LOCUS       NM_001330707            3286 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 131 (ZNF131), transcript variant
            6, mRNA.
ACCESSION   NM_001330707 XM_005248359
VERSION     NM_001330707.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3286)
  AUTHORS   Yin,G., Jia,S., Zhang,Y., Xian,Y., Guo,Y. and Liu,Q.
  TITLE     YAP1-activated ZNF131 promotes hepatocellular carcinoma cell
            proliferation through transcriptional regulation of PAIP1
  JOURNAL   Arch Biochem Biophys 754, 109921 (2024)
   PUBMED   38341068
  REMARK    GeneRIF: YAP1-activated ZNF131 promotes hepatocellular carcinoma
            cell proliferation through transcriptional regulation of PAIP1.
REFERENCE   2  (bases 1 to 3286)
  AUTHORS   Shen,X., Zhu,X., Hu,P., Ji,T., Qin,Y. and Zhu,J.
  TITLE     Knockdown circZNF131 Inhibits Cell Progression and Glycolysis in
            Gastric Cancer Through miR-186-5p/PFKFB2 Axis
  JOURNAL   Biochem Genet 60 (5), 1567-1584 (2022)
   PUBMED   35059934
  REMARK    GeneRIF: Knockdown circZNF131 Inhibits Cell Progression and
            Glycolysis in Gastric Cancer Through miR-186-5p/PFKFB2 Axis.
REFERENCE   3  (bases 1 to 3286)
  AUTHORS   Garipler,G., Lu,C., Morrissey,A., Lopez-Zepeda,L.S., Pei,Y.,
            Vidal,S.E., Zen Petisco Fiore,A.P., Aydin,B., Stadtfeld,M.,
            Ohler,U., Mahony,S., Sanjana,N.E. and Mazzoni,E.O.
  TITLE     The BTB transcription factors ZBTB11 and ZFP131 maintain
            pluripotency by repressing pro-differentiation genes
  JOURNAL   Cell Rep 38 (11), 110524 (2022)
   PUBMED   35294876
  REMARK    GeneRIF: The BTB transcription factors ZBTB11 and ZFP131 maintain
            pluripotency by repressing pro-differentiation genes.
REFERENCE   4  (bases 1 to 3286)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3286)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 3286)
  AUTHORS   Oh,Y. and Chung,K.C.
  TITLE     Small ubiquitin-like modifier (SUMO) modification of zinc finger
            protein 131 potentiates its negative effect on estrogen signaling
  JOURNAL   J Biol Chem 287 (21), 17517-17529 (2012)
   PUBMED   22467880
  REMARK    GeneRIF: SUMOylation is a novel regulator of ZNF131 action in
            estrogen signaling and breast cancer cell proliferation.
REFERENCE   7  (bases 1 to 3286)
  AUTHORS   Han,X., Guo,J., Deng,W., Zhang,C., Du,P., Shi,T. and Ma,D.
  TITLE     High-throughput cell-based screening reveals a role for ZNF131 as a
            repressor of ERalpha signaling
  JOURNAL   BMC Genomics 9, 476 (2008)
   PUBMED   18847501
  REMARK    GeneRIF: Interaction between ZNF131 and ERalpha interrupts or
            prevents ERalpha binding to the estrogen response element. ZNF131
            also suppresses the expression of TFF1.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3286)
  AUTHORS   Donaldson,N.S., Daniel,Y., Kelly,K.F., Graham,M. and Daniel,J.M.
  TITLE     Nuclear trafficking of the POZ-ZF protein Znf131
  JOURNAL   Biochim Biophys Acta 1773 (4), 546-555 (2007)
   PUBMED   17306895
  REMARK    GeneRIF: The mechanism of Znf131 nuclear localization, is reported.
REFERENCE   9  (bases 1 to 3286)
  AUTHORS   Trappe,R., Buddenberg,P., Uedelhoven,J., Glaser,B., Buck,A.,
            Engel,W. and Burfeind,P.
  TITLE     The murine BTB/POZ zinc finger gene Znf131: predominant expression
            in the developing central nervous system, in adult brain, testis,
            and thymus
  JOURNAL   Biochem Biophys Res Commun 296 (2), 319-327 (2002)
   PUBMED   12163020
REFERENCE   10 (bases 1 to 3286)
  AUTHORS   Tommerup,N. and Vissing,H.
