LOCUS       NM_021030               2963 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 14 (ZNF14), mRNA.
ACCESSION   NM_021030
VERSION     NM_021030.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2963)
  AUTHORS   Cornelis,M.C., Fornage,M., Foy,M., Xun,P., Gladyshev,V.N.,
            Morris,S., Chasman,D.I., Hu,F.B., Rimm,E.B., Kraft,P., Jordan,J.M.,
            Mozaffarian,D. and He,K.
  TITLE     Genome-wide association study of selenium concentrations
  JOURNAL   Hum Mol Genet 24 (5), 1469-1477 (2015)
   PUBMED   25343990
REFERENCE   2  (bases 1 to 2963)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   3  (bases 1 to 2963)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   4  (bases 1 to 2963)
  AUTHORS   Vissing,H., Meyer,W.K., Aagaard,L., Tommerup,N. and Thiesen,H.J.
  TITLE     Repression of transcriptional activity by heterologous KRAB domains
            present in zinc finger proteins
  JOURNAL   FEBS Lett 369 (2-3), 153-157 (1995)
   PUBMED   7649249
REFERENCE   5  (bases 1 to 2963)
  AUTHORS   Rousseau-Merck,M.F., Hillion,J., Jonveaux,P., Couillin,P.,
            Seite,P., Thiesen,H.J. and Berger,R.
  TITLE     Chromosomal localization of 9 KOX zinc finger genes: physical
            linkages suggest clustering of KOX genes on chromosomes 12, 16, and
            19
  JOURNAL   Hum Genet 92 (6), 583-587 (1993)
   PUBMED   8262519
REFERENCE   6  (bases 1 to 2963)
  AUTHORS   Thiesen,H.J.
  TITLE     Multiple genes encoding zinc finger domains are expressed in human
            T cells
  JOURNAL   New Biol 2 (4), 363-374 (1990)
   PUBMED   2288909
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM836276.1, AK074832.1,
            AB021644.1, CD358782.1, AV726241.1, BE392040.1, AA286756.1,
            CA414092.1 and AW675436.1.
            
            On Nov 22, 2018 this sequence version replaced NM_021030.2.
            
            Summary: The protein encoded by this gene contains a zinc finger
            and a Kruppel-associated box (KRAB) domain. KRAB domain is known to
            be involved in the transcriptional repression of a number of zinc
            finger proteins. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.1775.1,
                                           SRR1803612.154877.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153427, SAMN03267778
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344099.4/ ENSP00000340514.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BM836276.1         1-15
            16-50               AK074832.1         1-35
            51-973              AB021644.1         1-923
            974-1510            CD358782.1         94-630
            1511-1692           AV726241.1         344-525
            1693-2194           AB021644.1         1643-2144
            2195-2257           BE392040.1         23-85
            2258-2418           AA286756.1         45-205
            2419-2551           CA414092.1         431-563             c
            2552-2963           AW675436.1         5-416               c
FEATURES             Location/Qualifiers
     source          1..2963
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..2963
                     /gene="ZNF14"
                     /gene_synonym="GIOT-4; KOX6"
                     /note="zinc finger protein 14"
                     /db_xref="GeneID:7561"
