LOCUS       NM_001352452            2654 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens zinc finger protein 133 (ZNF133), transcript variant
            19, mRNA.
ACCESSION   NM_001352452
VERSION     NM_001352452.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2654)
  AUTHORS   Li,L., Wang,X., Hu,K., Liu,X., Qiu,L., Bai,C., Cui,Y., Wang,B.,
            Wang,Z., Wang,H., Cheng,R., Hua,J., Hai,L., Wang,M., Liu,M.,
            Song,Z., Xiao,C. and Li,B.
  TITLE     ZNF133 is a potent suppressor in breast carcinogenesis through
            dampening L1CAM, a driver for tumor progression
  JOURNAL   Oncogene 42 (27), 2166-2182 (2023)
   PUBMED   37221223
  REMARK    GeneRIF: ZNF133 is a potent suppressor in breast carcinogenesis
            through dampening L1CAM, a driver for tumor progression.
REFERENCE   2  (bases 1 to 2654)
  AUTHORS   Jung,E.S., Choi,K.W., Kim,S.W., Hubenthal,M., Mucha,S., Park,J.,
            Park,Z., Ellinghaus,D., Schreiber,S., Franke,A., Oh,W.Y. and
            Cheon,J.H.
  TITLE     ZNF133 is associated with infliximab responsiveness in patients
            with inflammatory bowel diseases
  JOURNAL   J Gastroenterol Hepatol 34 (10), 1727-1735 (2019)
   PUBMED   30851117
  REMARK    GeneRIF: ZNF133 SNPs are associated with infliximab responsiveness
            in patients crohn's disease and ulcerative colitis.
REFERENCE   3  (bases 1 to 2654)
  AUTHORS   Miyamoto-Sato,E., Fujimori,S., Ishizaka,M., Hirai,N., Masuoka,K.,
            Saito,R., Ozawa,Y., Hino,K., Washio,T., Tomita,M., Yamashita,T.,
            Oshikubo,T., Akasaka,H., Sugiyama,J., Matsumoto,Y. and Yanagawa,H.
  TITLE     A comprehensive resource of interacting protein regions for
            refining human transcription factor networks
  JOURNAL   PLoS One 5 (2), e9289 (2010)
   PUBMED   20195357
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2654)
  AUTHORS   Lee,S.J., Lee,J.R., Hahn,H.S., Kim,Y.H., Ahn,J.H., Bae,C.D.,
            Yang,J.M. and Hahn,M.J.
  TITLE     PIAS1 interacts with the KRAB zinc finger protein, ZNF133, via zinc
            finger motifs and regulates its transcriptional activity
  JOURNAL   Exp Mol Med 39 (4), 450-457 (2007)
   PUBMED   17934332
  REMARK    GeneRIF: the transcriptional repressor activity of ZNF133 is
            regulated by both the KRAB domain and the zinc finger motifs, and
            that the repressive effect by zinc finger motifs is mediated by
            PIAS1
REFERENCE   5  (bases 1 to 2654)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   6  (bases 1 to 2654)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 2654)
  AUTHORS   Moosmann,P., Georgiev,O., Thiesen,H.J., Hagmann,M. and Schaffner,W.
  TITLE     Silencing of RNA polymerases II and III-dependent transcription by
            the KRAB protein domain of KOX1, a Kruppel-type zinc finger factor
  JOURNAL   Biol Chem 378 (7), 669-677 (1997)
   PUBMED   9278146
REFERENCE   8  (bases 1 to 2654)
  AUTHORS   Vissing,H., Meyer,W.K., Aagaard,L., Tommerup,N. and Thiesen,H.J.
  TITLE     Repression of transcriptional activity by heterologous KRAB domains
            present in zinc finger proteins
  JOURNAL   FEBS Lett 369 (2-3), 153-157 (1995)
   PUBMED   7649249
REFERENCE   9  (bases 1 to 2654)
  AUTHORS   Tommerup,N. and Vissing,H.
  TITLE     Isolation and fine mapping of 16 novel human zinc finger-encoding
            cDNAs identify putative candidate genes for developmental and
            malignant disorders
  JOURNAL   Genomics 27 (2), 259-264 (1995)
   PUBMED   7557990
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL049646.19.
