LOCUS       NM_001282657            2807 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens zinc finger protein 143 (ZNF143), transcript variant
            3, mRNA.
ACCESSION   NM_001282657 XM_005253124
VERSION     NM_001282657.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2807)
  AUTHORS   Geng,T., Sun,Q., He,J., Chen,Y., Cheng,W., Shen,J., Liu,B.,
            Zhang,M., Wang,S., Asan,K., Song,M., Gao,Q., Song,Y., Liu,R.,
            Liu,X., Ding,Y., Jing,A., Ye,X., Ren,H., Zeng,K., Zhou,Y.,
            Zhang,B., Ma,S., Liu,W., Liu,S. and Ji,J.
  TITLE     CXXC5 drove inflammation and ovarian cancer proliferation via
            transcriptional activation of ZNF143 and EGR1
  JOURNAL   Cell Signal 119, 111180 (2024)
   PUBMED   38642782
  REMARK    GeneRIF: CXXC5 drove inflammation and ovarian cancer proliferation
            via transcriptional activation of ZNF143 and EGR1.
REFERENCE   2  (bases 1 to 2807)
  AUTHORS   Li,M., Chen,J., Zhang,H., Zhang,Y., Wang,J., Shen,Z., Chen,Y.,
            Hou,W. and Chi,C.
  TITLE     LOC644656 promotes cisplatin resistance in cervical cancer by
            recruiting ZNF143 and activating the transcription of E6-AP
  JOURNAL   Cell Signal 117, 111115 (2024)
   PUBMED   38395183
  REMARK    GeneRIF: LOC644656 promotes cisplatin resistance in cervical cancer
            by recruiting ZNF143 and activating the transcription of E6-AP.
REFERENCE   3  (bases 1 to 2807)
  AUTHORS   Chen,Y., Li,J., Ma,J. and Bao,Y.
  TITLE     ZNF143 facilitates the growth and migration of glioma cells by
            regulating KPNA2-mediated Hippo signalling
  JOURNAL   Sci Rep 13 (1), 11097 (2023)
   PUBMED   37423952
  REMARK    GeneRIF: ZNF143 facilitates the growth and migration of glioma
            cells by regulating KPNA2-mediated Hippo signalling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2807)
  AUTHORS   Mei,J., Liu,Y., Sheng,Y., Liu,Y., Chen,L., Wang,H., Cheng,M.,
            Zhai,Z. and Xu,L.
  TITLE     ATF1 promotes the malignancy of lung adenocarcinoma cells by
            transcriptionally regulating ZNF143 expression
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (5), 769-782 (2023)
   PUBMED   37158648
  REMARK    GeneRIF: ATF1 promotes the malignancy of lung adenocarcinoma cells
            by transcriptionally regulating ZNF143 expression.
REFERENCE   5  (bases 1 to 2807)
  AUTHORS   Rao,P., Li,C., Wang,L., Jiang,Y., Yang,L., Li,H., Yang,P., Tao,J.,
            Lu,D. and Sun,L.
  TITLE     ZNF143 regulates autophagic flux to alleviate myocardial
            ischemia/reperfusion injury through Raptor
  JOURNAL   Cell Signal 99, 110444 (2022)
   PUBMED   35988805
  REMARK    GeneRIF: ZNF143 regulates autophagic flux to alleviate myocardial
            ischemia/reperfusion injury through Raptor.
REFERENCE   6  (bases 1 to 2807)
  AUTHORS   Schuster,C., Krol,A. and Carbon,P.
  TITLE     Two distinct domains in Staf to selectively activate small nuclear
            RNA-type and mRNA promoters
  JOURNAL   Mol Cell Biol 18 (5), 2650-2658 (1998)
   PUBMED   9566884
REFERENCE   7  (bases 1 to 2807)
  AUTHORS   Schaub,M., Myslinski,E., Schuster,C., Krol,A. and Carbon,P.
  TITLE     Staf, a promiscuous activator for enhanced transcription by RNA
            polymerases II and III
  JOURNAL   EMBO J 16 (1), 173-181 (1997)
   PUBMED   9009278
REFERENCE   8  (bases 1 to 2807)
  AUTHORS   Schuster,C., Myslinski,E., Krol,A. and Carbon,P.
  TITLE     Staf, a novel zinc finger protein that activates the RNA polymerase
            III promoter of the selenocysteine tRNA gene
  JOURNAL   EMBO J 14 (15), 3777-3787 (1995)
   PUBMED   7641696
REFERENCE   9  (bases 1 to 2807)
  AUTHORS   Tommerup,N. and Vissing,H.
