LOCUS       NM_001348429            9685 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens zinc finger protein 148 (ZNF148), transcript variant
            7, mRNA.
ACCESSION   NM_001348429
VERSION     NM_001348429.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9685)
  AUTHORS   Yao,X., Xu,K., Tao,N., Cheng,S., Chen,H., Zhang,D., Yang,M.,
            Tan,M., Yu,H., Chen,P., Zhan,Z., He,S., Li,R., Wang,C., Wu,D. and
            Ren,J.
  TITLE     ZNF148 inhibits HBV replication by downregulating RXRalpha
            transcription
  JOURNAL   Virol J 21 (1), 35 (2024)
   PUBMED   38297280
  REMARK    GeneRIF: ZNF148 inhibits HBV replication by downregulating RXRalpha
            transcription.
            Erratum:[Virol J. 2024 Jun 25;21(1):145. doi:
            10.1186/s12985-024-02420-z.. PMID: 38918845]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9685)
  AUTHORS   Szakszon,K., Lourenco,C.M., Callewaert,B.L., Genevieve,D.,
            Rouxel,F., Morin,D., Denomme-Pichon,A.S., Vitobello,A.,
            Patterson,W.G., Louie,R., Pinto E Vairo,F., Klee,E., Kaiwar,C.,
            Gavrilova,R.H., Agre,K.E., Jacquemont,S., Khadije,J., Giltay,J.,
            van Gassen,K., Mero,G., Gerkes,E., Van Bon,B.W., Rinne,T.,
            Pfundt,R., Brunner,H.G., Caluseriu,O., Grasshoff,U., Kehrer,M.,
            Haack,T.B., Khelifa,M.M., Bergmann,A.K., Cueto-Gonzalez,A.M.,
            Martorell,A.C., Ramachandrappa,S., Sawyer,L.B., Fasel,P., Braun,D.,
            Isis,A., Superti-Furga,A., McNiven,V., Chitayat,D., Ahmed,S.A.,
            Brennenstuhl,H., Schwaibolf,E.M., Battisti,G., Parmentier,B. and
            Stevens,S.J.C.
  TITLE     Further delineation of the rare GDACCF (global developmental delay,
            absent or hypoplastic corpus callosum, dysmorphic facies syndrome):
            genotype and phenotype of 22 patients with ZNF148 mutations
  JOURNAL   J Med Genet 61 (2), 132-141 (2024)
   PUBMED   37580113
  REMARK    GeneRIF: Further delineation of the rare GDACCF (global
            developmental delay, absent or hypoplastic corpus callosum,
            dysmorphic facies syndrome): genotype and phenotype of 22 patients
            with ZNF148 mutations.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9685)
  AUTHORS   Cheng,S., Liu,L., Wang,D., Li,Y., Li,S., Yuan,J., Huang,S., Xu,Z.,
            Jia,B., Li,Z. and Dong,J.
  TITLE     Upregulation of the ZNF148/PTX3 axis promotes malignant
            transformation of dendritic cells in glioma stem-like cells
            microenvironment
  JOURNAL   CNS Neurosci Ther 29 (9), 2690-2704 (2023)
   PUBMED   37063077
  REMARK    GeneRIF: Upregulation of the ZNF148/PTX3 axis promotes malignant
            transformation of dendritic cells in glioma stem-like cells
            microenvironment.
REFERENCE   4  (bases 1 to 9685)
  AUTHORS   de Klerk,E., Xiao,Y., Emfinger,C.H., Keller,M.P., Berrios,D.I.,
            Loconte,V., Ekman,A.A., White,K.L., Cardone,R.L., Kibbey,R.G.,
            Attie,A.D. and Hebrok,M.
  TITLE     Loss of ZNF148 enhances insulin secretion in human pancreatic beta
            cells
  JOURNAL   JCI Insight 8 (11), e157572 (2023)
   PUBMED   37288664
  REMARK    GeneRIF: Loss of ZNF148 enhances insulin secretion in human
            pancreatic beta cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9685)
  AUTHORS   Kuang,L.W., Zhang,C.C., Li,B.H., Liu,H.Z., Wang,H. and Li,G.C.
