LOCUS       NM_001379659           11290 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 142 (ZNF142), transcript variant
            11, mRNA.
ACCESSION   NM_001379659 XM_011511784
VERSION     NM_001379659.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11290)
  AUTHORS   Mir,A., Song,Y., Lee,H., Montazer-Zohouri,M., Reisi,M. and
            Tabatabaiefar,M.A.
  TITLE     A deleterious frameshift insertion mutation in the ZNF142 gene
            leads to intellectual developmental disorder with impaired speech
            in three affected siblings: Clinical features and literature review
  JOURNAL   Mol Genet Genomic Med 11 (12), e2261 (2023)
   PUBMED   37496384
  REMARK    GeneRIF: A deleterious frameshift insertion mutation in the ZNF142
            gene leads to intellectual developmental disorder with impaired
            speech in three affected siblings: Clinical features and literature
            review.
            Review article
REFERENCE   2  (bases 1 to 11290)
  AUTHORS   Christensen,M.B., Levy,A.M., Mohammadi,N.A., Niceta,M.,
            Kaiyrzhanov,R., Dentici,M.L., Al Alam,C., Alesi,V., Benoit,V.,
            Bhatia,K.P., Bierhals,T., Bosselmann,C.M., Buratti,J.,
            Callewaert,B., Ceulemans,B., Charles,P., De Wachter,M.,
            Dehghani,M., D'haenens,E., Doco-Fenzy,M., Gessner,M., Gobert,C.,
            Guliyeva,U., Haack,T.B., Hammer,T.B., Heinrich,T., Hempel,M.,
            Herget,T., Hoffmann,U., Horvath,J., Houlden,H., Keren,B.,
            Kresge,C., Kumps,C., Lederer,D., Lermine,A., Magrinelli,F.,
            Maroofian,R., Vahidi Mehrjardi,M.Y., Moudi,M., Muller,A.J.,
            Oostra,A.J., Pletcher,B.A., Ros-Pardo,D., Samarasekera,S.,
            Tartaglia,M., Van Schil,K., Vogt,J., Wassmer,E., Winkelmann,J.,
            Zaki,M.S., Zech,M., Lerche,H., Radio,F.C., Gomez-Puertas,P.,
            Moller,R.S. and Tumer,Z.
  TITLE     Biallelic variants in ZNF142 lead to a syndromic neurodevelopmental
            disorder
  JOURNAL   Clin Genet 102 (2), 98-109 (2022)
   PUBMED   35616059
  REMARK    GeneRIF: Biallelic variants in ZNF142 lead to a syndromic
            neurodevelopmental disorder.
REFERENCE   3  (bases 1 to 11290)
  AUTHORS   Kamal,N., Khamirani,H.J., Mohammadi,S., Dastgheib,S.A.,
            Dianatpour,M. and Tabei,S.M.B.
  TITLE     ZNF142 mutation causes neurodevelopmental disorder with speech
            impairment and seizures: Novel variants and literature review
  JOURNAL   Eur J Med Genet 65 (7), 104522 (2022)
   PUBMED   35618198
  REMARK    GeneRIF: ZNF142 mutation causes neurodevelopmental disorder with
            speech impairment and seizures: Novel variants and literature
            review.
            Review article
REFERENCE   4  (bases 1 to 11290)
  AUTHORS   Kameyama,S., Mizuguchi,T., Fukuda,H., Moey,L.H., Keng,W.T.,
            Okamoto,N., Tsuchida,N., Uchiyama,Y., Koshimizu,E., Hamanaka,K.,
            Fujita,A., Miyatake,S. and Matsumoto,N.
  TITLE     Biallelic null variants in ZNF142 cause global developmental delay
            with familial epilepsy and dysmorphic features
  JOURNAL   J Hum Genet 67 (3), 169-173 (2022)
   PUBMED   34531528
  REMARK    GeneRIF: Biallelic null variants in ZNF142 cause global
            developmental delay with familial epilepsy and dysmorphic features.
REFERENCE   5  (bases 1 to 11290)
  AUTHORS   Ahmeti,K.B., Ajroud-Driss,S., Al-Chalabi,A., Andersen,P.M.,
            Armstrong,J., Birve,A., Blauw,H.M., Brown,R.H., Bruijn,L., Chen,W.,
            Chio,A., Comeau,M.C., Cronin,S., Diekstra,F.P., Soraya Gkazi,A.,
            Glass,J.D., Grab,J.D., Groen,E.J., Haines,J.L., Hardiman,O.,
            Heller,S., Huang,J., Hung,W.Y., Jaworski,J.M., Jones,A., Khan,H.,
            Landers,J.E., Langefeld,C.D., Leigh,P.N., Marion,M.C.,
            McLaughlin,R.L., Meininger,V., Melki,J., Miller,J.W., Mora,G.,
            Pericak-Vance,M.A., Rampersaud,E., Robberecht,W., Russell,L.P.,
            Salachas,F., Saris,C.G., Shatunov,A., Shaw,C.E., Siddique,N.,
            Siddique,T., Smith,B.N., Sufit,R., Topp,S., Traynor,B.J., Vance,C.,
            van Damme,P., van den Berg,L.H., van Es,M.A., van Vught,P.W.,
            Veldink,J.H., Yang,Y. and Zheng,J.G.
