LOCUS       NM_001387317            2556 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 133 (ZNF133), transcript variant
            54, mRNA.
ACCESSION   NM_001387317
VERSION     NM_001387317.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2556)
  AUTHORS   Li,L., Wang,X., Hu,K., Liu,X., Qiu,L., Bai,C., Cui,Y., Wang,B.,
            Wang,Z., Wang,H., Cheng,R., Hua,J., Hai,L., Wang,M., Liu,M.,
            Song,Z., Xiao,C. and Li,B.
  TITLE     ZNF133 is a potent suppressor in breast carcinogenesis through
            dampening L1CAM, a driver for tumor progression
  JOURNAL   Oncogene 42 (27), 2166-2182 (2023)
   PUBMED   37221223
  REMARK    GeneRIF: ZNF133 is a potent suppressor in breast carcinogenesis
            through dampening L1CAM, a driver for tumor progression.
REFERENCE   2  (bases 1 to 2556)
  AUTHORS   Jung,E.S., Choi,K.W., Kim,S.W., Hubenthal,M., Mucha,S., Park,J.,
            Park,Z., Ellinghaus,D., Schreiber,S., Franke,A., Oh,W.Y. and
            Cheon,J.H.
  TITLE     ZNF133 is associated with infliximab responsiveness in patients
            with inflammatory bowel diseases
  JOURNAL   J Gastroenterol Hepatol 34 (10), 1727-1735 (2019)
   PUBMED   30851117
  REMARK    GeneRIF: ZNF133 SNPs are associated with infliximab responsiveness
            in patients crohn's disease and ulcerative colitis.
REFERENCE   3  (bases 1 to 2556)
  AUTHORS   Miyamoto-Sato,E., Fujimori,S., Ishizaka,M., Hirai,N., Masuoka,K.,
            Saito,R., Ozawa,Y., Hino,K., Washio,T., Tomita,M., Yamashita,T.,
            Oshikubo,T., Akasaka,H., Sugiyama,J., Matsumoto,Y. and Yanagawa,H.
  TITLE     A comprehensive resource of interacting protein regions for
            refining human transcription factor networks
  JOURNAL   PLoS One 5 (2), e9289 (2010)
   PUBMED   20195357
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2556)
  AUTHORS   Lee,S.J., Lee,J.R., Hahn,H.S., Kim,Y.H., Ahn,J.H., Bae,C.D.,
            Yang,J.M. and Hahn,M.J.
  TITLE     PIAS1 interacts with the KRAB zinc finger protein, ZNF133, via zinc
            finger motifs and regulates its transcriptional activity
  JOURNAL   Exp Mol Med 39 (4), 450-457 (2007)
   PUBMED   17934332
  REMARK    GeneRIF: the transcriptional repressor activity of ZNF133 is
            regulated by both the KRAB domain and the zinc finger motifs, and
            that the repressive effect by zinc finger motifs is mediated by
            PIAS1
REFERENCE   5  (bases 1 to 2556)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   6  (bases 1 to 2556)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 2556)
  AUTHORS   Moosmann,P., Georgiev,O., Thiesen,H.J., Hagmann,M. and Schaffner,W.
  TITLE     Silencing of RNA polymerases II and III-dependent transcription by
            the KRAB protein domain of KOX1, a Kruppel-type zinc finger factor
  JOURNAL   Biol Chem 378 (7), 669-677 (1997)
   PUBMED   9278146
REFERENCE   8  (bases 1 to 2556)
  AUTHORS   Vissing,H., Meyer,W.K., Aagaard,L., Tommerup,N. and Thiesen,H.J.
  TITLE     Repression of transcriptional activity by heterologous KRAB domains
            present in zinc finger proteins
  JOURNAL   FEBS Lett 369 (2-3), 153-157 (1995)
   PUBMED   7649249
REFERENCE   9  (bases 1 to 2556)
  AUTHORS   Tommerup,N. and Vissing,H.
