LOCUS       NM_003441              12601 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 141 (ZNF141), transcript variant
            1, mRNA.
ACCESSION   NM_003441
VERSION     NM_003441.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12601)
  AUTHORS   Deng,H., Tan,T. and Yuan,L.
  TITLE     Advances in the molecular genetics of non-syndromic polydactyly
  JOURNAL   Expert Rev Mol Med 17, e18 (2015)
   PUBMED   26515020
  REMARK    GeneRIF: To date, at least ten loci and four non-syndromic
            polydactyly-causing genes, including the GLI3 gene, the ZNF141
            gene, the MIPOL1 gene and the PITX1 gene, have been identified.
            (Review)
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12601)
  AUTHORS   Kalsoom,U.E., Klopocki,E., Wasif,N., Tariq,M., Khan,S., Hecht,J.,
            Krawitz,P., Mundlos,S. and Ahmad,W.
  TITLE     Whole exome sequencing identified a novel zinc-finger gene ZNF141
            associated with autosomal recessive postaxial polydactyly type A
  JOURNAL   J Med Genet 50 (1), 47-53 (2013)
   PUBMED   23160277
  REMARK    GeneRIF: This study revealed involvement of a zinc finger gene
            ZNF141 in causing autosomal recessive PAP type A, which may open up
            interesting perspectives into the function of this protein in limb
            development.
REFERENCE   3  (bases 1 to 12601)
  AUTHORS   Varrault,A., Ciani,E., Apiou,F., Bilanges,B., Hoffmann,A.,
            Pantaloni,C., Bockaert,J., Spengler,D. and Journot,L.
  TITLE     hZAC encodes a zinc finger protein with antiproliferative
            properties and maps to a chromosomal region frequently lost in
            cancer
  JOURNAL   Proc Natl Acad Sci U S A 95 (15), 8835-8840 (1998)
   PUBMED   9671765
REFERENCE   4  (bases 1 to 12601)
  AUTHORS   Vissing,H., Meyer,W.K., Aagaard,L., Tommerup,N. and Thiesen,H.J.
  TITLE     Repression of transcriptional activity by heterologous KRAB domains
            present in zinc finger proteins
  JOURNAL   FEBS Lett 369 (2-3), 153-157 (1995)
   PUBMED   7649249
REFERENCE   5  (bases 1 to 12601)
  AUTHORS   Tommerup,N., Aagaard,L., Lund,C.L., Boel,E., Baxendale,S.,
            Bates,G.P., Lehrach,H. and Vissing,H.
  TITLE     A zinc-finger gene ZNF141 mapping at 4p16.3/D4S90 is a candidate
            gene for the Wolf-Hirschhorn (4p-) syndrome
  JOURNAL   Hum Mol Genet 2 (10), 1571-1575 (1993)
   PUBMED   8268908
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079140.6 and AC092574.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003441.3.
            
            Summary: The protein encoded by this gene is a zinc finger protein
            that may be a tumor suppressor. Defects in this gene have been
            associated with autosomal recessive postaxial polydactyly type A.
            [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP200889.1, SRR1660805.125396.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000240499.8/ ENSP00000240499.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               AC079140.6         120981-121153
            174-300             AC079140.6         126949-127075
            301-396             AC079140.6         127502-127597
            397-12601           AC092574.2         1566-13770