  CONSRTM   ITALSGEN consortium; ALSGEN Consortium
  TITLE     Age of onset of amyotrophic lateral sclerosis is modulated by a
            locus on 1p34.1
  JOURNAL   Neurobiol Aging 34 (1), 357 (2013)
   PUBMED   22959728
REFERENCE   6  (bases 1 to 11290)
  AUTHORS   Tommerup,N. and Vissing,H.
  TITLE     Isolation and fine mapping of 16 novel human zinc finger-encoding
            cDNAs identify putative candidate genes for developmental and
            malignant disorders
  JOURNAL   Genomics 27 (2), 259-264 (1995)
   PUBMED   7557990
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079810.4 and AC012510.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 10, 2020 this sequence version replaced XM_011511784.2.
            
            Summary: The protein encoded by this gene belongs to the Kruppel
            family of C2H2-type zinc finger proteins. It contains 31 C2H2-type
            zinc fingers and may be involved in transcriptional regulation.
            Alternatively spliced transcript variants have been found for this
            gene. [provided by RefSeq, Jan 2013].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.4384999.1,
                                           SRR14372080.4152144.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000411696.7/ ENSP00000398798.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               AC079810.4         1469-1723           c
            256-406             AC079810.4         1080-1230           c
            407-582             AC079810.4         801-976             c
            583-896             AC012510.8         103267-103580       c
            897-1496            AC012510.8         98818-99417         c
            1497-1664           AC012510.8         97476-97643         c
            1665-2489           AC012510.8         95752-96576         c
            2490-2667           AC012510.8         93288-93465         c
            2668-5704           AC012510.8         89145-92181         c
            5705-5810           AC012510.8         87781-87886         c
            5811-11290          AC012510.8         80446-85925         c
FEATURES             Location/Qualifiers
     source          1..11290
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..11290
                     /gene="ZNF142"
                     /gene_synonym="HA4654; NEDISHM; pHZ-49"
                     /note="zinc finger protein 142"
                     /db_xref="GeneID:7701"
                     /db_xref="HGNC:HGNC:12927"
                     /db_xref="MIM:604083"
     exon            1..255
                     /gene="ZNF142"
                     /gene_synonym="HA4654; NEDISHM; pHZ-49"
                     /inference="alignment:Splign:2.1.0"
     exon            256..406
                     /gene="ZNF142"
                     /gene_synonym="HA4654; NEDISHM; pHZ-49"
                     /inference="alignment:Splign:2.1.0"
     exon            407..582
                     /gene="ZNF142"
                     /gene_synonym="HA4654; NEDISHM; pHZ-49"
                     /inference="alignment:Splign:2.1.0"
     exon            583..896
                     /gene="ZNF142"
                     /gene_synonym="HA4654; NEDISHM; pHZ-49"
                     /inference="alignment:Splign:2.1.0"
     CDS             617..6280
