LOCUS       NM_003442               2900 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens zinc finger protein 143 (ZNF143), transcript variant
            1, mRNA.
ACCESSION   NM_003442
VERSION     NM_003442.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2900)
  AUTHORS   Geng,T., Sun,Q., He,J., Chen,Y., Cheng,W., Shen,J., Liu,B.,
            Zhang,M., Wang,S., Asan,K., Song,M., Gao,Q., Song,Y., Liu,R.,
            Liu,X., Ding,Y., Jing,A., Ye,X., Ren,H., Zeng,K., Zhou,Y.,
            Zhang,B., Ma,S., Liu,W., Liu,S. and Ji,J.
  TITLE     CXXC5 drove inflammation and ovarian cancer proliferation via
            transcriptional activation of ZNF143 and EGR1
  JOURNAL   Cell Signal 119, 111180 (2024)
   PUBMED   38642782
  REMARK    GeneRIF: CXXC5 drove inflammation and ovarian cancer proliferation
            via transcriptional activation of ZNF143 and EGR1.
REFERENCE   2  (bases 1 to 2900)
  AUTHORS   Li,M., Chen,J., Zhang,H., Zhang,Y., Wang,J., Shen,Z., Chen,Y.,
            Hou,W. and Chi,C.
  TITLE     LOC644656 promotes cisplatin resistance in cervical cancer by
            recruiting ZNF143 and activating the transcription of E6-AP
  JOURNAL   Cell Signal 117, 111115 (2024)
   PUBMED   38395183
  REMARK    GeneRIF: LOC644656 promotes cisplatin resistance in cervical cancer
            by recruiting ZNF143 and activating the transcription of E6-AP.
REFERENCE   3  (bases 1 to 2900)
  AUTHORS   Chen,Y., Li,J., Ma,J. and Bao,Y.
  TITLE     ZNF143 facilitates the growth and migration of glioma cells by
            regulating KPNA2-mediated Hippo signalling
  JOURNAL   Sci Rep 13 (1), 11097 (2023)
   PUBMED   37423952
  REMARK    GeneRIF: ZNF143 facilitates the growth and migration of glioma
            cells by regulating KPNA2-mediated Hippo signalling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2900)
  AUTHORS   Mei,J., Liu,Y., Sheng,Y., Liu,Y., Chen,L., Wang,H., Cheng,M.,
            Zhai,Z. and Xu,L.
  TITLE     ATF1 promotes the malignancy of lung adenocarcinoma cells by
            transcriptionally regulating ZNF143 expression
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (5), 769-782 (2023)
   PUBMED   37158648
  REMARK    GeneRIF: ATF1 promotes the malignancy of lung adenocarcinoma cells
            by transcriptionally regulating ZNF143 expression.
REFERENCE   5  (bases 1 to 2900)
  AUTHORS   Rao,P., Li,C., Wang,L., Jiang,Y., Yang,L., Li,H., Yang,P., Tao,J.,
            Lu,D. and Sun,L.
  TITLE     ZNF143 regulates autophagic flux to alleviate myocardial
            ischemia/reperfusion injury through Raptor
  JOURNAL   Cell Signal 99, 110444 (2022)
   PUBMED   35988805
  REMARK    GeneRIF: ZNF143 regulates autophagic flux to alleviate myocardial
            ischemia/reperfusion injury through Raptor.
REFERENCE   6  (bases 1 to 2900)
  AUTHORS   Schuster,C., Krol,A. and Carbon,P.
  TITLE     Two distinct domains in Staf to selectively activate small nuclear
            RNA-type and mRNA promoters
  JOURNAL   Mol Cell Biol 18 (5), 2650-2658 (1998)
   PUBMED   9566884
REFERENCE   7  (bases 1 to 2900)
  AUTHORS   Schaub,M., Myslinski,E., Schuster,C., Krol,A. and Carbon,P.
  TITLE     Staf, a promiscuous activator for enhanced transcription by RNA
            polymerases II and III
  JOURNAL   EMBO J 16 (1), 173-181 (1997)
   PUBMED   9009278
REFERENCE   8  (bases 1 to 2900)
  AUTHORS   Schuster,C., Myslinski,E., Krol,A. and Carbon,P.
  TITLE     Staf, a novel zinc finger protein that activates the RNA polymerase
            III promoter of the selenocysteine tRNA gene
  JOURNAL   EMBO J 14 (15), 3777-3787 (1995)
   PUBMED   7641696
REFERENCE   9  (bases 1 to 2900)
  AUTHORS   Tommerup,N. and Vissing,H.