            
            On Jun 2, 2019 this sequence version replaced NM_001352452.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.107343.1,
                                           SRR1803613.105789.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000425686.3/ ENSP00000406638.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AL049646.19        45048-45125
            79-156              AL049646.19        54506-54583
            157-332             AL049646.19        54810-54985
            333-503             AL049646.19        61529-61699
            504-630             AL049646.19        62202-62328
            631-726             AL049646.19        62819-62914
            727-2654            AL049646.19        71590-73517
FEATURES             Location/Qualifiers
     source          1..2654
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.23"
     gene            1..2654
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /note="zinc finger protein 133"
                     /db_xref="GeneID:7692"
                     /db_xref="HGNC:HGNC:12917"
                     /db_xref="MIM:604075"
     exon            1..78
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /inference="alignment:Splign:2.1.0"
     exon            79..156
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /inference="alignment:Splign:2.1.0"
     exon            157..332
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /inference="alignment:Splign:2.1.0"
     exon            333..503
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /inference="alignment:Splign:2.1.0"
     exon            504..630
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /inference="alignment:Splign:2.1.0"
     CDS             510..2474
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /note="isoform c is encoded by transcript variant 19; zinc
                     finger protein 133 (clone pHZ-13); zinc finger protein 150
                     (pHZ-66)"
                     /codon_start=1
                     /product="zinc finger protein 133 isoform c"
                     /protein_id="NP_001339381.2"
                     /db_xref="CCDS:CCDS63234.1"
                     /db_xref="GeneID:7692"
                     /db_xref="HGNC:HGNC:12917"
                     /db_xref="MIM:604075"
                     /translation="MAFRDVAVDFTQDEWRLLSPAQRTLYREVMLENYSNLVSLGISF
                     SKPELITQLEQGKETWREEKKCSPATCPADPEPELYLDPFCPPGFSSQKFPMQHVLCN
                     HPPWIFTCLCAEGNIQPGDPGPGDQEKQQQASEGRPWSDQAEGPEGEGAMPLFGRTKK
                     RTLGAFSRPPQRQPVSSRNGLRGVELEASPAQSGNPEETDKLLKRIEVLGFGTVNCGE
                     CGLSFSKMTNLLSHQRIHSGEKPYVCGVCEKGFSLKKSLARHQKAHSGEKPIVCRECG
                     RGFNRKSTLIIHERTHSGEKPYMCSECGRGFSQKSNLIIHQRTHSGEKPYVCRECGKG
                     FSQKSAVVRHQRTHLEEKTIVCSDCGLGFSDRSNLISHQRTHSGEKPYACKECGRCFR
                     QRTTLVNHQRTHSKEKPYVCGVCGHSFSQNSTLISHRRTHTGEKPYVCGVCGRGFSLK
                     SHLNRHQNIHSGEKPIVCKDCGRGFSQQSNLIRHQRTHSGEKPMVCGECGRGFSQKSN
                     LVAHQRTHSGERPYVCRECGRGFSHQAGLIRHKRKHSREKPYMCRQCGLGFGNKSALI
                     THKRAHSEEKPCVCRECGQGFLQKSHLTLHQMTHTGEKPYVCKTCGRGFSLKSHLSRH
                     RKTTSVHHRLPVQPDPEPCAGQPSDSLYSL"
     exon            631..726
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /inference="alignment:Splign:2.1.0"
     exon            727..2654
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2625..2630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /note="hexamer: AATAAA"
