LOCUS       NM_003437               3601 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 136 (ZNF136), transcript variant
            1, mRNA.
ACCESSION   NM_003437 XM_936978
VERSION     NM_003437.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3601)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3601)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3601)
  AUTHORS   Helleboid,P.Y., Heusel,M., Duc,J., Piot,C., Thorball,C.W.,
            Coluccio,A., Pontis,J., Imbeault,M., Turelli,P., Aebersold,R. and
            Trono,D.
  TITLE     The interactome of KRAB zinc finger proteins reveals the
            evolutionary history of their functional diversification
  JOURNAL   EMBO J 38 (18), e101220 (2019)
   PUBMED   31403225
REFERENCE   4  (bases 1 to 3601)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3601)
  AUTHORS   Liu,C. and Chen,X.
  TITLE     A potential cellular host factor homologous to ZNF-136 can interact
            with truncated nonstructural protein 2 of hepatitis C virus
  JOURNAL   Arch Virol 159 (4), 785-789 (2014)
   PUBMED   24136724
  REMARK    GeneRIF: Through peptide mass fingerprinting, the hepatitis C virus
            NS2-interacting protein was found to be homologous to a repressor
            of transcription, ZNF136.
REFERENCE   6  (bases 1 to 3601)
  AUTHORS   Vissing,H., Meyer,W.K., Aagaard,L., Tommerup,N. and Thiesen,H.J.
  TITLE     Repression of transcriptional activity by heterologous KRAB domains
            present in zinc finger proteins
  JOURNAL   FEBS Lett 369 (2-3), 153-157 (1995)
   PUBMED   7649249
REFERENCE   7  (bases 1 to 3601)
  AUTHORS   Tommerup,N. and Vissing,H.
  TITLE     Isolation and fine mapping of 16 novel human zinc finger-encoding
            cDNAs identify putative candidate genes for developmental and
            malignant disorders
  JOURNAL   Genomics 27 (2), 259-264 (1995)
   PUBMED   7557990
REFERENCE   8  (bases 1 to 3601)
  AUTHORS   Abrink,M., Aveskogh,M. and Hellman,L.
  TITLE     Isolation of cDNA clones for 42 different Kruppel-related zinc
            finger proteins expressed in the human monoblast cell line U-937
  JOURNAL   DNA Cell Biol 14 (2), 125-136 (1995)
   PUBMED   7865130
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL537987.3, BC006421.1,
            DB369850.1, BQ574220.1, CN429121.1 and BP420506.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003437.4.
            
            Summary: This gene encodes a zinc finger protein containing a
            Kruppel-associated box (KRAB) A-box domain at its N-terminus,
            followed by fourteen contiguous C2H2 zinc finger domains and a
            degenerate zinc finger. The KRAB A-box showed weak transcriptional
            repressor activity in a reporter gene assay. Alternative splicing
            results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Dec 2016].
            
            Transcript Variant: This variant (1) encodes the longer/longest*
            isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BJ991067.1, SRR1660805.43816.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343979.6/ ENSP00000344162.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AL537987.3         50-60
            12-2522             BC006421.1         4-2514
            2523-2844           DB369850.1         1-322               c
            2845-2979           BQ574220.1         18-152              c
            2980-3148           CN429121.1         413-581
            3149-3601           BP420506.1         1-453
FEATURES             Location/Qualifiers
     source          1..3601
