LOCUS       NM_001085384            6907 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 154 (ZNF154), transcript variant
            1, mRNA.
ACCESSION   NM_001085384 XM_001128735 XM_001132208
VERSION     NM_001085384.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6907)
  AUTHORS   He,W., Lin,S., Guo,Y., Wu,Y., Zhang,L.L., Deng,Q., Du,Z.M., Wei,M.,
            Zhu,W., Chen,W.J., Shao,J.Y. and Xu,G.L.
  TITLE     Targeted demethylation at ZNF154 promotor upregulates ZNF154
            expression and inhibits the proliferation and migration of
            Esophageal Squamous Carcinoma cells
  JOURNAL   Oncogene 41 (40), 4537-4546 (2022)
   PUBMED   36064578
  REMARK    GeneRIF: Targeted demethylation at ZNF154 promotor upregulates
            ZNF154 expression and inhibits the proliferation and migration of
            Esophageal Squamous Carcinoma cells.
REFERENCE   2  (bases 1 to 6907)
  AUTHORS   Miller,B.F., Petrykowska,H.M. and Elnitski,L.
  TITLE     Assessing ZNF154 methylation in patient plasma as a multicancer
            marker in liquid biopsies from colon, liver, ovarian and pancreatic
            cancer patients
  JOURNAL   Sci Rep 11 (1), 221 (2021)
   PUBMED   33420235
  REMARK    GeneRIF: Assessing ZNF154 methylation in patient plasma as a
            multicancer marker in liquid biopsies from colon, liver, ovarian
            and pancreatic cancer patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6907)
  AUTHORS   Wiesmueller,F., Kopke,J., Aust,D., Roy,J., Dahl,A., Pilarsky,C. and
            Grutzmann,R.
  TITLE     Silenced ZNF154 Is Associated with Longer Survival in Resectable
            Pancreatic Cancer
  JOURNAL   Int J Mol Sci 20 (21), 5437 (2019)
   PUBMED   31683647
  REMARK    GeneRIF: Data show a significant association between zinc finger
            protein 154 (ZNF154) promoter hypermethylation and better
            postoperative survival.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6907)
  AUTHORS   Zhang,W., Shu,P., Wang,S., Song,J., Liu,K., Wang,C. and Ran,L.
  TITLE     ZNF154 is a promising diagnosis biomarker and predicts biochemical
            recurrence in prostate cancer
  JOURNAL   Gene 675, 136-143 (2018)
   PUBMED   29966681
  REMARK    GeneRIF: Hypermethylation level of ZNF154 lead to gene expression
            inhibition and function loss, which contribute to the development
            and poor outcomes in Prostate cancer. In addition, the mean
            methylation level of ZNF154 can be used as an independent risk
            factor to predict biochemical recurrence.
REFERENCE   5  (bases 1 to 6907)
  AUTHORS   Sanchez-Vega,F., Gotea,V., Petrykowska,H.M., Margolin,G.,
            Krivak,T.C., DeLoia,J.A., Bell,D.W. and Elnitski,L.
  TITLE     Recurrent patterns of DNA methylation in the ZNF154, CASP8, and VHL
            promoters across a wide spectrum of human solid epithelial tumors
            and cancer cell lines
  JOURNAL   Epigenetics 8 (12), 1355-1372 (2013)
   PUBMED   24149212
  REMARK    GeneRIF: Epigenetic modifications affecting the promoters of
            ZNF154, CASP8, and VHL are shared across a vast array of tumor
            types and may therefore be important for understanding the genomic
            landscape of cancer.
REFERENCE   6  (bases 1 to 6907)
  AUTHORS   Reinert,T., Borre,M., Christiansen,A., Hermann,G.G., Orntoft,T.F.
            and Dyrskjot,L.
  TITLE     Diagnosis of bladder cancer recurrence based on urinary levels of
            EOMES, HOXA9, POU4F2, TWIST1, VIM, and ZNF154 hypermethylation
  JOURNAL   PLoS One 7 (10), e46297 (2012)
   PUBMED   23056278
  REMARK    GeneRIF: Methylation levels of EOMES, HOXA9, POU4F2, TWIST1, VIM,
            and ZNF154 in urine specimens are promising diagnostic biomarkers
            for bladder cancer recurrence surveillance
REFERENCE   7  (bases 1 to 6907)
  AUTHORS   Tommerup,N. and Vissing,H.