FEATURES             Location/Qualifiers
     source          1..12601
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..12601
                     /gene="ZNF141"
                     /gene_synonym="D4S90; pHZ-44"
                     /note="zinc finger protein 141"
                     /db_xref="GeneID:7700"
                     /db_xref="HGNC:HGNC:12926"
                     /db_xref="MIM:194648"
     exon            1..173
                     /gene="ZNF141"
                     /gene_synonym="D4S90; pHZ-44"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1595
                     /gene="ZNF141"
                     /gene_synonym="D4S90; pHZ-44"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 141 (clone pHZ-44)"
                     /codon_start=1
                     /product="zinc finger protein 141 isoform 1"
                     /protein_id="NP_003432.1"
                     /db_xref="CCDS:CCDS33931.1"
                     /db_xref="GeneID:7700"
                     /db_xref="HGNC:HGNC:12926"
                     /db_xref="MIM:194648"
                     /translation="MELLTFRDVAIEFSPEEWKCLDPDQQNLYRDVMLENYRNLVSLG
                     VAISNPDLVTCLEQRKEPYNVKIHKIVARPPAMCSHFTQDHWPVQGIEDSFHKLILRR
                     YEKCGHDNLQLRKGCKSLNECKLQKGGYNEFNECLSTTQSKILQCKASVKVVSKFSNS
                     NKRKTRHTGEKHFKECGKSFQKFSHLTQHKVIHAGEKPYTCEECGKAFKWSLIFNEHK
                     RIHTGEKPFTCEECGSIFTTSSHFAKHKIIHTGEKPYKCEECGKAFNRFTTLTKHKRI
                     HAGEKPITCEECRKIFTSSSNFAKHKRIHTGEKPYKCEECGKAFNRSTTLTKHKRIHT
                     GEKPYTCEECGKAFRQSSKLNEHKKVHTGERPYKCDECGKAFGRSRVLNEHKKIHTGE
                     KPYKCEECGKAFRRSTDRSQHKKIHSADKPYKCKECDKAFKQFSLLSQHKKIHTVDKP
                     YKCKDCDKAFKRFSHLNKHKKIHT"
     exon            174..300
                     /gene="ZNF141"
                     /gene_synonym="D4S90; pHZ-44"
                     /inference="alignment:Splign:2.1.0"
     exon            301..396
                     /gene="ZNF141"
                     /gene_synonym="D4S90; pHZ-44"
                     /inference="alignment:Splign:2.1.0"
     exon            397..12601
                     /gene="ZNF141"
                     /gene_synonym="D4S90; pHZ-44"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7949..7954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF141"
                     /gene_synonym="D4S90; pHZ-44"
                     /note="hexamer: AATACA"
     polyA_site      7974
                     /gene="ZNF141"
                     /gene_synonym="D4S90; pHZ-44"
                     /note="major polyA site"
     regulatory      8585..8590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF141"
                     /gene_synonym="D4S90; pHZ-44"
                     /note="hexamer: AATAAA"
     polyA_site      8603
                     /gene="ZNF141"
                     /gene_synonym="D4S90; pHZ-44"
     regulatory      8826..8831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF141"
                     /gene_synonym="D4S90; pHZ-44"
                     /note="hexamer: ATTAAA"
     polyA_site      8847
                     /gene="ZNF141"
                     /gene_synonym="D4S90; pHZ-44"
     regulatory      11684..11689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF141"