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..3601
                     /gene="ZNF136"
                     /gene_synonym="pHZ-20"
                     /note="zinc finger protein 136"
                     /db_xref="GeneID:7695"
                     /db_xref="HGNC:HGNC:12920"
                     /db_xref="MIM:604078"
     exon            1..111
                     /gene="ZNF136"
                     /gene_synonym="pHZ-20"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1731
                     /gene="ZNF136"
                     /gene_synonym="pHZ-20"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 136 isoform 1"
                     /protein_id="NP_003428.1"
                     /db_xref="CCDS:CCDS32916.1"
                     /db_xref="GeneID:7695"
                     /db_xref="HGNC:HGNC:12920"
                     /db_xref="MIM:604078"
                     /translation="MDSVAFEDVDVNFTQEEWALLDPSQKNLYRDVMWETMRNLASIG
                     KKWKDQNIKDHYKHRGRNLRSHMLERLYQTKDGSQRGGIFSQFANQNLSKKIPGVKLC
                     ESIVYGEVSMGQSSLNRHIKDHSGHEPKEYQEYGEKPDTRNQCWKPFSSHHSFRTHEI
                     IHTGEKLYDCKECGKTFFSLKRIRRHIITHSGYTPYKCKVCGKAFDYPSRFRTHERSH
                     TGEKPYECQECGKAFTCITSVRRHMIKHTGDGPYKCKVCGKPFHSLSSFQVHERIHTG
                     EKPFKCKQCGKAFSCSPTLRIHERTHTGEKPYECKQCGKAFSYLPSLRLHERIHTGEK
                     PFVCKQCGKAFRSASTFQIHERTHTGEKPYECKECGEAFSCIPSMRRHMIKHTGEGPY
                     KCKVCGKPFHSLSPFRIHERTHTGEKPYVCKHCGKAFVSSTSIRIHERTHTGEKPYEC
                     KQCGKAFSYLNSFRTHEMIHTGEKPFECKRCGKAFRSSSSFRLHERTHTGQKPYHCKE
                     CGKAYSCRASFQRHMLTHAEDGPPYKCMWESL"
     exon            112..238
                     /gene="ZNF136"
                     /gene_synonym="pHZ-20"
                     /inference="alignment:Splign:2.1.0"
     exon            239..299
                     /gene="ZNF136"
                     /gene_synonym="pHZ-20"
                     /inference="alignment:Splign:2.1.0"
     exon            300..3601
                     /gene="ZNF136"
                     /gene_synonym="pHZ-20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2958..2963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF136"
                     /gene_synonym="pHZ-20"
                     /note="hexamer: AATAAA"
     polyA_site      2979
                     /gene="ZNF136"
                     /gene_synonym="pHZ-20"
                     /note="major polyA site"
     regulatory      3583..3588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF136"
                     /gene_synonym="pHZ-20"
                     /note="hexamer: AATAAA"
     polyA_site      3601
                     /gene="ZNF136"
                     /gene_synonym="pHZ-20"
ORIGIN      
        1 gctagtccca gaggcccaga gtggctcgcc tggagtctct gtggcgcggt ttcctgtacc
       61 tgccttggga tccggaggga ggaagctggg acacccggga gtcaggaaat ggactcggtg
      121 gcttttgagg atgtagatgt gaacttcacc caggaggagt gggctttgct agatccttcc
      181 cagaagaatc tctacagaga tgtgatgtgg gaaaccatga ggaatctggc ctctataggg
      241 aaaaaatgga aggaccagaa cattaaagat cactacaaac accgagggag aaatctaaga
      301 agtcatatgt tagaaagact ctatcaaact aaggatggta gtcagcgtgg aggaattttt
      361 agccagtttg caaatcagaa tctgagcaag aaaatccctg gagtgaaact ctgtgaaagc
      421 attgtatatg gagaagtcag catgggtcag tcatccctta atagacacat caaagatcac
      481 agtggacatg aaccaaagga atatcaggaa tatggagaga agccagatac acgtaaccag
      541 tgttggaaac ccttcagttc tcaccactcc tttcgaacac atgagataat tcacactgga
      601 gagaaactct atgattgtaa ggaatgtgga aaaaccttct tttctctcaa aagaattaga
      661 agacacatca tcacacacag tggatataca ccatataaat gtaaggtgtg tgggaaagct