                     /gene="ZNF142"
                     /gene_synonym="HA4654; NEDISHM; pHZ-49"
                     /note="isoform 3 is encoded by transcript variant 11; zinc
                     finger protein 142 (clone pHZ-49)"
                     /codon_start=1
                     /product="zinc finger protein 142 isoform 3"
                     /protein_id="NP_001366588.1"
                     /db_xref="CCDS:CCDS92944.1"
                     /db_xref="GeneID:7701"
                     /db_xref="HGNC:HGNC:12927"
                     /db_xref="MIM:604083"
                     /translation="MTDPLLDSQPASSTGEMDGLCPELLLIPPPLSNRGILGPVQSPC
                     PSRDPAPIPTEPGCLLVEATATEEGPGNMEIIVETVAGTLTPGAPGETPGVLVKVVEV
                     YFCERCEQSFAEPTLLALHQCSETHIQPVQGLSSPPCSVELPPSNPTLPGPLQGQSPP
                     VSPLSCPVCRQEFAQPQALKSHFKIHRGTPDTFSCPESGCVFSAEDRKGLQHHLRQTH
                     RAVPVPCSFRGCPLLFGSQQGMELHRQAHYPFHCSHCSFIGSNVKLFRQHQRSHGAGT
                     QGELSAVQGLPSQELLPAPKLPPGEREPSQEAGTPLPGQETAEEENVEKEEKSDTQKD
                     SQKAVDKGQGAQRLEGDVVSGTESLFKTHMCPECKRCFKKRTHLVEHLHLHFPDPSLQ
                     CPNCQKFFTSKSKLKTHLLRELGEKAHHCPLCHYSAVERNALNRHMASMHEDISNFYS
                     DTYACPVCREEFRLSQALKEHLKSHTAAAAAEPLPLRCFQEGCSYAAPDRKAFIKHLK
                     ETHGVRAVECRHHSCPMLFATAEAMEAHHKSHYAFHCPHCDFACSNKHLFRKHKKQGH
                     PGSEELRCTFCPFATFNPVAYQDHVGKMHAHEKIHQCPECNFATAHKRVLIRHMLLHT
                     GEKPHKCELCDFTCRDVSYLSKHMLTHSNTKDYMCTECGYVTKWKHYLRVHMRKHAGD
                     LRYQCNQCSYRCHRADQLSSHKLRHQGKSLMCEVCAFACKRKYELQKHMASQHHPGTP
                     APLYPCHYCSYQSRHKQAVLSHENCKHTRLREFHCALCDYRTFSNTTLLFHKRKAHGY
                     VPGDQAWQLRYASQEPEGAMQGPTPPPDSEPSNQLSARPEGPGHEPGTVVDPSLDQAL
                     PEMSEEVNTGRQEGSEAPHGGDLGGSPSPAEVEEGSCTLHLEALGVELESVTEPPLEE
                     VTETAPMEFRPLGLEGPDGLEGPELSSFEGIGTSDLSAEENPLLEKPVSEPSTNPPSL
                     EEAPNNWVGTFKTTPPAETAPLPPLPESESLLKALRRQDKEQAEALVLEGRVQMVVIQ
                     GEGRAFRCPHCPFITRREKALNLHSRTGCQGRREPLLCPECGASFKQQRGLSTHLLKK
                     CPVLLRKNKGLPRPDSPIPLQPVLPGTQASEDTESGKPPPASQEAELLLPKDAPLELP
                     REPEETEEPLATVSGSPVPPAGNSLPTEAPKKHCFDPVPPAGNSSPTEAPKKHHLDPV
                     PPAGNSSPTEALKKHRFEQGKFHCNSCPFLCSRLSSITSHVAEGCRGGRGGGGKRGTP
                     QTQPDVSPLSNGDSAPPKNGSTESSSGDGDTVLVQKQKGARFSCPTCPFSCQQERALR
                     THQIRGCPLEESGELHCSLCPFTAPAATALRLHQKRRHPTAAPARGPRPHLQCGDCGF
                     TCKQSRCMQQHRRLKHEGVKPHQCPFCDFSTTRRYRLEAHQSRHTGIGRIPCSSCPQT
                     FGTNSKLRLHRLRVHDKTPTHFCPLCDYSGYLRHDITRHVNSCHQGTPAFACSQCEAQ
                     FSSETALKQHALRRHPEPAQPAPGSPAETTEGPLHCSRCGLLCPSPASLRGHTRKQHP
                     RLECGACQEAFPSRLALDEHRRQQHFSHRCQLCDFAARERVGLVKHYLEQHEETSAAV
                     AASDGDGDAGQPPLHCPFCDFTCRHQLVLDHHVKGHGGTRLYKCTDCAYSTKNRQKIT
                     WHSRIHTGEKPYHCHLCPYACADPSRLKYHMRIHKEERKYLCPECGYKCKWVNQLKYH
                     MTKHTGLKPYQCPECEYCTNRADALRVHQETRHREARAFMCEQCGKAFKTRFLLRTHL
                     RKHSEAKPYVCNVCHRAFRWAAGLRHHALTHTDRHPFFCRLCNYKAKQKFQVVKHVRR
                     HHPDQADPNQGVGKDPTTPTVHLHDVQLEDPSPPAPAAPHTGPEG"
     exon            897..1496
                     /gene="ZNF142"
                     /gene_synonym="HA4654; NEDISHM; pHZ-49"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1664
