LOCUS       NM_003440               2349 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 140 (ZNF140), transcript variant
            1, mRNA.
ACCESSION   NM_003440
VERSION     NM_003440.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2349)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2349)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   3  (bases 1 to 2349)
  AUTHORS   Nishimura,T., Narita,T., Miyazaki,E., Ito,T., Nishimoto,N.,
            Yoshizaki,K., Martial,J.A., Bellfroid,E.J., Vissing,H. and
            Taniyama,T.
  TITLE     Characterization of the human Fc gamma RIIB gene promoter: human
            zinc-finger proteins (ZNF140 and ZNF91) that bind to different
            regions function as transcription repressors
  JOURNAL   Int Immunol 13 (8), 1075-1084 (2001)
   PUBMED   11470777
REFERENCE   4  (bases 1 to 2349)
  AUTHORS   Vissing,H., Meyer,W.K., Aagaard,L., Tommerup,N. and Thiesen,H.J.
  TITLE     Repression of transcriptional activity by heterologous KRAB domains
            present in zinc finger proteins
  JOURNAL   FEBS Lett 369 (2-3), 153-157 (1995)
   PUBMED   7649249
REFERENCE   5  (bases 1 to 2349)
  AUTHORS   Tommerup,N. and Vissing,H.
  TITLE     Isolation and fine mapping of 16 novel human zinc finger-encoding
            cDNAs identify putative candidate genes for developmental and
            malignant disorders
  JOURNAL   Genomics 27 (2), 259-264 (1995)
   PUBMED   7557990
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK122741.1 and BC022291.1.
            
            On Aug 11, 2020 this sequence version replaced NM_003440.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040561.1, AK122741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355557.7/ ENSP00000347755.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-989               AK122741.1         722-1710
            990-2349            BC022291.1         969-2328
FEATURES             Location/Qualifiers
     source          1..2349
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..2349
                     /gene="ZNF140"
                     /gene_synonym="pHZ-39"
                     /note="zinc finger protein 140"
                     /db_xref="GeneID:7699"
                     /db_xref="HGNC:HGNC:12925"
                     /db_xref="MIM:604082"
     exon            1..150
                     /gene="ZNF140"
                     /gene_synonym="pHZ-39"
                     /inference="alignment:Splign:2.1.0"
     exon            151..207
                     /gene="ZNF140"
                     /gene_synonym="pHZ-39"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1572
                     /gene="ZNF140"
                     /gene_synonym="pHZ-39"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 140 isoform 1"
                     /protein_id="NP_003431.2"
                     /db_xref="CCDS:CCDS9282.1"
                     /db_xref="GeneID:7699"
                     /db_xref="HGNC:HGNC:12925"
                     /db_xref="MIM:604082"
                     /translation="MSQGSVTFRDVAIDFSQEEWKWLQPAQRDLYRCVMLENYGHLVS
                     LGLSISKPDVVSLLEQGKEPWLGKREVKRDLFSVSESSGEIKDFSPKNVIYDDSSQYL
                     IMERILSQGPVYSSFKGGWKCKDHTEMLQENQGCIRKVTVSHQEALAQHMNISTVERP
                     YGCHECGKTFGRRFSLVLHQRTHTGEKPYACKECGKTFSQISNLVKHQMIHTGKKPHE
                     CKDCNKTFSYLSFLIEHQRTHTGEKPYECTECGKAFSRASNLTRHQRIHIGKKQYICR
                     KCGKAFSSGSELIRHQITHTGEKPYECIECGKAFRRFSHLTRHQSIHTTKTPYECNEC
                     RKAFRCHSFLIKHQRIHAGEKLYECDECGKVFTWHASLIQHTKSHTGEKPYACAECDK
                     AFSRSFSLILHQRTHTGEKPYVCKVCNKSFSWSSNLAKHQRTHTLDNPYEYENSFNYH
                     SFLTEHQ"
     exon            208..334
                     /gene="ZNF140"
