LOCUS       NM_001283005            2003 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 133 (ZNF133), transcript variant
            13, mRNA.
ACCESSION   NM_001283005
VERSION     NM_001283005.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2003)
  AUTHORS   Li,L., Wang,X., Hu,K., Liu,X., Qiu,L., Bai,C., Cui,Y., Wang,B.,
            Wang,Z., Wang,H., Cheng,R., Hua,J., Hai,L., Wang,M., Liu,M.,
            Song,Z., Xiao,C. and Li,B.
  TITLE     ZNF133 is a potent suppressor in breast carcinogenesis through
            dampening L1CAM, a driver for tumor progression
  JOURNAL   Oncogene 42 (27), 2166-2182 (2023)
   PUBMED   37221223
  REMARK    GeneRIF: ZNF133 is a potent suppressor in breast carcinogenesis
            through dampening L1CAM, a driver for tumor progression.
REFERENCE   2  (bases 1 to 2003)
  AUTHORS   Jung,E.S., Choi,K.W., Kim,S.W., Hubenthal,M., Mucha,S., Park,J.,
            Park,Z., Ellinghaus,D., Schreiber,S., Franke,A., Oh,W.Y. and
            Cheon,J.H.
  TITLE     ZNF133 is associated with infliximab responsiveness in patients
            with inflammatory bowel diseases
  JOURNAL   J Gastroenterol Hepatol 34 (10), 1727-1735 (2019)
   PUBMED   30851117
  REMARK    GeneRIF: ZNF133 SNPs are associated with infliximab responsiveness
            in patients crohn's disease and ulcerative colitis.
REFERENCE   3  (bases 1 to 2003)
  AUTHORS   Miyamoto-Sato,E., Fujimori,S., Ishizaka,M., Hirai,N., Masuoka,K.,
            Saito,R., Ozawa,Y., Hino,K., Washio,T., Tomita,M., Yamashita,T.,
            Oshikubo,T., Akasaka,H., Sugiyama,J., Matsumoto,Y. and Yanagawa,H.
  TITLE     A comprehensive resource of interacting protein regions for
            refining human transcription factor networks
  JOURNAL   PLoS One 5 (2), e9289 (2010)
   PUBMED   20195357
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2003)
  AUTHORS   Lee,S.J., Lee,J.R., Hahn,H.S., Kim,Y.H., Ahn,J.H., Bae,C.D.,
            Yang,J.M. and Hahn,M.J.
  TITLE     PIAS1 interacts with the KRAB zinc finger protein, ZNF133, via zinc
            finger motifs and regulates its transcriptional activity
  JOURNAL   Exp Mol Med 39 (4), 450-457 (2007)
   PUBMED   17934332
  REMARK    GeneRIF: the transcriptional repressor activity of ZNF133 is
            regulated by both the KRAB domain and the zinc finger motifs, and
            that the repressive effect by zinc finger motifs is mediated by
            PIAS1
REFERENCE   5  (bases 1 to 2003)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   6  (bases 1 to 2003)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 2003)
  AUTHORS   Moosmann,P., Georgiev,O., Thiesen,H.J., Hagmann,M. and Schaffner,W.
  TITLE     Silencing of RNA polymerases II and III-dependent transcription by
            the KRAB protein domain of KOX1, a Kruppel-type zinc finger factor
  JOURNAL   Biol Chem 378 (7), 669-677 (1997)
   PUBMED   9278146
REFERENCE   8  (bases 1 to 2003)
  AUTHORS   Vissing,H., Meyer,W.K., Aagaard,L., Tommerup,N. and Thiesen,H.J.
  TITLE     Repression of transcriptional activity by heterologous KRAB domains
            present in zinc finger proteins
  JOURNAL   FEBS Lett 369 (2-3), 153-157 (1995)
   PUBMED   7649249
REFERENCE   9  (bases 1 to 2003)
  AUTHORS   Tommerup,N. and Vissing,H.
  TITLE     Isolation and fine mapping of 16 novel human zinc finger-encoding
            cDNAs identify putative candidate genes for developmental and
            malignant disorders
  JOURNAL   Genomics 27 (2), 259-264 (1995)
   PUBMED   7557990
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL049646.19.