  TITLE     Isolation and fine mapping of 16 novel human zinc finger-encoding
            cDNAs identify putative candidate genes for developmental and
            malignant disorders
  JOURNAL   Genomics 27 (2), 259-264 (1995)
   PUBMED   7557990
REFERENCE   10 (bases 1 to 2900)
  AUTHORS   Sloan,J.L., Carrillo,N., Adams,D. and Venditti,C.P.
  TITLE     Disorders of Intracellular Cobalamin Metabolism
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301503
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG825506.1, BC020219.1, AK297214.1 and AW162015.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003442.5.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291133.1, SRR1803611.43289.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396602.7/ ENSP00000379847.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-418               BG825506.1         48-465
            419-1369            BC020219.1         465-1415
            1370-1839           AK297214.1         1269-1738
            1840-2441           BC020219.1         1886-2487
            2442-2900           AW162015.1         9-467               c
FEATURES             Location/Qualifiers
     source          1..2900
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..2900
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /note="zinc finger protein 143"
                     /db_xref="GeneID:7702"
                     /db_xref="HGNC:HGNC:12928"
                     /db_xref="MIM:603433"
     exon            1..65
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            66..184
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1989
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /EC_number="2.7.10.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SPH-binding factor; transcriptional activator Staf; hStaf;
                     selenocysteine tRNA gene transcription-activating factor"
                     /codon_start=1
                     /product="zinc finger protein 143 isoform 1"
                     /protein_id="NP_003433.3"
                     /db_xref="CCDS:CCDS7799.2"
                     /db_xref="GeneID:7702"
                     /db_xref="HGNC:HGNC:12928"
                     /db_xref="MIM:603433"
                     /translation="MLLAQINRDSQGMTEFPGGGMEAQHVTLCLTEAVTVADGDNLEN
                     MEGVSLQAVTLADGSTAYIQHNSKDAKLIDGQVIQLEDGSAAYVQHVPIPKSTGDSLR
                     LEDGQAVQLEDGTTAFIHHTSKDSYDQSALQAVQLEDGTTAYIHHAVQVPQSDTILAI
                     QADGTVAGLHTGDATIDPDTISALEQYAAKVSIDGSESVAGTGMIGENEQEKKMQIVL
                     QGHATRVTAKSQQSGEKAFRCEYDGCGKLYTTAHHLKVHERSHTGDRPYQCEHAGCGK
                     AFATGYGLKSHVRTHTGEKPYRCSEDNCTKSFKTSGDLQKHIRTHTGERPFKCPFEGC
                     GRSFTTSNIRKVHVRTHTGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVP
                     GCDKRFTEYSSLYKHHVVHTHSKPYNCNHCGKTYKQISTLAMHKRTAHNDTEPIEEEQ
                     EAFFEPPPGQGEDVLKGSQITYVTGVEGDDVVSTQVATVTQSGLSQQVTLISQDGTQH
                     VNISQADMQAIGNTITMVTQDGTPITVPAHDAVISSAGTHSVAMVTAEGTEGEQVAIV
                     AQDLAAFHTASSEMGHQQHSHHLVTTETRPLTLVATSNGTQIAVQLGEQPSLEEAIRI
                     ASRIQQGETPGLDD"
     exon            185..277
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            278..361
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            362..445
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            446..642
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            643..717
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            718..837
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            838..913
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1039
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1219
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1447
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1596
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1758
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1905
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2900
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2408..2413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /note="hexamer: AATAAA"
