LOCUS       NM_001271639            2579 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens zinc finger protein 138 (ZNF138), transcript variant
            7, mRNA.
ACCESSION   NM_001271639
VERSION     NM_001271639.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2579)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2579)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2579)
  AUTHORS   Helleboid,P.Y., Heusel,M., Duc,J., Piot,C., Thorball,C.W.,
            Coluccio,A., Pontis,J., Imbeault,M., Turelli,P., Aebersold,R. and
            Trono,D.
  TITLE     The interactome of KRAB zinc finger proteins reveals the
            evolutionary history of their functional diversification
  JOURNAL   EMBO J 38 (18), e101220 (2019)
   PUBMED   31403225
REFERENCE   4  (bases 1 to 2579)
  AUTHORS   Tommerup,N. and Vissing,H.
  TITLE     Isolation and fine mapping of 16 novel human zinc finger-encoding
            cDNAs identify putative candidate genes for developmental and
            malignant disorders
  JOURNAL   Genomics 27 (2), 259-264 (1995)
   PUBMED   7557990
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073349.11.
            
            On Dec 8, 2018 this sequence version replaced NM_001271639.1.
            
            Transcript Variant: This variant (7) includes an alternate in-frame
            exon, compared to variant 1. The encoded isoform (6) is longer than
            isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.188778.1,
                                           SRR1163655.694110.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307355.12/ ENSP00000303533.7
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AC073349.11        43052-43195
            145-271             AC073349.11        63542-63668
            272-349             AC073349.11        64200-64277
            350-2579            AC073349.11        80075-82304
FEATURES             Location/Qualifiers
     source          1..2579
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.21"
     gene            1..2579
                     /gene="ZNF138"
                     /gene_synonym="pHZ-32"
                     /note="zinc finger protein 138"
                     /db_xref="GeneID:7697"
                     /db_xref="HGNC:HGNC:12922"
                     /db_xref="MIM:604080"
     exon            1..144
                     /gene="ZNF138"
                     /gene_synonym="pHZ-32"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1101
                     /gene="ZNF138"
                     /gene_synonym="pHZ-32"
                     /note="isoform 6 is encoded by transcript variant 7; zinc
                     finger protein 138 (clone pHZ-32)"
                     /codon_start=1
                     /product="zinc finger protein 138 isoform 6"
                     /protein_id="NP_001258568.2"
                     /db_xref="CCDS:CCDS64660.1"
                     /db_xref="GeneID:7697"
                     /db_xref="HGNC:HGNC:12922"
                     /db_xref="MIM:604080"
                     /translation="MGPLTFMDVAIEFSLEEWQCLDTAQRNVYRHVMLENYRNLVFLD
                     LITCLEQGKEPWNMKRHEMVVAKHSALCSRFAQDLWLEQNIKDSFQKVTLSRYGKYGH
                     KNLQLRKGCKSVDECKGHQGGFNGLNQCLKITTSKIFQCNKYVKVMHKFSNSNRHKIR
                     HTENKHFRCKECDKSLCMLSRLTQHKKIHTRENFYKCEECGKTFNWSTNLSKPKKIHT
                     GEKPYKCEVCGKAFHQSSILTKHKIIRTGEKPYKCAHCGKAFKQSSHLTRHKIIHTEE
                     KPYKCEQCGKVFKQSPTLTKHQIIYTGEEPYKCEECGKAFNLS"
     exon            145..271
                     /gene="ZNF138"
                     /gene_synonym="pHZ-32"
                     /inference="alignment:Splign:2.1.0"
     exon            272..349
                     /gene="ZNF138"
                     /gene_synonym="pHZ-32"
