagctcag ccctcattca gcaccagggc
     1621 gtgcacacag gcgacaagcc ctacgcctgc cacgagtgtg ggaagacctt tggtcgcagc
     1681 tccaacctca tccttcacca gcgagtccac actggagaga agccctatga atgtactgaa
     1741 tgtggaaaaa ccttcagcca gagctcaacc ctcattcagc atcagaggat tcataatggg
     1801 ctgaagcccc atgaatgtaa ccagtgtggt aaagccttca accgaagctc aaatctcatt
     1861 caccaccaga aagttcatac tggggaaaaa ccctacacct gtgttgaatg tggtaagggc
     1921 ttcagccaga gctcacacct cattcagcat cagataatcc acacgggcga gcgcccctac
     1981 aaatgcagtg agtgtgggaa agccttcagt cagcgttcgg tcctcatcca gcaccagagg
     2041 attcacactg gggtgaagcc ctatgactgt gctgcttgtg ggaaagcctt cagccagcga
     2101 tcaaagttga tcaaacacca gttgattcac accagggaat aggctgttgg gctggcagga
     2161 gtgaaaccga gcatagtttc ctctccaact cctctttggc cattgtctca gcctctgcca
     2221 cttcccagac cgaaagcctg gactcagctc actgcctaca tccagtggcc acatagcctg
     2281 ggaccctcct ttgaaacatc ctttacaggc tcccttctca ctgccactgc tcttgcctct
     2341 tgtgatgtct tgggtttggg cttgttttta cagcttgtga acggactgca cgtttgttac
     2401 aagggagaag attatggagg ctgcatattc atgaatagag tttattatta taatgaaaag
     2461 ttaccaaaaa agtaaagtga cgtttggttt gagataacca tagtagtttg tttgattggt
     2521 aa
//