     polyA_site      2441
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /note="major polyA site"
     regulatory      2634..2639
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /note="hexamer: ATTAAA"
     polyA_site      2651
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
     regulatory      2877..2882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /note="hexamer: AATACA"
     polyA_site      2900
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
ORIGIN      
        1 acggctgttt cctgtcctgg tgcatggtgg tcggacgaag gaattgttgg aaaattttct
       61 cggaggtaga agatgttgtt agcccaaata aatcgagatt ctcagggaat gacagagttt
      121 cctggaggag ggatggaggc gcaacatgtt acgctgtgct tgacagaggc agtcaccgtg
      181 gcagatggtg acaacttaga aaatatggaa ggcgtaagct tgcaagcagt aacacttgca
      241 gatggttcta ctgcttacat acaacacaat tctaaagatg caaaactcat agatggccag
      301 gtcattcagt tggaagatgg ttctgcggcc tatgttcaac atgtacccat acctaaaagt
      361 acaggggaca gtttgcgtct agaggatggt caagcagtac agttagaaga tggtaccaca
      421 gcatttattc accacacctc caaagatagt tatgaccaga gtgcattaca ggcggttcag
      481 ctggaagatg gtaccacagc ttatatccac catgcagtgc aagtcccgca gtctgacacc
      541 atcttggcaa ttcaggctga tgggacagtg gcaggtctgc acactgggga tgctacaatt
      601 gaccctgaca ccatcagtgc tttggaacag tatgcagcaa aggtgtccat tgatggaagt
      661 gaaagtgtag caggtactgg aatgattgga gaaaatgagc aagagaaaaa aatgcagatt
      721 gttttacaag gacatgctac aagagtaact gctaaatctc aacagagtgg agagaaggca
      781 tttcgatgtg aatatgatgg atgtggaaaa ttatatacaa cagctcatca tctcaaggtc
      841 catgagaggt cacacacagg agatcggcct tatcagtgtg agcatgcagg ctgtgggaag
      901 gcatttgcaa caggttatgg attaaaaagt cacgtcagaa ctcatacagg agaaaagcca
      961 tatcggtgtt cggaagataa ttgtactaaa tctttcaaaa cttcaggaga tctacagaaa
     1021 cacatcagaa ctcatacagg agaaaggccc tttaagtgtc ccttcgaagg ctgcggtcgg
     1081 tcctttacaa catcaaatat cagaaaagtg cacgttagga cacacacagg agaaagacct
     1141 tattactgca cagagccagg atgtgggagg gcatttgcca gtgcaacaaa ttataaaaac
     1201 catgtgagga tacacacagg agaaaagcca tatgtttgta cagttcctgg gtgtgacaaa
     1261 aggtttacag aatattccag tttgtacaaa catcatgttg tccacactca ttccaaacct
     1321 tacaactgta accactgtgg gaagacatac aagcagatct ccacgctggc catgcacaaa
     1381 cggacagccc acaacgacac tgagcccatc gaggaggagc aggaagcctt ctttgagccg
     1441 cccccaggtc aaggtgaaga tgttcttaaa gggtcccaga ttacgtatgt tacaggtgta
     1501 gaaggggacg acgttgtttc tacacaagta gccacagtaa cccaatctgg actgagtcaa
     1561 caagttacac tcatatccca ggatgggact cagcatgtca acatatctca agctgacatg
     1621 caggccattg gcaacaccat cacaatggta acgcaggatg gcacgcccat cacagtcccc
     1681 gcccatgatg cagtcatctc ctcagcagga acgcactctg ttgctatggt tactgctgag
     1741 ggtacagaag gggaacaggt tgcaattgta gctcaagact tggcagcatt ccatactgcc
     1801 tcatcagaaa tggggcacca gcagcatagc catcacttag taaccacaga aaccagacct
     1861 ctgaccttag tagcaacatc caatggcacc cagattgcag ttcagcttgg agaacagcca
     1921 tctctggaag aagccatcag aatagcgtct agaatccaac aaggagaaac gccagggttg
     1981 gatgattaat cctcagaaca atggagcaat aaagcagaag gagtctttca tcttctggca
     2041 gcagaaatcc atgaagcccg ggcccaggaa aattagaagt tttccattcc tgatacactg
     2101 tacacatttt tatgcgagag tggagaacat tttattcttg acacttttgt gtatataacc
     2161 cttggaatag attctcagag tgattcattg tgtacaagga agtatgaaat tagggcaata
     2221 cagtaaattt tcatgttact cttttatcag atcacaaact cctagagtct acatgcaaga
     2281 ctagtaaagt cttatggagt cttatgatgg atttttaact tcccgtggaa aaaaaaataa
     2341 aggctgtatc taaaatatca aaggttctat atgtcacaca atcgtaattc caaaagccat
     2401 tatggataat aaagggtgta aagccttcag atatttcccc agttagtaga gtgtctgcgg
     2461 tttttgttct actatatgct tgtccatttt tatttgtatc tcatggtttg cagactgttt
     2521 gaataattta tagtttccca tccctgttaa aaaccagctc ttcaagctga aatgctaatt
     2581 atattggcat tacattgaat tatgtacaaa attataaaat ttggttattt aaaattaaaa
     2641 agttaaatcc agtggttttg ttaaagattt tgcttagtat tcaattttta ttactgtttt
     2701 ttaaaaataa tgaatcatca aagtttaacc acaggctggt gcccgggata acagtactgt
     2761 aattggaaat ggctttactc tgaaaattag gttagtgggt tggtgtaaat tatttatttt
     2821 tgcttatgta cttttgtttt aaagcttatt taccccaaag tttattatta attttgaata
     2881 cagcaatttt taaaatgtta
//