  TITLE     Isolation and fine mapping of 16 novel human zinc finger-encoding
            cDNAs identify putative candidate genes for developmental and
            malignant disorders
  JOURNAL   Genomics 27 (2), 259-264 (1995)
   PUBMED   7557990
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN280337.1, AC004017.1 and
            U20648.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001085384.2.
            
            Summary: This gene encodes a protein that belongs to the zinc
            finger Kruppel family of transcriptional regulators, whose members
            are thought to function in normal and abnormal cell growth and
            differentiation. Hypermethylation of this gene is associated with
            the recurrence of non muscle invasive bladder cancer. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Mar 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.54009.1,
                                           SRR1803613.280096.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267770, SAMN04284274
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684351.1/ ENSP00000507206.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-580               CN280337.1         8-587
            581-581             AC004017.1         41266-41266         c
            582-719             CN280337.1         589-726
            720-1283            AC004017.1         40564-41127         c
            1284-1574           U20648.1           1-291
            1575-1575           AC004017.1         40272-40272         c
            1576-1790           U20648.1           292-506
            1791-1791           AC004017.1         40056-40056         c
            1792-1891           U20648.1           507-606
            1892-1892           AC004017.1         39955-39955         c
            1893-1992           U20648.1           608-707
            1993-1993           AC004017.1         39854-39854         c
            1994-2057           U20648.1           709-772
            2058-2069           AC004017.1         39778-39789         c
            2070-2077           U20648.1           784-791
            2078-6907           AC004017.1         34940-39769         c
FEATURES             Location/Qualifiers
     source          1..6907
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..6907
                     /gene="ZNF154"
                     /gene_synonym="pHZ-92"
                     /note="zinc finger protein 154"
                     /db_xref="GeneID:7710"
                     /db_xref="HGNC:HGNC:12939"
                     /db_xref="MIM:604085"
     exon            1..266
                     /gene="ZNF154"
                     /gene_synonym="pHZ-92"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1547
                     /gene="ZNF154"
                     /gene_synonym="pHZ-92"
                     /codon_start=1
                     /product="zinc finger protein 154"
                     /protein_id="NP_001078853.1"
                     /db_xref="CCDS:CCDS42639.1"
                     /db_xref="GeneID:7710"
                     /db_xref="HGNC:HGNC:12939"
                     /db_xref="MIM:604085"
                     /translation="MAAATLRTPTQGTVTFEDVAVHFSWEEWGLLDEAQRCLYRDVML
                     ENLALLTSLDVHHQKQHLGEKHFRSNVGRALFVKTCTFHVSGEPSTCREVGKDFLAKL