                     /db_xref="HGNC:HGNC:12924"
                     /db_xref="MIM:194556"
     exon            1..157
                     /gene="ZNF14"
                     /gene_synonym="GIOT-4; KOX6"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..2083
                     /gene="ZNF14"
                     /gene_synonym="GIOT-4; KOX6"
                     /note="zinc finger protein 14 (KOX 6); zinc finger protein
                     KOX6; gonadotropin inducible transcription repressor-4;
                     gonadotropin-inducible ovary transcription repressor 4"
                     /codon_start=1
                     /product="zinc finger protein 14"
                     /protein_id="NP_066358.2"
                     /db_xref="CCDS:CCDS12409.1"
                     /db_xref="GeneID:7561"
                     /db_xref="HGNC:HGNC:12924"
                     /db_xref="MIM:194556"
                     /translation="MDSVSFEDVAVNFTLEEWALLDSSQKKLYEDVMQETFKNLVCLG
                     KKWEDQDIEDDHRNQGKNRRCHMVERLCESRRGSKCGETTSQMPNVNINKETFTGAKP
                     HECSFCGRDFIHHSSLNRHMRSHTGQKPNEYQEYEKQPCKCKAVGKTFSYHHCFRKHE
                     RTHTGVKPYECKQCGKAFIYYQPFQRHERTHAGQKPYECKQCGKTFIYYQSFQKHAHT
                     GKKPYECKQCGKAFICYQSFQRHKRTHTGEKPYECKQCGKAFSCPTYFRTHERTHTGE
                     KPYKCKECGKAFSFLSSFRRHKRTHSGEKPYECKECGKAFFYSASFRAHVIIHTGARP
                     YKCKECGKAFNSSNSCRVHERTHIGEKPYECKRCGKSFSWSISLRLHERTHTGEKPYE
                     CKQCHKTFSFSSSLREHETTHTGEKPYECKQCGKTFSFSSSLQRHERTHNAEKPYECK
                     QCGKAFRCSSYFRIHERSHTGEKPYECKQCGKVFIRSSSFRLHERTHTGEKPYECKLC
                     GKTFSFSSSLREHEKIHTGNKPFECKQCGKAFLRSSQIRLHERTHTGEKPYQCKQCGK
                     AFISSSKFRMHERTHTGEKPYRCKQCGKAFRFSSSVRIHERSHTGEKPYECKQCGKAF
                     ISSSHFRLHERTHMGEKV"
     exon            158..284
                     /gene="ZNF14"
                     /gene_synonym="GIOT-4; KOX6"
                     /inference="alignment:Splign:2.1.0"
     exon            285..345
                     /gene="ZNF14"
                     /gene_synonym="GIOT-4; KOX6"
                     /inference="alignment:Splign:2.1.0"
     exon            346..2963
                     /gene="ZNF14"
                     /gene_synonym="GIOT-4; KOX6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2886..2891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF14"
                     /gene_synonym="GIOT-4; KOX6"
                     /note="hexamer: AATAAA"
     polyA_site      2911
                     /gene="ZNF14"
                     /gene_synonym="GIOT-4; KOX6"
     regulatory      2944..2949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF14"
                     /gene_synonym="GIOT-4; KOX6"
                     /note="hexamer: AATAAA"
     polyA_site      2963
                     /gene="ZNF14"
                     /gene_synonym="GIOT-4; KOX6"
                     /note="major polyA site"
ORIGIN      
        1 agtgcggacg tcgccattcc tggcccatgg gaagattgcg tttcacctgc tcctgaaggc
       61 cgaaggtggc tctagcgcat cctttgtcgc gccgtgacct gcaggtactg acagatccgt
      121 agggaggaca ccgtgacttc ccggacgctg ggaaatggac tcagtctcct ttgaggatgt
      181 ggccgtgaac ttcaccctgg aggagtgggc tttgctggat tcttcacaga aaaagctcta
      241 tgaagatgtg atgcaggaga ccttcaaaaa cctggtttgt ctaggaaaaa agtgggaaga