                     /gene="ZNF142"
                     /gene_synonym="HA4654; NEDISHM; pHZ-49"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..2489
                     /gene="ZNF142"
                     /gene_synonym="HA4654; NEDISHM; pHZ-49"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2667
                     /gene="ZNF142"
                     /gene_synonym="HA4654; NEDISHM; pHZ-49"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..5704
                     /gene="ZNF142"
                     /gene_synonym="HA4654; NEDISHM; pHZ-49"
                     /inference="alignment:Splign:2.1.0"
     exon            5705..5810
                     /gene="ZNF142"
                     /gene_synonym="HA4654; NEDISHM; pHZ-49"
                     /inference="alignment:Splign:2.1.0"
     exon            5811..11290
                     /gene="ZNF142"
                     /gene_synonym="HA4654; NEDISHM; pHZ-49"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6450..6455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF142"
                     /gene_synonym="HA4654; NEDISHM; pHZ-49"
                     /note="hexamer: TATAAA"
     polyA_site      6474
                     /gene="ZNF142"
                     /gene_synonym="HA4654; NEDISHM; pHZ-49"
     regulatory      6682..6687
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF142"
                     /gene_synonym="HA4654; NEDISHM; pHZ-49"
                     /note="hexamer: TATAAA"
     polyA_site      6703
                     /gene="ZNF142"
                     /gene_synonym="HA4654; NEDISHM; pHZ-49"
                     /note="major polyA site"
     polyA_site      7443
                     /gene="ZNF142"
                     /gene_synonym="HA4654; NEDISHM; pHZ-49"
     regulatory      8264..8269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF142"
                     /gene_synonym="HA4654; NEDISHM; pHZ-49"
                     /note="hexamer: AATAAA"
     polyA_site      8281
                     /gene="ZNF142"
                     /gene_synonym="HA4654; NEDISHM; pHZ-49"
     regulatory      11251..11256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF142"
                     /gene_synonym="HA4654; NEDISHM; pHZ-49"
                     /note="hexamer: AATAAA"
     polyA_site      11290
                     /gene="ZNF142"
                     /gene_synonym="HA4654; NEDISHM; pHZ-49"
ORIGIN      
        1 acgccactct accccagagc tctcgatggt gcttctccgg cttcagggct ggagtggggg
       61 tggagggcgg gaaaaaccac agagacaaaa catagagtac cccggcagcc ggcaagagga
      121 agagagagtg gcttccacat ccccaatatc ctagaggcgg ctgagccgga ggcggtcgca
      181 caaagcgggc cccgggggcc gttccagccg cggccgacca tagagatgcg gctcccgccg
      241 gctctgggtc tggagccttc caggttacaa accgcctttc cagttcgctg gctcttatga
      301 tccagctcct gcccgacgat gtggacactg tcatcacctc cattttacag ataggaaagc
      361 tgaggcccag agaagcgaag cgactgtgtc tgtccaagac cacgcgccct cctgcccgga
      421 agataagcgt atttcttctc tggtgcccac ctgtctccta cctcaccctg ccctcccgca
      481 ggtgaaggtt cttaatcttg acggctcagc gtcctccttg gctccccccg gaggccatgt
      541 atggtcaagc ttgaagattc cccagaacag cgataatatt cacatttaag aagccaaaac
      601 acacaagtcg gtggtgatga cagaccccct tttggactca cagccagcca gtagcaccgg
      661 ggagatggat ggactgtgcc ctgagctatt gctgatcccc ccgcctctct ctaaccgtgg