                     GFLHQQAAHTGEQSNSKSDGGAISHRGKTHYNCGEHTKAFSGKHTLVQQQRTLTTERC
                     YICSECGKSFSKSYSLNDHWRLHTGEKPYECRECGKSFRQSSSLIQHRRVHTAVRPHE
                     CDECGKLFSNKSNLIKHRRVHTGERPYECSECGKSFSQRSALLQHRGVHTGERPYECS
                     ECGKFFTYHSSLIKHQKVHSGSRPYECSECGKSFSQNSSLIEHHRVHTGERPYKCSEC
                     GKSFSQRSALLQHRGVHTGERPYECSECGKFFPYSSSLRKHQRVHTGSRPYECSECGK
                     SFTQNSGLIKHRRVHTGEKPYECTECGKSFSHNSSLIKHQRIHSR"
     exon            267..393
                     /gene="ZNF154"
                     /gene_synonym="pHZ-92"
                     /inference="alignment:Splign:2.1.0"
     exon            394..6907
                     /gene="ZNF154"
                     /gene_synonym="pHZ-92"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5816
                     /gene="ZNF154"
                     /gene_synonym="pHZ-92"
                     /note="major polyA site"
     regulatory      5929..5934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF154"
                     /gene_synonym="pHZ-92"
                     /note="hexamer: AATACA"
     polyA_site      5948
                     /gene="ZNF154"
                     /gene_synonym="pHZ-92"
                     /note="major polyA site"
ORIGIN      
        1 gtggcggcca ttttagcttc tctgaggtgt gttcaccgga tcagagatag cagagcgccg
       61 agttggggcc acgaaggcgt gaggggagtc gtcgtccctc ctgcacgaaa gcgtctaagc
      121 cttggcgacg ccgccctggg ggacccacgt caggcctggg atagggaccg ctgtccccgg
      181 gtccctacca atgtcgcccg tcgctcccgg cccagctcta cccgcagagt ctgatggcag
      241 cggccactct gaggacgcca actcagggca ctgtgacctt tgaagatgtg gccgtacact
      301 tctcctggga ggaatggggt ctccttgatg aggctcaaag atgcctgtac cgtgatgtga
      361 tgctggagaa cttggctctt ttaacctctc tagatgttca tcatcagaag cagcaccttg
      421 gagaaaaaca tttcagaagc aatgtgggca gagccttgtt tgtgaagacc tgcacattcc
      481 atgtgtcagg ggagccttcc acctgcagag aagttgggaa ggacttcctg gccaagttgg
      541 gatttctcca tcaacaggct gctcacactg gggagcaatc aaatagcaaa agcgacggtg
      601 gggccatcag tcacagagga aaaactcatt acaactgtgg agaacacaca aaagcattca
      661 gcggtaaaca cacacttgtt cagcagcaga gaaccctcac tacagaaaga tgttacatat
      721 gcagtgaatg tgggaaatcc tttagcaaaa gctacagtct caatgaccat tggagacttc
      781 acactggaga aaagccttat gaatgtcgag agtgtgggaa gtcctttagg caaagctcta
      841 gtctcattca gcaccggaga gttcacactg cagtacgacc tcatgaatgt gatgaatgtg
      901 gaaaattatt tagcaacaag tctaacctca ttaaacatcg gagagttcac actggggaaa
      961 ggccatatga gtgcagtgaa tgtgggaaat cctttagcca aaggtctgca ctccttcaac
     1021 atcggggagt tcacactggg gagaggcctt atgagtgcag tgaatgtggg aagtttttta
     1081 catatcattc cagtctcata aaacaccaga aagttcacag tggatccagg ccttatgagt
     1141 gcagcgaatg tgggaagtca tttagccaaa actctagcct cattgaacac catagggttc
     1201 acactggaga aaggccttat aagtgcagcg aatgtgggaa atcctttagc caaaggtctg
     1261 cactccttca acatcgggga gttcacactg gggagaggcc ttatgagtgc agtgaatgtg
     1321 ggaagttctt tccctacagc tccagtctcc gaaaacacca gagagttcac actggatcaa
     1381 gaccctatga gtgcagtgaa tgtgggaaat cctttactca aaattccggc ctcattaagc
     1441 acaggagggt tcacactggg gagaagcctt atgagtgcac ggaatgtggg aaatccttta
     1501 gccataactc cagccttatt aaacatcaga gaattcatag tcgataaaag ccttatgagt
     1561 ggcaaatgtg gaaaatctgt tagcaccctg gagaaagtcc ttgagtacac agtgaatgtc
