LOCUS       NM_007145               3347 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens zinc finger protein 146 (ZNF146), transcript variant
            1, mRNA.
ACCESSION   NM_007145
VERSION     NM_007145.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3347)
  AUTHORS   Zhao,R., Song,N., Ning,X., Chen,X. and Ma,R.
  TITLE     ZNF146 regulates cell cycle progression via TFDP1 and DEPDC1B in
            ovarian cancer cells
  JOURNAL   Reproduction 168 (1), e230484 (2024)
   PUBMED   38614125
  REMARK    GeneRIF: ZNF146 regulates cell cycle progression via TFDP1 and
            DEPDC1B in ovarian cancer cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3347)
  AUTHORS   Jiang,F., Huang,X., Ling,L., Tang,S., Zhou,H., Cai,X. and Wang,Y.
  TITLE     Long Noncoding RNA ZBED5-AS1 Facilitates Tumor Progression and
            Metastasis in Lung Adenocarcinoma via ZNF146/ATR/Chk1 Axis
  JOURNAL   Int J Mol Sci 24 (18), 13925 (2023)
   PUBMED   37762228
  REMARK    GeneRIF: Long Noncoding RNA ZBED5-AS1 Facilitates Tumor Progression
            and Metastasis in Lung Adenocarcinoma via ZNF146/ATR/Chk1 Axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3347)
  AUTHORS   Creamer,K.M., Larsen,E.C. and Lawrence,J.B.
  TITLE     ZNF146/OZF and ZNF507 target LINE-1 sequences
  JOURNAL   G3 (Bethesda) 12 (3) (2022)
   PUBMED   35100360
  REMARK    GeneRIF: ZNF146/OZF and ZNF507 target LINE-1 sequences.
REFERENCE   4  (bases 1 to 3347)
  AUTHORS   Zhu,S., Chen,C.Y. and Hao,Y.
  TITLE     LncRNA KCNQ1OT1 acts as miR-216b-5p sponge to promote colorectal
            cancer progression via up-regulating ZNF146
  JOURNAL   J Mol Histol 52 (3), 479-490 (2021)
   PUBMED   33394291
  REMARK    GeneRIF: LncRNA KCNQ1OT1 acts as miR-216b-5p sponge to promote
            colorectal cancer progression via up-regulating ZNF146.
REFERENCE   5  (bases 1 to 3347)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3347)
  AUTHORS   Ferbus,D., Flechon,A., Muleris,M., Li,Y., Hanash,S., Terris,B.,
            Hammel,P., Pibouin,L., Dutrillaux,B. and Goubin,G.
  TITLE     Amplification and over-expression of OZF, a gene encoding a zinc
            finger protein, in human pancreatic carcinomas
  JOURNAL   Int J Cancer 80 (3), 369-372 (1999)
   PUBMED   9935176
REFERENCE   7  (bases 1 to 3347)
  AUTHORS   Blottiere,L., Apiou,F., Ferbus,D., Guenzi,C., Dutrillaux,B.,
            Prosperi,M.T. and Goubin,G.
  TITLE     Cloning, characterization, and chromosome assignment of Zfp146 the
            mouse ortholog of human ZNF146, a gene amplified and overexpressed
            in pancreatic cancer, and Zfp260 a closely related gene
  JOURNAL   Cytogenet Cell Genet 85 (3-4), 297-300 (1999)
   PUBMED   10449921
REFERENCE   8  (bases 1 to 3347)
  AUTHORS   Ferbus,D., Le Chalony,C., Prosperi,M.T., Muleris,M.,
            Vincent-Salomon,A. and Goubin,G.
  TITLE     Identification, nuclear localization, and binding activities of
            OZF, a human protein solely composed of zinc-finger motifs
  JOURNAL   Eur J Biochem 236 (3), 991-995 (1996)
   PUBMED   8665923
REFERENCE   9  (bases 1 to 3347)
  AUTHORS   Hayes,H., Le Chalony,C., Goubin,G., Mercier,D., Payen,E., Bignon,C.
            and Kohno,K.
  TITLE     Localization of ZNF164, ZNF146, GGTA1, SOX2, PRLR and EEF2 on
            homoeologous cattle, sheep and goat chromosomes by fluorescent in
            situ hybridization and comparison with the human gene map
  JOURNAL   Cytogenet Cell Genet 72 (4), 342-346 (1996)
   PUBMED   8641144
REFERENCE   10 (bases 1 to 3347)
  AUTHORS   Le Chalony,C., Prosperi,M.T., Haluza,R., Apiou,F., Dutrillaux,B.
            and Goubin,G.