            
            On Sep 30, 2020 this sequence version replaced NM_001283005.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK316386.1, SRR3476690.1175063.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AL049646.19        45048-45125
            79-2003             AL049646.19        71593-73517
FEATURES             Location/Qualifiers
     source          1..2003
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.23"
     gene            1..2003
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /note="zinc finger protein 133"
                     /db_xref="GeneID:7692"
                     /db_xref="HGNC:HGNC:12917"
                     /db_xref="MIM:604075"
     exon            1..78
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /inference="alignment:Splign:2.1.0"
     exon            79..2003
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1823
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /note="isoform i is encoded by transcript variant 13; zinc
                     finger protein 133 (clone pHZ-13); zinc finger protein 150
                     (pHZ-66)"
                     /codon_start=1
                     /product="zinc finger protein 133 isoform i"
                     /protein_id="NP_001269934.2"
                     /db_xref="CCDS:CCDS74703.2"
                     /db_xref="GeneID:7692"
                     /db_xref="HGNC:HGNC:12917"
                     /db_xref="MIM:604075"
                     /translation="MQHVLCNHPPWIFTCLCAEGNIQPGDPGPGDQEKQQQASEGRPW
                     SDQAEGPEGEGAMPLFGRTKKRTLGAFSRPPQRQPVSSRNGLRGVELEASPAQSGNPE
                     ETDKLLKRIEVLGFGTVNCGECGLSFSKMTNLLSHQRIHSGEKPYVCGVCEKGFSLKK
                     SLARHQKAHSGEKPIVCRECGRGFNRKSTLIIHERTHSGEKPYMCSECGRGFSQKSNL
                     IIHQRTHSGEKPYVCRECGKGFSQKSAVVRHQRTHLEEKTIVCSDCGLGFSDRSNLIS
                     HQRTHSGEKPYACKECGRCFRQRTTLVNHQRTHSKEKPYVCGVCGHSFSQNSTLISHR
                     RTHTGEKPYVCGVCGRGFSLKSHLNRHQNIHSGEKPIVCKDCGRGFSQQSNLIRHQRT
                     HSGEKPMVCGECGRGFSQKSNLVAHQRTHSGERPYVCRECGRGFSHQAGLIRHKRKHS
                     REKPYMCRQCGLGFGNKSALITHKRAHSEEKPCVCRECGQGFLQKSHLTLHQMTHTGE
                     KPYVCKTCGRGFSLKSHLSRHRKTTSVHHRLPVQPDPEPCAGQPSDSLYSL"
     regulatory      1974..1979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /note="hexamer: AATAAA"
     polyA_site      2003
                     /gene="ZNF133"
                     /gene_synonym="pHZ-13; pHZ-66; ZNF150"
                     /note="major polyA site"
ORIGIN      
        1 gtagtgtagt cctggcgccc cgctggagga gctccccagc tggtggctgg agcgacccct
       61 tgttctttgg tggcgctgat ccagagccag agctctacct cgatcctttc tgccctccgg
      121 gtttctccag tcagaaattc cccatgcagc atgtgctgtg taatcatccc ccctggatct
      181 tcacatgctt gtgtgcagaa ggtaacatcc agcctgggga tccgggccca ggggaccagg
      241 agaagcagca acaagcctct gaggggagac cctggagtga tcaagcagaa ggtcctgagg
      301 gagaaggtgc catgcctttg tttggaagaa ccaagaaaag gactctggga gcgttctcca
      361 ggccacccca gaggcagcca gtcagctctc ggaacggcct cagaggggtg gagttagaag
      421 ccagcccagc tcagtcaggg aaccctgagg aaacagacaa attgttgaag aggatagaag
      481 tcttaggatt tggaacagtc aactgtggag agtgtggact gagcttcagc aagatgacaa
      541 acctgctcag tcaccagcgg atacactcag gggagaagcc ctacgtgtgt ggggtatgtg
      601 agaagggctt cagcctaaag aagagcctcg ccagacacca gaaggcacac tcgggggaga
      661 agccaattgt gtgcagggag tgtggacgag gctttaaccg gaagtcaacg ctaatcatac
      721 acgaacggac acactccggt gagaaacctt acatgtgcag tgagtgtggg cgaggcttca
      781 gccagaagtc aaacctcatc atacaccaga ggacacactc aggggaaaag ccttacgtgt
      841 gccgggaatg tggcaaaggc ttcagccaga agtcagctgt cgtgagacac cagaggacac
      901 acttggagga gaagaccatc gtgtgcagtg actgtggcct gggcttcagc gacaggtcaa
      961 acctcatctc ccaccagagg acgcactctg gggagaagcc ctacgcctgc aaggagtgtg
     1021 ggcgatgctt caggcagagg accacccttg tcaaccacca gaggacacac tcaaaggaga
     1081 agccctatgt gtgcggggtg tgtgggcaca gcttcagcca gaattcaacc ctcatctctc
     1141 acaggcggac acacactggg gagaagccgt atgtttgtgg ggtgtgtggg cgaggcttta
     1201 gtctcaagtc acacctcaac agacaccaga acatacactc aggagagaag cccattgtgt
     1261 gcaaggactg tggccggggc ttcagccagc aatccaacct catcagacac cagaggacgc
     1321 actcaggcga gaagcccatg gtgtgtgggg agtgcgggcg aggcttcagc cagaagtcaa
     1381 accttgttgc acaccagagg acgcactcag gggagaggcc gtatgtgtgc cgagagtgcg
     1441 ggcgaggctt tagccaccag gccggtctca tcaggcacaa gcggaagcac tcgagggaga
     1501 agccctacat gtgcaggcag tgtggactgg gctttggcaa taagtcagct ctaattacac
     1561 acaagcgggc tcactcggaa gagaagcctt gtgtgtgcag agagtgtggc caaggctttc
     1621 tccaaaagtc acacctcacc ttacatcaaa tgacacatac gggggagaag ccatatgtgt
     1681 gcaagacgtg tgggcggggc ttcagcctca agtctcacct cagcagacac aggaagacca
     1741 cgtctgtcca ccacagactg ccagtgcagc ccgaccctga gccgtgtgca gggcaacctt
     1801 cggattcctt atactctctc tgaaggcaaa gatggggaca aggactaaga gtcagaatgt
     1861 tgacactttg atgaaatgga gtagagaaat gcattctgta agtggtcaaa ggacatttga
     1921 ctgtttactt tctccacact aagtcttctc catgttttgt ggccttcggt tgtaataaac
     1981 ttggcttctt tatacatctg taa
//