  TITLE     Identification of the MALAT1/miR-106a-5p/ZNF148 feedback loop in
            regulating HaCaT cell proliferation, migration and apoptosis
  JOURNAL   Regen Med 18 (3), 239-258 (2023)
   PUBMED   36710662
  REMARK    GeneRIF: Identification of the MALAT1/miR-106a-5p/ZNF148 feedback
            loop in regulating HaCaT cell proliferation, migration and
            apoptosis.
REFERENCE   6  (bases 1 to 9685)
  AUTHORS   Law,D.J., Tarle,S.A. and Merchant,J.L.
  TITLE     The human ZBP-89 homolog, located at chromosome 3q21, represses
            gastrin gene expression
  JOURNAL   Mamm Genome 9 (2), 165-167 (1998)
   PUBMED   9457682
REFERENCE   7  (bases 1 to 9685)
  AUTHORS   Taniuchi,T., Mortensen,E.R., Ferguson,A., Greenson,J. and
            Merchant,J.L.
  TITLE     Overexpression of ZBP-89, a zinc finger DNA binding protein, in
            gastric cancer
  JOURNAL   Biochem Biophys Res Commun 233 (1), 154-160 (1997)
   PUBMED   9144414
REFERENCE   8  (bases 1 to 9685)
  AUTHORS   Merchant,J.L., Iyer,G.R., Taylor,B.R., Kitchen,J.R.,
            Mortensen,E.R., Wang,Z., Flintoft,R.J., Michel,J.B. and
            Bassel-Duby,R.
  TITLE     ZBP-89, a Kruppel-like zinc finger protein, inhibits epidermal
            growth factor induction of the gastrin promoter
  JOURNAL   Mol Cell Biol 16 (12), 6644-6653 (1996)
   PUBMED   8943318
REFERENCE   9  (bases 1 to 9685)
  AUTHORS   Tommerup,N. and Vissing,H.
  TITLE     Isolation and fine mapping of 16 novel human zinc finger-encoding
            cDNAs identify putative candidate genes for developmental and
            malignant disorders
  JOURNAL   Genomics 27 (2), 259-264 (1995)
   PUBMED   7557990
REFERENCE   10 (bases 1 to 9685)
  AUTHORS   Wang,Y., Kobori,J.A. and Hood,L.
  TITLE     The ht beta gene encodes a novel CACCC box-binding protein that
            regulates T-cell receptor gene expression
  JOURNAL   Mol Cell Biol 13 (9), 5691-5701 (1993)
   PUBMED   8355710
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC108688.5, BQ441085.1,
            BU178504.1 and AA481164.1.
            
            On Jun 14, 2017 this sequence version replaced NM_001348429.1.
            
            Summary: The protein encoded by this gene is a member of the
            Kruppel family of zinc finger DNA binding proteins. The encoded
            protein activates transcription of the T-cell receptor and
            intestinal alkaline phosphatase genes but represses transcription
            of the ornithine decarboxylase, vimentin, gastrin, stomelysin, and
            enolase genes. Increased expression of this gene results in
            decreased patient survival rates from colorectal cancer, while
            mutations in this gene have been associated with global
            developmental delay, hypoplastic corpus callosum, and dysmorphic
            facies. [provided by RefSeq, Feb 2017].