  TITLE     Isolation and fine mapping of 16 novel human zinc finger-encoding
            cDNAs identify putative candidate genes for developmental and
            malignant disorders
  JOURNAL   Genomics 27 (2), 259-264 (1995)
   PUBMED   7557990
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC106800.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001330707.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.74747.1,
                                           SRR1803617.242141.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682664.1/ ENSP00000507111.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               AC106800.2         153333-153542       c
            211-349             AC106800.2         152279-152417       c
            350-451             AC106800.2         151146-151247       c
            452-596             AC106800.2         135147-135291       c
            597-1279            AC106800.2         112525-113207       c
            1280-1410           AC106800.2         101008-101138       c
            1411-3286           AC106800.2         98134-100009        c
FEATURES             Location/Qualifiers
     source          1..3286
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p12"
     gene            1..3286
                     /gene="ZNF131"
                     /gene_synonym="pHZ-10; ZBTB35"
                     /note="zinc finger protein 131"
                     /db_xref="GeneID:7690"
                     /db_xref="HGNC:HGNC:12915"
                     /db_xref="MIM:604073"
     exon            1..210
                     /gene="ZNF131"
                     /gene_synonym="pHZ-10; ZBTB35"
                     /inference="alignment:Splign:2.1.0"
     exon            211..349
                     /gene="ZNF131"
                     /gene_synonym="pHZ-10; ZBTB35"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..2097
                     /gene="ZNF131"
                     /gene_synonym="pHZ-10; ZBTB35"
                     /note="isoform 1 is encoded by transcript variant 6; zinc
                     finger protein 131 (clone pHZ-10); zinc finger and BTB
                     domain containing 35"
                     /codon_start=1
                     /product="zinc finger protein 131 isoform 1"
                     /protein_id="NP_001317636.1"
                     /db_xref="CCDS:CCDS78005.1"
                     /db_xref="GeneID:7690"
                     /db_xref="HGNC:HGNC:12915"
                     /db_xref="MIM:604073"
                     /translation="MEAEETMECLQEFPEHHKMILDRLNEQREQDRFTDITLIVDGHH
                     FKAHKAVLAACSKFFYKFFQEFTQEPLVEIEGVSKMAFRHLIEFTYTAKLMIQGEEEA
                     NDVWKAAEFLQMLEAIKALEVRNKENSAPLEENTTGKNEAKKRKIAETSNVITESLPS
                     AESEPVEIEVEIAEGTIEVEDEGIETLEEVASAKQSVKYIQSTGSSDDSALALLADIT
                     SKYRQGDRKGQIKEDGCPSDPTSKQVEGIEIVELQLSHVKDLFHCEKCNRSFKLFYHF
                     KEHMKSHSTESFKCEICNKRYLRESAWKQHLNCYHLEEGGVSKKQRTGKKIHVCQYCE
                     KQFDHFGHFKEHLRKHTGEKPFECPNCHERFARNSTLKCHLTACQTGVGAKKGRKKLY
                     ECQVCNSVFNSWDQFKDHLVIHTGDKPNHCTLCDLWFMQGNELRRHLSDAHNISERLV
                     TEEVLSVETRVQTEPVTSMTIIEQVGKVHVLPLLQVQVDSAQVTVEQVHPDLLQDSQV
                     HDSHMSELPEQVQVSYLEVGRIQTEEGTEVHVEELHVERVNQMPVEVQTELLEADLDH
                     VTPEIMNQEERESSQADAAEAAREDHEDAEDLETKPTVDSEAEKAENEDRTALPVLE"
     exon            350..451
                     /gene="ZNF131"
                     /gene_synonym="pHZ-10; ZBTB35"
                     /inference="alignment:Splign:2.1.0"
     exon            452..596
                     /gene="ZNF131"
                     /gene_synonym="pHZ-10; ZBTB35"
                     /inference="alignment:Splign:2.1.0"
     exon            597..1279
                     /gene="ZNF131"
                     /gene_synonym="pHZ-10; ZBTB35"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1410
                     /gene="ZNF131"
                     /gene_synonym="pHZ-10; ZBTB35"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..3286
                     /gene="ZNF131"
                     /gene_synonym="pHZ-10; ZBTB35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3190..3195
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF131"
                     /gene_synonym="pHZ-10; ZBTB35"
                     /note="hexamer: AATAAA"
     polyA_site      3211
                     /gene="ZNF131"
                     /gene_synonym="pHZ-10; ZBTB35"