      721 tttgattatc ccagtagatt tcgaacacat gaaagaagtc acactggaga gaaaccctat
      781 gaatgtcagg aatgtggaaa agccttcact tgtatcacaa gtgttcgaag acacatgata
      841 aagcacactg gagatggacc ttataaatgt aaggtatgtg ggaaaccctt tcattctctg
      901 agttcatttc aagtgcatga aagaattcac actggagaaa aaccctttaa atgtaagcaa
      961 tgtggtaaag ccttcagttg ttccccaacc ttacgaatac atgaaagaac ccatactgga
     1021 gagaaacctt atgaatgcaa gcagtgtggg aaggccttca gttatctccc ctcccttcga
     1081 ctacatgaaa gaattcacac tggtgagaaa cccttcgtat gtaaacaatg tggtaaagcc
     1141 tttagatctg ccagtacctt tcaaatacat gaaaggactc acactggaga aaaaccttat
     1201 gaatgtaagg aatgtgggga agcattcagt tgtatcccaa gtatgcgaag acacatgata
     1261 aaacatactg gagaaggacc ttataaatgt aaggtatgtg ggaaaccctt tcattctctg
     1321 agtccatttc gaatacatga aagaactcac actggagaga aaccttatgt atgtaaacat
     1381 tgtggtaaag ctttcgtttc ttcaacatca attcgaatac atgaaagaac tcatactgga
     1441 gagaaaccct atgagtgtaa gcaatgtggg aaagccttca gttatctcaa ctcctttcga
     1501 acacatgaaa tgattcacac tggtgagaaa ccctttgaat gtaagcgatg tggtaaagcc
     1561 tttagatctt ctagttcctt tcgactacat gaaaggactc acactggaca gaaaccctat
     1621 cattgcaagg aatgtgggaa agcctattct tgccgtgcca gctttcagag acacatgtta
     1681 acacatgctg aagatggacc accttataaa tgcatgtggg aaagccttta atgctctggg
     1741 ttcatgtcag atacattaaa atactcactg aagagaagcc ctatgaatgt aagtaacgtg
     1801 ggaaagcatg aaattctgtc agtgcctttt ttaatacatg aaagaattct agagagaagc
     1861 catatacatg taagtaacat gggaaagctt tcaatcattt tagttccttt caaatacatg
     1921 aaagaactca tcatggagaa aaccaaacaa atgctttttg gaaaggaacc catatttgag
     1981 agaaaccctg ggtaaagggt gtaggaaagg ttttgtcatc acacaaccct gtcacacatg
     2041 aatgtgtagt ggagagaacc ttggtaaatg taaagagtgt gggagagcct ttagtcattt
     2101 tagttccact tgaagccatg aaagaacaca caaaagagaa agctcttgaa tataagcaat
     2161 gtccacacgt ttttagccag cccacatgct ttcaacaaca tgtaagaatg taccctggat
     2221 caaaacacta taaatgtgaa aactacaagg aaggttttcc attatacttt taaagtcatt
     2281 tgagggctct ggctctgtgg ctttgtgggt taaagtactt gtctggcaaa caggagatgc
     2341 tggatttcaa tcccagcagg gcctcactag ttgaggtatt gaatttgaac agatgttttg
     2401 gctctggctg ggtgtggtgg ctcacacctg taatcccagc actttgggag gctgaggcag
     2461 gaggatcact tgaggtcagg agtttgagac cagtgtgcaa aacatagcaa gacctcatct
     2521 cagaaaaaaa aaaaaagtca tttgaaaact tctaatacag caaaatccta taaatgtaag
     2581 tacttcaaaa agcctcatgc atagcgggtc atgtagtctc tagaaaatac ataacctgat
     2641 ggaaatgtag aagctatatg tatattttgt taattagtgg ctcatattta aaatagttct
     2701 ctgactatgg atttcaaatg cttaatctca caaagaaatg ttaaattgat ataatcctgt
     2761 aagtaatctg aaagcaatag tgcatgaatt tcataggtag tgttgtttta ggtcagtaaa
     2821 taaaatattt gtctttccat tttgaaatgt gtttaatcca acaatgaatt taaatgtgtt
     2881 tctcatattc aggtatgtta aattgtatat ggttgcttaa ttgttctgtg attgaggacc
     2941 actgaaaaat aagtcttaat aaatgttggt atgaacctac ttgcttcatt tagcaggttc
     3001 ttgattccct ttccacatta tatacattcc atcatattta ttggaacagc tccttttttt
     3061 tccttttttc ttttttcttt cttctttttt ctttttgaga cagggtctcg ctctgtgctc
     3121 tgttgcccaa gctggagtac agtggcatga tctcggctca ttgcaacctc tgccttctgg
     3181 gttcaagtga ttctcccacc ttagcctcct aggaagctgg gactacaggc atgtgccacc
     3241 acacctggct aattttttgt atttctagta gagatggggt ttcaccatgt tggccaggct
     3301 ggtagaactc ctgacctcaa gtgatccacc cacctcagcc tcctaaagtc tgggattaca
     3361 cgtgtgagcc atcacaccta gcccattttt tttttcttgg ctcaaataat tttattttgc
     3421 ttcctattaa agagttgttg ttaattctaa gtatgtaaag tttatcacag actgtagtct
     3481 cgtgaattat tattttaacc tgttgttctt tactccttgt tatttattct ggctgctctt
     3541 tgtataattg attttgggat aaggagacag ctatgataga ataataaaat ctaaaatggg
     3601 a
//
