LOCUS       NM_001289401            3334 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens zinc finger protein 135 (ZNF135), transcript variant
            6, mRNA.
ACCESSION   NM_001289401 XM_005259212
VERSION     NM_001289401.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3334)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3334)
  AUTHORS   Bai,S.W., Herrera-Abreu,M.T., Rohn,J.L., Racine,V., Tajadura,V.,
            Suryavanshi,N., Bechtel,S., Wiemann,S., Baum,B. and Ridley,A.J.
  TITLE     Identification and characterization of a set of conserved and new
            regulators of cytoskeletal organization, cell morphology and
            migration
  JOURNAL   BMC Biol 9, 54 (2011)
   PUBMED   21834987
  REMARK    Erratum:[BMC Biol. 2024 Oct 10;22(1):228. doi:
            10.1186/s12915-024-02036-3.. PMID: 39390519]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3334)
  AUTHORS   Tommerup,N. and Vissing,H.
  TITLE     Isolation and fine mapping of 16 novel human zinc finger-encoding
            cDNAs identify putative candidate genes for developmental and
            malignant disorders
  JOURNAL   Genomics 27 (2), 259-264 (1995)
   PUBMED   7557990
REFERENCE   4  (bases 1 to 3334)
  AUTHORS   Huebner,K., Druck,T., LaForgia,S., Lasota,J., Croce,C.M.,
            Lanfrancone,L., Donti,E., Pengue,G., La Mantia,G., Pelicci,P.G. et
            al.
  TITLE     Chromosomal localization of four human zinc finger cDNAs
  JOURNAL   Hum Genet 91 (3), 217-222 (1993)
   PUBMED   8478004
REFERENCE   5  (bases 1 to 3334)
  AUTHORS   Lichter,P., Bray,P., Ried,T., Dawid,I.B. and Ward,D.C.
  TITLE     Clustering of C2-H2 zinc finger motif sequences within telomeric
            and fragile site regions of human chromosomes
  JOURNAL   Genomics 13 (4), 999-1007 (1992)
   PUBMED   1505991
REFERENCE   6  (bases 1 to 3334)
  AUTHORS   Bray,P., Lichter,P., Thiesen,H.J., Ward,D.C. and Dawid,I.B.
  TITLE     Characterization and mapping of human genes encoding zinc finger
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9563-9567 (1991)
   PUBMED   1946370
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC046434.1, AK094202.1, AL833637.1, BX647775.1 and BM993886.1.
            
            On Feb 27, 2020 this sequence version replaced NM_001289401.1.
            
            Transcript Variant: This variant (6) uses an alternate in-frame
            splice site in the 3' coding region, and includes an alternate exon
            that results in a distinct 5' UTR and uses of an alternate start
            codon, compared to variant 1. The encoded isoform (6) is shorter
            and has a distinct N-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046434.1, SRR14038192.4162087.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313434.10/ ENSP00000321406.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               BC046434.1         39-165
            128-788             AK094202.1         493-1153
            789-2825            AL833637.1         364-2400
            2826-2826           BC046434.1         2864-2864
            2827-3178           BX647775.1         2807-3158
            3179-3179           BM993886.1         159-159             c
            3180-3334           BX647775.1         3160-3314
FEATURES             Location/Qualifiers
     source          1..3334
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..3334
                     /gene="ZNF135"
                     /gene_synonym="pHZ-17; pT3; ZNF61; ZNF78L1"
                     /note="zinc finger protein 135"
                     /db_xref="GeneID:7694"
                     /db_xref="HGNC:HGNC:12919"