      721 aatcctgggg cctgtccaga gcccctgtcc ttcccgggac cctgcaccta tacctactga
      781 gccaggctgc ctgctggtag aggccacagc aactgaagag ggaccaggga acatggagat
      841 cattgtggag acagtagctg gaaccctgac cccaggtgct cctggagaga ccccaggtgt
      901 cctggtaaag gtggtggagg tgtacttctg tgagcgctgt gaacagagct tcgcagagcc
      961 cactctgctg gccctgcacc agtgcagtga gacccatata cagcctgtgc agggcctctc
     1021 tagcccccca tgctctgtag agctgcctcc cagcaaccca accctccctg gccctctgca
     1081 gggccagagc ccgccagtta gccccctatc atgccctgtg tgtagacagg agtttgccca
     1141 accccaggcc ctgaagagcc acttcaagat tcaccggggc actcctgaca ccttctcctg
     1201 cccagaatct ggctgtgtgt tctctgctga agatcgcaag ggtctgcagc accacctgag
     1261 gcagactcac agagcagttc ctgtgccctg ttctttccgg ggctgccccc tgcttttcgg
     1321 gagccagcag ggcatggagc tgcaccggca ggcgcattac cctttccact gcagccactg
     1381 cagcttcata ggctccaacg tcaaactctt ccggcagcat cagcggagcc atggtgctgg
     1441 gacacaggga gaactttctg ccgttcaggg ccttccatcc caggagctgc tgccagctcc
     1501 caaactgcct ccaggagaga gagaaccttc acaggaagca ggtacaccct tgcctgggca
     1561 ggagacagct gaagaggaga atgtagagaa agaagagaag agtgacaccc agaaggactc
     1621 ccaaaaggct gtggataaag gccaaggggc tcagcggctg gaaggggatg tggtctctgg
     1681 caccgagtcc ctcttcaaga cccatatgtg tccagagtgt aagcgctgct ttaagaagcg
     1741 gactcatctg gtggagcacc tgcatctcca cttcccagac cccagcctcc agtgccctaa
     1801 ctgccagaag ttcttcacca gtaagagcaa gctcaagacc catctgctgc gggagctggg
     1861 tgaaaaggcc caccactgcc cactgtgcca ctacagtgcg gtggagagga atgcactcaa
     1921 ccgccacatg gccagcatgc atgaagatat ttccaacttc tactcagaca cctatgcctg
     1981 tcctgtctgc cgtgaggaat tccgcctcag ccaggcccta aaggagcacc tcaagagcca
     2041 cacggcagca gccgcagcag agccattacc ccttcgctgc tttcaggagg gctgcagcta
     2101 tgcagcaccc gaccgcaagg ccttcattaa gcacctgaag gagacccatg gggtgcgggc
     2161 tgtggagtgc cgccatcact catgtcccat gctctttgcc acagccgaag ccatggaggc
     2221 ccaccacaag agtcactacg ccttccactg cccccactgt gattttgctt gttccaataa
     2281 gcacctattc cgtaaacaca agaagcaggg ccaccctggc agtgaagagc tgcgctgcac
     2341 cttctgcccc tttgccacct tcaacccagt ggcttaccag gatcatgtag gcaagatgca
     2401 tgctcatgaa aagatccacc agtgtcctga gtgcaacttt gccactgccc acaagagggt
     2461 gctcatccga cacatgcttc tacatacggg tgagaagccc cacaagtgtg agctgtgtga
     2521 cttcacatgc cgagacgtga gctacctatc caagcacatg ctgacccact ccaacaccaa
     2581 ggattacatg tgcactgaat gtggctatgt caccaagtgg aagcactacc tccgtgtgca
     2641 catgcgaaaa catgcagggg acctcaggta tcagtgcaac cagtgctcct atcgctgtca
     2701 ccgggctgat cagctgagca gccacaagct gcggcatcag ggcaagtctc tgatgtgtga
     2761 ggtgtgtgcc ttcgcctgca agcggaagta tgagctgcag aagcacatgg cttcccagca
     2821 ccaccctggc acaccggccc cactctaccc ttgccactac tgcagttacc agagccgcca
     2881 caagcaggct gtgctgagcc atgagaactg caagcatacc cgcctccgtg agttccactg
     2941 tgccctctgt gactaccgca ccttcagcaa caccacactc ttgttccata aacgcaaggc
     3001 ccatggctat gtacctggag accaggcctg gcagctccgc tatgcaagcc aggagccaga
     3061 aggggccatg cagggcccaa cacccccacc agattcagag ccctcaaacc agctgtcagc
     3121 ccgacctgag gggccaggtc acgaacctgg gactgtggtg gaccccagct tggaccaggc
     3181 cctgccagag atgagtgagg aggtcaacac tggaagacag gagggcagtg aggctcccca
     3241 tgggggtgac ctgggtggca gtcccagccc agcagaggtg gaggagggca gctgcacact
     3301 acacctagag gccctgggag tagagctgga gtctgtgact gagccacccc ttgaggaggt