  TITLE     Isolation and fine mapping of 16 novel human zinc finger-encoding
            cDNAs identify putative candidate genes for developmental and
            malignant disorders
  JOURNAL   Genomics 27 (2), 259-264 (1995)
   PUBMED   7557990
REFERENCE   10 (bases 1 to 2807)
  AUTHORS   Sloan,J.L., Carrillo,N., Adams,D. and Venditti,C.P.
  TITLE     Disorders of Intracellular Cobalamin Metabolism
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301503
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG825506.1, AK297214.1, BC014458.1, CN295530.1 and BF515092.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001282657.1.
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1, resulting in
            an isoform (3) that is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK297214.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BG825506.1         48-55
            9-542               AK297214.1         1-534
            543-549             BC014458.1         621-627
            550-1746            AK297214.1         542-1738
            1747-1749           BC014458.1         1827-1829
            1750-1929           AK297214.1         1739-1918
            1930-2357           CN295530.1         116-543
            2358-2807           BF515092.1         17-466              c
FEATURES             Location/Qualifiers
     source          1..2807
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..2807
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /note="zinc finger protein 143"
                     /db_xref="GeneID:7702"
                     /db_xref="HGNC:HGNC:12928"
                     /db_xref="MIM:603433"
     exon            1..65
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            66..184
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1896
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /EC_number="2.7.10.2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     SPH-binding factor; transcriptional activator Staf; hStaf;
                     selenocysteine tRNA gene transcription-activating factor"
                     /codon_start=1
                     /product="zinc finger protein 143 isoform 3"
                     /protein_id="NP_001269586.1"
                     /db_xref="CCDS:CCDS60721.1"
                     /db_xref="GeneID:7702"
                     /db_xref="HGNC:HGNC:12928"
                     /db_xref="MIM:603433"
                     /translation="MLLAQINRDSQGMTEFPGGGMEAQHVTLCLTEAVTVADAKLIDG
                     QVIQLEDGSAAYVQHVPIPKSTGDSLRLEDGQAVQLEDGTTAFIHHTSKDSYDQSALQ
                     AVQLEDGTTAYIHHAVQVPQSDTILAIQADGTVAGLHTGDATIDPDTISALEQYAAKV
                     SIDGSESVAGTGMIGENEQEKKMQIVLQGHATRVTAKSQQSGEKAFRCEYDGCGKLYT
                     TAHHLKVHERSHTGDRPYQCEHAGCGKAFATGYGLKSHVRTHTGEKPYRCSEDNCTKS
                     FKTSGDLQKHIRTHTGERPFKCPFEGCGRSFTTSNIRKVHVRTHTGERPYYCTEPGCG
                     RAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHSKPYNCNHCG
                     KTYKQISTLAMHKRTAHNDTEPIEEEQEAFFEPPPGQGEDVLKGSQITYVTGVEGDDV
                     VSTQVATVTQSGLSQQVTLISQDGTQHVNISQADMQAIGNTITMVTQDGTPITVPAHD
                     AVISSAGTHSVAMVTAEGTEGEQVAIVAQDLAAFHTASSEMGHQQHSHHLVTTETRPL
                     TLVATSNGTQIAVQLGEQPSLEEAIRIASRIQQGETPGLDD"
     exon            185..268
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            269..352
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            353..549
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            550..624
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            625..744
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            745..820
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            821..946
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1126
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1354
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1503
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1665
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1812
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..2807