            
            Transcript Variant: This variant (7) differs in the 5' UTR compared
            to variant 1. Variants 1-11 all encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.14166.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               AC108688.5         174268-174520       c
            254-329             AC108688.5         130324-130399       c
            330-465             AC108688.5         122475-122610       c
            466-582             AC108688.5         114103-114219       c
            583-858             AC108688.5         112547-112822       c
            859-1575            BQ441085.1         1-717
            1576-2100           BU178504.1         284-808
            2101-9159           AC108688.5         25331-32389         c
            9160-9685           AA481164.1         1-526               c
FEATURES             Location/Qualifiers
     source          1..9685
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.2"
     gene            1..9685
                     /gene="ZNF148"
                     /gene_synonym="BERF-1; BFCOL1; GDACCF; HT-BETA; pHZ-52;
                     ZBP-89; ZFP148"
                     /note="zinc finger protein 148"
                     /db_xref="GeneID:7707"
                     /db_xref="HGNC:HGNC:12933"
                     /db_xref="MIM:601897"
     exon            1..253
                     /gene="ZNF148"
                     /gene_synonym="BERF-1; BFCOL1; GDACCF; HT-BETA; pHZ-52;
                     ZBP-89; ZFP148"
                     /inference="alignment:Splign:2.1.0"
     exon            254..329
                     /gene="ZNF148"
                     /gene_synonym="BERF-1; BFCOL1; GDACCF; HT-BETA; pHZ-52;
                     ZBP-89; ZFP148"
                     /inference="alignment:Splign:2.1.0"
     exon            330..465
                     /gene="ZNF148"
                     /gene_synonym="BERF-1; BFCOL1; GDACCF; HT-BETA; pHZ-52;
                     ZBP-89; ZFP148"
                     /inference="alignment:Splign:2.1.0"
     exon            466..582
                     /gene="ZNF148"
                     /gene_synonym="BERF-1; BFCOL1; GDACCF; HT-BETA; pHZ-52;
                     ZBP-89; ZFP148"
                     /inference="alignment:Splign:2.1.0"
     exon            583..931
                     /gene="ZNF148"
                     /gene_synonym="BERF-1; BFCOL1; GDACCF; HT-BETA; pHZ-52;
                     ZBP-89; ZFP148"
                     /inference="alignment:Splign:2.1.0"
     CDS             599..2983
                     /gene="ZNF148"
                     /gene_synonym="BERF-1; BFCOL1; GDACCF; HT-BETA; pHZ-52;
                     ZBP-89; ZFP148"
                     /note="isoform a is encoded by transcript variant 7;
                     CLL-associated antigen KW-10; CACCC box-binding protein;
                     transcription factor ZBP-89; zinc finger DNA-binding
                     protein 89"
                     /codon_start=1
                     /product="zinc finger protein 148 isoform a"
                     /protein_id="NP_001335358.1"
                     /db_xref="CCDS:CCDS3031.1"
                     /db_xref="GeneID:7707"
                     /db_xref="HGNC:HGNC:12933"
                     /db_xref="MIM:601897"