     3361 cactgaaaca gcccctatgg agttcaggcc cctgggactg gaagggccag atggactgga
     3421 aggaccagag ctatctagct ttgaaggtat tgggacttct gacttgagtg ctgaagaaaa
     3481 tccccttctg gaaaagccag tgtctgagcc ctccacaaat cctccatcct tagaggaggc
     3541 tcctaacaac tgggtaggaa ccttcaagac aactccacct gctgagacag cacccttgcc
     3601 cccattacct gagtcagagt cattactcaa ggccctaagg agacaggaca aagaacaagc
     3661 agaggcattg gtgctagagg ggcgggtgca gatggtagtg atccagggag aggggcgagc
     3721 cttccgctgc ccacactgcc cttttatcac tcgccgggag aaggccctga atctgcactc
     3781 caggactggg tgccaaggcc gccgagagcc cctgctgtgc cccgagtgtg gggctagctt
     3841 caagcaacaa cgcggcctca gcacccacct gctgaagaag tgccctgttc tactcagaaa
     3901 gaacaagggc ttgcccagac cagattcacc catccctctg caacctgtgc tcccaggtac
     3961 ccaggcctca gaggacacag aaagtgggaa gcccccacct gcatcacaag aagcagagct
     4021 actgcttcca aaagatgctc ctttggagct tcccagggag ccagaagaaa cagaagagcc
     4081 tcttgccaca gtctctggtt ccccagtccc tcctgcagga aactccttgc ccacagaggc
     4141 ccctaagaag cactgctttg acccagtccc tcctgcagga aactcctcac ccacggaggc
     4201 ccctaagaag caccaccttg acccagtccc tcctgcagga aactcctcac ccacagaggc
     4261 cctgaagaag caccgctttg agcagggcaa gtttcactgc aactcctgcc cattcctttg
     4321 ttcccggctc tcctctatta cctctcacgt ggctgaaggc tgcagggggg gacgtggcgg
     4381 gggaggaaaa cgagggaccc cccagaccca gcctgatgtg tccccgttga gcaatgggga
     4441 ctctgctccc ccgaagaatg ggagtacaga gtccagctct ggtgatgggg atacagttct
     4501 ggttcaaaag cagaaggggg ctcgcttctc ctgccctaca tgtcccttta gctgccagca
     4561 ggaacgggct ctgaggactc accagatccg gggctgcccc ctcgaggagt ctggagagct
     4621 gcactgcagc ctctgcccat tcactgctcc tgctgccact gccttaaggc tccaccagaa
     4681 gcggaggcac cccactgcag ccccagcccg tgggccccgg ccccatctac agtgtgggga
     4741 ctgtggcttc acctgtaaac agagccgttg catgcagcag caccggcggc tcaagcacga
     4801 gggggtgaag ccccatcagt gccccttctg tgacttttcg accaccagac ggtaccggtt
     4861 agaggctcac cagtcccgac acacaggcat tggccgcatc ccctgcagct cttgccccca
     4921 gacgtttggt accaactcga aactgcgctt gcaccggtta agggtacatg acaaaacacc
     4981 tacccacttc tgtccacttt gtgactatag tggctacctt cgccatgaca tcactcgtca
     5041 tgtcaacagc tgccaccaag gcaccccagc ctttgcctgc tcccagtgtg aagcccagtt
     5101 cagctcagag acagcactta agcagcatgc tctgcgccga caccccgagc ctgcacagcc
     5161 tgcccctggc tctcctgcag agaccactga gggccccctg cactgttccc gctgtgggtt
     5221 gctgtgcccc agccctgcca gcttacgagg acacacccgt aaacagcacc cacggcttga
     5281 gtgtggggcc tgccaggagg ccttccctag ccgactggct ctggatgagc accggaggca
     5341 gcagcatttc agccaccgct gtcagctctg tgactttgct gcccgggagc gggtgggcct
     5401 ggtaaagcac tacctggaac agcatgagga gacttcagca gccgtggcag cctcagatgg
     5461 ggatggggat gctggccagc ccccgctaca ctgccccttt tgtgacttca catgccgcca
     5521 tcagctggta ctagatcacc atgtgaaagg gcatgggggc actcgtctct acaagtgcac
     5581 cgattgtgct tacagcacca agaaccgaca gaagatcacc tggcacagcc gcatccacac
     5641 tggggaaaag ccttaccact gtcacctctg cccctatgcc tgtgctgatc cctctcgtct
     5701 caagtaccac atgcggatcc acaaggagga acggaagtac ctgtgccctg agtgtggcta
     5761 caagtgcaag tgggtcaacc agctgaaata ccacatgacc aagcatacag gactgaagcc
     5821 ataccagtgt cccgagtgtg agtactgcac caaccgggct gatgcactgc gtgtgcacca
     5881 ggagacccgg catcgagaag cacgggcttt catgtgtgag cagtgtggca aggccttcaa
     5941 gacgcgcttc ctgctgcgca cccaccttcg caagcacagt gaggccaaac cctatgtgtg