                     /gene_synonym="pHZ-39"
                     /inference="alignment:Splign:2.1.0"
     exon            335..430
                     /gene="ZNF140"
                     /gene_synonym="pHZ-39"
                     /inference="alignment:Splign:2.1.0"
     exon            431..2349
                     /gene="ZNF140"
                     /gene_synonym="pHZ-39"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2325..2330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF140"
                     /gene_synonym="pHZ-39"
                     /note="hexamer: AATAAA"
     polyA_site      2349
                     /gene="ZNF140"
                     /gene_synonym="pHZ-39"
                     /note="major polyA site"
ORIGIN      
        1 gtctggcctg tgttggctgt aggcaacgaa aggagccctc ccggtctgcg ccggatggcc
       61 ccgggcggtg actcggtccg gagccctgga acgctacgcc cacctggcgg aaagcaccac
      121 ggaaacgcat ccttctgtgg ccactgttag gtctgccatt ttacactttt ctgatctcct
      181 ccttcccttc tgtgagctat gtctcagggg tcagtgacat tcagagatgt ggccatagac
      241 ttctcccagg aggagtggaa atggcttcag cctgctcaaa gagatttgta cagatgtgta
      301 atgttggaga actatggcca tctggtctca ctgggtcttt ccatttctaa gccagatgtg
      361 gtttccttat tggagcaagg gaaagaaccc tggctgggga aaagggaagt gaaaagagat
      421 ctgttttcag tttcagagtc aagtggtgag atcaaagact tttcaccaaa aaatgtcatt
      481 tatgatgact catcccagta tttgatcatg gaaagaattc taagtcaagg ccctgtgtat
      541 tccagtttta aaggaggctg gaaatgcaag gatcatactg agatgctgca agaaaatcag
      601 ggatgtatta ggaaagtaac agtctctcat caagaagccc tggctcaaca tatgaatatc
      661 agtactgtgg agaggcccta tggatgccat gaatgtggaa aaacttttgg tcgacgcttt
      721 tccctggtgt tacaccagag gactcatact ggagagaaac catatgcatg taaggaatgt
      781 ggcaaaacct ttagccagat ttcaaacctt gtgaaacacc aaatgataca tactggaaag
      841 aaaccccatg agtgtaagga ctgtaataaa acattcagtt acctttcatt tcttattgaa
      901 caccagagaa cgcacactgg ggagaaacct tatgaatgta ctgagtgtgg aaaggccttt
      961 agccgtgcct ccaacctcac tcgacatcaa agaattcaca taggaaagaa acaatatata
     1021 tgtaggaaat gtggtaaagc atttagcagt ggctcagaac tcattcgcca ccagattaca
     1081 catactggag agaaacctta tgaatgcatt gaatgtggga aggcatttcg ccgtttctca
     1141 caccttactc gacatcagag catccataca accaaaaccc cgtatgaatg taatgaatgt
     1201 aggaaagctt tccgttgtca ctcattcctt attaaacatc agagaattca tgctggagaa
     1261 aagctctatg aatgtgatga atgtggtaaa gttttcactt ggcatgcatc ccttattcaa
     1321 catacgaaga gtcacactgg agagaaaccc tatgcgtgtg ctgaatgtga taaagccttc
     1381 agccggagct tttccctcat tctacatcag agaactcata ctggagagaa accctatgta
     1441 tgtaaggtat gcaacaaatc cttcagctgg agctcaaacc ttgctaaaca tcagaggaca
     1501 cacactcttg acaaccccta tgaatatgaa aattcattta attaccactc attccttact
     1561 gaacaccagt gaatttacac tgcaaagaaa aactatgaat gtatggaatt ttttaaaaag
     1621 aagtataatg ccttacttca gagaactctt ggaaagaagc cttatgtgaa agtgatgact
     1681 gtgaagtaat atggcccaca ctttattcac caccctggag aaaaaaaaac ccaggaatat
     1741 gtggaaaagc cattaataac cactctttta tttttttgca ataacaaggt gaaatcaata
     1801 ttgttgagaa gattcttcca tctggtaatg ttgagaagac ttcatttggt aggagtccct
     1861 tactttacgt gtgtaaattc ctaccaggaa agaatacata tccaatagat tggagaaagc
     1921 cagagattag ccctcattcc gcatctgtca accaggacag aaagcatgga caagggatga
     1981 gctttacaaa gatgatgcac tttggagatc agaaaattca tatttaagca aagtgataca
     2041 aacacagtga tttgggaatg ccttcattta caatgcaata cttacatttt aatactcttg
     2101 taggagaaaa agcaactgta taaatgaatg tagagtgact ttctgcaata tttcaaacct
     2161 atatcagaga attacactgt gggaaaacta ccattgtaat aagtgtagca aaatctcctt
     2221 agatatctga aaagtcatac tggatggaat ctgtaggaaa cggttctatt ttgagggaag
     2281 ggggattcct ttttgttttt taagtgaatt cagaaaatgt tataaataaa tcttttggtt
     2341 tattataaa
//