                     /translation="MNIDDKLEGLFLKCGGIDEMQSSRTMVVMGGVSGQSTVSGELQD
                     SVLQDRSMPHQEILAADEVLQESEMRQQDMISHDELMVHEETVKNDEEQMETHERLPQ
                     GLQYALNVPISVKQEITFTDVSEQLMRDKKQIREPVDLQKKKKRKQRSPAKILTINED
                     GSLGLKTPKSHVCEHCNAAFRTNYHLQRHVFIHTGEKPFQCSQCDMRFIQKYLLQRHE
                     KIHTGEKPFRCDECGMRFIQKYHMERHKRTHSGEKPYQCEYCLQYFSRTDRVLKHKRM
                     CHENHDKKLNRCAIKGGLLTSEEDSGFSTSPKDNSLPKKKRQKTEKKSSGMDKESALD
                     KSDLKKDKNDYLPLYSSSTKVKDEYMVAEYAVEMPHSSVGGSHLEDASGEIHPPKLVL
                     KKINSKRSLKQPLEQNQTISPLSTYEESKVSKYAFELVDKQALLDSEGNADIDQVDNL
                     QEGPSKPVHSSTNYDDAMQFLKKKRYLQAASNNSREYALNVGTIASQPSVTQAAVASV
                     IDESTTASILESQALNVEIKSNHDKNVIPDEVLQTLLDHYSHKANGQHEISFSVADTE
                     VTSSISINSSEVPEVTPSENVGSSSQASSSDKANMLQEYSKFLQQALDRTSQNDAYLN
                     SPSLNFVTDNQTLPNQPAFSSIDKQVYATMPINSFRSGMNSPLRTTPDKSHFGLIVGD
                     SQHSFPFSGDETNHASATSTQDFLDQVTSQKKAEAQPVHQAYQMSSFEQPFRAPYHGS
                     RAGIATQFSTANGQVNLRGPGTSAEFSEFPLVNVNDNRAGMTSSPDATTGQTFG"
     exon            932..1057
                     /gene="ZNF148"
                     /gene_synonym="BERF-1; BFCOL1; GDACCF; HT-BETA; pHZ-52;
                     ZBP-89; ZFP148"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1181
                     /gene="ZNF148"
                     /gene_synonym="BERF-1; BFCOL1; GDACCF; HT-BETA; pHZ-52;
                     ZBP-89; ZFP148"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1265
                     /gene="ZNF148"
                     /gene_synonym="BERF-1; BFCOL1; GDACCF; HT-BETA; pHZ-52;
                     ZBP-89; ZFP148"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1384
                     /gene="ZNF148"
                     /gene_synonym="BERF-1; BFCOL1; GDACCF; HT-BETA; pHZ-52;
                     ZBP-89; ZFP148"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..9655
                     /gene="ZNF148"
                     /gene_synonym="BERF-1; BFCOL1; GDACCF; HT-BETA; pHZ-52;
                     ZBP-89; ZFP148"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4019..4024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF148"
                     /gene_synonym="BERF-1; BFCOL1; GDACCF; HT-BETA; pHZ-52;
                     ZBP-89; ZFP148"
                     /note="hexamer: AATAAA"
     polyA_site      4055
                     /gene="ZNF148"
                     /gene_synonym="BERF-1; BFCOL1; GDACCF; HT-BETA; pHZ-52;
                     ZBP-89; ZFP148"
                     /note="major polyA site"
     regulatory      4287..4292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF148"
                     /gene_synonym="BERF-1; BFCOL1; GDACCF; HT-BETA; pHZ-52;
                     ZBP-89; ZFP148"
                     /note="hexamer: AATAAA"
     polyA_site      4310
                     /gene="ZNF148"
                     /gene_synonym="BERF-1; BFCOL1; GDACCF; HT-BETA; pHZ-52;
                     ZBP-89; ZFP148"
                     /note="major polyA site"
     regulatory      7855..7860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF148"
                     /gene_synonym="BERF-1; BFCOL1; GDACCF; HT-BETA; pHZ-52;
                     ZBP-89; ZFP148"
                     /note="hexamer: ATTAAA"