                     /db_xref="MIM:604077"
     exon            1..29
                     /gene="ZNF135"
                     /gene_synonym="pHZ-17; pT3; ZNF61; ZNF78L1"
                     /inference="alignment:Splign:2.1.0"
     exon            30..96
                     /gene="ZNF135"
                     /gene_synonym="pHZ-17; pT3; ZNF61; ZNF78L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..2040
                     /gene="ZNF135"
                     /gene_synonym="pHZ-17; pT3; ZNF61; ZNF78L1"
                     /note="isoform 6 is encoded by transcript variant 6; zinc
                     finger protein 61; zinc finger protein 135 (clone pHZ-17);
                     zinc finger protein 78-like 1 (pT3)"
                     /codon_start=1
                     /product="zinc finger protein 135 isoform 6"
                     /protein_id="NP_001276330.1"
                     /db_xref="CCDS:CCDS74471.1"
                     /db_xref="GeneID:7694"
                     /db_xref="HGNC:HGNC:12919"
                     /db_xref="MIM:604077"
                     /translation="MTPGVRVSTDPEQVTFEDVVVGFSQEEWGQLKPAQRTLYRDVML
                     DTFRLLVSVGHWLPKPNVISLLEQEAELWAVESRLPQGVYPDLETRPKVKLSVLKQGI
                     SEEISNSVILVERFLWDGLWYCRGEDTEGHWEWSCESLESLAVPVAFTPVKTPVLEQW
                     QRNGFGENISLNPDLPHQPMTPERQSPHTWGTRGKREKPDLNVLQKTCVKEKPYKCQE
                     CGKAFSHSSALIEHHRTHTGERPYECHECLKGFRNSSALTKHQRIHTGEKPYKCTQCG
                     RTFNQIAPLIQHQRTHTGEKPYECSECGKSFSFRSSFSQHERTHTGEKPYECSECGKA
                     FRQSIHLTQHLRIHTGEKPYQCGECGKAFSHSSSLTKHQRIHTGEKPYECHECGKAFT
                     QITPLIQHQRTHTGEKPYECGECGKAFSQSTLLTEHRRIHTGEKPYGCNECGKTFSHS
                     SSLSQHERTHTGEKPYECSQCGKAFRQSTHLTQHQRIHTGEKPYECNDCGKAFSHSSS
                     LTKHQRIHTGEKPYECNQCGRAFSQLAPLIQHQRIHTGEKPYECNQCGRAFSQSSLLI
                     EHQRIHTKEKPYGCNECGKSFSHSSSLSQHERTHTGEKPYECHDCGKSFRQSTHLTQH
                     RRIHTGEKPYACRDCGKAFTHSSSLTKHQRTHTG"
     exon            97..223
                     /gene="ZNF135"
                     /gene_synonym="pHZ-17; pT3; ZNF61; ZNF78L1"
                     /inference="alignment:Splign:2.1.0"
     exon            224..319
                     /gene="ZNF135"
                     /gene_synonym="pHZ-17; pT3; ZNF61; ZNF78L1"
                     /inference="alignment:Splign:2.1.0"
     exon            320..3334
                     /gene="ZNF135"
                     /gene_synonym="pHZ-17; pT3; ZNF61; ZNF78L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2719..2724
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF135"
                     /gene_synonym="pHZ-17; pT3; ZNF61; ZNF78L1"
                     /note="hexamer: TATAAA"
     polyA_site      2738
                     /gene="ZNF135"
                     /gene_synonym="pHZ-17; pT3; ZNF61; ZNF78L1"
     polyA_site      2987
                     /gene="ZNF135"
                     /gene_synonym="pHZ-17; pT3; ZNF61; ZNF78L1"
                     /note="major polyA site"
ORIGIN      
        1 gccgcggcct ttgtctcgca gtcaggagga gcagggccag ccgttcctgc cagaagccag
       61 ggcatgaccc ctggggtgcg cgtctccaca gacccggagc aagtgacgtt tgaggacgtg
      121 gtagtgggct tcagccagga ggagtggggg cagctgaagc ctgcccagag gaccctgtac
      181 cgtgatgtaa tgctggacac cttcaggctt ctggtctctg tgggacattg gttaccgaag
      241 ccgaatgtca tctccctgct ggagcaagag gcagagctgt gggcggtgga gtctagactt
      301 ccccaaggcg tgtacccaga cttggaaact agacccaaag tcaaactgtc agttctaaag
      361 caaggcatct ctgaagaaat atccaacagt gtcatcttgg tagaaagatt cctgtgggat
      421 ggtctgtggt actgcagggg tgaggacact gagggccact gggaatggag ttgtgagagt