      301 ccaggacatt gaagatgacc acagaaacca ggggaaaaat cgaagatgtc atatggttga
      361 gagactctgt gaaagtagaa gaggtagcaa atgtggagaa accactagcc agatgccaaa
      421 tgttaatatc aacaaggaaa cttttactgg agcaaaacca catgaatgca gcttttgtgg
      481 aagagacttc attcatcatt cgtcccttaa taggcacatg agatctcaca ctggacagaa
      541 accaaatgag tatcaggaat atgaaaagca accatgtaaa tgtaaagcag ttgggaaaac
      601 cttcagttat caccactgct ttcgcaaaca tgaaagaact cacactggag tgaagcccta
      661 tgaatgtaaa cagtgtggga aagcctttat atattaccag ccatttcaaa gacatgaaag
      721 gactcatgct ggacagaaac cctatgaatg taagcaatgt ggaaaaacct ttatatatta
      781 ccagtctttt caaaaacatg ctcatactgg aaagaaaccc tatgaatgta aacagtgtgg
      841 gaaagccttt atatgttacc aatcttttca aagacacaaa aggactcaca ctggagagaa
      901 accctatgaa tgtaagcaat gtggtaaggc tttcagttgt cccacatact ttcgaactca
      961 tgaaagaact cacactggag aaaaacccta caaatgtaaa gaatgtggta aagccttcag
     1021 ttttctcagt tcttttcgaa ggcataaaag gactcatagt ggagagaaac cctatgaatg
     1081 taaagaatgt ggaaaagcct tcttttattc tgcaagcttt cgagcacatg taataataca
     1141 cactggggct cgaccttata aatgtaaaga atgtgggaaa gccttcaact cttctaattc
     1201 ctgtcgagtg catgaaagaa ctcatattgg agaaaaacca tatgaatgta aacgatgtgg
     1261 caaatcattc agttggtcca tttctcttcg attgcatgaa agaactcata ctggagagaa
     1321 accttatgag tgtaaacagt gtcataaaac cttcagtttt tcaagttccc ttcgagaaca
     1381 cgaaacaact cacactggag agaaacccta tgaatgtaaa caatgtggta aaaccttcag
     1441 tttttcaagt tcccttcaaa gacatgaaag gactcacaat gcagagaaac cctatgaatg
     1501 taaacagtgt gggaaagcct tcaggtgttc aagttatttt cgaattcatg aaaggtcaca
     1561 cactggagag aaaccctatg aatgtaaaca gtgtggaaaa gttttcattc gttccagttc
     1621 ctttcgactg catgaaagaa cacacactgg agagaaaccc tatgaatgta aactatgcgg
     1681 taaaaccttc agtttttcaa gttcccttcg agaacatgaa aaaattcaca ctggaaataa
     1741 gccttttgag tgtaagcaat gtggtaaggc cttccttcgt tccagtcaaa ttcgattgca
     1801 tgaaaggact cacactggag agaaaccgta tcaatgtaaa caatgtggaa aagccttcat
     1861 ttcttccagt aaatttcgaa tgcatgagag aactcacacg ggagagaaac cctatcgatg
     1921 taaacaatgt gggaaagcct tcagattttc aagttctgtt cgaattcatg aaaggtctca
     1981 cactggagag aaaccttatg aatgcaaaca atgtggaaaa gccttcattt cttccagtca
     2041 ctttcgactg catgaaagga ctcatatggg agagaaagtc taagaatata agcaacattc
     2101 tgaagccttc ggttgttcca gctccttctg aatacacaaa agagttcata ctggacagaa
     2161 gctgtgtgaa tacaaacatt gttctaaagc ccttaattgt tccagtttct tttgagcacg
     2221 aaagaattcc cactggtgag aaacagtatg aatgtaaaca ttgtgattaa gccttcagtt
     2281 gacctaattc atttcaaaga caggactcgt gctgcagtga aatctgtttt gttttttgtt
     2341 ttttgttttt ttaaaaaagg ccaagcttgt tggctcatgc ctatagtccc agcactttgg
     2401 gaggccaagg tgcaaggcag gcagatcatt tgaggtcaga aattcgagac cagcgtggtc
     2461 aacatggtgt aaccccatct ctactaaaaa ttaccaaaaa atgaaccagg catggtagtg
     2521 catgcctcta atcccagcta ctcaggaggc taaggcagga gaatcacttg aacctggaga
     2581 cagaggttgc agtgagctga gatcacgcca ctgcattcca gcctgtgcga cagaatgaga
     2641 cactgtctca agaaaaaata aaagtgggaa aatcttccaa ctgtcctcta gagtgtgaat
     2701 atatgaaagg agtcagagtg gggtgaaagt ctataaatgt aagacatttg ggaaagcctt
     2761 cacacagcct tttgagcaca catgagaatg tatactggag agaaacccta taaatattaa
     2821 gaatgtggga aattcttcat cctagttctt ttgttgttgt tgatgataca aaaatatttt
     2881 catttaataa agattgtcag gttatattta ataagaaaga aagtatcatg taaacagccc
     2941 agtaataaaa ttttacaatc tta
//