     polyA_site      7875
                     /gene="ZNF148"
                     /gene_synonym="BERF-1; BFCOL1; GDACCF; HT-BETA; pHZ-52;
                     ZBP-89; ZFP148"
     regulatory      7958..7963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF148"
                     /gene_synonym="BERF-1; BFCOL1; GDACCF; HT-BETA; pHZ-52;
                     ZBP-89; ZFP148"
                     /note="hexamer: AATAAA"
     polyA_site      7984
                     /gene="ZNF148"
                     /gene_synonym="BERF-1; BFCOL1; GDACCF; HT-BETA; pHZ-52;
                     ZBP-89; ZFP148"
     regulatory      9632..9637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF148"
                     /gene_synonym="BERF-1; BFCOL1; GDACCF; HT-BETA; pHZ-52;
                     ZBP-89; ZFP148"
                     /note="hexamer: AATAAA"
     polyA_site      9655
                     /gene="ZNF148"
                     /gene_synonym="BERF-1; BFCOL1; GDACCF; HT-BETA; pHZ-52;
                     ZBP-89; ZFP148"
ORIGIN      
        1 ggcgaccgcg gcggcgctct agctgcggca tgtctgcgtc tctactgctc tgggaggagg
       61 aagagaagga ggaagaggag gaggaggagg agggggagga agaggagaaa ggcgcagggg
      121 tgggagctgt tgccgaagct gccacagcaa aagttctccc ccctcccccc ttcccctcct
      181 ctcaaggccc ctagaaaggt tggagctgcc gccgcctgca gtcggtgacc gcgcgactcg
      241 gcgcccgccc gcgagggagg aatcagcagc ttggaaattc aagcacgtga tctggcggga
      301 tgggcgtttg cctaacgtat ttaatggagg aatcggatgg cataagtgat taaggtggta
      361 ttgaggattt ctgaagccta tgaaaggtag aaactcaacc atgatttctt tttcaactct
      421 acagcattcc tttccttgaa gtcttcgttt ttaccttagt ctcggggtct tattctgtca
      481 cctaggtgga gtgcagtagt acagtcacag ctcactgcag ccccaacatc ctgggctcaa
      541 gccatcctcc tgcctcagcc tcccaagtag ctgggaccac aggcagttat acttaagcat
      601 gaacattgac gacaaactgg aaggattgtt tcttaaatgt ggcggcatag acgaaatgca
      661 gtcttccagg acaatggttg taatgggtgg agtgtctggc cagtctactg tgtctggaga
      721 gctacaggat tcagtacttc aagatcgaag tatgcctcac caggagatcc ttgctgcaga
      781 tgaagtgtta caagaaagtg aaatgagaca acaggatatg atatcacatg atgaactcat
      841 ggtccatgag gagacagtga aaaatgatga agagcagatg gaaacacatg aaagacttcc
      901 tcaaggacta cagtatgcac ttaatgtccc tataagcgta aagcaggaaa ttacttttac
      961 tgatgtatct gagcaactga tgagagacaa aaaacaaatc agagagccag tagacttaca
     1021 gaaaaagaag aagcggaaac aacgttctcc cgcaaaaatc cttacaataa atgaggatgg
     1081 atcacttggt ttgaaaaccc ctaaatctca cgtttgtgag cactgcaatg ctgcctttag
     1141 aacgaactat cacttacaga gacatgtctt cattcataca ggtgaaaaac catttcaatg
     1201 tagtcaatgt gacatgcgtt tcatacagaa gtacctgctt cagagacatg agaagattca
     1261 tactggtgaa aaaccatttc gctgtgatga atgtggtatg agattcatac aaaaatatca
     1321 tatggaaagg cataagagaa ctcatagtgg agaaaaacct taccagtgtg aatactgttt
     1381 acagtatttt tccagaacag atcgtgtatt gaaacataaa cgtatgtgcc atgaaaatca
     1441 tgacaaaaaa ctaaatagat gtgccatcaa aggtggcctt ctgacatctg aggaagattc
     1501 tggcttttct acatcaccaa aagacaactc actgccaaaa aagaaaaggc agaaaacgga
     1561 gaaaaaatca tctggaatgg acaaagagag tgctttggac aaatctgacc tgaaaaaaga
     1621 caaaaatgat tacttgcctc tttattcttc aagtactaaa gtaaaagatg agtatatggt
     1681 tgcagaatat gctgttgaaa tgccacattc gtcagttggg ggctcgcatt tagaagatgc
     1741 gtcaggagaa atacacccac ctaagttagt tctcaaaaaa attaatagta agagaagtct
