LOCUS       NM_003446               2516 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 157 (ZNF157), mRNA.
ACCESSION   NM_003446
VERSION     NM_003446.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2516)
  AUTHORS   Macgregor,S., Hewitt,A.W., Hysi,P.G., Ruddle,J.B., Medland,S.E.,
            Henders,A.K., Gordon,S.D., Andrew,T., McEvoy,B., Sanfilippo,P.G.,
            Carbonaro,F., Tah,V., Li,Y.J., Bennett,S.L., Craig,J.E.,
            Montgomery,G.W., Tran-Viet,K.N., Brown,N.L., Spector,T.D.,
            Martin,N.G., Young,T.L., Hammond,C.J. and Mackey,D.A.
  TITLE     Genome-wide association identifies ATOH7 as a major gene
            determining human optic disc size
  JOURNAL   Hum Mol Genet 19 (13), 2716-2724 (2010)
   PUBMED   20395239
REFERENCE   2  (bases 1 to 2516)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   3  (bases 1 to 2516)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   4  (bases 1 to 2516)
  AUTHORS   Thiselton,D.L., McDowall,J., Brandau,O., Ramser,J., d'Esposito,F.,
            Bhattacharya,S.S., Ross,M.T., Hardcastle,A.J. and Meindl,A.
  TITLE     An integrated, functionally annotated gene map of the DXS8026-ELK1
            interval on human Xp11.3-Xp11.23: potential hotspot for
            neurogenetic disorders
  JOURNAL   Genomics 79 (4), 560-572 (2002)
   PUBMED   11944989
  REMARK    Erratum:[Genomics 2002 Jun;79(6):891]
REFERENCE   5  (bases 1 to 2516)
  AUTHORS   Derry,J.M., Jess,U. and Francke,U.
  TITLE     Cloning and characterization of a novel zinc finger gene in Xp11.2
  JOURNAL   Genomics 30 (2), 361-365 (1995)
   PUBMED   8586441
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL591503.9 and AL590223.12.
            
            On Dec 4, 2019 this sequence version replaced NM_003446.3.
            
            Summary: This gene product is a likely zinc finger family
            transcription factor. It contains KRAB-A and KRAB-B domains that
            act as transcriptional repressors in related proteins, and multiple
            zinc finger DNA binding motifs and finger linking regions
            characteristic of the Kruppel family. This gene is part of a gene
            cluster on chromosome Xp11.23. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: U28687.1, BC075003.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144120, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377073.4/ ENSP00000366273.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               AL591503.9         111180-111342
            164-290             AL591503.9         150878-151004
            291-386             AL591503.9         151282-151377
            387-2516            AL590223.12        2312-4441
FEATURES             Location/Qualifiers
     source          1..2516
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.3"
     gene            1..2516
                     /gene="ZNF157"
                     /gene_synonym="HZF22"
                     /note="zinc finger protein 157"
                     /db_xref="GeneID:7712"
                     /db_xref="HGNC:HGNC:12942"
                     /db_xref="MIM:300024"
     exon            1..163
                     /gene="ZNF157"
                     /gene_synonym="HZF22"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1612
                     /gene="ZNF157"
                     /gene_synonym="HZF22"
                     /note="zinc finger protein 22; zinc finger protein HZF22"
                     /codon_start=1
                     /product="zinc finger protein 157"
                     /protein_id="NP_003437.2"
                     /db_xref="CCDS:CCDS14278.1"
                     /db_xref="GeneID:7712"
                     /db_xref="HGNC:HGNC:12942"
                     /db_xref="MIM:300024"
                     /translation="MPANGTSPQRFPALIPGEPGRSFEGSVSFEDVAVDFTRQEWHRL
                     DPAQRTMHKDVMLETYSNLASVGLCVAKPEMIFKLERGEELWILEEESSGHGYSGSLS
                     LLCGNGSVGDNALRHDNDLLHHQKIQTLDQNVEYNGCRKAFHEKTGFVRRKRTPRGDK
                     NFECHECGKAYCRKSNLVEHLRIHTGERPYECGECAKTFSARSYLIAHQKTHTGERPF
                     ECNECGKSFGRKSQLILHTRTHTGERPYECTECGKTFSEKATLTIHQRTHTGEKPYEC
                     SECGKTFRVKISLTQHHRTHTGEKPYECGECGKNFRAKKSLNQHQRIHTGEKPYECGE