                     /gene_synonym="D4S90; pHZ-44"
                     /note="hexamer: AATAAA"
     polyA_site      11708
                     /gene="ZNF141"
                     /gene_synonym="D4S90; pHZ-44"
     regulatory      12577..12582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF141"
                     /gene_synonym="D4S90; pHZ-44"
                     /note="hexamer: AATAAA"
     polyA_site      12601
                     /gene="ZNF141"
                     /gene_synonym="D4S90; pHZ-44"
ORIGIN      
        1 gtctttgcgt ctggctacta ccagaccgcg ggttaggggc ttcatctctc tgcgttctca
       61 gttgtgggag gccttggtga ttcggccaca gctcagcctc cgtcgctctg tgacctgcgg
      121 gtattggatg attggtagct aagactcccg aatacttcag aagtggggaa atggaactct
      181 taacattcag ggatgtggcc atagaattct ctccagaaga gtggaaatgc ctggaccctg
      241 accagcagaa tttgtataga gatgtgatgt tggagaacta caggaacctg gtctccctgg
      301 gtgttgctat ctctaaccca gacctggtca cctgtctgga gcaaagaaaa gagccctaca
      361 atgtgaagat acataagatc gtagccagac ccccagctat gtgttctcat ttcacccaag
      421 accattggcc agtgcagggc atagaagatt cattccacaa acttatactg agaagatatg
      481 agaaatgtgg acatgataat ttacaattaa gaaaaggctg taaaagtttg aatgagtgta
      541 agttgcagaa aggaggttat aatgaattta atgaatgctt gtcaactacc cagagcaaaa
      601 tacttcagtg taaagcaagt gtcaaagttg ttagtaaatt ttcaaattca aacaaacgta
      661 agacaagaca tactggagag aaacacttta aagaatgtgg caaatcattt cagaagtttt
      721 cacacctaac tcaacataag gtaattcatg ctggagagaa accctacact tgtgaagaat
      781 gtggcaaagc ctttaaatgg tctttaatat ttaatgaaca taagagaatt catactggag
      841 agaaaccttt tacttgtgaa gaatgtggca gcatctttac cacatcctca cactttgcta
      901 agcataaaat aattcatact ggagaaaaac cctataaatg tgaagaatgt ggcaaagcct
      961 ttaataggtt cacaaccctt actaaacata agagaattca tgctggagag aaacccatca
     1021 catgtgaaga atgtaggaaa atctttacct catcctcaaa ctttgccaaa cataagcgaa
     1081 ttcatactgg agagaaaccc tacaaatgtg aagaatgtgg caaagccttt aataggtcca
     1141 caacccttac taaacataag agaattcata ctggagagaa accctacaca tgtgaagaat
     1201 gtggcaaagc ttttagacag tcctcaaaac tgaatgaaca taagaaagtt catactggag
     1261 agcggcccta caaatgtgat gaatgtggca aagcctttgg acggtccagg gtcctgaatg
     1321 aacataaaaa aattcatact ggagagaaac cctacaaatg tgaagaatgt ggcaaagcct
     1381 ttagacggtc cacagatcgg agtcaacata agaaaattca tagtgcagat aaaccctaca
     1441 aatgtaaaga atgtgacaaa gcctttaaac aattttcgct cctgagtcaa cataagaaaa
     1501 ttcatactgt agataaaccc tacaaatgta aagattgtga caaagccttt aaacggttct
     1561 cacacctgaa taaacataag aaaattcata cttgagagaa atcctacaaa tgtaaagaat
     1621 gtggcaaacc tttggatgat ccacaaacct taatgaacat gagaaaattt atactgtaga
     1681 gaaaccctgg aaatgtgaag aacgtggcaa agttctttac ctcattctca aaccttgata
     1741 aacataagag aattcatacc ggagagaaac tgtacaaatg tgaagaatat ggcaaagcct
     1801 gtgaatggtc cacaaacctg aatgagcaga agaaaattat tactggagat aaaccctgca
     1861 aatgtaaaga gtgtaacaaa acctttaaac agccctcacc ggtgaataaa cataagaaaa
     1921 atcatgctgg agggaagccc tacacatgtg gcagaatgtg gcaaagcatt taattggtcc
     1981 tcaatgctta ataaatataa ttcatgctgg agagaaactt cacatgtgaa ccgtgtggca
     2041 aagcctttaa atggtcctca acccttaatg aacgtaagtg aattcatgct ggagcaaaat
     2101 gcttcacatg cgaagaatgt ggcacagtct ttaccacatc ctcaaacttt gttaaacata
     2161 agagaattta taccagagag aaaccctaca catgtaaaga atgtggcaaa gccttcaata