  TITLE     The OZF gene encodes a protein consisting essentially of zinc
            finger motifs
  JOURNAL   J Mol Biol 236 (2), 399-404 (1994)
   PUBMED   8107129
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA395000.1, DR155969.1, DA645504.1, BC065568.1 and AI039686.1.
            
            On May 21, 2020 this sequence version replaced NM_007145.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, and 3 all encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065568.1, SRR18074968.394206.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000443387.3/ ENSP00000392095.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-386               DA395000.1         1-386
            387-969             DR155969.1         158-740
            970-1298            DA645504.1         1-329
            1299-3344           BC065568.1         1272-3317
            3345-3347           AI039686.1         30-32               c
FEATURES             Location/Qualifiers
     source          1..3347
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..3347
                     /gene="ZNF146"
                     /gene_synonym="OZF"
                     /note="zinc finger protein 146"
                     /db_xref="GeneID:7705"
                     /db_xref="HGNC:HGNC:12931"
                     /db_xref="MIM:601505"
     exon            1..91
                     /gene="ZNF146"
                     /gene_synonym="OZF"
                     /inference="alignment:Splign:2.1.0"
     exon            92..165
                     /gene="ZNF146"
                     /gene_synonym="OZF"
                     /inference="alignment:Splign:2.1.0"
     exon            166..237
                     /gene="ZNF146"
                     /gene_synonym="OZF"
                     /inference="alignment:Splign:2.1.0"
     exon            238..3347
                     /gene="ZNF146"
                     /gene_synonym="OZF"
                     /inference="alignment:Splign:2.1.0"
     CDS             1020..1898
                     /gene="ZNF146"
                     /gene_synonym="OZF"
                     /note="only zinc finger protein"
                     /codon_start=1
                     /product="zinc finger protein OZF"
                     /protein_id="NP_009076.2"
                     /db_xref="CCDS:CCDS12492.1"
                     /db_xref="GeneID:7705"
                     /db_xref="HGNC:HGNC:12931"
                     /db_xref="MIM:601505"
                     /translation="MSHLSQQRIYSGENPFACKVCGKVFSHKSNLTEHEHFHTREKPF
                     ECNECGKAFSQKQYVIKHQNTHTGEKLFECNECGKSFSQKENLLTHQKIHTGEKPFEC
                     KDCGKAFIQKSNLIRHQRTHTGEKPFVCKECGKTFSGKSNLTEHEKIHIGEKPFKCSE
                     CGTAFGQKKYLIKHQNIHTGEKPYECNECGKAFSQRTSLIVHVRIHSGDKPYECNVCG
                     KAFSQSSSLTVHVRSHTGEKPYGCNECGKAFSQFSTLALHLRIHTGKKPYQCSECGKA
                     FSQKSHHIRHQKIHTH"
     regulatory      3323..3328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF146"
                     /gene_synonym="OZF"
                     /note="hexamer: ATTAAA"
     polyA_site      3347
                     /gene="ZNF146"
                     /gene_synonym="OZF"
                     /note="major polyA site"
ORIGIN      
        1 gagtgcgcaa gcgcagcgca ccgagtggac attttggtct ttgtccgcgg gtcagtacgg
       61 cccctgggtc cacgtggcgc gaaagtagga ggaagacata ggccaaggag ccagacttcc
      121 tgtgttaact ccttcctctg ccacttttta ccttggggac ctcagttaat atgatcctct
      181 gttgaagcaa gaagacaaac tgtatggtgg agaaagaagt gggaaggatc tgcgcggaag
      241 aagcctgaga agatgatgca cagatagaga ggcaccagga cttgagaggc accaggactt
      301 gggaggcatg ttgatccatc tccaggaaag actgagaaaa agagcgttga atataagaaa
      361 aaatacttcc tctgttctca gatcgtattt gttttaaggc cacacctttt tgaagttttc