     6001 caatgtgtgc caccgtgctt tccgctgggc tgctggcctg cgccatcatg ccctcaccca
     6061 caccgaccgc caccccttct tttgccgcct ctgcaactac aaggccaagc aaaagttcca
     6121 ggtggtcaag cacgtacgca ggcaccaccc tgaccaagcc gacccaaacc agggtgtggg
     6181 caaagacccc accaccccca cagtgcacct gcatgatgtg cagctggagg atcccagccc
     6241 tcctgctcct gccgctcccc acactggacc tgagggctga aagcctgccc cacctcctgt
     6301 ataggaagag ggtatggtct gagatgtgca gactgggacc agcgctagcc tgaggagctc
     6361 agagcctaag gaaagactgg cttttggggt acaagggtga ctagaacctt cctgggactc
     6421 tggctatagt actttgaaat tatcacccat ataaaagagg gacatggact ataacgttga
     6481 tttcttattg ctgtacattg cgtttttaac ctgcaagttc tcagtttctt caccatcact
     6541 ccatcaaagt ccctggctat aagatctgga ttttacccac tccatcttct ctttccttct
     6601 tactgtgtca attcctattt tctttcagaa tcttctaaaa acagttgtat ctaaccgcat
     6661 gtgctgttgt gcctaatgct ctataaagca tgttaaacag aaagtggtta ctacattata
     6721 gattcatcca aatccctgtc ttaacatttc caggctgtca tcttgatcaa ctctgtcccc
     6781 tctcagacct ctgcctccct tttgtccctt ccatcttcac tcagtattga tactgaaaca
     6841 ggcctaggtc tgccttctcc ctgtccttga gccatcttga cccttgacct gctccctact
     6901 tccaagctcc tttgtctacc tgtatctata gagggaggat tgctacccac taagcctcct
     6961 cctagaagca actttagctc atcatcaatc ctcagactgg ctcagcagct acactaaggt
     7021 gttaaagcac aaggatacta tggaaaggca gatgactaga gaggaaaatc tccaattcag
     7081 aattctataa ctgcttcaca gtataattct gtagtgcctt actatataat tgatcatcta
     7141 aactgagaca cactgggaaa acttaaagag ggtactatta ataattatgc tgggacaaca
     7201 gacataaacc aggatggttc cagccagact cttcaggaag gctgggacca cataaccttt
     7261 tgtctgcttt tgccctgatt cttaaaagcc atactctgtg tccttcctat gtagcacatg
     7321 caagaggtct cctgggaacc tctttctcta ccttttcctt gtctcacctg actacccaga
     7381 tgtccccaca acccttgtac ctccccttct tgcccaacaa tgacagacca tattgaagcc
     7441 aaattggaga gagatgtatt tataccagtg gggctaagga ggaagcagtc cagtggggga
     7501 ctttgagtgc tgtgcagtgt tctcttaaga gtcgtagtac agtcctgggg tcaagtctct
     7561 ttccctaatc tttgctgggg aagccttgag ccttgattta tccttccctt ggctttgggc
     7621 tttgaggaag ttggggatgg aggggatgat gcttctttag gtttctctat tccaagcccc
     7681 tctgaatttc tagttgcaac ctgccttcac acagagttga tgggaaagat tagttgtaga
     7741 tgtcggtatg ggattgagcc tacagcaaga ggaagaaggg aactccagta tagagtacac
     7801 aaaggaaaag ggcaggaaag ataccaaagg cttatgaaaa caaaggaagg gaagaaaaga
     7861 gaaaaaaggt ggaaaatcag gtcccagatt gcttgttagg aagaatgagg taattttgtg
     7921 cctaggaatg cacaatccaa agcttgattt tcaccacctc catttgttct ctcgagcatc
     7981 cttccagatg tttctccccg tctaaagcca gcacaccaac ccttcccgtg aaatgcccac
     8041 ctcaggactc atccccctcc aggccttcct ggatgcagat atacacaaag atggaagctg
     8101 ggcggaggct gatgccatct ttggacagca ggtgaatgtg gcggtaacct ggaaggggca
     8161 ggaggacagc attaggaagg cagccagagc tggggtattg gccaggggcc aaaggggctg
     8221 gctcaccttg ttgcatgcag gtccaaggca gggtgtactg accaataaag tcatttcggg
     8281 atttccagtc ataatccatt accacaaaac gcagcatggc aagttcaggc accagcaccc
     8341 ggaaacatag tgtctgcccc cagtatggat taaaacctga gttggtggac agaaagaaat
     8401 aagaagacat tatgacagtt ttcttgactg ggttgctttt cttgtgttct catttaatct
     8461 agatggcaat cagcatttta caggtaagga aaaaggctca gagtaagcaa gtaatttgcc
     8521 caggtcactg gagcttttaa gtgaagagcc aggattcttt gtactgttcc acactgcctc
     8581 ccatgtgggg acatgcaata acagatgcta tacttaatgg aagacagact agaaggaaaa