     2221 ggttctcaac ccttactgtg cacaagataa ttcattctgg ggaaaaaaat gctacaaatg
     2281 tgaaaaacgt ggcagagcct tcagaccatc cacaaacctt tatgaaaatt catatttgag
     2341 agtagaagat tcattccaca aacttacatt gagaagatat gaaagatgaa tataagaatt
     2401 catcctagat ataaaaccat agaaatgtaa aagatgtgac aaaaccttta agccatactc
     2461 caggcttctt aaacataatg agaactcata ctggaggaaa gtcttacaaa tgtgaagaat
     2521 gtggcagtct ttaaatcttc ctcagtcttt tctaatcata agataattca cactgaagag
     2581 aaactgcaaa cgtggaaagt gtgacaaagc ttgcaaccac actcaatcta ttctaaatat
     2641 aagagaaatg atattggtga gaagccacaa aaatatgaaa aatgtggcaa agccttcaaa
     2701 tgcttgtcac atcttactgt atatatataa ttcctactga agaaatcccc tggaaatgca
     2761 aaaaatgtgg caggattttt accaatgctc atctttttgc acatgatatc ctttatattc
     2821 gagaaaagtt atagaaatat aaaaaatata gaaaagtcat atctcctcac attttactaa
     2881 ctagcaatgt tcatacttaa taaaaacatt ataaatgtaa tttctgttga aagacttcag
     2941 aaaatatagg cctttaaagt gaagaagagt attcttaaga caaacaatac aaatataaag
     3001 agggttgtag tacctgtact tctctcatgg attttgttgt acacatttta taatagggga
     3061 aaacactgaa ggagactttc ttcaacatca gaaaatttat attggagaga aatcctacaa
     3121 atgtaataaa tgtggaaaaa catttgttca aaaactgcag cttaaacagt ttacactaga
     3181 aaatattttg tagatgcagt aaatgtgaag aaatatttag tctaaaaaga agagtatgta
     3241 aacatcagag gatttacagt agaaagaact aaggaactaa cactttagac actgcagtaa
     3301 atcagagtat taagtattaa aaaaatccaa agttgaacct attagagaat ttctttgtat
     3361 ataagttgaa aagaagattt ttgaagagat actacattta aagtatattt tttcacttga
     3421 aaaaagtata gattttttga aaagcatata atagttaatt caactcaaat tatttcatac
     3481 tgtttcaaca ttcctgttta tgtgaaagca tgtgatgaat tgttgctgca tcagagataa
     3541 gagagattct ttttcattag gtgggcatta tttgtgaatt tttacaagaa agagtgagga
     3601 cagaaatgaa agatccatga tgaaaatcta gcagagaggc ttttttgtag ttgacaatat
     3661 tgagtgatgc atgaggtagg tgttcagagt aatattcttc tgcattatag tgagagaaaa
     3721 tctgttttag tagtaaattg ttttaccaat tatacattta tgtaataaga tacagtaaat
     3781 tttaaaatta ttttaagatt atgtgggaac ataatttttt aactaaacaa aatttttaac
     3841 gtgttgaaat aattgttgct tgaatgaagt gtcattatgc caccaactta aacctatccc
     3901 accttactca atggtgtagg taaaagatgg taacaatggt aacatagttg aatgacattt
     3961 ttagtattct ctttttccag tggctttaaa tagcaaatac attgaagaat atcattccca
     4021 tatgttgtat tttcactctt gttattttcc gaaatttttg tgggtacata gtatgcatat
     4081 ttatctatgg catatatggg ttattttctt atacaggcat acaacatgta atataccaga
     4141 gtaaatgagt tattcatcac ctcaagcatt catcctttgt attacacaca atccaattat
     4201 acactttaat tatttctaaa tgtacaatta tgattgtagt attatatcag tataattata
     4261 attcatacat ttatgcatcc tgaatacttc taaaaaatgt tttacatttc tctttgaaca
     4321 tgtggcatct tttcctgcaa acttatacaa actttagttc catttacatg aagttaagta
     4381 tgtaaatgtg ttgctgtaaa gataaacctt aggtgtaaga aaattataga gcaagcaatt
     4441 gtgtttatgt gagtttgtac ctattttcca aagaaaatag caatattaga acaaagaaga
     4501 ttatgttaat accatggata atttactgga aatctagaag cctgaaacat tctatatttt
     4561 cttcttttta tttaatgact ctagaatcta atggattgtc gttgagaatc tccccataca
     4621 aactccttgt ttttatttgt ctggtgctca tgctagagct ataatttctt tgattctctt
     4681 ttttgttttc acttcatgaa gtgtttatta tgtgagctgg tcagaaatta taagaatgat
     4741 ttttataaaa tgtagtgaat gtaaaatttt tagatgtaat ttcataatat atgtattaag