     1801 gaaacagcca ctggagcaaa atcaaacaat ttcaccttta tccacatatg aagagagcaa
     1861 agtttcaaag tatgcttttg aacttgtgga taaacaggct ttactggact cagaaggcaa
     1921 tgctgacatt gatcaggttg ataatttgca ggaggggccc agtaaacctg tgcatagtag
     1981 tactaattat gatgatgcca tgcagttttt gaagaagaag cggtatcttc aagcagcaag
     2041 taacaacagc agggaatatg cgctgaatgt gggtaccata gcttctcagc cttctgtaac
     2101 acaagcagct gtggcaagtg tcattgatga aagtaccacg gcatccatat tagagtcaca
     2161 ggcactgaat gtggagatta agagtaatca tgacaaaaat gttattccag atgaggtact
     2221 gcagactctg ttggatcatt attcccacaa agctaatgga cagcatgaga tatccttcag
     2281 tgttgcagat actgaagtga cttctagcat atcaataaat tcttcagaag taccagaggt
     2341 caccccgtca gagaatgttg gatcaagctc ccaagcatcc tcatcagata aagccaacat
     2401 gttgcaggaa tactccaagt ttctgcagca ggctttggac agaactagcc aaaatgatgc
     2461 ctatttgaat agcccgagcc ttaactttgt gactgataac cagaccctcc caaatcagcc
     2521 agcattctct tccatagaca agcaggtcta tgccaccatg cccatcaata gctttcgatc
     2581 aggaatgaat tctccactaa gaacaactcc agataagtcc cactttggac taatagttgg
     2641 tgattcacag cactcatttc ccttttcagg tgatgagaca aaccatgctt ctgccacatc
     2701 aacacaggac tttctggatc aagtgacttc tcagaagaaa gctgaggccc agcctgtcca
     2761 ccaagcttac caaatgagct cctttgaaca gcccttccgt gctccctatc atggatcaag
     2821 agctggaata gctactcaat ttagcactgc caatggacag gtgaaccttc ggggaccagg
     2881 gacaagtgct gaattttcag aatttccctt ggtgaatgta aatgataata gagctgggat
     2941 gacatcttca cctgatgcca caactggcca gacttttggc taaaaaaaaa aaaaaagtgt
     3001 aaataatact ggcactttag aacagattaa tcaagagtgg ggttactctg tgtaaatgga
     3061 gtgctgtaca gatttaagag caatgcgtaa taacaagtta agctgatatg aatagcaaga
     3121 taatccaata actgcatttc gtttggttag tcagcattct ttgaactgcc ttacatgttg
     3181 tcacctttat agaagcaatg cattacttgt tttagatcag aaacttgcta ttccacccac
     3241 accaagttaa aaaggaaaaa aaaaagactt tcgcacaatt gtttcctaac tgataacatt
     3301 gtacattctt aggagattag taattgtgtg aaatttactc atactgtttc taagtttttc
     3361 agcatagtca ttgcacttca gcagggaatc tgagtatact ttacagacag agtgaactta
     3421 aaagtttaat gtcaagagat tatggcttaa ataaattagt gtgtcctata gggggaaaaa
     3481 aaccaagaaa ccacctttta aaaagaatga tatgccatat acccttgatt ttcattttgc
     3541 attatattga cgtgtttttt tgaaggaaaa aaagtaataa aaatctgata gtctaagact
     3601 ccactattta aaagcctaat tactttaaaa atatgcatac tttcagaact tttaccaaaa
     3661 cacacaactg ttgaagcagt cacttctcta tggaagtatg catattggtg tcagtttctt
     3721 tgtacagttg tacttagata ttttttatga tttttcatgt gcaggtatca aggttttgaa
     3781 gttttagtaa aagaaattct gtagattaca ttcccaagaa cataatgctt acacaaaatg
     3841 tatattccac gttttaaagc ttaattgtat tttactttac atatacactt cagttaacat
     3901 agagcactta gaatctattt ggtatttttg atttctcaaa gtaaaaaaaa aattagattt
     3961 ttaggtttga tatggttgtg tcataatcat ctcgtaattg acaattttaa cttttggcaa
     4021 taaaaggaaa ttgggatatc tttggaactg taaaacctgg tttaatcttt ttctttctag
     4081 actcttgata gattggataa ttaaacagta tccagagaaa ctaaagaaat gggcatttta
     4141 attgcatatt ttatcttgag ttacttttta atgaacactg ctcattacaa ctttacaaac
     4201 caaaagtgtt tactaattcc agtaactacc atttcttttt cagctagatg agtgatcgga
     4261 aaatttttgt tgcatttcaa aatctaaata aactacagac tttatcctta taccatgaat
     4321 gttttttttt aatactctgt cttaaaataa tacagcatgg tacaataaat agtgctttta
     4381 tgtatatata cacacacaca cttttctgaa gaatgatggt ttgagttatg cgttgggcag