      481 ctagagagcc tggcagtgcc ggtggccttc acgcctgtga agacgcctgt tctggagcag
      541 tggcagagga atgggtttgg ggaaaacata agtctgaacc ctgatctccc acatcaacca
      601 atgactcctg aaagacaaag cccccacaca tggggaacac gtggaaaaag ggagaagcca
      661 gacctaaatg ttttacagaa aacctgtgta aaagagaaac cctacaaatg tcaggaatgc
      721 ggaaaggcct ttagtcacag ctcagcactt atcgaacacc accggacgca cacaggagag
      781 agaccttacg aatgtcacga atgcttaaaa ggcttccgga acagctcggc acttaccaaa
      841 caccagagaa tccatactgg ggagaaaccc tataaatgca ctcagtgtgg gaggaccttc
      901 aaccaaattg ccccactgat ccagcaccag agaactcaca caggtgagaa gccctatgaa
      961 tgcagcgaat gtgggaaatc cttcagtttt aggtcctcct tcagccagca cgagcgaact
     1021 cacacaggcg agaagcccta cgagtgcagt gagtgtggga aagccttccg gcaaagcatc
     1081 cacctcaccc agcatctgcg aatccacact ggggagaaac cctatcagtg tggtgagtgt
     1141 ggcaaggcct tcagccacag ctcatccttg accaaacacc agcgaatcca cacaggggag
     1201 aagccctacg agtgccatga gtgtggaaaa gccttcaccc agatcacacc actgattcag
     1261 caccagagga cccacacagg agaaaagccc tatgagtgtg gtgagtgtgg gaaagccttc
     1321 agtcagagca cactcctgac cgagcatcgg aggattcaca caggagagaa gccctatgga
     1381 tgcaacgagt gtgggaaaac cttcagccac agctcctcac tcagccagca tgagcggaca
     1441 cacacaggag agaagcccta tgagtgcagt cagtgtggga aggccttccg gcagagcaca
     1501 cacctcaccc aacaccagcg aatccacaca ggggagaagc cctatgaatg caatgactgc
     1561 ggcaaggcat tcagtcacag ctcgtccctc accaaacatc agcgaatcca cactggggag
     1621 aagccctacg aatgcaacca gtgtggcaga gccttcagcc agcttgctcc cctcattcag
     1681 catcagagga tccacacagg agagaaaccc tatgaatgta accagtgtgg cagagccttc
     1741 agccagagct cccttctcat cgaacaccag aggattcaca ccaaggaaaa gccgtatggg
     1801 tgcaatgagt gtgggaaatc cttcagccac agctcctcgc tcagccagca cgaaaggacg
     1861 cacactgggg aaaagcccta tgagtgtcac gattgcggaa agtcctttag gcagagcacc
     1921 cacctcactc agcaccggag gatccacaca ggagagaagc catatgcatg cagggactgt
     1981 ggaaaggcct ttacccacag ctcctccctt accaagcacc agagaactca cactggataa
     2041 acccactcca catgtgctgg ggacatagga agaccttaag ccatagctca tccctttcta
     2101 gatttgaccc aatcatacac atgagaaacg tacattcata cacaagcctt ttcacacagc
     2161 actcccctca gacaccctca gagagttcac actgatggga aatgaccatg ggaccaccaa
     2221 gctctaggtc atccatctct gcatccaaat agtagggaaa cgtggagata atcaacactc
     2281 aggaccttca gccttgaacg cccattagtg ctatgttata gaacctacaa aaaagaaatg
     2341 gaacaaatgt agtggatcca gggaacgctt ttgtccaagg attcaccgta ttccaaacca
     2401 gagatgttca aattggtgag aaacccaaca aatgcctttc atatatacga gaaccaaatg
     2461 aagtcagaat ttgccattat tgcacatcac atttttgggg gggaaagtgc ttatgaatgg
     2521 tgcaggttga ctctgatatt cattcccaaa tgacagtatg gcagagtgtt ccagaaatga
     2581 gagtggcatc tttatggaat cactgtggat actgactgtc tcagtaaaca gctgtcttgt
     2641 ctgtgtgtat attgtttgat cagggtacat ggcagccagt cacagattgg aattacatat
     2701 gacaaagtat cagtgtacta taaacaggtt tttagttatc cctgcattat ttttgcaatt
     2761 aatctttata tgcaatgaga ttgaaaagct ttgtatggga agactcaaaa tgtaaagctg
     2821 cttccgtaga gtctcactga ttctgagatg gcttttgctg ctctgttctc cctctacatt
     2881 tctctgcaga actcgcgtta gaaacacaga tatttgtttt acaaaaaggg agatttttcc
     2941 tttgttaaac catcgtctta taagcaatag caaattcatg ttagaaactt ctgttttgca
     3001 agattcatct tttttgggat atgttcaagt taatcctctc aaactgcttt ttcattgttt
     3061 tcatacaatt taacattttg ttaaacccta agtccacaaa tagcagtctt tctgacaact
     3121 ataaccttta aatggtgact tgctgccctc attagaaatt gcattggctg gccaggcgcg
     3181 gtgacttatg cctgtaatcc cagcactttg ggaggccaag gtgggaggat cacctgaggt
     3241 cgggagatgg aggttgcagt gagctgagat cgtaccattg cactccagcc tgggcaacaa
     3301 gagtgaaact ctgtctcaga aaaaaaaaaa aaaa
//