     4801 ttattttagt tagaacattt cattttgttg ttttaattta agaaccctat ataagctgtt
     4861 ttctttagtt attgttcctt tcagtttttg taattgacat aaatgagttt attttgccaa
     4921 tttgttcagg taagtacttg gaaaactttg tcagtcatgg ggatgttttg atctattatt
     4981 gtagtgaaca aacaaagttc tgggtgtgta atagatgctt cataattagc cataaatatt
     5041 cctggagtta gtttgtagct ccaagtaaga gattgaaaat aatctgtggc gaacaaatgg
     5101 cattaattgt gcatgtggag aggacgtctg ttctcaggct gcagaaccaa ctcattatga
     5161 atgtaaagag gatttctttt cttattttct aattatcttc agttttgtga tatctttatg
     5221 atttatcccc agctatgtat gcctcagagc ctttcttcat ttttgcgtta tggctagttt
     5281 gtcactgttc tcttcattcc acgtaatttc acgtggactt taggttaact ggggtgtttg
     5341 aggttattta taggttatca gtgcaacatt tagatcactt gagataagag taattcacta
     5401 tcaacaggta agaggattaa gtcagttggc attgtttttc tgtgtttgta aaagaaaaat
     5461 tgtatgagat tctatcataa agtgtgtaaa atgtaacaaa agttagaata agtaaaacat
     5521 taatataagt gggttgtata ttgtaccacc atatgaagaa acatcagaat tttgaaattt
     5581 cttaagagga aatatatctt agaaataaaa tttttaggcc aggtggcggt ggttcacacc
     5641 tgtaatccca gcactttggg aggccgagat gggtgggtca tgaagtcaag agagcaagat
     5701 catcctggca aacatggtga aaccccatct ctactaaaaa tacaaaaatt agcagggcgt
     5761 ggtggcatgt gcctgtagtc ccagctactc gggaagctga ggcaggagaa tcgcttgaac
     5821 ccaggatgca gaggttgcag tgagctgatg ttgtgccact gcagtgcagc ctgccaacag
     5881 agtaagaccc gtctcaacaa caacaacaaa aaagaagaaa atttttagga gacaatggta
     5941 agtgaggaat tttacattta attttctgtg acatagcaaa acatttttcc atacaaaatc
     6001 ttctatttat ttatttattt tagatggagc cccactctgt caccaggctg gagtgcagtg
     6061 gtgcaatctc agctcactgc aacctccgcc tcccaggttc aagtgattct cctgcctcag
     6121 cctcctgagt taactgggac tacaatcgcc tgccaccacg cccagttaat ttttatattt
     6181 ttagtagaga tggggtttca ccatgttggc caggatggtc tcgatctttt gacctcatga
     6241 tctgcctgcc ttggcctcct gaagtactgg gattacaggc atgagccacc gtgcctggcc
     6301 agaatattat atctttgagt gtgaatgtta aatggtggaa aaacaataga atgatctctg
     6361 tagattcaaa atctgcactg atcttttttg tccagattca tattacaatc ttgaggaatt
     6421 tctcataatt ctttgtttta gtggatgcat ttcatgggct acagttttca tttttactca
     6481 cctaacttta tccaagtcct tggtcacctt ctctggaaaa aaatttgaag attatggcag
     6541 ctgttgaatc caaacagttt ctcagtgatt tttttttttt tttttttttt tttttgagat
     6601 ggagtcttgc tctgtcaccc aggctggagt gcagtggcac aatctcagct cattgcaacc
     6661 tccacctctc gggttcaagc aattctcctg cctcagcctc ccaagtagct gggattacag
     6721 gtgcccacca ccacacccag ctaatttttg tatttttaat agagatgagg tttcactctg
     6781 ttggccaggc tggtctcgag ctcctgtcct cgtgatccac gcacgtcagc ctcccaaagt
     6841 gctgggatta ccggtgtgag ccactgtgcc cagcctctca gtgatttttg atgcaaattc
     6901 atttactgtg ttcacgaagt ggccaatttt gggaccttta gcatcacttg cccttttagt
     6961 gtcttacata tgtatgatta ccatcagcac tagaaattcc aggtacttca agcttaaaag
     7021 taagagctct agagtgtatt gtcttgtatt atatattgtt ctgggtctaa gccatgctag
     7081 taaatattag agttcctatg attattttct tctttatttt atttttgaga cggagtctcg
     7141 ctctgtcgcc aggctggagt acagtggtgc gatctcagct cactgcaacc tccgcctctc
     7201 aggttcaggc gattctcctg cctcagcctc cttattagct ggcattacag gtgtgcacca
     7261 ccatgcctgg ctaattttta tattgttagt agagatgcgg tttgactatg ttggccaggc
     7321 tggtctcaaa ctcctgaccc tgtgatcctg ccaccttggc ctcccaaagt tctggaatta