     1621 agaaagcttc agctgaaggc catatctcat tgagtgccac acagttcaca agggaaagac
     1681 acttttgata tgtagggatg tccagttgat ataacagctc tgaaggagat cccttatgag
     1741 ggtggcatca gcctgaattg aacatcctat atctgaacat ctgcataaat tccaggtatg
     1801 tgtgaactgc attgcacctt ttgccctgcc cagggcccat gtcagattta tgtctctgct
     1861 gatactatag tggaagccat tttacctcta ctgcctggca ggtgaccacc agtgtgcacc
     1921 actcacccat cccagtgtat tcaggtaagt gaaccttggt gttctgttca tgggaggaat
     1981 ttgtaaatag cctaagcatt tattccgttt tttttttttc ctttctgatg agttaggcca
     2041 tggacctgac ccagtttggc ccagaggact ctgctggtga cctgaaaaga gggactacat
     2101 atttcaggat attgttggtc tcacatgact cttgatagag tttgccagcc ttcaaatcac
     2161 caactgtggg aaccaactgc ctcttattgc cttggtttgt acaataacaa aggccttatt
     2221 aatcttgggg gttctatatg tatgggttgg tttgaaaaca gttgggttct gctaacatga
     2281 aggggtgaat aacttttttt ggagatccca aacattgtgt agctcaacag ggacagggac
     2341 agggacagta ggatggcaga atatagctct ctctctagtt tgagcctagt tttcattgct
     2401 attcaaggcc tctgagaaaa aactacaggg tattgtccta atttatatcc tggatgccat
     2461 agaggtcagc ctgaggaggc agcagttact tgacatcctt tgatgtttct gaaagcaaca
     2521 tgaaattgtt ctcttgttca caaggaatac tgcatcgtgt tcagtgccag tgggggaaat
     2581 ctgttcccca ggtcctgtat gccttgatat cctgaattcc acagggtagc accacaggtg
     2641 gtaagattat agtaggaatt ataattgtta tagaagtact ggattgatag agagtggaaa
     2701 actgcaataa cactgcaata aatagaatgt gcccctttta cagaggtttc catgatgttc
     2761 gttattatgg ctcttaagga tgagcaggta cagaaatcct caggacctac agaattgtgt
     2821 atcttgtgta gctgaggtca ttgtcagaaa ttttatggaa tcctgtagcc tctgggattt
     2881 tcacctcaag gtcattgcta tgcaggcagg aaaacaagga tagagaaggg aggtctaggc
     2941 cattgataca gcctttgtga tccagccaac atttctgttg agtcaggtgg aaatggcctt
     3001 cactgttcac ttgtatttgt gatcactgag gcaaaatcct ctcccaggac atgaggagag
     3061 agatggtgga atcaacatag ggttgtcaaa cctgattttc caaaaacaat aggaaattca
     3121 gacttttatt ttgaaccata ttttgttagg ttggtgcaaa agtaactgtg gttttgaacc
     3181 atgatttatt tttattttta tttttttttg agtcagagtc ttgctctgtt gcccagtctg
     3241 gagggcaatg gcactatctc agctcattgc aacctccgcc tcccaggttc aagcgattct
     3301 tctgcctcag cctcccaggt agctgggatt acaggcaccc gccaccacgc ccatctgagt
     3361 tttgcatttt tagtagacat ggggtttcac catgttggcc aggctggtct tgaactcctg
     3421 acttcatgtg atccacccac cttggcctcc caaagtgctg ggatttacag gcatgagcca
     3481 ctgcgcccag ccaagctttt tcaccattcc aatttccttc aaatgctgaa cagccgtgga
     3541 atggttgaca ttgagttctt aggcaacttc tcatgtagtt gtaagaggat cagcttctaa
     3601 tattgctctc aattggtcat tgtcaacttc cagtggctgg ccactacttc tcttcaaggc
     3661 tcttgtctcc tttgcaaaac ttcttgaacc accactgcac tgtacattcg ttagcagttc
     3721 ctgggccaaa tgtgtttata tcgtgagttg tctctgctgc tttacgaccc attgggaact
     3781 caagtaagaa aatctcagcc gggtgcggtg gctcacgcct gtaatcccag cactttggga
     3841 ggctgaagta ggtggatcac aaggtcagga gttagagacc agcctgacca acatattgaa
     3901 acctcatctc tactaaaaat acaaaaatta gccgggcgtg gtggcatgtg cctgtagtcc
     3961 cagctacttg ggaggctgag gcaggagaat cacttgaacc cgggaggcag aagtcacagt
     4021 gagccaagat cacgccactg cactccagcc tggacgacag acaaaacaag actccgtctc
     4081 aaaaaaaaga ggccagatgc ggtggcttac acctgtaatc ccagcacttt gggaggccga
     4141 ggtgggtgga tcacaggtca cgagttcgag accagcctgg ccaacatggt gaaaccccgt
     4201 ctctactaaa aatacaaaaa ttagctgggc atagtggcat gcacctgtaa tcccagctac