     4441 ttttgatttt tggaagttat attagttatt gactctttgt tacaactttt tcatttttac
     4501 attttaaatt ttctgccatc gttgtcacaa tgcacatcct gatatagcac cagtgaaaat
     4561 ctaaaattaa tacccttgga aaatgaaaat attcttaatt tccattttga ctcttatact
     4621 ggccctatag ctctgcagtc tttgtttcaa tatagaatat gttatccatt taaattattt
     4681 tttcttttat ttaatgttat cccaagactg ttctcataaa gaaagggaag aaataactat
     4741 ccacccttaa catccttcat ttattttgaa tatattggtg tttttatgat aaggaatata
     4801 aattatattt aatgtggttt cctgtatact ttggttatta agttttgctt gaaatagtag
     4861 ttttcccgtt tgacagcttt ctttgctgcc aaagttttca agaatttaag acttctttga
     4921 agtaaatatt taagttctgc cattattgac tcttaagatt gtgtgtgttg tgttgtgcat
     4981 tacataatta caaaaaggct tcattcaggt gatacgttaa aaatggaact gtgctcaccc
     5041 taaataggca ttggtatttt tctcttttgg tgagagtagg catttatttc ttgagttgtt
     5101 ttggagcctg atcaaaaatt ttgttcatgg agaacttgat gcaattttga tacagtggag
     5161 aggttttttt cggttgtttt aacatcacca gcatagtttt tagaatgtga ctcttgctga
     5221 gcatttaggg tgagcttggg aaggaaggcc tttgaaaatg gtagttatgc aagcagactt
     5281 tcaggtgttg cattcctgtt ttcaacacat ttctttaaat ctacataatg gcagactttt
     5341 ctaccaggtt ataagcagtt tttagataag tgatactcag ccagcataac ttattgactt
     5401 accatttacg tatagtcatc actctcttac tgtgaaattc caaatgccta ccagagttac
     5461 cttgttctat cataatatga caaacatctc aacagttttg gatttcccca ctttggttca
     5521 gaaggttatt taatttctat ctgggcatta atggagaaaa taagtagcct tgtgtgctgc
     5581 ttcagattga aacatggagg atatgagata ttcttctgca attcatgttt ctcatttctc
     5641 aaagtgagca cattgttcta taaaaacatg ctggtacacc cttaaacttt tgatcaatct
     5701 gagtgaggtg tgcttttcct cttgggacct actcacgttt gaagattgga aacatcacgt
     5761 taggcgaggc agtatctctt gaacatcttc taaagggttt tttaaaacct tattctcaca
     5821 tatttcattt gtcttgaata tttaagtggc tcttaaacgt tttgggtcta catgcaaatg
     5881 tggtacttaa caaggtagga atccatcttc ttagctctgg ctgagggtgc cagccatcgg
     5941 tcaggtcatt tttatctcaa gaggcagaag gcagttatgt caagaattgt gctcagggca
     6001 ggatttcgtt tccacagagg agagacactt gcagagtgcc agctaggtta gatcttttgc
     6061 cgcttctttc atttgattaa tttgggtttt taaagggctg tttaaaaaaa aaaaaaaaag
     6121 gccgggaaac tttaaaagta ggcattactg tagtactgca tttcttagaa cattttaaac
     6181 tagaactcat ttttttttca cagtatattt acttgaagaa gcactataat aatcattgag
     6241 aagtattttg agtctgaaat ttaatttaat tttccgtttc aaattgcttt atttcaggga
     6301 aataattttc cagttgtttt gctatattct gcaaataaaa accgtgtttc cttttttcac
     6361 ttaaactttg gtaggaaaca aactaaagca gacaaacatt tcttgttatg tttgttgctt
     6421 tctttaatcc aatggataaa aaagtaaaac cctgtaaaca ttattttatt tttttatgca
     6481 ataccatgct gtaaatatgg ttcatcaaat aaggatgtac ctatgattga atctttaatt
     6541 ctgcacagtt agagtttata tataaacgtg tcttgacaat caaggacttt tatgtgagtc
     6601 ttcctttatg atgtttatta atgttatgca ttccatttgt tttgaagtga gtaccaatgt
     6661 gctaatttgt attgtctgaa agtatgtaat gtttttacag cttgttttta agaatctgta
     6721 aatatgtaca aacaaatcac agtactgctt tatgttagaa ggcatatgat gttgtactgt
     6781 atgtaagcaa taatacatag cagtgctaac tttacaagta gcatcaggaa agttctaaaa
     6841 acatttcaga gttattaatt atccttattt catttaataa tgattatctt taatcagttt
     6901 ttataagcaa attccattgt tcctcctatt ggaacgtaac actgtttaca cagcataatt
     6961 gaagttgcag gggagacagg ctaaatctga cttcatctgt actcactttc actaagcatt
     7021 gaatggcctt accactcttc tgcaagatgg aggaagaccg caaaacttag tgcccatcac