     8641 ctaatcatgc tcctaccccc acctccccag cactgccagt ttctcaccat tgttctccac
     8701 atagttggtc tcctgccgtg ctgtgtctag acgaacgcca aagatctgca ctttcaccag
     8761 tggatccaca atggacccct ctttggtctt gtccactttg gggagttgct gaccgctgat
     8821 cacctgtagt cagggctctg gaatctcaca agttcctgct cagcccagcc ccacccgacc
     8881 ctactcccaa ccccagggga gaagaagctt tttggtttgt aaaacatcct ccatgggtaa
     8941 tatattttct tctagtattc tatctgcaat ttaaaatgca cccaaaggcc gggcacggtg
     9001 gctcacacct gtaatcccaa cacttcagga ggccgaggtg ggcagatcac ttgaaaccag
     9061 gagaccagcc tggccaacat ggtgaaaccc tatctctact aaaaatacaa aaattagcca
     9121 ggcatggtgg cgggcgcctg tagtcccagc tactcggaag gctcagatgg gagaatcact
     9181 tgaacccagg aggcggaggt tgcagtgagc caagatcatg ccactgcact ccagcctgca
     9241 gcagagcaag actctgtctc agaataaaca aataaattaa atggatccag gtagaaattc
     9301 aacagtttga aagtaggcat gctaatgaca gcagccactt tttttttttc aaagagacac
     9361 gatcatactc ttgaccaagc tggaatgcag tggggcagtc atagctcact gcaacctcca
     9421 tctcctgggc taaagtgacc ctccagcctt agcctcctga gtagccagga ctatctatag
     9481 tcatgtgcca ccatgccagg ctaattttta aattttttgt agagacggga gtctctacaa
     9541 aatttttaaa ttttttgttg agaccagttt cagactggtc tcaaactcct gggctcaagc
     9601 agtcctcctg ccttggcctc caaagcgctg ggattacagg tgtaagctat cgctcccagc
     9661 cagcctcttt tatagcactt cctgtgtgcc aggaattgta agaactttat attaactgtt
     9721 atactcctta taaccctgtg aggcaggtgg tagtgttacc cctattttgc aggtgagcag
     9781 actgaggtat ggagaggtta aggaacttgc ccaacattac ccaattagga agttgtggtt
     9841 tgaagctagg cagctggctc caaaagctaa aactagacac tgttaatagg ctatccggcc
     9901 tctacattcc ggtcaggcct agccacctct tccctcactt ctatcccagt tatctcagtt
     9961 tcttcccaac agtttatttc cactgtacct ggattaagag agtctgggct ttgaaagggc
    10021 tgatgggctt ctcagggtgg aaagaactct ggatatcacg caggaagtct ggcttcagca
    10081 catagccaca gccgccattc tggcggaaat gcccatcaca gatgtccatt tcaagccctg
    10141 cagtctgcat attcatggcc actgagggcc ccaggagaaa agaagagcaa gattcaccat
    10201 ggaggccttc cagcccctct ttcagggagt taagaagata ggtactgggt gcacggtacc
    10261 tgctggtaat atccactgat agcatttctc agcctagcaa ttttcttgag cattccccaa
    10321 ccctaccatc actagagaac ttatttccca cctgctgctc ctccactccc tcttcccagt
    10381 ccctgctgcc tcctcaccca tctggcagcc tgcattccag agttcctggg ggttgtagtt
    10441 ggaagagtct gtcctcaggc cgctgggata cacacggctt aactgccaag tattgtgctg
    10501 cacaaactca ttgcctgtaa aagggtatag agagggagat ggaagtgggg tggaatctcc
    10561 cacttcccta gtcccaagga ccatgcctac tcttcaccct tctctccagc atctgaagct
    10621 ggctccagaa agtttcactg tgcctctcta ctctgtccat ccagaccagc tttcctgccc
    10681 ctagaccctt gagccactat tcataactcc tctgcccttg tctgctctaa ggagtttctg
    10741 aactccttca tctctcctta gctaccttgt cttttttctt gggacttacc tgccagtcca
    10801 tcaggcctga acctatccat cccacttccc tccccatccc tccattttgg tcctgaccag
    10861 cctccttgat gaggcgcttg gccttggttt cagagaaaga tgatatctcg tagaagtggt
    10921 agtgctcctt tgaatgtgtg aagctgcgga atgagacaga cttcaagtag ataaccaggg
    10981 aagagagggc tggacacaag atgggcttgg atttctggag aaggtggaaa agaagatgga
    11041 attgaaccct cagcagtctg agagagaaga agataatggc catccaacct aaacctctgc
    11101 ccactgcctc cccactgtat tctccctcct gcctcacctg ccgggacaag agaagggact
    11161 caggcttgga aataggagcc tgggccacaa tctgacaaca gatagacgga caaaacagcg
    11221 ggcacgtcac aacctggggg tgggaatggg aataaaggcg gtctgcatgt actgctggga
    11281 tcagtgtcaa
//