     4261 tggggagcct gaggcacgag aattgtttga accccgggag gtggaggttg cagtgagcca
     4321 agatcatgtc actgcactcc agcctgggca acagagcaag actctatctc aaaaaaatcg
     4381 ctgaaatttg agttttgtct aacatttcca tagtctaaaa taaacataaa cagcaagtag
     4441 taagtcagca aaaaaacata aagcgagaaa tgcctattaa aatgatgtat aaccacattt
     4501 atttaagaat gttttccaat ataaaatggc aaaatccaac atgcaaaaac ggcaattact
     4561 tttgcactaa cctgataata attttaataa gaataaatgg tacatattta aactatataa
     4621 tttgatcagc tttgatattc atattaacct gtaattgctc ccaccatgcc aattttgaaa
     4681 ctgccaacat gttactgaat gtagaattgg gaagagttgc tgatagcatc ctaatatatt
     4741 ctgtttctac catactgata cagtggccac gaataacctc aagaatgtag aaaataaaat
     4801 gtagtgaaat gattaggaag aagttgtttc ttcacaatca tgacaatgaa cgtgtcattc
     4861 cacaagttac ctcattgtcc tttaataatt atctgcctat aggcaactat tgatttactt
     4921 tccattataa tacattagtt ttcatttgct agaattttat atgattgaaa ccataatgta
     4981 tttactcttt tttaatccct gggtatagtc acgtatttat tttgagattc atcattatac
     5041 ctctatgagt agtttctttt ttttgtattg ctgagaagta tgatgttctg tggatatacc
     5101 agtattcgtt tattcattca ttcatttgtt atggatattt tgagtagttt tttaaagtag
     5161 tttgaggtat aatggaactt aaagtgctta tatttaaaat gcatattttg atattttcat
     5221 acatgcttac accctggaac gcagtttcct tctgtctttt tagttcattc tcaacatata
     5281 aaattaattt tcattgtgta aaattactgg tacaatgaca tattttgtct cctgttacag
     5341 ctgtgttcaa ttacaaaaaa agatggaaaa gactgttatg aagccagatg aacctttctc
     5401 cagtcttcct tcactatttt tttttccttc accatttatc atttcatagt catttatgtt
     5461 tcatcggtcc tcatgtgtac tagtgcgtta ttttacttat actcccggat atcatattat
     5521 ttaatgcata gcctcttcag aatgcaattt taaaatgtaa aggctctttt ataacccccc
     5581 aaaaaatcac acaaatatat tttaaaatgt aaatatttta tcgcttctgt tttctcagtt
     5641 gtctaaaaca atgtgtttct taaggaagat catttttatt caggatccaa atgtatattt
     5701 aatagctttc agtagttgta tctcataagt ctgtaaccta caggttccat ttacctttgt
     5761 tttcttattt cttgaagttg ctgagtcatt ttttaattag aatttgctgt attctagatg
     5821 tggcttattg aatctctaac attgtttaac ttgtacacta gatgttgatg aaatcggtga
     5881 ttgagatttt gtcccagcag acaggtgtgt gatggcaaca gtgaaataaa tacaaaacct
     5941 tctcccaacc cagaaatcct ctccacgaag gtagagacag aaaacgcttt tattaagcat
     6001 taaaccagaa tgtgatgcac atcacagaca atccactaag aaattgcaag gtaagaaaaa
     6061 agcctcactc cttcatatgg cctagcagat gtagcccatt acacacgttt tcaagataaa
     6121 caacaacaag tcctcaaata cgaatttgac agcaccattt gtcacacata gttcatccta
     6181 acaggtgatg ctctattacc ttactggctt tacctagagg aaaagcaaac atcatatctt
     6241 tatgacagag gataatgagg ggagctgcct tggggctgct ggatgataca tcgggacagg
     6301 acagtgcgag cttccagcaa ggcagctcta gttggagccc tgatttcttt ccaaggtgag
     6361 gagagggtga tgatagtatc cttgggaagg ggagtgaaaa gtgctgaggg actgtattta
     6421 tagctgaggg atttcctggg tgctgtgggt ctcttgtctt tgccactctg cctcaacact
     6481 gaaactgtcc attccctact tggaggctgc acccaaaacc tccctctgcc ttcatgctct
     6541 ggcctccccc tgcaagttac caccctgggt cttggtgctt gcagcacttc cggtgcctgg
     6601 ctgccccagg ccctctgctc cctctgctgc ctgggtttaa tccctcctct gccactgccc
     6661 agcatcagga ctctgctggt tttgcagcct cttggtacct cagttttatg tttgtggaat
     6721 aggagtgctc acagtactct ctgggatcct ggcaaaaggt gtggtaggca ggtggtaagc
     6781 agggccgagc actatcccca gcacctagtg agttgatgcc ttatcattta cctgatccag
     6841 gcaggtctta aggtacaaga gaaagagaaa tggggcttct tagaaccccc tgaccccaca
     6901 gcttcta
//
