LOCUS       NM_003433               2962 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 132 (ZNF132), mRNA.
ACCESSION   NM_003433
VERSION     NM_003433.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2962)
  AUTHORS   Liu,Z., Liu,J., Liu,R., Xue,M., Zhang,W., Zhao,X., Zhu,J. and
            Xia,P.
  TITLE     Downregulated ZNF132 predicts unfavorable outcomes in breast Cancer
            via Hypermethylation modification
  JOURNAL   BMC Cancer 21 (1), 367 (2021)
   PUBMED   33827486
  REMARK    GeneRIF: Downregulated ZNF132 predicts unfavorable outcomes in
            breast Cancer via Hypermethylation modification.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2962)
  AUTHORS   Jiang,D., He,Z., Wang,C., Zhou,Y., Li,F., Pu,W., Zhang,X., Feng,X.,
            Zhang,M., Yecheng,X., Xu,Y., Jin,L., Guo,S., Wang,J. and Wang,M.
  TITLE     Epigenetic silencing of ZNF132 mediated by methylation-sensitive
            Sp1 binding promotes cancer progression in esophageal squamous cell
            carcinoma
  JOURNAL   Cell Death Dis 10 (1), 1 (2018)
   PUBMED   30578410
  REMARK    GeneRIF: results suggest that ZNF132 plays an important role in the
            development of esophageal squamous cell carcinoma as a tumor
            suppressor gene and support the underlying mechanism caused by the
            DNA hypermethylation-mediated Sp1-binding decay and gene silencing.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2962)
  AUTHORS   Abildgaard,M.O., Borre,M., Mortensen,M.M., Ulhoi,B.P., Torring,N.,
            Wild,P., Kristensen,H., Mansilla,F., Ottosen,P.D., Dyrskjot,L.,
            Orntoft,T.F. and Sorensen,K.D.
  TITLE     Downregulation of zinc finger protein 132 in prostate cancer is
            associated with aberrant promoter hypermethylation and poor
            prognosis
  JOURNAL   Int J Cancer 130 (4), 885-895 (2012)
   PUBMED   21445975
  REMARK    GeneRIF: downregulation of ZNF132 is associated with aggressive
            prostate cancer.
REFERENCE   4  (bases 1 to 2962)
  AUTHORS   Luke,M.M., O'Meara,E.S., Rowland,C.M., Shiffman,D., Bare,L.A.,
            Arellano,A.R., Longstreth,W.T. Jr., Lumley,T., Rice,K., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Gene variants associated with ischemic stroke: the cardiovascular
            health study
  JOURNAL   Stroke 40 (2), 363-368 (2009)
   PUBMED   19023099
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 2962)
  AUTHORS   Shiffman,D., O'Meara,E.S., Bare,L.A., Rowland,C.M., Louie,J.Z.,
            Arellano,A.R., Lumley,T., Rice,K., Iakoubova,O., Luke,M.M.,
            Young,B.A., Malloy,M.J., Kane,J.P., Ellis,S.G., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Association of gene variants with incident myocardial infarction in
            the Cardiovascular Health Study
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (1), 173-179 (2008)
   PUBMED   17975119
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 2962)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 2962)
  AUTHORS   Tommerup,N. and Vissing,H.