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2315..2320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /note="hexamer: AATAAA"
     polyA_site      2348
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /note="major polyA site"
     regulatory      2541..2546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /note="hexamer: ATTAAA"
     polyA_site      2558
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
     regulatory      2784..2789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /note="hexamer: AATACA"
     polyA_site      2807
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
ORIGIN      
        1 acggctgttt cctgtcctgg tgcatggtgg tcggacgaag gaattgttgg aaaattttct
       61 cggaggtaga agatgttgtt agcccaaata aatcgagatt ctcagggaat gacagagttt
      121 cctggaggag ggatggaggc gcaacatgtt acgctgtgct tgacagaggc agtcaccgtg
      181 gcagatgcaa aactcataga tggccaggtc attcagttgg aagatggttc tgcggcctat
      241 gttcaacatg tacccatacc taaaagtaca ggggacagtt tgcgtctaga ggatggtcaa
      301 gcagtacagt tagaagatgg taccacagca tttattcacc acacctccaa agatagttat
      361 gaccagagtg cattacaggc ggttcagctg gaagatggta ccacagctta tatccaccat
      421 gcagtgcaag tcccgcagtc tgacaccatc ttggcaattc aggctgatgg gacagtggca
      481 ggtctgcaca ctggggatgc tacaattgac cctgacacca tcagtgcttt ggaacagtat
      541 gcagcaaagg tgtccattga tggaagtgaa agtgtagcag gtactggaat gattggagaa
      601 aatgagcaag agaaaaaaat gcagattgtt ttacaaggac atgctacaag agtaactgct
      661 aaatctcaac agagtggaga gaaggcattt cgatgtgaat atgatggatg tggaaaatta
      721 tatacaacag ctcatcatct caaggtccat gagaggtcac acacaggaga tcggccttat
      781 cagtgtgagc atgcaggctg tgggaaggca tttgcaacag gttatggatt aaaaagtcac
      841 gtcagaactc atacaggaga aaagccatat cggtgttcgg aagataattg tactaaatct
      901 ttcaaaactt caggagatct acagaaacac atcagaactc atacaggaga aaggcccttt
      961 aagtgtccct tcgaaggctg cggtcggtcc tttacaacat caaatatcag aaaagtgcac
     1021 gttaggacac acacaggaga aagaccttat tactgcacag agccaggatg tgggagggca
     1081 tttgccagtg caacaaatta taaaaaccat gtgaggatac acacaggaga aaagccatat
     1141 gtttgtacag ttcctgggtg tgacaaaagg tttacagaat attccagttt gtacaaacat
     1201 catgttgtcc acactcattc caaaccttac aactgtaacc actgtgggaa gacatacaag
     1261 cagatctcca cgctggccat gcacaaacgg acagcccaca acgacactga gcccatcgag
     1321 gaggagcagg aagccttctt tgagccgccc ccaggtcaag gtgaagatgt tcttaaaggg
     1381 tcccagatta cgtatgttac aggtgtagaa ggggacgacg ttgtttctac acaagtagcc
     1441 acagtaaccc aatctggact gagtcaacaa gttacactca tatcccagga tgggactcag
     1501 catgtcaaca tatctcaagc tgacatgcag gccattggca acaccatcac aatggtaacg
     1561 caggatggca cgcccatcac agtccccgcc catgatgcag tcatctcctc agcaggaacg
     1621 cactctgttg ctatggttac tgctgagggt acagaagggg aacaggttgc aattgtagct
     1681 caagacttgg cagcattcca tactgcctca tcagaaatgg ggcaccagca gcatagccat
     1741 cacttagtaa ccacagaaac cagacctctg accttagtag caacatccaa tggcacccag
     1801 attgcagttc agcttggaga acagccatct ctggaagaag ccatcagaat agcgtctaga
     1861 atccaacaag gagaaacgcc agggttggat gattaatcct cagaacaatg gagcaataaa
     1921 gcagaaggag tctttcatct tctggcagca gaaatccatg aagcccgggc ccaggaaaat
     1981 tagaagtttt ccattcctga tacactgtac acatttttat gcgagagtgg agaacatttt
     2041 attcttgaca cttttgtgta tataaccctt ggaatagatt ctcagagtga ttcattgtgt
     2101 acaaggaagt atgaaattag ggcaatacag taaattttca tgttactctt ttatcagatc
     2161 acaaactcct agagtctaca tgcaagacta gtaaagtctt atggagtctt atgatggatt
     2221 tttaacttcc cgtggaaaaa aaaataaagg ctgtatctaa aatatcaaag gttctatatg
     2281 tcacacaatc gtaattccaa aagccattat ggataataaa gggtgtaaag ccttcagata
     2341 tttccccagt tagtagagtg tctgcggttt ttgttctact atatgcttgt ccatttttat
     2401 ttgtatctca tggtttgcag actgtttgaa taatttatag tttcccatcc ctgttaaaaa
     2461 ccagctcttc aagctgaaat gctaattata ttggcattac attgaattat gtacaaaatt
     2521 ataaaatttg gttatttaaa attaaaaagt taaatccagt ggttttgtta aagattttgc
     2581 ttagtattca atttttatta ctgtttttta aaaataatga atcatcaaag tttaaccaca
     2641 ggctggtgcc cgggataaca gtactgtaat tggaaatggc tttactctga aaattaggtt
     2701 agtgggttgg tgtaaattat ttatttttgc ttatgtactt ttgttttaaa gcttatttac
     2761 cccaaagttt attattaatt ttgaatacag caatttttaa aatgtta
//