                     /note="major polyA site"
     regulatory      3268..3273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF131"
                     /gene_synonym="pHZ-10; ZBTB35"
                     /note="hexamer: AGTAAA"
     polyA_site      3286
                     /gene="ZNF131"
                     /gene_synonym="pHZ-10; ZBTB35"
ORIGIN      
        1 ggggccgcgg ccgcccgggt gcccaaccga acgcacgtgc gccagcgggg cccgagcaga
       61 aggggagccc cggctctcac gaagaaaatg gagggcgacc cacgggttag gggtcaggaa
      121 aggcgtgggg cgcattatgc cctgggaggg gaaagcacgg aacaagaggc tctgagggac
      181 ggagaggaag gagggcgacc cacgagctag agcagcccga cggccatgga ggctgaagag
      241 acgatggaat gccttcagga gttccctgaa catcataaaa tgatcctcga ccgattgaat
      301 gaacagcgag agcaggaccg gtttactgac atcaccctaa ttgtcgacgg acaccatttt
      361 aaggctcaca aggctgtttt ggctgcttgt agtaagttct tctacaaatt ctttcaggag
      421 tttacccaag aaccattggt ggagatagaa ggtgttagta aaatggcctt tcgccattta
      481 attgagttca catatacagc aaaattaatg atacaaggag aagaagaagc caatgatgta
      541 tggaaagcag cagagtttct acaaatgcta gaagctatca aagcccttga agtcaggaac
      601 aaagaaaact cagctccctt agaggaaaat accacaggaa aaaatgaggc caaaaaaagg
      661 aagattgcag aaacttcaaa tgttatcact gagtcattgc catctgcaga atcagaacct
      721 gttgaaattg aggtagagat tgccgaaggc accattgaag tggaagatga aggcatcgaa
      781 acattagagg aagtggcttc tgccaagcag tccgtaaagt acatacagag cacaggttcc
      841 tctgatgatt ctgctctagc actgttggca gatattacca gcaagtaccg tcaaggtgac
      901 agaaaagggc agattaaaga agatggctgt ccatctgacc ccacgagcaa acaggtagaa
      961 ggtattgaaa ttgtggaact tcagctgtca catgtgaagg acttgttcca ttgtgagaaa
     1021 tgtaaccgtt catttaaatt gttttaccat tttaaggagc acatgaaatc acactccact
     1081 gagagtttca agtgtgaaat atgcaataaa cgatatcttc gagagagcgc atggaaacag
     1141 cacctaaatt gttaccacct tgaagaaggt ggagtcagta agaagcaaag aactgggaaa
     1201 aaaattcatg tatgtcagta ctgtgagaaa cagtttgacc attttggaca ttttaaagaa
     1261 catcttcgaa aacatacagg tgaaaaacct tttgaatgtc caaattgtca tgaacgattt
     1321 gctagaaata gcactctgaa atgtcacctc actgcatgcc aaactggagt aggggcaaaa
     1381 aaaggaagga agaagctcta cgaatgccag gtctgcaaca gtgtgtttaa cagctgggac
     1441 cagttcaaag atcacttggt aatacacact ggagataaac ccaaccattg tactttatgt
     1501 gatttgtggt ttatgcaagg aaatgaatta aggaggcatc tcagtgatgc tcacaatatt
     1561 tcagagcgtc tagtaacgga agaagttctt tcagtagaaa cacgtgtgca aactgaacct
     1621 gtaacatcaa tgactattat agaacaagtt gggaaggtgc atgtgctacc attgcttcag
     1681 gttcaggtgg attcagcaca agtgactgtg gaacaagtcc atccagatct gctccaggac
     1741 agccaggtgc acgattcaca catgagtgag cttccagagc aggtccaagt gagttatcta
     1801 gaagtgggcc gaattcagac tgaagaaggt actgaagtac atgtagagga gctgcatgtt
     1861 gaacgggtca atcaaatgcc agtggaagta caaactgaac ttctagaagc agatttggac
     1921 cacgtgaccc cagaaatcat gaaccaagag gagagagagt ctagccaagc agatgctgct
     1981 gaggctgcca gggaagatca cgaagatgct gaggatttag agaccaagcc aacagtggat
     2041 tctgaagcag aaaaggcaga gaatgaggac agaacagctc tgccagtttt agaatgaaat
     2101 tacacatgaa tatattttta aatttacttg ttgggttttt gaactgatta tgggcagttt
     2161 gactgtcctt aattaagcct aacagacaag tggaccaaag ttaagctgtt tcctgttgtg
     2221 ctgaactgtt gtccgttgaa acacattgat tcccctcccc ctacttattg ccacagagga
     2281 gggatctttt ccataactga aggggagttt tgagaagtat atttctggaa acttaaatgg
     2341 attatattct tattatatag ttgggtacga atgtatctat tttcattgtg gtaaaagttc
     2401 ttccttttct ctttcccagg tcatgttctt cctcaaattt tttccatatt gtaaaatcaa
     2461 acttaaatca ttagaataca agtttatgta ttctaatgca tgttagaaaa ttgaataata
     2521 taggaaacac aaggctgcat gatgaaaagt gcattgttac tgtgcagtta aattttggct
     2581 tctggctttc tttagtttga acaaacgttc ttgtctaccc cagtagtcac agatgccatc
     2641 tttgcaacag aaagagtggt ggtggcaaaa tttctagaat gttaaaaaaa aaaaaaaatc
     2701 cacacccatg tgccttctca aaaccaactg aacttctata aagcatctct ggttctttca
     2761 aagtttgtgt tgtaaggagc aatgtagatg atgctataat actttatatt tttggttata
     2821 atgacaacca ccagttcttt ttcacttaag ttaggttgag aaattttatt taatggccac
     2881 tgaagggcca ttttcaattg ggaaaattta tttacatctg tggtaaactt tattttgatg
     2941 aaaagttgca ctagtatttt accaccagat gagaaaaaga tgagcagcat ttaaaaatta
     3001 atgtatttaa aataaagtac agagaaagac atgtatataa ttatcaggct ttgttttgaa
     3061 tggaatcttt tcccccaatt cttaatgtaa agatcttgtg ctataacttt taaagccata
     3121 caaataagag tgctaaactg tggacttaaa agtaggtgtg taaatatttt taatcagtat
     3181 tacttggaaa ataaaatata acaaacccat agaccaatat gctatttttt ttacctgtta
     3241 aatattggga gttctttaca ttttttaagt aaactttaaa attatg
//