      421 agtttgaaac acaacctgga ctgaaatcat gagggaggtt gtgtaggaaa gaatcatcaa
      481 gggacttagt tgggagcttc tctaccacag cttactcctt atggtattaa ccccctttaa
      541 gtgtaaatgt ctttggttta aaacgtttgt acctcatctg ttaccagagt gttcatactg
      601 gagagaaacc ctatgaattt actgaatgtg ggggaactgt tactcatatg ttgcatttcg
      661 tcgaacgtgc aagtcatgct gaagagaaac cctgtgcttc taaggagtat tgacaagccc
      721 ttagctagat gacaatctca ttgagaagca gaaaattcat gctggagaga aactagtgaa
      781 ggtagcaata cttcattgaa tattagaaaa tttttctaga gagaaagcat tgaatatact
      841 gagtatgata acatttcctc tcaaacctta tcccttactc tgcatttggg agatcataca
      901 cagagaagcc ttataaatgt aagagatgtg gaaatatctt cagccaaaag taaatcctca
      961 ctcatcaaga aatttttact ggagagaaac cttgtgaatg tgggaaagct tccattcaga
     1021 tgtcacacct cagccagcag agaatttaca gtggggaaaa cccctttgcc tgtaaggtat
     1081 gtggaaaagt cttcagccac aaatcaaacc tcactgagca tgagcatttt cacacgagag
     1141 agaaaccttt tgaatgtaac gagtgtggaa aagcctttag ccaaaagcag tatgtcatta
     1201 aacatcagaa cacccatact ggcgagaagc ttttcgaatg taatgaatgt ggaaaatcat
     1261 ttagccagaa ggaaaacctc cttacgcacc agaaaattca cactggagaa aaaccttttg
     1321 agtgtaaaga ttgcgggaaa gctttcattc agaagtcaaa cctcatcaga caccagagaa
     1381 ctcacacagg agagaagccc tttgtatgta aggagtgtgg aaaaaccttc agtggcaaat
     1441 ccaaccttac tgagcatgag aaaatccata ttggagagaa gccttttaaa tgtagtgaat
     1501 gtggaacagc ctttggccag aagaagtacc tcataaaaca tcagaacatt cacactggag
     1561 agaaacccta tgaatgtaac gaatgtggaa aagccttctc tcagcgaaca tcacttattg
     1621 tacatgtgag gattcattca ggtgataaac cttacgaatg caatgtttgt ggaaaagcct
     1681 tctctcagag ctcatctctc actgtgcatg tgagaagcca tacaggggag aagccctatg
     1741 gttgtaatga atgtgggaaa gctttctctc agttctcaac ccttgctctg catttgagaa
     1801 tacacacagg taagaagcct tatcagtgca gtgaatgtgg gaaagctttc agccagaagt
     1861 cacaccacat tagacaccag aaaattcata ctcactaaaa accccatgaa agccttgaaa
     1921 gtgggaaagc tttcattaga aatttgcacc tcatcatgcc ccagaaataa tccttctgaa
     1981 gcaaagcacc acgaatgagg ttaactttaa caagtactaa aaacttaagg gacaccagaa
     2041 aatttgtact gaagagaaag acatgcatat gattaaaacc ctgtgtccaa cagagaaacc
     2101 tgcagcagag ataatggtga aagtttaggc acattttcac taaaagtggg aacagaaaat
     2161 ggaggcctgt tttttattgc taccaccata gatctggaga tcttcgccag taacaagaaa
     2221 aattaagttg taaatattgg aaaggaacag acaaaaatag atgacatggt catctacaac
     2281 taatattaag actcctgtgg tattgattga gcagagcaga agagatttca aaaaaagacc
     2341 tatgcattta ttagaatttg gaatatgata caagtggcat caggaaatga ggaaataatg
     2401 gaactatttt ttttaagtgg aggtagtttg ttctccaagg gggaaaaata gaccatgaac
     2461 tatacacaaa agtgaatcca gagattaaaa acagaaatat ggaaaagcta tgtactaaaa
     2521 tgcatatgac cttgggaata gggaaacatt ccttggaaca atttgagaaa tacttagcgg
     2581 ttctacttat gagtatgaat gctcaggaaa tacgcactag gatatttact gtggcttgat
     2641 ttgtagtagc caaaaattag aaacaactga gaaagcccat cacgaacaat atgggaaatt
     2701 cttatgtaat actatatatc tgtaaaatgc aacaaatgaa atccacatgt attaacagaa
     2761 agatcccaga attgttgagg ggggatcaag ttgcagaatg atacagatag tacaatgact
     2821 tttttgtaaa tttgaattaa aagtttcctc ataaaactca gtactatcta ttggtaatgg
     2881 atgcatatat gtatgtacat gtttttgaaa cggattggaa ggatacagac caaactcttg
     2941 atagtggtca cctgtgaaga gtggagaagg gaaaataatg agtgtgggag gtgggatggg
     3001 tattggttaa aggggacttc agctttttat ataaacatcc acttctcttt caaaagactt
     3061 caagtaaata taagaagata ctgattgatt ctggattgtg gtatagggat atcttgtctt
     3121 attttttgta cttttctgta tttttaaaat ttctcaaaat aggaatggga gtgaggatgg
     3181 gaatgctgta tctgtggaag tcatgttata ctggattcat ttccaattaa atactaaaca
     3241 ttttatagaa aatatttcta aaattttatc acggatgaat ggatggactt gctctctatg
     3301 taatatgaaa ttaatctatt ttattaaaat ttaaaaggac agcacaa
//