     polyA_site      2654
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /note="major polyA site"
ORIGIN      
        1 gtagtgtagt cctggcgccc cgctggagga gctccccagc tggtggctgg agcgacccct
       61 tgttctttgg tggcgctgat ctaccttctg agatatcatc cttcttcagg gagataagga
      121 aaaaaagcca cagggtcccg gagagccagg ggaatgcttc aaaagttctg ctgcctgaga
      181 gtaacgtcac agtaatggaa cgggaagatt ctggaatctg tgtccccacc tagacaacga
      241 ttatactggc aggatctatc aggtgtacct attttggaac tctggagtct agttgaaggc
      301 ctccagttcc cagggggaag gaagcatgga ggtgtgtcct ccatttggaa gtagtgctaa
      361 gaaaattaaa agaataaaac tgggcagggg catgagaata ggatgcaaag atgaattttt
      421 ggactgagtg gccaagaagc tccatggtga gcactcacag tctaaggctg gaagtttaat
      481 gaactgtttt ctacatttca caggcacaca tggcattcag ggatgtggct gtggatttca
      541 cccaggatga gtggaggctg ctgagccctg ctcaaaggac tctgtacaga gaggtgatgc
      601 tggagaacta cagcaacctg gtctcactgg gaatttcatt ttctaaacca gaactcatca
      661 cccagctgga gcaagggaaa gagacctgga gagaggaaaa aaaatgttca ccggcaacct
      721 gtccagcaga tccagagcca gagctctacc tcgatccttt ctgccctccg ggtttctcca
      781 gtcagaaatt ccccatgcag catgtgctgt gtaatcatcc cccctggatc ttcacatgct
      841 tgtgtgcaga aggtaacatc cagcctgggg atccgggccc aggggaccag gagaagcagc
      901 aacaagcctc tgaggggaga ccctggagtg atcaagcaga aggtcctgag ggagaaggtg
      961 ccatgccttt gtttggaaga accaagaaaa ggactctggg agcgttctcc aggccacccc
     1021 agaggcagcc agtcagctct cggaacggcc tcagaggggt ggagttagaa gccagcccag
     1081 ctcagtcagg gaaccctgag gaaacagaca aattgttgaa gaggatagaa gtcttaggat
     1141 ttggaacagt caactgtgga gagtgtggac tgagcttcag caagatgaca aacctgctca
     1201 gtcaccagcg gatacactca ggggagaagc cctacgtgtg tggggtatgt gagaagggct
     1261 tcagcctaaa gaagagcctc gccagacacc agaaggcaca ctcgggggag aagccaattg
     1321 tgtgcaggga gtgtggacga ggctttaacc ggaagtcaac gctaatcata cacgaacgga
     1381 cacactccgg tgagaaacct tacatgtgca gtgagtgtgg gcgaggcttc agccagaagt
     1441 caaacctcat catacaccag aggacacact caggggaaaa gccttacgtg tgccgggaat
     1501 gtggcaaagg cttcagccag aagtcagctg tcgtgagaca ccagaggaca cacttggagg
     1561 agaagaccat cgtgtgcagt gactgtggcc tgggcttcag cgacaggtca aacctcatct
     1621 cccaccagag gacgcactct ggggagaagc cctacgcctg caaggagtgt gggcgatgct
     1681 tcaggcagag gaccaccctt gtcaaccacc agaggacaca ctcaaaggag aagccctatg
     1741 tgtgcggggt gtgtgggcac agcttcagcc agaattcaac cctcatctct cacaggcgga
     1801 cacacactgg ggagaagccg tatgtttgtg gggtgtgtgg gcgaggcttt agtctcaagt
     1861 cacacctcaa cagacaccag aacatacact caggagagaa gcccattgtg tgcaaggact
     1921 gtggccgggg cttcagccag caatccaacc tcatcagaca ccagaggacg cactcaggcg
     1981 agaagcccat ggtgtgtggg gagtgcgggc gaggcttcag ccagaagtca aaccttgttg
     2041 cacaccagag gacgcactca ggggagaggc cgtatgtgtg ccgagagtgc gggcgaggct
     2101 ttagccacca ggccggtctc atcaggcaca agcggaagca ctcgagggag aagccctaca
     2161 tgtgcaggca gtgtggactg ggctttggca ataagtcagc tctaattaca cacaagcggg
     2221 ctcactcgga agagaagcct tgtgtgtgca gagagtgtgg ccaaggcttt ctccaaaagt
     2281 cacacctcac cttacatcaa atgacacata cgggggagaa gccatatgtg tgcaagacgt
     2341 gtgggcgggg cttcagcctc aagtctcacc tcagcagaca caggaagacc acgtctgtcc
     2401 accacagact gccagtgcag cccgaccctg agccgtgtgc agggcaacct tcggattcct
     2461 tatactctct ctgaaggcaa agatggggac aaggactaag agtcagaatg ttgacacttt
     2521 gatgaaatgg agtagagaaa tgcattctgt aagtggtcaa aggacatttg actgtttact
     2581 ttctccacac taagtcttct ccatgttttg tggccttcgg ttgtaataaa cttggcttct
     2641 ttatacatct gtaa
//