  TITLE     Isolation and fine mapping of 16 novel human zinc finger-encoding
            cDNAs identify putative candidate genes for developmental and
            malignant disorders
  JOURNAL   Genomics 27 (2), 259-264 (1995)
   PUBMED   7557990
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL049646.19.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AL049646.19        45048-45125
            79-254              AL049646.19        46420-46595
            255-394             AL049646.19        62189-62328
            395-490             AL049646.19        62819-62914
            491-628             AL049646.19        66690-66827
            629-2556            AL049646.19        71590-73517
FEATURES             Location/Qualifiers
     source          1..2556
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.23"
     gene            1..2556
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /note="zinc finger protein 133"
                     /db_xref="GeneID:7692"
                     /db_xref="HGNC:HGNC:12917"
                     /db_xref="MIM:604075"
     exon            1..78
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /inference="alignment:Splign:2.1.0"
     exon            79..254
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /inference="alignment:Splign:2.1.0"
     exon            255..394
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /inference="alignment:Splign:2.1.0"
     exon            395..490
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /inference="alignment:Splign:2.1.0"
     exon            491..628
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /inference="alignment:Splign:2.1.0"
     CDS             601..2376
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /note="isoform e is encoded by transcript variant 54; zinc
                     finger protein 133 (clone pHZ-13); zinc finger protein 150
                     (pHZ-66)"
                     /codon_start=1
                     /product="zinc finger protein 133 isoform e"
                     /protein_id="NP_001374246.1"
                     /db_xref="GeneID:7692"
                     /db_xref="HGNC:HGNC:12917"
                     /db_xref="MIM:604075"
                     /translation="MCNGRKTVLADPEPELYLDPFCPPGFSSQKFPMQHVLCNHPPWI
                     FTCLCAEGNIQPGDPGPGDQEKQQQASEGRPWSDQAEGPEGEGAMPLFGRTKKRTLGA
                     FSRPPQRQPVSSRNGLRGVELEASPAQSGNPEETDKLLKRIEVLGFGTVNCGECGLSF
                     SKMTNLLSHQRIHSGEKPYVCGVCEKGFSLKKSLARHQKAHSGEKPIVCRECGRGFNR
                     KSTLIIHERTHSGEKPYMCSECGRGFSQKSNLIIHQRTHSGEKPYVCRECGKGFSQKS
                     AVVRHQRTHLEEKTIVCSDCGLGFSDRSNLISHQRTHSGEKPYACKECGRCFRQRTTL
                     VNHQRTHSKEKPYVCGVCGHSFSQNSTLISHRRTHTGEKPYVCGVCGRGFSLKSHLNR
                     HQNIHSGEKPIVCKDCGRGFSQQSNLIRHQRTHSGEKPMVCGECGRGFSQKSNLVAHQ
                     RTHSGERPYVCRECGRGFSHQAGLIRHKRKHSREKPYMCRQCGLGFGNKSALITHKRA
                     HSEEKPCVCRECGQGFLQKSHLTLHQMTHTGEKPYVCKTCGRGFSLKSHLSRHRKTTS
                     VHHRLPVQPDPEPCAGQPSDSLYSL"
     exon            629..2556
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2527..2532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /note="hexamer: AATAAA"
     polyA_site      2556