     7381 caggcgtgag ccactgcgcc cagcctctat ggttattata ttacaaaaac agcacaaaaa
     7441 ctatatattt tttataatac tcaagttgtt tgacaaagat actcatcatt tgcaacatta
     7501 ttctgtaatt tttaaaatat atttgttaat tgacagataa aatatcctgt agaatatggt
     7561 gttttgtagt atatatacat tgtcaaaagc ttaattctag ctgcttaaca aatacttcac
     7621 cacacataat tacttttggg ataagagctc ataacattga ctgtgttagc attttccaaa
     7681 aatacattat tgttaactgt agtcaccatg ctgtacaata gatttcttga atttattcct
     7741 cctaggcaac tatgtgttgt tttacagaca tgtctccaga tgcccctttc ttgtaaatac
     7801 ccaagcatct ggtaaccagc attctactct ctggcttatt tcacttagca tagtgtcttc
     7861 cacatttatc cacattgttt caaatgaaaa gatttcctcc cttttaacgt tgaattgtat
     7921 ttccttgtgt ataccacgtt tttggaaaaa tacattcatt tcttggttga aaaactcacg
     7981 tgatgagaag atatttctgt attaaagcat gtattggaat tccgtatata catgttttag
     8041 taatagttga tttctaccaa atgctaacca taatactgta tatgtgttaa taaattttat
     8101 tttcggccag gcgtggtggc tcacacctgt aatcccagca ctttgggcgc ccaaggcagg
     8161 tggatcatga ggtcaggagt ttgagaccag tctggccaac atggtgaaac cccgtctcta
     8221 ctacaaatat aaaaattagc tgggtgtggt gtcaggcgcc tgtaatccca gctactcaag
     8281 aggttgaggc aggagaatca gttgaacctg ggaggtggag attgcagtga gccaagatca
     8341 tgccattgca ctccagcctg ggtgacaaga gcaaaactcc atcccccctg cccaaaaaaa
     8401 aaaattaatt ttcacagaaa attaatagca taggtattat tatcctcatt ttacagagaa
     8461 agaaacagcc atagagaaaa atgacttgct cacaacacag gcaactttga ctctagagat
     8521 aacacttatt acagtaaaat ccctcttcag acacaaaata catgattatc ttaaacacat
     8581 tcttaataaa aatttaacaa aaattgttaa atgttgtcat atatgtgtgt gcaaaacgta
     8641 taaaatatac agaaaagaga aatacttcct gtatttaaac catataaact ctagaattgc
     8701 ccttcgatac tgacgtactt gggaacagct ttcctttcaa ctgtccttca ccaccccttt
     8761 agcaattcag aatatttata gcataatttt tacctatacc tgtagtcagt aaatgctgta
     8821 atgtaattaa atattattta ctacaaactc acatagtaca ttatgacttt attactgtta
     8881 taatacaaat ttatttcttg agttaaatat ttgactctat tagtttagtt tcctttgtgc
     8941 ctgtttctca gttttgccta aatgctacca attatcttac actggctccc caaataggtt
     9001 tttatttgtt tataaaactt taaatttatc tctaggaacc tcagccgagc agtcagaact
     9061 cacagctctg accaaacccc tagaactaag aaagaaccaa aaagttacta tttaatacag
     9121 acttcaaatg tgcttttttt tttttttttt tttttttttg agacgttgtc ttgctctgtc
     9181 gcccaggctg gagtgcagtg gtgcaatctc ggctcactgc aacctccgcc tcctgggttc
     9241 acacaatttg cctgcctcag ccccctgagt agctgggact aacaggtgcg ccccaccacg
     9301 cctgaaaaat ttttgtattt ttagtagaga cggggtttca ccatgttggc caggctggtc
     9361 tcaaactcct gaccttaagt gatccaccca gtcagcctcc caaagtgctg ggattacagg
     9421 cgtgagccac catgccctca aatatgcttt cttagtactc cacatttatg cagccatctg
     9481 ggaagaaagg agacttttta caacagagaa tacccctatt aaatatgggt cacagatttt
     9541 taccctagtc cagcctatcc acctaccaca gaaagtagct gtagttcatt gctggggcca
     9601 ccagaagggt caagatgaaa ttgctcagag aaacaggagg gctgaccaag cagctagggc
     9661 caccaccatc tctgggaact tttttttttt ttttttttga gacggagtct cactctcgcc
     9721 caggctggag tgcagtggct cgatctcggc tcactgcaag ctccacctcc caggttcacg
     9781 ccattctcct gcctcagcct cccaagtagc tgggactaca ggcacctgct accatgcccg
     9841 gctaattttt ttgtattttt agtagagacg gggtttcacc atgttagcca acaaggtctt
     9901 gatttcctga cctcgtgatc cgcctgcctc agcctaccaa agtgctggga ttacaggcat
     9961 gagccaccgc gcccggcctt agttgtgtgt gatttctatg tgtgctctag gcacttgccc