     7081 actgaaggaa gggatgtggt tttttttcct gcttctgtac tgctacctaa ctttgtgatt
     7141 tgctttggat tttaatattt gtttctgttt tagattcaag cccgtaagtt ttgaggtgac
     7201 ttcagctcca ttgtgaaata gatagttctc ttcatatttc ataactacat ttcaataatt
     7261 ctaaactttc tacattgatt tttagatact tatttttcaa gcttggtttc tcagctgatc
     7321 agatgaattt attcaacttc aatacaaaga aagacaaacc tattatagtt tcaagtgagt
     7381 agatattata ctgtacagga cagctatttg aacacacaca tcactgcttt agaaataaaa
     7441 ccgccaattt ataaatgtat atgacctaca ttttatagga aaaaatgttt ttaaatgcta
     7501 gtcatttata taatgtgctt tgaaggattt gctagtccac ttctgtcact ttttagtaca
     7561 ctggtatctt ttatatgtaa tgtatgcttt ttattattgt agcaaagcat ttcagtagaa
     7621 agaattttgc aacaatatgg gggaaatttt tcattgttgg atttgaatta tactggattt
     7681 tatctgtgta gtcttacttg tctttatttt aatgctgtct gaagggaact tggtatccaa
     7741 ataaagcagg taacctcatt ttacttcaag ggcatactgt gtagtgctga atttaatctg
     7801 aaaatctgat gattttgaaa agaaaaacaa gtttataaac attgtacaga agaaattaaa
     7861 tgtgtgtgat ggaaatcctg atggtggagc acgttgaatt ttctgatata tagtgttatt
     7921 ttcctgggat cccctatgcc ttctttgtat ttcaactaat aaaggaaaaa ccctgtcatt
     7981 aaaactggta agataatagg atattctgat tatacagtat tactattcct atcccatttt
     8041 ctgacctttt ctcaatcact gtaaattttt attttctatt tcctattgat aattaaatat
     8101 gtacataata tagacactgt tgtatagaac taaatgaatt gggttgctat gcttgagtgg
     8161 gtagtgaaat ggaaatattt gatgaatact gagagttcct aaaatgctag agcaaatttc
     8221 cgagggaaag gggggcatcg tgtgtcttgg gaaggttgca gcaggttgtt tcttcaactc
     8281 cctaagaaat cattgggaag gactcaactg caaactcggg atcagataca aaatgggtct
     8341 ttccttcccc tctcccccaa aaaataggag cactaaattt taaaatctac tcaggtgaca
     8401 gttgctttgc aatgaaactt atcacattga aattttcagt gttaaataaa aagagatttg
     8461 tgatattttt aaatataaac ttttacatca gtagtcagca gcctgacaat tgaaatttgg
     8521 taagtcgata tattttaaaa tattttgctc tccaaataga attgttttta aacaattggg
     8581 aggttttttg tttctttaaa tatgttttaa ttgtcattgt aaaaacaaaa tcttgcttga
     8641 ccctatatta tgccatgaat gaattgctga gcctttataa tacagtgaca gcttgtttca
     8701 tgcatagtca tggaacatag agatgttctt taaactgacc tattgataag aggtttaatg
     8761 agtttcacgg ctttcaacac tattgtcata tagttatctt tgccatttgg agtttataaa
     8821 accattttat gtattgtgat actaaaggaa gttgttttgc tttactttaa attgaattat
     8881 tagactaata tttgcaaatt ctgcatttta aatgtggaca ctggctgttt gaaaaataaa
     8941 atatagaata cagttttatg gataattttc gagctgaatt tttcacaata ttctgaacca
     9001 aataacgaat ggtaaatatg caaaaatcat ggtgcataga tataaccgta aagagaaaag
     9061 aatttctgtg tggaattaac agttacacaa attgggtaac aattatcagg gcctttatta
     9121 tagctttatg tggaatgtta ttctaaaatg caagagtcaa atgttactgt cattgaatat
     9181 tttagacttg aaacgtgttt atcatagagc gaagaaaata tgtgttcttt tctttacaga
     9241 taagactctg ttaacccact gtcagcatac gtgggatttc ttttcttttt tctttcatta
     9301 gtggagattt gttttcatcc atctaccacc ttgccagtac cctagcttgt gaccagcggg
     9361 atgcattgta agaaagttgt ctgtggttag gagtgcagtc tgggtccatg gaacaaattt
     9421 aaactaattg gccctcgcaa tgatcagtcc taggaccctg gccttattat tagcatggtg
     9481 ctttaaccaa ttgtacataa taataccact gatagtctac taatgcattt cctagatccc
     9541 agtttttctt gaatgattag gaatggtggg gagaggggag gggagatatt ctacatgata
     9601 cttctccaat cttctaaaga ttataagaaa aaataaaaaa ttgaagtcac ttgaaaaaaa
     9661 aaaaaaaaaa aaaaaaaaaa aaaaa
//