                     /inference="alignment:Splign:2.1.0"
     exon            350..2579
                     /gene="ZNF138"
                     /gene_synonym="pHZ-32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2553..2558
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF138"
                     /gene_synonym="pHZ-32"
                     /note="hexamer: TATAAA"
     polyA_site      2579
                     /gene="ZNF138"
                     /gene_synonym="pHZ-32"
                     /note="major polyA site"
ORIGIN      
        1 gtctcgctgc agcgggtgct gcaggtctgg ccttcacttt tctgcgtcct cttactccta
       61 gaggcccagc ctctgtggcg ctgtgatctg gttattggga gattcacagc taagacgcca
      121 ggatcccccg gaagcctaga aatgggacca ctgacattta tggatgtggc catagagttc
      181 tctttggagg agtggcagtg cctggacact gcacagcgga atgtatatag gcatgtgatg
      241 ttagagaact acagaaacct ggttttcttg gacctgatta cctgtctgga acaaggaaaa
      301 gagccctgga atatgaagag acatgagatg gtggtagcca aacattcagc tctgtgttct
      361 cgttttgccc aagacctttg gctagagcag aacataaaag attctttcca aaaagtgaca
      421 ctgagcagat atggaaaata tggacataag aatttacagt taagaaaagg ctgtaaaagt
      481 gtggatgagt gtaagggaca ccaaggaggt tttaatggac ttaaccaatg tttgaaaatt
      541 accacaagca aaatatttca atgtaataaa tatgtaaaag tcatgcataa attttcaaat
      601 tcaaatagac acaagataag acatactgaa aataaacatt tcagatgtaa agaatgtgac
      661 aaatcacttt gcatgctttc acgcctaact caacataaaa aaattcatac tagagagaat
      721 ttctacaaat gtgaagagtg tggaaaaacc tttaactggt ccacaaacct ttctaaacct
      781 aagaaaattc atactggaga aaaaccctac aaatgtgaag tatgtggaaa agcctttcac
      841 caatcctcaa tccttactaa acataagata attcgtactg gagaaaaacc ctataaatgt
      901 gcacactgtg gcaaagcctt taaacagtcc tcacacctta ctagacataa gataattcat
      961 actgaagaga aaccctacaa atgtgaacaa tgtggcaagg tctttaagca gtccccaacc
     1021 cttactaaac atcagataat ttatactgga gaggaaccat acaaatgtga ggaatgtggc
     1081 aaagctttta acctatctta acaacttact gaacataaga aaatttacac tagagagaaa
     1141 gcctacaaat gtgaagaatg tggcaaagcc tttaaccagt tttcaaccct tattacacat
     1201 aagataattc atagcggaga gaaaccccac aaatgtgaag aatgtggcag agcttttaac
     1261 cagtccgcaa agctcactga acataagtta attcatactg gagaaaaacc ctacaaatgt
     1321 aaagaatgtg gaaaagcttt tcaccgatac tcaatcctta gtacacataa gaaaattcat
     1381 actggggaga aaccccacaa atgtggagaa tgcggaaaag cctttaactg gtcctcaact
     1441 cttattacac ataagataat tcacagtgga gaaaaaccct acaaatgtga agaatgtggc
     1501 aaagctttta accagtcctc acaccttatg agacataaga aaattcatag taaagagaaa
     1561 ccctacaaat gtgaacagtg tggcaaggtc tttaagaagt cctcaactct tactgcacat
     1621 aagatcattc atactggaga gaaaccttac aaatgtgagg aatgtggcaa aggttttagc
     1681 caactctcaa accttactaa acacaagaag attcatacta gagagaaacc ctacaaatgt
     1741 gaagaatgtg gcatatcttt taaccagttc tcacaacttg ctatacataa gatgattcac
     1801 acttgaatga aaccctacaa atgtgaacga tgtggcagtt gttttaacta gttctcgaac
     1861 tttactatgc ataagaaaat tcaaactgga gagaaactct acaaatgtga agaatgtggc
     1921 aaagctttta accaagtctc aacacttact atacataaga taatttatac tggagcaaaa
     1981 ccttggaaat tcaaagaatg tggtaaaact tacaatcctc aaaacttctt acacctaaaa
     2041 ttcatgcagg agagaaacac cacaaatgtg aaaaatttgg taaattcttt aacaagtctt
     2101 caaccctttc tgcacataat ataattcata ctggagagaa accccacaaa tatgaagaat
     2161 gtggtaatgc ttttaaccaa ttctcaaatc ttactaaaca aaattaatac tgaaaatgtt
     2221 acaaaccaga aaaatgtgaa aatgatttta acaaaacctt caaatttttc taaacataaa
     2281 ggaaatcata ctggtaagaa attataaaaa tgtgaagaat gtgacaaagc ctttaaatgg
     2341 ttgtcacact tgattgtagg taagataatt catactggca gaaactccca gaagtgtgaa
     2401 gaatatggca aaactttaat tcctatacct tattgcacag gaaagcattt atacttcaga
     2461 aaatgttgta ctgatataaa gaatgtagaa aagccattaa tatgtgctta catcttattc
     2521 aacattagag agttagtact taataaaagc attataaatg caattactgt caaaactca
//