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /note="major polyA site"
ORIGIN      
        1 gtagtgtagt cctggcgccc cgctggagga gctccccagc tggtggctgg agcgacccct
       61 tgttctttgg tggcgctggt tcattcctga tgctgttaag gaataggagg tactgccctg
      121 ctggagagga tttcccttga ttttcttgaa cgctttttgt tcttgttctg cctccctgtg
      181 gctcctgtct gcccagagag gactgcctgc tggggaaagg gggtactcct gagctcctga
      241 cagcccagct tcagttttgt gttacaggca cacatggcat tcagggatgt ggctgtggat
      301 ttcacccagg atgagtggag gctgctgagc cctgctcaaa ggactctgta cagagaggtg
      361 atgctggaga actacagcaa cctggtctca ctgggaattt cattttctaa accagaactc
      421 atcacccagc tggagcaagg gaaagagacc tggagagagg aaaaaaaatg ttcaccggca
      481 acctgtccag aaaaacagca gctcttacaa tgatgttgag cacattaaaa agaatgctgt
      541 acaatccaag gagcaagtca ttgtggttgc ccaggaagct gtcttggaaa cccaaaatat
      601 atgtgtaacg ggaggaagac tgttctagca gatccagagc cagagctcta cctcgatcct
      661 ttctgccctc cgggtttctc cagtcagaaa ttccccatgc agcatgtgct gtgtaatcat
      721 cccccctgga tcttcacatg cttgtgtgca gaaggtaaca tccagcctgg ggatccgggc
      781 ccaggggacc aggagaagca gcaacaagcc tctgagggga gaccctggag tgatcaagca
      841 gaaggtcctg agggagaagg tgccatgcct ttgtttggaa gaaccaagaa aaggactctg
      901 ggagcgttct ccaggccacc ccagaggcag ccagtcagct ctcggaacgg cctcagaggg
      961 gtggagttag aagccagccc agctcagtca gggaaccctg aggaaacaga caaattgttg
     1021 aagaggatag aagtcttagg atttggaaca gtcaactgtg gagagtgtgg actgagcttc
     1081 agcaagatga caaacctgct cagtcaccag cggatacact caggggagaa gccctacgtg
     1141 tgtggggtat gtgagaaggg cttcagccta aagaagagcc tcgccagaca ccagaaggca
     1201 cactcggggg agaagccaat tgtgtgcagg gagtgtggac gaggctttaa ccggaagtca
     1261 acgctaatca tacacgaacg gacacactcc ggtgagaaac cttacatgtg cagtgagtgt
     1321 gggcgaggct tcagccagaa gtcaaacctc atcatacacc agaggacaca ctcaggggaa
     1381 aagccttacg tgtgccggga atgtggcaaa ggcttcagcc agaagtcagc tgtcgtgaga
     1441 caccagagga cacacttgga ggagaagacc atcgtgtgca gtgactgtgg cctgggcttc
     1501 agcgacaggt caaacctcat ctcccaccag aggacgcact ctggggagaa gccctacgcc
     1561 tgcaaggagt gtgggcgatg cttcaggcag aggaccaccc ttgtcaacca ccagaggaca
     1621 cactcaaagg agaagcccta tgtgtgcggg gtgtgtgggc acagcttcag ccagaattca
     1681 accctcatct ctcacaggcg gacacacact ggggagaagc cgtatgtttg tggggtgtgt
     1741 gggcgaggct ttagtctcaa gtcacacctc aacagacacc agaacataca ctcaggagag
     1801 aagcccattg tgtgcaagga ctgtggccgg ggcttcagcc agcaatccaa cctcatcaga
     1861 caccagagga cgcactcagg cgagaagccc atggtgtgtg gggagtgcgg gcgaggcttc
     1921 agccagaagt caaaccttgt tgcacaccag aggacgcact caggggagag gccgtatgtg
     1981 tgccgagagt gcgggcgagg ctttagccac caggccggtc tcatcaggca caagcggaag
     2041 cactcgaggg agaagcccta catgtgcagg cagtgtggac tgggctttgg caataagtca
     2101 gctctaatta cacacaagcg ggctcactcg gaagagaagc cttgtgtgtg cagagagtgt
     2161 ggccaaggct ttctccaaaa gtcacacctc accttacatc aaatgacaca tacgggggag
     2221 aagccatatg tgtgcaagac gtgtgggcgg ggcttcagcc tcaagtctca cctcagcaga
     2281 cacaggaaga ccacgtctgt ccaccacaga ctgccagtgc agcccgaccc tgagccgtgt
     2341 gcagggcaac cttcggattc cttatactct ctctgaaggc aaagatgggg acaaggacta
     2401 agagtcagaa tgttgacact ttgatgaaat ggagtagaga aatgcattct gtaagtggtc
     2461 aaaggacatt tgactgttta ctttctccac actaagtctt ctccatgttt tgtggccttc
     2521 ggttgtaata aacttggctt ctttatacat ctgtaa
//