  TITLE     Isolation and fine mapping of 16 novel human zinc finger-encoding
            cDNAs identify putative candidate genes for developmental and
            malignant disorders
  JOURNAL   Genomics 27 (2), 259-264 (1995)
   PUBMED   7557990
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK057460.1, BC109107.1, U09411.1 and BQ774411.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003433.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.65979.1, AK057460.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254166.4/ ENSP00000254166.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AK057460.1         70-206
            138-1180            BC109107.1         1-1043
            1181-1360           U09411.1           996-1175
            1361-2901           BC109107.1         1224-2764
            2902-2962           BQ774411.1         18-78               c
FEATURES             Location/Qualifiers
     source          1..2962
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..2962
                     /gene="ZNF132"
                     /gene_synonym="pHZ-12"
                     /note="zinc finger protein 132"
                     /db_xref="GeneID:7691"
                     /db_xref="HGNC:HGNC:12916"
                     /db_xref="MIM:604074"
     exon            1..395
                     /gene="ZNF132"
                     /gene_synonym="pHZ-12"
                     /inference="alignment:Splign:2.1.0"
     CDS             333..2453
                     /gene="ZNF132"
                     /gene_synonym="pHZ-12"
                     /codon_start=1
                     /product="zinc finger protein 132"
                     /protein_id="NP_003424.3"
                     /db_xref="CCDS:CCDS12980.1"
                     /db_xref="GeneID:7691"
                     /db_xref="HGNC:HGNC:12916"
                     /db_xref="MIM:604074"
                     /translation="MALPSPQVLMGLPALLMGPAQHTSWPCGSAVPTLKSMVTFEDVA
                     VYFSQEEWELLDAAQRHLYHSVMLENLELVTSLGSWHGVEGEGAHPKQNVSVEVLQVR
                     IPNADPSTKKANSCDMCGPFLKDILHLAEHQGTQSEEKPYTCGACGRDFWLNANLHQH
                     QKEHSGGKPFRWYKDRDALMKSSKVHLSENPFTCREGGKVILGSCDLLQLQAVDSGQK
                     PYSNLGQLPEVCTTQKLFECSNCGKAFLKSSTLPNHLRTHSEEIPFTCPTGGNFLEEK
                     SILGNKKFHTGEIPHVCKECGKAFSHSSKLRKHQKFHTEVKYYECIACGKTFNHKLTF
                     VHHQRIHSGERPYECDECGKAFSNRSHLIRHEKVHTGERPFECLKCGRAFSQSSNFLR
                     HQKVHTQVRPYECSQCGKSFSRSSALIQHWRVHTGERPYECSECGRAFNNNSNLAQHQ
                     KVHTGERPFECSECGRDFSQSSHLLRHQKVHTGERPFECCDCGKAFSNSSTLIQHQKV
                     HTGQRPYECSECRKSFSRSSSLIQHWRIHTGEKPYECSECGKAFAHSSTLIEHWRVHT
                     KERPYECNECGKFFSQNSILIKHQKVHTGEKPYKCSECGKFFSRKSSLICHWRVHTGE
                     RPYECSECGRAFSSNSHLVRHQRVHTQERPYECIQCGKAFSERSTLVRHQKVHTRERT
                     YECSQCGKLFSHLCNLAQHKKIHT"
     exon            396..564
                     /gene="ZNF132"
                     /gene_synonym="pHZ-12"
                     /inference="alignment:Splign:2.1.0"
     exon            565..2962
                     /gene="ZNF132"
                     /gene_synonym="pHZ-12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2938..2943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF132"
                     /gene_synonym="pHZ-12"
                     /note="hexamer: AATAAA"
     polyA_site      2962
                     /gene="ZNF132"
                     /gene_synonym="pHZ-12"
                     /note="major polyA site"
ORIGIN      
        1 attgcggtcc tcattttgct gctggtgggt tgggctacag caggcctctg gagccacacc