                     CGKFFRMKMTLNNHQRTHTGEKPYQCNECGKSFRVHSSLGIHQRIHTGEKPYECNECG
                     NAFYVKARLIEHQRMHSGEKPYECSECGKIFSMKKSLCQHRRTHTGEKPYECSECGNA
                     FYVKVRLIEHQRIHTGERPFECQECGKAFCRKAHLTEHQRTHIGWSWRCTMKKASH"
     exon            164..290
                     /gene="ZNF157"
                     /gene_synonym="HZF22"
                     /inference="alignment:Splign:2.1.0"
     exon            291..386
                     /gene="ZNF157"
                     /gene_synonym="HZF22"
                     /inference="alignment:Splign:2.1.0"
     exon            387..2516
                     /gene="ZNF157"
                     /gene_synonym="HZF22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2496..2501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF157"
                     /gene_synonym="HZF22"
                     /note="hexamer: CATAAA"
     polyA_site      2516
                     /gene="ZNF157"
                     /gene_synonym="HZF22"
                     /note="major polyA site"
ORIGIN      
        1 cattgagcct taccccttac tggaggctgc aggaccctct acacacagac agctgtccag
       61 cacggaaggt gggctgaggc ccagggtgaa catgccagct aatgggacat caccccagag
      121 attccctgcc ctgattccag gagaacctgg cagatctttt gaggggtccg tgtcattcga
      181 ggatgtggct gtggatttca cccgacagga gtggcacaga ctggaccctg ctcagaggac
      241 catgcacaag gatgtgatgc tggagaccta cagcaacctg gcatctgtgg gcctctgcgt
      301 ggccaaacca gagatgatct tcaagttgga gcgaggagaa gagctgtgga tattagagga
      361 ggaatcctca ggccatggtt actcaggatc tctctcactg ctgtgtggca atggttctgt
      421 tggggataat gccctcaggc atgataatga ccttcttcac catcagaaga ttcaaacatt
      481 ggatcaaaat gttgaatata atggatgcag gaaagccttc catgagaaaa caggctttgt
      541 tagacgtaaa agaacaccca gaggagataa aaactttgaa tgtcatgaat gtgggaaagc
      601 ttactgtagg aagtcaaacc ttgttgaaca tctgagaata cacacaggag agagacccta
      661 tgaatgcggt gaatgtgcaa aaaccttcag tgcaagatca tacctcattg ctcatcagaa
      721 aactcacaca ggggagaggc cctttgaatg taatgaatgt gggaaatctt ttggcaggaa
      781 gtcacaactc atcctacata caagaacaca cactggagag agaccctatg aatgtactga
      841 atgtgggaaa accttttctg agaaggcaac cctcacgatt catcagagaa ctcacacagg
      901 ggagaaaccc tatgaatgta gtgaatgtgg gaaaacattt cgtgtaaaga tatcccttac
      961 ccaacaccac agaactcata caggggagaa accttatgaa tgtggggagt gtgggaaaaa
     1021 cttccgtgca aagaaatccc taaatcagca tcaaagaatt cacacaggtg agaaacccta
     1081 tgagtgtggt gaatgtggga aattcttccg aatgaagatg actctcaata atcatcaaag
     1141 aactcacaca ggtgaaaagc cctatcagtg taatgaatgt gggaaatctt tcagggtgca
     1201 ctcatctctt gggatccatc agagaattca cacaggagag aaaccttacg aatgtaatga
     1261 gtgtggtaat gctttctatg tgaaagcacg cctaattgaa catcagagga tgcattcagg
     1321 agagaaaccc tacgaatgta gtgaatgtgg gaaaatcttc agtatgaaga aatccctttg
     1381 tcaacaccgg agaactcaca caggagagaa accttatgaa tgtagtgaat gtggaaatgc
     1441 cttctatgtg aaagtacgcc tcattgaaca tcagcgaatt cacacaggag agagaccctt
     1501 tgagtgtcaa gaatgtggga aagctttctg ccggaaagca cacctcacag aacatcagag
     1561 aactcacata ggctggtcct ggcgttgtac aatgaagaaa gcctctcact gaagacttcc
     1621 ctcaccattg gatcaagctc cttgggggca tatgatcacc agggcacaca gtgtgcctgt
     1681 gaaaatttgg cacctacatt tgtatcaaag tatgtcctga tccccttagg ggatagctca
     1741 ttgtttttat tcagatttcc ctaattagtg gtgtgtgaac atcttatctg ttgattggct
     1801 atttgggttt tttcttctgt gcattgactg ttcatgtcct ctgctcattg ttttcaaatg
     1861 ggctgttcat ctcttgcttt ttggtttaaa tgttgttttt taacatatga gaatataaaa
     1921 atcctttttt tttcagtcat atgtgttgca aatatcttct cccagactgt cgttggtttt
     1981 ttaaattttg ccatctgttt tcttctgctg aagttttata ttttatttat ttatttttta
     2041 tttttttgag atggagtctc actctgtcac ccaggctgga gtgcaatggc atgacctcag
     2101 ctcatttcaa ccttcgcctc ccgggttcaa gcgattctcc tgcctcagtc tcccaagtag
     2161 ctgggattac aggtgtgcac caccatgcct ggctaatttt tgtattttta gtaaagacgg
     2221 ggtttcacca tgttggccag gctggtctct aactcctgac ctcaggtgat ccacctgcct
     2281 cggcctccaa aagtgttggg attacaggtg tgagccaccg tgcccggcta aagttttata
     2341 ttttaatatt atcagtttca aggtgataat attcacctat actttcctct aaaggttttc
     2401 ctttcaacat ttagaatttt aatctcctgt gagatttttt tgttatagca tgaagtgtgc
     2461 aatacatact actatattgt ctttatataa ttttacataa atgggctcac actgta
//