    10021 tatagctgct cctaaatgtg gggtcttaga aaacatcttg tcccttcgaa gcatactctg
    10081 ctggttggct aaattgcact gggaaaaaat agcagcagcc ctattgctat gtcacttgcc
    10141 tgcagagcaa aagttgattc aggaacagta atttgacttt gtctatatta aaaatcataa
    10201 atagtcaaca aatgcaaaaa atgcaaagaa tttgtaggta tgattagtgc attataggtg
    10261 ttttcaaatt tctcctatga taaattaaaa atgtaatgtt gggcattaat ttcctaaacc
    10321 cagtgctcag caattttctc aaattgttta cagtttttcc aagagacttc agaaccattc
    10381 cctggagtga attatttcca atggtgaaga gtaatggatg gatggcatga gattctcaaa
    10441 aaaatcttgc tcctatttca gaagtgtcac tccagcccct tgaaggtcca ggaaacctgg
    10501 ctgagtagtg tggtctatgg aggtgcatgg gcttcagaat caggccaacg ttgatcctga
    10561 gtcccagcca gctgcttagt agctgtggga tagttacaca agacacatct acaagaaaag
    10621 tcatgataaa attgattgca aaaacagcaa tttgaaaaat ttcttattgt attcatgtcc
    10681 ttggaaatgg cttttatagt cgttcctatc aagagacaga ttctgtttcc caaaccttga
    10741 acttctcttg acttatctgc actggcacag ggtgccagtt tggggcccag gtttaaaggt
    10801 cctaaatgct tctgttatct ttttcagaat tcttccatct ctatgacaac aagcccattt
    10861 tagctttctg gagaatagca tctgagaaaa gccaaagtgc ctcagtttac agacagctca
    10921 ctcacagaag cagagccacc taattcacca gcatctaacc actcacacct gaaggagcca
    10981 aactgagccc agaagaatgg cccggctgag cccagcctaa atttctaacc agctcaatcc
    11041 tgagctagta tgtttcggga ttgttatgca gttataagtt agtaatatat acacccatta
    11101 aagacaggat ctcaggacag attgatcaca aataacctgc aaatgcttgc caccctgtaa
    11161 gtattgattt tcttttttcc tttatttaaa gttagatttg ttgtaagatg atattgagtt
    11221 acacagaagt taggcaggag aatagggttt ggaggcaggg aacttaaggc caattcgtgc
    11281 tgacttccta caagaaaaaa caccaaggtc tgggagcagg gaacctaaag ccagttaacg
    11341 tgaacttcct acatctaaac caaaaggaaa gacctcatct acacccgagt agcaaaggat
    11401 cgaaggcgac tgtcgctaca accctccccc ttgtaccagt tctctgatag aaaaggacag
    11461 tgccttggag tggccgtggg ccaagcacag gccatgcctt catctgcata gggtaccaat
    11521 tcgcctcaac ctttgattag ccaaggacca aatccttcat tcagataagg ggtagctgat
    11581 aggaacctca aaaggagtac ttaaaaccca gaaaacattg taaccgggtc cttgggcggc
    11641 ttgctggggc tcacacccac cctgtagagt gctttctcac tttaataaaa tcttgctttt
    11701 gctattccct tcctgttttt cattcctttg tgtgctttgt tcaatttttt tgttcgaaat
    11761 gtcaaggacc tggacagttc acactcacgg ccttccttct ggtaacagaa gtgcaggtat
    11821 atgtggatgc atgtgattgg tacttaaact cacacagtgc cccataccac aggagaaaaa
    11881 cacacagttc cagcctggca attaggtcca aagataaata gcaaaacaag aagtttgcct
    11941 ttaatctatt ccctccacat ctaaactctg gagggcaagg ctgtgaggag atctgaagac
    12001 atggtgctct ctcttcctgt ggacccatca ttccttgttt accatctgat atttgaaaag
    12061 aagaggaacc cctgagaaag gaggcagagg ctggttagga agatagggag ggaaggtctt
    12121 gggagatgaa aaacacccac gggaccacac ctgcaccacc catgtagcta gcaggaagaa
    12181 atgtggttaa gaacttcctc ttatgccagg gtgttgatca gaagagactg tcccacttag
    12241 gcccaggtgt aatgaatcaa cctaaatgtc attaacttga cccagctcct tataatgtta
    12301 ctaacatgac ataaatattt tggttttagc ttcactcttt ccacctgctg tcggttttgc
    12361 ttgggcactc atgggtaata accaagatgg agtcactgtg gtcaactcca ggcatgcaca
    12421 gatacaacac ccttagcggg gaaatttacc cctcccattt gggcagaacc cacagaagac
    12481 ttcctcgttc ttgccacata aaagacccag aactcagccc catttctggc aacctgcttt
    12541 catgtcccct ttctgctgag agctttcctt ttgcttaata aatcctattc tgctttattc
    12601 a
//