       61 agggcacggg agtgggtgca gggaccgtca ccgcgccttc acacgcacca tagtgcccgg
      121 ctaattactc tgcttttatg agccaaggtg ttcccgaaag tggagccagc gccacgcgtc
      181 tccagggtct ccatacccag ccttcgtccc tgcggtgccc agaggccttg cgcgcatttt
      241 gcatttggga agacaggtcc tgagtgcgac cgtcacccag cggaagtgtg agggttcggc
      301 ccagcggcag ggctagccct gggcctcctg ttatggccct gcccagccca caggttctaa
      361 tggggttgcc agcgttgctg atgggcccgg cgcagcatac ttcttggccc tgtggctcag
      421 ctgtccccac attgaagagc atggtaacct ttgaagatgt ggctgtatac ttctcccaag
      481 aggagtggga gctccttgat gcagcccaga ggcacctgta ccacagtgtg atgctggaaa
      541 accttgagct tgtgacctca cttggttctt ggcatggagt agagggtgag ggggcccatc
      601 ccaagcagaa tgtttctgta gaagtgttac aggtcaggat ccctaatgca gatccttcca
      661 ccaagaaagc taactcctgt gacatgtgtg ggccattctt gaaagacatt ttgcacctgg
      721 ctgagcatca gggaacacag tctgaggaga aaccctacac atgtggagca tgtgggagag
      781 acttttggtt gaatgcaaac cttcaccagc accagaagga gcacagtgga gggaagccct
      841 ttagatggta caaggacagg gacgcactta tgaagagctc taaagtccac ctgtcagaga
      901 accccttcac ttgcagggaa ggtgggaagg tcatcctggg cagctgtgac ctcctccagc
      961 ttcaagctgt tgacagtggg cagaagccat attccaatct tgggcagctt ccagaagtct
     1021 gtaccacaca gaaactcttc gagtgcagca actgtggaaa agccttcctg aagagctcca
     1081 ctctccccaa ccatctgaga actcactctg aagagatacc atttacatgc ccaacaggtg
     1141 gaaatttctt agaggagaaa tcaatccttg gtaataaaaa gtttcacact ggggaaatac
     1201 cccatgtgtg taaggagtgt gggaaggcct ttagtcactc atctaagctg aggaagcacc
     1261 agaaatttca cactgaagta aaatattatg agtgcattgc atgtgggaaa accttcaacc
     1321 acaaactcac atttgttcat catcagagaa ttcactcagg agaaagacct tatgagtgtg
     1381 atgaatgtgg gaaagccttc agtaacagat cacacctcat tcggcatgag aaagttcaca
     1441 ctggagaaag gccttttgag tgcctgaaat gtggaagagc cttcagccaa agctccaatt
     1501 tccttcggca tcagaaagtt cacacacagg taagacctta tgagtgcagt caatgtggta
     1561 aatccttcag ccgaagctct gctctcattc agcactggag agttcacact ggagaaagac
     1621 cgtatgaatg cagtgaatgt ggaagagctt ttaacaataa ctccaacctt gctcagcacc
     1681 agaaagttca caccggagaa cggccttttg agtgcagtga atgtggaaga gacttcagcc
     1741 aaagctccca tctccttcga catcagaaag ttcacactgg agaacggcct tttgaatgct
     1801 gtgattgtgg taaagccttc agtaatagct ccaccctcat ccagcaccag aaagtacata
     1861 ctgggcaaag gccttatgag tgcagcgaat gtaggaaatc cttcagccgc agctccagcc
     1921 tgattcagca ctggagaatt cacactggag aaaagcctta cgagtgtagt gagtgtggga
     1981 aagcctttgc tcacagctcc actctcattg aacactggag agttcacaca aaagaaaggc
     2041 cttatgagtg caatgaatgt gggaaattct ttagccaaaa ctccattctc attaagcatc
     2101 agaaagttca tactggagaa aagccttata aatgcagtga atgtgggaaa ttctttagcc
     2161 gaaaatccag ccttatttgt cactggagag ttcacactgg agaaaggcct tacgaatgca
     2221 gtgaatgtgg gagagccttt agcagtaact cccacctggt tcgtcatcag agagttcaca
     2281 cacaagaaag gccctatgag tgcatccagt gtggaaaagc ctttagtgaa agatctacac
     2341 ttgttcggca ccagaaagtt cacaccagag aaaggactta tgagtgtagc cagtgtggga
     2401 aactcttcag ccatctttgt aaccttgcac agcataaaaa gattcatacc tgagtggagc
     2461 cttatggaag tggtctttgt gagaaaatct tcagccaagt caaacttcat gcagcagaat
     2521 ccccatacca gaaaaattac ctacatgtac tgctaatgtg gaaaagcctt cagaagctac
     2581 tctgtttctg accagcccag gaacctttgc agggccatct cacccatgca gcataaggca
     2641 gaagccatag tcactttcca tcttgcctgg atccaaaaat ttgcagcagt cctgtcctca
     2701 tgcatgggga aaacagtacc ctgagccttc cttcctgtgt tctctaggga ttcaggactg
     2761 tgctcagctg aaccgatgct ggttgagggg ccttgaggga aatctaattt gagctcagga
     2821 agatgcacat tccttgtgga tgtggtcaag tctgtgttta acccctaaga tgtgtccatt
     2881 gaggccacaa atcaccctcc actggaatca cctaccttgc ctgcactaac tggtgataat
     2941 aaagacctta ttgatcaggt ca
//
